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1. 发明授权

US11615951B2 Pulsatile flow atmospheric real time ionization 有权
公开(公告)号：US11615951B2
公开(公告)日：2023-03-28
申请号：US17708736
申请日：2022-03-30
申请人： IonSense, Inc.
发明人： Scott Oro , Brian Musselman
IPC分类号： H01J49/16 , H01J49/14 , H01J49/42
摘要： This disclosure presents inventions for ionization, for example, for use in mass spectrometer devices and methods. In an embodiment, a device is provided for introduction of pulses of a first carrier gas into an ionization chamber and introduction of a second carrier gas into the ionization chamber. Electrodes in the chamber ionize the carrier gas and direct the ionized gas toward a sample for analysis. The second carrier gas can either assist in washing out the first carrier gas or may become ionized along with the first carrier gas to improve ionization of an analyte. In an embodiment, a method for producing ionized carrier gasses is provided.

2. 发明申请

US20220013347A1 PULSATILE FLOW ATMOSPHERIC REAL TIME IONIZATION 有权
公开(公告)号：US20220013347A1
公开(公告)日：2022-01-13
申请号：US17266246
申请日：2020-10-26
申请人： IonSense Inc..
发明人： Scott Oro , Brian D Musselman
IPC分类号： H01J49/16 , H01J49/14 , H01J49/42
摘要： In an embodiment of the present ambient ionization experiment, the abundance of background chemicals relative to ions of interest is decreased by pulsing the carrier gas used to generate the excited species directed at the sample. The excited species are stepwise directed at the sample reducing the overall abundance of background chemicals introduced into the ionizing region. In an embodiment of the present ambient ionization experiment, the combination of stepping the sample in front of the excited species and pulsing the carrier gas used to generate the excited species increases the sensitivity of detection.

3. 发明申请

US20210327699A1 APPARATUS AND METHOD FOR THERMAL ASSISTED DESORPTION IONIZATION SYSTEMS 有权
公开(公告)号：US20210327699A1
公开(公告)日：2021-10-21
申请号：US17356753
申请日：2021-06-24
申请人： IONSENSE INC.
发明人： Jordan Krechmer , Brian D. Musselman
IPC分类号： H01J49/04 , H01J49/14 , G01N27/622 , G01N27/64 , H01J49/00 , H01J27/26 , H01J49/12 , G01N27/626 , H01J49/10 , H01J49/24
摘要： The present invention is directed to a method and device to desorb an analyte using heat to allow desorption of the analyte molecules, where the desorbed analyte molecules are ionized with ambient temperature ionizing species. In various embodiments of the invention a current is passed through a mesh upon which the analyte molecules are present. The current heats the mesh and results in desorption of the analyte molecules which then interact with gas phase metastable neutral molecules or atoms to form analyte ions characteristic of the analyte molecules.

4. 发明授权

US09960029B2 Apparatus and method for thermal assisted desorption ionization systems 有权
公开(公告)号：US09960029B2
公开(公告)日：2018-05-01
申请号：US15368490
申请日：2016-12-02
申请人： IONSENSE INC.
发明人： Jordan Krechmer , Brian D. Musselman
IPC分类号： H01J49/04 , H01J49/14 , G01N27/62 , G01N27/64 , H01J49/00 , H01J27/26 , H01J49/12 , H01J49/10 , H01J49/24
CPC分类号： H01J49/049 , G01N27/622 , G01N27/626 , G01N27/64 , H01J27/26 , H01J49/004 , H01J49/04 , H01J49/0431 , H01J49/10 , H01J49/126 , H01J49/14 , H01J49/24 , Y10T436/24
摘要： The present invention is directed to a method and device to desorb an analyte using heat to allow desorption of the analyte molecules, where the desorbed analyte molecules are ionized with ambient temperature ionizing species. In various embodiments of the invention a current is passed through a mesh upon which the analyte molecules are present. The current heats the mesh and results in desorption of the analyte molecules which then interact with gas phase metastable neutral molecules or atoms to form analyte ions characteristic of the analyte molecules.

5. 发明申请

US20170148622A1 APPARATUS AND METHOD FOR GENERATING CHEMICAL SIGNATURES USING DIFFERENTIAL DESORPTION 有权
公开(公告)号：US20170148622A1
公开(公告)日：2017-05-25
申请号：US15418524
申请日：2017-01-27
申请人： IONSENSE INC.
发明人： BRIAN D MUSSELMAN
IPC分类号： H01J49/16 , H01J49/04
CPC分类号： H01J49/165 , G01N1/4022 , G01N2001/028 , G01N2030/009 , G01N2030/062 , H01J49/0031 , H01J49/045 , H01J49/16
摘要： The present invention is directed to a method and device to generate a chemical signature for a mixture of analytes. The present invention involves using a SPME surface to one or both absorb and adsorb the mixture of analytes. In an embodiment of the invention, the surface is then exposed to different temperature ionizing species chosen with appropriate spatial resolution to desorb a chemical signature for the mixture of analytes.

6. 发明授权

US09337007B2 Apparatus and method for generating chemical signatures using differential desorption 有权
标题翻译：使用差分解吸法生成化学特征的装置和方法
公开(公告)号：US09337007B2
公开(公告)日：2016-05-10
申请号：US14738899
申请日：2015-06-14
申请人： IONSENSE INC.
发明人： Brian D Musselman
IPC分类号： H01J49/00 , H01J49/16
CPC分类号： H01J49/165 , G01N1/4022 , G01N2001/028 , G01N2030/009 , G01N2030/062 , H01J49/0031 , H01J49/045 , H01J49/16
摘要： The present invention is directed to a method and device to generate a chemical signature for a mixture of analytes. The present invention involves using a SPME surface to one or both absorb and adsorb the mixture of analytes. In an embodiment of the invention, the surface is then exposed to different temperature ionizing species chosen with appropriate spatial resolution to desorb a chemical signature for the mixture of analytes.
摘要翻译：本发明涉及一种生成分析物混合物的化学特征的方法和装置。本发明涉及使用SPME表面吸收和吸附分析物混合物中的一种或两种。在本发明的一个实施方案中，然后将表面暴露于用适当的空间分辨率选择的不同温度的离子化物质以解吸分析物混合物的化学特征。

7. 发明申请

US20160042931A1 APPARATUS AND METHOD FOR THERMAL ASSISTED DESORPTION IONIZATION SYSTEMS 审中-公开
公开(公告)号：US20160042931A1
公开(公告)日：2016-02-11
申请号：US14876677
申请日：2015-10-06
申请人： IONSENSE INC.
发明人： Jordan Krechmer , Brian D. Musselman
IPC分类号： H01J49/04 , H01J49/24 , H01J49/00 , G01N27/62 , H01J27/26
CPC分类号： H01J49/049 , G01N27/622 , G01N27/626 , G01N27/64 , H01J27/26 , H01J49/004 , H01J49/04 , H01J49/0431 , H01J49/10 , H01J49/126 , H01J49/14 , H01J49/24 , Y10T436/24
摘要： The present invention is directed to a method and device to desorb an analyte using heat to allow desorption of the analyte molecules, where the desorbed analyte molecules are ionized with ambient temperature ionizing species. In various embodiments of the invention a current is passed through a mesh upon which the analyte molecules are present. The current heats the mesh and results in desorption of the analyte molecules which then interact with gas phase metastable neutral molecules or atoms to form analyte ions characteristic of the analyte molecules.

8. 发明申请

US20150206730A1 APPARATUS AND METHOD FOR THERMAL ASSISTED DESORPTION IONIZATION SYSTEMS 审中-公开
标题翻译：用于热辅助离子浓度系统的装置和方法
公开(公告)号：US20150206730A1
公开(公告)日：2015-07-23
申请号：US14589687
申请日：2015-01-05
申请人： IONSENSE INC.
发明人： Jordan Krechmer , Brian D. Musselman
IPC分类号： H01J49/04 , H01J49/10 , G01N27/62 , H01J49/24
CPC分类号： H01J49/049 , G01N27/622 , G01N27/626 , G01N27/64 , H01J27/26 , H01J49/004 , H01J49/04 , H01J49/0431 , H01J49/10 , H01J49/126 , H01J49/14 , H01J49/24 , Y10T436/24
摘要： The present invention is directed to a method and device to desorb an analyte using heat to allow desorption of the analyte molecules, where the desorbed analyte molecules are ionized with ambient temperature ionizing species. In various embodiments of the invention a current is passed through a mesh upon which the analyte molecules are present. The current heats the mesh and results in desorption of the analyte molecules which then interact with gas phase metastable neutral molecules or atoms to form analyte ions characteristic of the analyte molecules.
摘要翻译：本发明涉及一种使用热解析分析物以允许分析物分子解吸的方法和装置，其中解吸的分析物分子与环境温度电离物质电离。在本发明的各种实施方案中，电流通过其上存在分析物分子的网。电流加热网格并导致分析物分子的解吸，然后分析物分子与气相亚稳态的中性分子或原子相互作用以形成分析物分子特征的分析物离子。

9. 发明申请

US20190371592A1 APPARATUS AND METHOD FOR REDUCING MATRIX EFFECTS 审中-公开
公开(公告)号：US20190371592A1
公开(公告)日：2019-12-05
申请号：US16422339
申请日：2019-05-24
申请人： IonSense Inc.
发明人： Brian D Musselman
IPC分类号： H01J49/14
摘要： In an embodiment of the present ambient ionization experiment, the abundance of background chemicals relative to ions of interest is decreased by reducing the overall abundance of background chemicals introduced into the ionizing region. In an embodiment of the present invention, the reduction of unwanted background chemicals in the ionization region can be effected by limiting the area which the sample volume is deposited. In an embodiment of the present invention, the reduction of unwanted background chemicals in the ionization region can be effected by decreasing the duration of time that the sample is exposed to the atmospheric pressure ionization source. In an embodiment of the present invention, the reduction of unwanted background chemicals in the ionization region can be effected by limiting the sample volume. In an embodiment of the present invention dilution of the sample with water can be used to reduce the contribution of the background chemicals. In an embodiment of the present ambient ionization experiment, an ion intensifier is used to suppress ionization of background chemicals to permit more efficient ionization and detection of the molecules of interest.

10. 发明申请

US20190252177A1 APPARATUS AND METHOD FOR GENERATING CHEMICAL SIGNATURES USING DIFFERENTIAL DESORPTION 审中-公开
公开(公告)号：US20190252177A1
公开(公告)日：2019-08-15
申请号：US16388784
申请日：2019-04-18
申请人： IONSENSE INC.
发明人： BRIAN D MUSSELMAN
IPC分类号： H01J49/16 , H01J49/00 , H01J49/04 , G01N1/40
CPC分类号： H01J49/165 , G01N1/4022 , G01N2001/028 , G01N2030/009 , G01N2030/062 , H01J49/0031 , H01J49/045 , H01J49/16
摘要： The present invention is directed to a method and device to generate a chemical signature for a mixture of analytes. The present invention involves using a SPME surface to one or both absorb and adsorb the mixture of analytes. In an embodiment of the invention, the surface is then exposed to different temperature ionizing species chosen with appropriate spatial resolution to desorb a chemical signature for the mixture of analytes.

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