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1. 发明授权

US5734019A Hepatitis C virus antigen polypeptide, production method therefor, and antibody detection method 失效
标题翻译：丙型肝炎病毒抗原多肽，其制备方法和抗体检测方法
公开(公告)号：US5734019A
公开(公告)日：1998-03-31
申请号：US952543
申请日：1992-12-11
申请人： Tatsuo Miyamura , Izumu Saito , Shizuko Harada , Yoshiharu Matsuura , Joe Chiba
发明人： Tatsuo Miyamura , Izumu Saito , Shizuko Harada , Yoshiharu Matsuura , Joe Chiba
IPC分类号： G01N33/576 , A61K39/29 , C07K14/005 , C07K14/02 , C07K14/10 , C07K14/18 , C07K14/195 , C12N15/09 , C12N15/51 , C12P21/00 , C12P21/02 , C12R1/91 , G01N33/569
CPC分类号： C07K14/005 , C12N2710/14143 , C12N2770/24222 , Y10S530/826 , Y10S930/223
摘要： A hepatitis C virus antigen polypeptide having a molecular weight of approximately 22 kilodaltons expressed from a hepatitis C virus structural gene region; a production method for a hepatitis C virus antigen polypeptide having a molecular weight of 22 kilodaltons and/or a peptide related thereto, wherein an expression vector having inserted thereinto a cDNA fragment of a hepatitis C virus structural gene region is inserted into a cultured cell line and the transfected cell line thus obtained is cultured; and a detection method for a hepatitis C virus antibody, wherein a hepatitis C virus antigen polypeptide is used as an antigen, and an antibody specific thereto is detected.
摘要翻译： PCT No.PCT / JP91 / 00724 Sec。 371日期：1992年12月11日 102（e）日期1992年12月11日PCT 1991年5月29日PCT PCT。出版物WO91 / 19744 1991年12月26日，由丙型肝炎病毒结构基因区域表达的分子量约22千道尔顿的丙型肝炎病毒抗原多肽; 一种分子量为22千道尔顿的丙型肝炎病毒抗原多肽和/或与其相关的肽的制备方法，其中将插入有丙型肝炎病毒结构基因区域的cDNA片段的表达载体插入培养的细胞系培养由此获得的转染细胞系; 以及丙型肝炎病毒抗体的检测方法，其中使用丙型肝炎病毒抗原多肽作为抗原，并检测其特异性抗体。

2. 发明授权

US08901099B2 Method for immunizing animal, composition for immunization, method for producing antibody, method for producing hybridoma, and method for producing monoclonal antibody 有权
标题翻译：免疫动物的方法，免疫组合物，抗体的制造方法，杂交瘤的制造方法以及单克隆抗体的制造方法
公开(公告)号：US08901099B2
公开(公告)日：2014-12-02
申请号：US13681700
申请日：2012-11-20
申请人： Joe Chiba , Sekisui Chemical Co., Ltd.
发明人： Joe Chiba , Jun-ichi Hata , Naoki Nishiguchi , Masahiro Furutani
IPC分类号： A61K48/00 , C12N5/04 , C12N15/06 , A61K39/00 , A61K39/385 , C07K16/28
CPC分类号： A61K39/00 , A61K39/0005 , A61K39/385 , A61K2039/53 , A61K2039/6068 , C07K16/2869 , C07K2319/35
摘要： It is an object of the present invention to a method whereby a humoral immune response is induced more efficiently in producing an antibody against an antigen protein by gene immunization. A fusion gene composed of a gene encoding the full-length of a part of the antigen protein or a gene encoding a chaperonin subunit or a chaperonin subunit linkage linked thereto is administered to express the fusion gene in the animal, thereby inducing a humoral immune response to an antigen protein by administering. An example of the chaperonin includes Escherichia coli GroEL. There is also provided with a composition for immunization, a method for producing an antibody, a method for producing a hybridoma, and a method for producing a monoclonal antibody.
摘要翻译：本发明的目的是提供一种通过基因免疫在产生针对抗原蛋白的抗体中更有效地诱导体液免疫应答的方法。施用由编码全长一部分抗原蛋白的基因或编码伴侣伴侣亚基的基因或与其相连的伴侣伴侣亚基的基因组成的融合基因，以表达动物中的融合基因，由此诱导体液免疫应答通过给予抗原蛋白。伴侣蛋白的一个实例包括大肠杆菌GroEL。还提供了用于免疫的组合物，抗体的制备方法，杂交瘤的制备方法和单克隆抗体的制备方法。

3. 发明申请

US20090041761A1 Method of immunizing animal, composition for immunization, method for producing antibody, method for producing hybridoma and method for producing monoclonal antibody 有权
标题翻译：动物免疫方法，免疫组合物，抗体制造方法，杂交瘤的制造方法及单克隆抗体的制造方法
公开(公告)号：US20090041761A1
公开(公告)日：2009-02-12
申请号：US11665270
申请日：2005-10-14
申请人： Joe Chiba , Jun-ichi Hata , Naoki Nishiguchi , Masahiro Furutani
发明人： Joe Chiba , Jun-ichi Hata , Naoki Nishiguchi , Masahiro Furutani
IPC分类号： A61K39/395 , A61K39/00 , C12N5/16 , A61P31/00 , C12P21/08
CPC分类号： A61K39/00 , A61K39/0005 , A61K39/385 , A61K2039/53 , A61K2039/6068 , C07K16/2869 , C07K2319/35
摘要： It is an object of the present invention to a method whereby a humoral immune response is induced more efficiently in producing an antibody against an antigen protein by gene immunization. A fusion gene composed of a gene encoding the full-length of a part of the antigen protein or a gene encoding a chaperonin subunit or a chaperonin subunit linkage linked thereto is administered to express the fusion gene in the animal, thereby inducing a humoral immune response to an antigen protein by administering. An example of the chaperonin includes Escherichia coli GroEL. There is also provided with a composition for immunization, a method for producing an antibody, a method for producing a hybridoma, and a method for producing a monoclonal antibody.
摘要翻译：本发明的目的是提供一种通过基因免疫在产生针对抗原蛋白的抗体中更有效地诱导体液免疫应答的方法。施用由编码全长一部分抗原蛋白的基因或编码伴侣伴侣亚基的基因或与其相连的伴侣伴侣亚基的基因组成的融合基因，以表达动物中的融合基因，由此诱导体液免疫应答通过给予抗原蛋白。伴侣蛋白的一个实例包括大肠杆菌GroEL。还提供了用于免疫的组合物，抗体的制备方法，杂交瘤的制备方法和单克隆抗体的制备方法。

4. 发明授权

US5714314A Hepatitis C virus antigen polypeptide, production method therefor, and antibody detection method 失效
标题翻译：丙型肝炎病毒抗原多肽，其制备方法和抗体检测方法
公开(公告)号：US5714314A
公开(公告)日：1998-02-03
申请号：US452287
申请日：1995-05-26
申请人： Tatsuo Miyamura , Izumu Saito , Shizuko Harada , Yoshiharu Matsuura , Joe Chiba
发明人： Tatsuo Miyamura , Izumu Saito , Shizuko Harada , Yoshiharu Matsuura , Joe Chiba
IPC分类号： G01N33/576 , A61K39/29 , C07K14/005 , C07K14/02 , C07K14/10 , C07K14/18 , C07K14/195 , C12N15/09 , C12N15/51 , C12P21/00 , C12P21/02 , C12R1/91 , C12Q1/70 , G01N33/53 , G01N33/68
CPC分类号： C07K14/005 , C12N2710/14143 , C12N2770/24222 , Y10S530/826 , Y10S930/223
摘要： A hepatitis C virus antigen polypeptide having a molecular weight of approximately 22 kilodaltons expressed from a hepatitis C virus structural gene region; a production method for a hepatitis C virus antigen polypeptide having a molecular weight of 22 kilodaltons and/or a peptide related thereto, wherein an expression vector having inserted thereinto a cDNA fragment of a hepatitis C virus structural gene region is inserted into a cultured cell line and the transfected cell line thus obtained is cultured; and a detection method for a hepatitis C virus antibody, wherein a hepatitis C virus antigen polypeptide is used as an antigen, and an antibody specific thereto is detected.
摘要翻译：由丙型肝炎病毒结构基因区域表达的分子量约22千道尔顿的丙型肝炎病毒抗原多肽; 一种分子量为22千道尔顿的丙型肝炎病毒抗原多肽和/或与其相关的肽的制备方法，其中将插入有丙型肝炎病毒结构基因区域的cDNA片段的表达载体插入培养的细胞系培养由此获得的转染细胞系; 以及丙型肝炎病毒抗体的检测方法，其中使用丙型肝炎病毒抗原多肽作为抗原，并检测其特异性抗体。

5. 发明授权

US4146132A Non-partition packaging dividers and method 失效
标题翻译：非分隔包装分隔件和方法
公开(公告)号：US4146132A
公开(公告)日：1979-03-27
申请号：US839019
申请日：1977-10-03
申请人： Joe Chiba
发明人： Joe Chiba
IPC分类号： B65D57/00 , B65D71/00
CPC分类号： B65D57/00 , Y10S206/82
摘要： Packaging dividers are comprised of a plurality of axially linked-together separator sections. Each separator section is formed to have a preselected height and cross-sectional configuration which may be circular or cross-shaped. Each separator section is formed in axial attachment to its adjacent separator section with a reduced cross-section portion therebetween to constitute severing means. One or more separator sections may be separated from an adjacent separator section and positioned within a carton containing objects to separate said objects.
摘要翻译：包装分隔件由多个轴向连接在一起的分离器部分组成。每个分离器部分形成为具有可以是圆形或十字形的预选高度和横截面形状。每个分离器部分以与其相邻的分离器部分轴向连接形成，其间具有减小的横截面部分，以构成切断装置。一个或多个分离器部分可以与相邻的分离器部分分离并且定位在包含对象的纸箱内以分离所述对象。

6. 发明申请

US20130109057A1 METHOD FOR IMMUNIZING ANIMAL, COMPOSITION FOR IMMUNIZATION, METHOD FOR PRODUCING ANTIBODY, METHOD FOR PRODUCING HYBRIDOMA, AND METHOD FOR PRODUCING MONOCLONAL ANTIBODY 有权
标题翻译：用于免疫动物的方法，用于免疫的组合物，用于产生抗体的方法，用于生产杂交瘤的方法和用于产生单克隆抗体的方法
公开(公告)号：US20130109057A1
公开(公告)日：2013-05-02
申请号：US13681700
申请日：2012-11-20
申请人： Joe Chiba , Sekisui Chemical Co., Ltd.
发明人： Joe CHIBA , Jun-ichi HATA , Naoki NISHIGUCHI , Masahiro FURUTANI
IPC分类号： A61K39/00
CPC分类号： A61K39/00 , A61K39/0005 , A61K39/385 , A61K2039/53 , A61K2039/6068 , C07K16/2869 , C07K2319/35
摘要： It is an object of the present invention to a method whereby a humoral immune response is induced more efficiently in producing an antibody against an antigen protein by gene immunization. A fusion gene composed of a gene encoding the full-length of a part of the antigen protein or a gene encoding a chaperonin subunit or a chaperonin subunit linkage linked thereto is administered to express the fusion gene in the animal, thereby inducing a humoral immune response to an antigen protein by administering. An example of the chaperonin includes Escherichia coli GroEL. There is also provided with a composition for immunization, a method for producing an antibody, a method for producing a hybridoma, and a method for producing a monoclonal antibody.
摘要翻译：本发明的目的是提供一种通过基因免疫在产生针对抗原蛋白的抗体中更有效地诱导体液免疫应答的方法。施用由编码全长一部分抗原蛋白的基因或编码伴侣伴侣亚基的基因或与其相连的伴侣伴侣亚基的基因组成的融合基因，以表达动物中的融合基因，由此诱导体液免疫应答通过给予抗原蛋白。伴侣蛋白的一个实例包括大肠杆菌GroEL。还提供了用于免疫的组合物，抗体的制备方法，杂交瘤的制备方法和单克隆抗体的制备方法。

7. 发明授权

US5302507A Antigenic peptide for detecting anti-hepatitis C virus antibodies and use thereof 失效
标题翻译：用于检测抗丙型肝炎病毒抗体的抗原肽及其用途
公开(公告)号：US5302507A
公开(公告)日：1994-04-12
申请号：US744427
申请日：1991-08-13
申请人： Joe Chiba , Tatsuo Miyamura , Izumu Saito , Shizuko Harada , Yoshiharu Matsuura
发明人： Joe Chiba , Tatsuo Miyamura , Izumu Saito , Shizuko Harada , Yoshiharu Matsuura
IPC分类号： G01N33/576 , A61K39/29 , C07K7/08 , C07K14/00 , C07K14/02 , C07K14/10 , C07K14/18 , C07K16/10 , C12Q1/70
CPC分类号： C07K14/005 , C12N2770/24222 , Y10S436/82
摘要： The antigenic peptide represented by the following amino acid sequence (SEQ ID NO: 1) ##STR1## and a method of the detection of anti-HCV antibodies wherein the above peptide is brought into contact with a sample under the conditions that the peptide is bound to anti-HCV antibodies present in the sample to form an immunological complex and the formation of the immunological complex is measured to confirm the existence of the anti HCV antibodies in the sample. The method is highly specific and sensitive to anti-HCV antibodies.
摘要翻译：由以下氨基酸序列（SEQ ID NO：1）表示的抗原肽（*化学结构*）和检测抗HCV抗体的方法，其中上述肽在样品的条件下与样品接触肽与样品中存在的抗HCV抗体结合以形成免疫复合物，并测量免疫复合物的形成以证实样品中抗HCV抗体的存在。该方法对抗HCV抗体具有高度的特异性和敏感性。

8. 发明授权

US08349807B2 Method of immunizing animal, composition for immunization, method for producing antibody, method for producing hybridoma and method for producing monoclonal antibody 有权
公开(公告)号：US08349807B2
公开(公告)日：2013-01-08
申请号：US11665270
申请日：2005-10-14
申请人： Joe Chiba , Jun-ichi Hata , Naoki Nishiguchi , Masahiro Furutani
发明人： Joe Chiba , Jun-ichi Hata , Naoki Nishiguchi , Masahiro Furutani
IPC分类号： A61K48/00 , C12N5/04 , C12N15/06
CPC分类号： A61K39/00 , A61K39/0005 , A61K39/385 , A61K2039/53 , A61K2039/6068 , C07K16/2869 , C07K2319/35
摘要： It is an object of the present invention to a method whereby a humoral immune response is induced more efficiently in producing an antibody against an antigen protein by gene immunization. A fusion gene composed of a gene encoding the full-length of a part of the antigen protein or a gene encoding a chaperonin subunit or a chaperonin subunit linkage linked thereto is administered to express the fusion gene in the animal, thereby inducing a humoral immune response to an antigen protein by administering. An example of the chaperonin includes Escherichia coli GroEL. There is also provided with a composition for immunization, a method for producing an antibody, a method for producing a hybridoma, and a method for producing a monoclonal antibody.

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