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1. 发明授权

US08379197B2 Spectroscopic systems and methods for classifying and pharmaceutically treating cells 有权
标题翻译：用于分类和药物治疗细胞的光谱系统和方法
公开(公告)号：US08379197B2
公开(公告)日：2013-02-19
申请号：US12462350
申请日：2009-08-03
申请人： Janice Panza , John S. Maier , Jason Neiss
发明人： Janice Panza , John S. Maier , Jason Neiss
IPC分类号： G01J3/00 , G01J3/44
CPC分类号： G01J3/44 , G01J3/10 , G01J3/36 , G01N15/1475 , G01N21/6458 , G01N21/65 , G01N2015/1006 , G01N2015/1488 , G02B21/0096
摘要： A system and method to distinguish normal cells from cells having undergone a biochemical change. A pre-determined vector space is selected where the vector space mathematically describes a first plurality of reference spectral data sets for normal cells and a second plurality of reference spectral data sets for cells having undergone a biochemical change. A sample is irradiated to generate a target spectral data set based on photons absorbed, reflected, emitted, or scattered by the sample. The target spectral data set is transformed into a pre-determined vector space. A distribution of transformed data is analyzed in the pre-determined vector space. Based on the analysis, the sample is classified as containing normal cells, cells having undergone a biochemical change, and combinations thereof. The method includes treating the sample with a pharmaceutical agent prior to irradiating the sample and using the classification to assess the efficiency of the pharmaceutical agent.
摘要翻译：将正常细胞与经历生物化学变化的细胞区分开的系统和方法。选择预定向量空间，其中矢量空间数学地描述正常小区的第一多个参考频谱数据集，以及经历生物化学变化的小区的第二多个参考频谱数据集。照射样品以基于样品吸收，反射，发射或散射的光子产生目标光谱数据集。将目标光谱数据集转换为预定向量空间。在预定向量空间中分析变换数据的分布。基于该分析，将样品分类为含有正常细胞，经历生物化学变化的细胞及其组合。该方法包括在照射样品之前用药剂处理样品并使用分类来评估药剂的效率。

2. 发明授权

US07705981B2 Method and apparatus for super montage large area spectroscopic imaging 有权
标题翻译：超级蒙太奇大面积光谱成像方法与装置
公开(公告)号：US07705981B2
公开(公告)日：2010-04-27
申请号：US12180344
申请日：2008-07-25
申请人： John S. Maier , Jason H. Neiss
发明人： John S. Maier , Jason H. Neiss
IPC分类号： G01J3/44
CPC分类号： G06T5/006 , G01J2003/2826 , G06T5/50
摘要： The disclosure relates to Method and Apparatus for Super Montage Large area Spectroscopic Imaging. In one embodiment of the disclosure, a method for producing a spectroscopic image of an object includes the steps of (a) irradiating the object with light to thereby produce from the object scattered and/or emitted (interchangeably “scattered”) light for each of a plurality of wavelengths; (b) producing separately for each of the plurality of wavelengths a plurality of substantially contiguous sub-images of the object; (c) compensating for spatial aberrations in ones of the sub-images for a select one of the plurality of wavelengths; (d) compensating for intensity aberrations between ones of the substantially contiguous sub-images for one of the plurality of wavelengths; and (e) combining the sub-images for the select one wavelength to thereby produce said spectroscopic image of the object.
摘要翻译：本公开涉及超级蒙太奇大面积光谱成像方法和装置。在本公开的一个实施例中，用于产生物体的分光图像的方法包括以下步骤：（a）用光照射物体，从而从物体散射和/或发射（互换地“散射”）的光中产生多个波长; （b）为所述多个波长中的每一个分别产生所述物体的多个基本相邻的子图像; （c）补偿所述多个波长中的选择一个的子图像中的空间像差; （d）补偿所述多个波长中的一个波长的所述基本连续的子图像中的一个的强度像差; 和（e）组合所选择的一个波长的子图像，从而产生该对象的所述分光图像。

3. 发明授权

US07623232B2 Raman spectral analysis of pathogens 有权
标题翻译：拉曼光谱分析病原体
公开(公告)号：US07623232B2
公开(公告)日：2009-11-24
申请号：US12191496
申请日：2008-08-14
申请人： Shona Stewart , John S. Maier , Patrick J. Treado
发明人： Shona Stewart , John S. Maier , Patrick J. Treado
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , A61B18/20 , G01J3/10 , G01J3/44 , G01N21/31 , G01N21/645 , G01N21/6458 , G01N21/6486 , G01N21/658 , G01N2021/6423 , G01N2021/656
摘要： A method of ablating a viable biological pathogen in a sample. A viable biological pathogen in a portion of the sample is identified by irradiating the sample; assessing radiation scattered from the sample for radiation that exhibits a Raman shift characteristic of the viable biological pathogen, and delivering an ablating agent to the identified portion.
摘要翻译：一种在样品中消融活的生物病原体的方法。通过照射样品来鉴定样品部分中的活的生物病原体; 评估从样品中散射的辐射的辐射，其表现出活的生物病原体的拉曼位移特征，并将消融剂递送到所识别的部分。

4. 发明申请

US20080316468A1 SYSTEM AND METHOD FOR THE DEPOSITION, IMAGING, DETECTION AND IDENTIFICATION OF THREAT AGENTS 有权
标题翻译：沉积物成像，成像，检测和鉴定的系统和方法
公开(公告)号：US20080316468A1
公开(公告)日：2008-12-25
申请号：US11351329
申请日：2006-02-09
申请人： Patrick J. Treado , Charles W. Gardner, JR. , John S. Maier
发明人： Patrick J. Treado , Charles W. Gardner, JR. , John S. Maier
IPC分类号： G01N21/47 , G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01N21/65
摘要： A system and method for depositing a sample of a threat agent onto a substrate. The deposition of the threat agent onto the substrate is visually observed by analyzing the elastic scattered photons produced by the threat agent using elastic scatter imaging to form an image of the threat agent on the substrate, wherein depositing of the threat agent is substantially coincident in time with visually observing of the deposition of the threat agent.A system and method for depositing a sample of a threat agent onto a substrate. A single illumination source illuminates the threat agent on the substrate with a plurality of photons to thereby produce elastic scattered photons. Deposition of the threat agent onto the substrate is visually observed by analyzing the elastic scattered photons produced by the threat agent using elastic scatter imaging to form an image of the threat agent on the substrate.
摘要翻译：一种用于将威胁剂样品沉积到基底上的系统和方法。通过使用弹性散射成像分析由威胁剂产生的弹性散射光子以形成威胁剂在基材上的图像，目视观察威胁剂沉积在基材上，其中威胁剂的沉积在时间上基本一致在视觉上观察威胁剂的沉积。一种用于将威胁剂样品沉积到基底上的系统和方法。单个照明源用多个光子照射基板上的威胁剂，从而产生弹性散射的光子。通过使用弹性散射成像分析由威胁剂产生的弹性散射光子以在基底上形成威胁剂的图像，目视观察威胁剂在基材上的沉积。

5. 发明申请

US20080297789A1 Raman Spectral Analysis of Pathogens 有权
标题翻译：病原体拉曼光谱分析
公开(公告)号：US20080297789A1
公开(公告)日：2008-12-04
申请号：US12191496
申请日：2008-08-14
申请人： Shona Stewart , John S. Maier , Patrick J. Treado
发明人： Shona Stewart , John S. Maier , Patrick J. Treado
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , A61B18/20 , G01J3/10 , G01J3/44 , G01N21/31 , G01N21/645 , G01N21/6458 , G01N21/6486 , G01N21/658 , G01N2021/6423 , G01N2021/656
摘要： A method of ablating a viable biological pathogen in a sample. A viable biological pathogen in a portion of the sample is identified by irradiating the sample; assessing radiation scattered from the sample for radiation that exhibits a Raman shift characteristic of the viable biological pathogen, and delivering an ablating agent to the identified portion.
摘要翻译：一种在样品中消融活的生物病原体的方法。通过照射样品来鉴定样品部分中的活的生物病原体; 评估从样品中散射的辐射的辐射，其表现出活的生物病原体的拉曼位移特征，并将消融剂递送到所识别的部分。

6. 发明授权

US07428045B2 Raman spectral analysis of pathogens 有权
标题翻译：拉曼光谱分析病原体
公开(公告)号：US07428045B2
公开(公告)日：2008-09-23
申请号：US11206007
申请日：2005-08-17
申请人： Shona Stewart , John S. Maier , Patrick J. Treado
发明人： Shona Stewart , John S. Maier , Patrick J. Treado
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , A61B18/20 , G01J3/10 , G01J3/44 , G01N21/31 , G01N21/645 , G01N21/6458 , G01N21/6486 , G01N21/658 , G01N2021/6423 , G01N2021/656
摘要： Raman scattering of radiation applied to a water sample is used to assess occurrence of a pathogen in the sample. The method is useful for detecting pathogens that are difficult to detect using other methods, such as protozoa. Examples of organisms that can be detected in water samples using these methods include protozoa of the genus Cryptosporidium and the genus Giardia. The methods described herein have important applications, such as for detection of Cryptosporidium organisms in municipal water systems.
摘要翻译：使用施加到水样品的辐射的拉曼散射来评估样品中病原体的发生。该方法可用于检测使用其他方法（如原生动物）难以检测的病原体。使用这些方法可以在水样中检测的生物体的实例包括隐孢子虫属和贾第虫属的原生动物。本文描述的方法具有重要的应用，例如用于在市政水系统中检测隐孢子虫生物体。

7. 发明授权

US07317526B2 System and method for dynamic chemical imaging 有权
标题翻译：动态化学成像系统和方法
公开(公告)号：US07317526B2
公开(公告)日：2008-01-08
申请号：US11399032
申请日：2006-04-06
申请人： Thomas C. Voigt , David Tuschel , John S. Maier
发明人： Thomas C. Voigt , David Tuschel , John S. Maier
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/6456 , G01J3/12 , G01J3/1256 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/1269 , G01N21/3563 , G01N21/3577 , G01N21/65
摘要： A system and method for detecting dynamic changes that occur in a sample between a first time interval and a second time interval using a series of at least first and second sequential chemical images of the sample. During the first time interval: (i) the sample is illuminated with a plurality of photons to thereby produce photons scattered or emitted by the sample; (ii) a two-dimensional array of detection elements is used to simultaneously detect scattered or emitted photons in a first predetermined wavelength band from different locations on or within the sample; and (iii) the two-dimensional array of detection elements is thereafter used one or more further times to simultaneously detect scattered or emitted photons in one or more further predetermined wavelength band(s) from different locations on or within the sample. The outputs of the two-dimensional array of detection elements during the first time interval are then combined to generate the first chemical image of the sample. The process is repeated during the second time interval to generate the second chemical image of the sample. Dynamic changes occurring in the sample between the first time interval and the second time interval are detected based on one or more differences between the first and second chemical images.
摘要翻译：一种系统和方法，用于使用所述样本的至少第一和第二顺序化学图像的一系列来检测在第一时间间隔和第二时间间隔之间在样本中发生的动态变化。在第一时间间隔期间：（i）样品用多个光子照射，从而产生样品散射或发射的光子; （ii）检测元件的二维阵列用于同时从样品上或样品内的不同位置检测来自第一预定波长带的散射或发射的光子; 然后，（iii）检测元件的二维阵列此后再被使用一次或多次，以同时检测来自样品上或样品内的不同位置的一个或多个另外的预定波长带中的散射或发射的光子。然后组合在第一时间间隔期间检测元件的二维阵列的输出以产生样本的第一化学图像。该过程在第二时间间隔期间重复以产生样品的第二化学图像。基于第一和第二化学图像之间的一个或多个差异来检测在第一时间间隔和第二时间间隔之间在样本中发生的动态变化。

8. 发明授权

US07256875B2 Method for detection of pathogenic microorganisms 有权
标题翻译：检测病原微生物的方法
公开(公告)号：US07256875B2
公开(公告)日：2007-08-14
申请号：US11440845
申请日：2006-05-25
申请人： John S. Maier , Charles W. Gardner, Jr. , Matthew P. Nelson , Robert C. Schweitzer , Patrick J. Treado , G. Steven Vanni , Julianne Wolfe
发明人： John S. Maier , Charles W. Gardner, Jr. , Matthew P. Nelson , Robert C. Schweitzer , Patrick J. Treado , G. Steven Vanni , Julianne Wolfe
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/6486 , G01J3/02 , G01J3/0218 , G01J3/2823 , G01J3/44 , G01N21/31 , G01N21/33 , G01N21/359 , G01N21/645 , G01N21/6456 , G01N21/6458 , G01N21/65 , G01N2021/1736 , G01N2021/6421 , G01N2021/6423 , G01N2021/656
摘要： A method for the detection and identification of pathogenic microorganisms using Raman scattered light and transmitted light in the near infrared spectral region. The method may include passing the Raman scattered light and transmitted light through a FAST fiber array spectral translator.
摘要翻译：一种使用拉曼散射光和近红外光谱区域的透射光检测和鉴定病原微生物的方法。该方法可以包括使拉曼散射光和透射光通过FAST光纤阵列光谱转换器。

9. 发明授权

US07239383B2 Method and apparatus for spectral modulation compensation 有权
标题翻译：光谱调制补偿的方法和装置
公开(公告)号：US07239383B2
公开(公告)日：2007-07-03
申请号：US10879632
申请日：2004-06-30
申请人： John S. Maier , Jason N. Neiss , Shona Stewart , Matthew P. Nelson , Joseph Demuth , Patrick J. Treado
发明人： John S. Maier , Jason N. Neiss , Shona Stewart , Matthew P. Nelson , Joseph Demuth , Patrick J. Treado
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01J3/0297 , G01J3/44 , G01N2021/656
摘要： The embodiments disclosed herein generally relate to identifying and removing background noise in spectroscopic imaging of a sample. Because white-light has essentially constant intensity at every wavelength, background noise caused by white light can be identified and removed from spectroscopic measurements including Raman spectroscopy. Thus, once the Raman spectrum for a sample is obtained, it may be corrected to remove the white-light dispersive spectrum in accordance with the embodiments disclosed herein.
摘要翻译：本文公开的实施例通常涉及在样本的光谱成像中识别和去除背景噪声。因为白光在每个波长处具有基本恒定的强度，所以可以从包括拉曼光谱的光谱测量中识别和去除由白光引起的背景噪声。因此，一旦获得样品的拉曼光谱，就可以根据本文公开的实施方案来校正其去除白光色散谱。

10. 发明授权

US07012695B2 Method and apparatus for multiwavelength imaging spectrometer 有权
标题翻译：多波长成像光谱仪的方法和装置
公开(公告)号：US07012695B2
公开(公告)日：2006-03-14
申请号：US10893332
申请日：2004-07-19
申请人： John S. Maier , Patrick J. Treado , Chenhui Wang
发明人： John S. Maier , Patrick J. Treado , Chenhui Wang
IPC分类号： G01B9/02 , G02F1/1335
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0224 , G01J3/0229 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/10 , G01J3/44 , G01J3/4406 , G01N21/6456 , G01N2021/6417 , G01N2021/6423 , G01N2021/6471 , G01N2201/0221 , G01N2201/0627 , G02F1/133371 , G02F1/1347
摘要： The disclosure generally relates to a method and apparatus for multi-wavelength imaging spectrometer. More specifically, in one embodiment, the disclosure relates to an optical filter for passing photons therethrough. The filter includes a first filter stage and a second filter stage. The first filter stage may include a first retarder element and a first liquid crystal cell. The first element may include an input face and an output face. One of the first element faces is not oriented substantially normal to the trajectory of photons passing through the filter.
摘要翻译：本公开一般涉及用于多波长成像光谱仪的方法和装置。更具体地，在一个实施例中，本发明涉及一种用于使光子通过其的滤光器。该滤波器包括第一滤波器级和第二滤波级。第一滤波器级可以包括第一延迟元件和第一液晶单元。第一元件可以包括输入面和输出面。第一元件面之一不是基本上垂直于通过过滤器的光子的轨迹。

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