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1. 发明授权

US10203331B2 Single cell drug response measurements via live cell interferometry 有权
公开(公告)号：US10203331B2
公开(公告)日：2019-02-12
申请号：US14235547
申请日：2012-08-02
申请人： Jason C. Reed , Michael A. Teitell
发明人： Jason C. Reed , Michael A. Teitell
IPC分类号： G01N33/574 , G01B11/06 , G01B9/02 , G01N33/50
摘要： A central question in cancer therapy is how individual cells within a population of tumor cells respond to drugs designed to arrest their growth. However, the absolute growth of cells, their change in physical mass, whether cancerous or physiologic, is difficult to measure directly with traditional techniques. Embodiments of the invention provide live cell interferometry (LCI) for rapid, realtime quantification of cell mass in cells exposed to a changing environment. Overall, LCI provides a conceptual advance for assessing cell populations to identify, monitor, and measure single cell responses, such as to therapeutic drugs.

2. 发明授权

US5054412A Hydrodynamic skin-friction reduction 失效
标题翻译：水动力皮肤摩擦减少
公开(公告)号：US5054412A
公开(公告)日：1991-10-08
申请号：US429737
申请日：1989-10-31
申请人： Jason C. Reed , Dennis M. Bushnell , Leonard M. Weinstein
发明人： Jason C. Reed , Dennis M. Bushnell , Leonard M. Weinstein
IPC分类号： B63B1/38
CPC分类号： B63B1/38 , Y02T70/122
摘要： A process for reducing skin friction, inhibiting the effects of liquid turbulence, and decreasing heat transfer in a system involving flow of a liquid along a surface of a body includes applying a substantially integral sheet of a gas, e.g., air, immediately adjacent to the surface of the body, e.g., a marine vehicle, which has a longitudinally grooved surface in proximity with the liquid and with a surface material having high contact angle between the liquid and said wall to reduce interaction of the liquid, e.g., water, with the surface of the body, e.g., the hull of the marine vehicle.
摘要翻译：一种减少皮肤摩擦，抑制液体湍流的影响以及降低液体沿着身体表面流动的系统中的热传递的方法包括：将基本上一体的气体（例如空气）身体的表面，例如船用车辆，其具有靠近液体的纵向开槽的表面，并且具有在液体和所述壁之间具有高接触角的表面材料，以减少液体（例如水）与身体的表面，例如船体的船体。

3. 发明授权

US08566038B2 Compositions and methods for analyzing immobilized nucleic acids 有权
标题翻译：用于分析固定化核酸的组合物和方法
公开(公告)号：US08566038B2
公开(公告)日：2013-10-22
申请号：US11582938
申请日：2006-10-17
申请人： James K. Gimzewski , Bhubaneswar Mishra , Jason C. Reed
发明人： James K. Gimzewski , Bhubaneswar Mishra , Jason C. Reed
IPC分类号： G01Q10/00 , G01N33/48
CPC分类号： C12Q1/6834 , C12Q1/683 , C12Q2565/601 , C12Q2565/518 , C12Q2521/331 , C12Q2522/101
摘要： The present invention provides methods of detecting a nucleic acid analyte in a sample. The present invention further provides a method for assigning a profile of a feature to a nucleic acid. The present invention further provides a computer program product for use in a subject method. The present invention further provides a system for detecting a nucleic acid in a sample; and a system for assigning a profile of a feature to a nucleic acid. The present invention further provides a method for immobilizing a nucleic acid onto an insoluble support; and further provides insoluble support having nucleic acid(s) immobilized thereon. The present invention further provides a method of diagnosing a disorder or condition in an individual, where the method involves use of a subject method for detecting a nucleic acid analyte.
摘要翻译：本发明提供了检测样品中核酸分析物的方法。本发明还提供了将特征的轮廓分配给核酸的方法。本发明还提供一种用于本发明方法的计算机程序产品。本发明还提供了一种用于检测样品中核酸的系统; 以及用于将特征的轮廓分配给核酸的系统。本发明还提供了将核酸固定在不溶性载体上的方法; 并进一步提供其上固定有核酸的不溶性载体。本发明还提供了诊断个体中的病症或病症的方法，其中所述方法涉及使用本发明的方法来检测核酸分析物。

4. 发明申请

US20100284016A1 OPTICAL CYTOMETRY 有权
标题翻译：光学细胞计数
公开(公告)号：US20100284016A1
公开(公告)日：2010-11-11
申请号：US12436702
申请日：2009-05-06
申请人： Michael A. Teitell , James K. Gimzewski , Jason C. Reed
发明人： Michael A. Teitell , James K. Gimzewski , Jason C. Reed
IPC分类号： G01J3/45 , G02B21/24 , G02B21/36 , G01B9/021 , G02B3/10
CPC分类号： G01N33/5008 , G01J3/453 , G02B5/126 , G02B21/0056 , G02B21/32
摘要： The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.
摘要翻译：本发明提供了用于确定细胞特征的光学系统和方法，例如细胞类型，对生物化学事件的细胞反应，生物学状态等。所述方法通常涉及使用干涉测量来观察细胞中的膜特性，然后使用该信息来确定细胞的一个或多个特征。本发明的方法对于诸如药物筛选以及诊断技术的应用是有用的。

5. 发明授权

US5445095A Polymer/riblet combination for hydrodynamic skin friction reduction 失效
标题翻译：聚合物/肋组合用于水动力皮肤摩擦减少
公开(公告)号：US5445095A
公开(公告)日：1995-08-29
申请号：US892066
申请日：1992-05-28
申请人： Jason C. Reed , Dennis M. Bushnell
发明人： Jason C. Reed , Dennis M. Bushnell
IPC分类号： B63B1/34 , B64C21/10 , B64C23/00 , B64C1/38
CPC分类号： B64C23/00 , B63B1/34 , B64C21/10 , B64C2230/20 , Y02T50/166 , Y02T70/121
摘要： A process for reducing skin friction and inhibiting the effects of liquid turbulence in a system involving the flow of a liquid along the surface of a body, e.g. a marine vehicle, includes injecting a drag reducing polymer into the valleys of adjacent, evenly spaced, longitudinal grooves extending along the length of the surface of the body, so that the rate of diffusion of the polymer from individual grooves into the liquid flow is predictably controlled by the groove dimensions. When the polymer has diffused over the tips of the grooves into the near wall region of the boundary layer, the polymer effectively reduces the turbulent skin friction. A substantial drag reducing effect is achieved with less polymer than must be used to lower skin friction when the surface of the body is smooth.
摘要翻译：一种用于减少皮肤摩擦并抑制液体湍流在涉及沿着身体表面的液体流动的系统中的方法，例如，船用车辆包括将减阻聚合物注入沿着主体表面的长度延伸的相邻的，均匀间隔的纵向槽的谷中，使得聚合物从单个槽扩散到液体流中的速率是可预测的由凹槽尺寸控制。当聚合物在沟槽的顶端扩散到边界层的近壁区域时，聚合物有效地减少了湍流的表面摩擦。使用较少的聚合物可以实现显着的减阻效果，而当聚合物的表面平滑时，聚合物比用于降低皮肤摩擦力要小。

6. 发明申请

US20140178865A1 RAPID, MASSIVELY PARALLEL SINGLE-CELL DRUG RESPONSE MEASUREMENTS VIA LIVE CELL INTERFEROMETRY 审中-公开
标题翻译：快速，大规模并行单细胞药物反应测量通过活细胞干扰
公开(公告)号：US20140178865A1
公开(公告)日：2014-06-26
申请号：US14235547
申请日：2012-08-02
申请人： Jason C. Reed , Michael A. Teitell
发明人： Jason C. Reed , Michael A. Teitell
IPC分类号： G01N33/574 , G01N33/50
CPC分类号： G01N33/57492 , G01B9/02057 , G01B9/02089 , G01B9/0209 , G01B11/0675 , G01N33/502 , G01N33/5026
摘要： A central question in cancer therapy is how individual cells within a population of tumor cells respond to drugs designed to arrest their growth. However, the absolute growth of cells, their change in physical mass, whether cancerous or physiologic, is difficult to measure directly with traditional techniques. Embodiments of the invention provide live cell interferometry (LCI) for rapid, realtime quantification of cell mass in cells exposed to a changing environment. Overall, LCI provides a conceptual advance for assessing cell populations to identify, monitor, and measure single cell responses, such as to therapeutic drugs.
摘要翻译：癌症治疗中的一个核心问题是肿瘤细胞群体内的单个细胞如何响应旨在阻止其生长的药物。然而，传统技术难以直接测量细胞的绝对生长，物理质量的变化，无论是癌性还是生理学变化。本发明的实施例提供了用于在暴露于不断变化的环境中的细胞中快速，实时定量细胞质量的活细胞干涉测量（LCI）。总体而言，LCI提供了评估细胞群体以鉴别，监测和测量单细胞反应（如治疗药物）的概念性进展。

7. 发明授权

US09995766B2 Methods and systems for measuring a property of a macromolecule 有权
公开(公告)号：US09995766B2
公开(公告)日：2018-06-12
申请号：US12817004
申请日：2010-06-16
申请人： Jason C. Reed , Bhubaneswar Mishra , Andrew Sundstrom
发明人： Jason C. Reed , Bhubaneswar Mishra , Andrew Sundstrom
IPC分类号： G06K9/00 , G01Q30/04 , B82Y35/00 , C12Q1/68 , G06T7/60 , G06F19/16 , G06F19/24
CPC分类号： G01Q30/04 , B82Y35/00 , C12Q1/68 , G06F19/16 , G06F19/24 , G06T7/60 , G06T2207/10024 , G06T2207/20036 , G06T2207/20072 , G06T2207/30004 , C12Q2565/601 , C12Q2525/204 , C12Q2563/131 , C12Q2521/301
摘要： The present disclosure provides methods of measuring a property of a macromolecule. The methods generally involve applying an empirically learned correction term to a test metric to generate a high-accuracy measurement. The present disclosure further provides a computer program product and a computer system for carrying out a subject method.

8. 发明授权

US08599383B2 Optical cytometry 有权
标题翻译：光学细胞计数
公开(公告)号：US08599383B2
公开(公告)日：2013-12-03
申请号：US12436702
申请日：2009-05-06
申请人： Michael A. Teitell , James K. Gimzewski , Jason C. Reed
发明人： Michael A. Teitell , James K. Gimzewski , Jason C. Reed
IPC分类号： G01N21/00 , G01J3/45
CPC分类号： G01N33/5008 , G01J3/453 , G02B5/126 , G02B21/0056 , G02B21/32
摘要： The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.
摘要翻译：本发明提供了用于确定细胞特征的光学系统和方法，例如细胞类型，对生物化学事件的细胞反应，生物学状态等。所述方法通常涉及使用干涉测量来观察细胞中的膜特性，然后使用该信息来确定细胞的一个或多个特征。本发明的方法对于诸如药物筛选以及诊断技术的应用是有用的。

9. 发明申请

US20110013820A1 METHODS AND SYSTEMS FOR MEASURING A PROPERTY OF A MACROMOLECULE 有权
标题翻译：测量大分子物质的方法和系统
公开(公告)号：US20110013820A1
公开(公告)日：2011-01-20
申请号：US12817004
申请日：2010-06-16
申请人： Jason C. Reed , Bhubaneswar Mishra , Andrew Sundstrom
发明人： Jason C. Reed , Bhubaneswar Mishra , Andrew Sundstrom
IPC分类号： G06K9/46 , G06K9/00
CPC分类号： G01Q30/04 , B82Y35/00 , C12Q1/68 , G06F19/16 , G06F19/24 , G06T7/60 , G06T2207/10024 , G06T2207/20036 , G06T2207/20072 , G06T2207/30004 , C12Q2565/601 , C12Q2525/204 , C12Q2563/131 , C12Q2521/301
摘要： The present disclosure provides methods of measuring a property of a macromolecule. The methods generally involve applying an empirically learned correction term to a test metric to generate a high-accuracy measurement. The present disclosure further provides a computer program product and a computer system for carrying out a subject method.
摘要翻译：本公开提供了测量大分子性质的方法。所述方法通常涉及将经验学习的校正项应用于测试度量以产生高精度测量。本公开还提供了一种用于执行主题方法的计算机程序产品和计算机系统。

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