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1. 发明授权

US07649618B2 System and method to perform raman imaging without luminescence 有权
标题翻译：不发光的拉曼成像系统和方法
公开(公告)号：US07649618B2
公开(公告)日：2010-01-19
申请号：US11728430
申请日：2007-03-26
申请人： David Tuschel , Jingyun Zhang
发明人： David Tuschel , Jingyun Zhang
IPC分类号： G01J3/44 , G01N21/64
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0218 , G01J3/0294 , G01J3/2803 , G01J3/2889 , G01J2003/4424 , G01N21/6456 , G01N21/65 , G01N2021/6417 , G01N2021/6423
摘要： A system and method for collecting Raman data sets without the “contaminating” effect of luminescence emitted photons. Using a frame transfer CCD for time resolved data collection, Raman imaging may be performed without photobleaching the sample. The system may include a light source, a frame transfer CCD, an optical lens and at least one controller. The light source illuminates the sample with a plurality of photons to generate scattered photons from the sample. The frame transfer CCD has an image array and a storage array. The optical lens collects scattered photons and directs the scattered photons to the image array. The controller transfers a Raman data set representative of the scattered photons from the image array to the storage array. The frame transfer CCD may be configured so as the image array integrates the scattered photons during a Raman integration time and the controller transfers the Raman data set from the image array to storage array during a parallel transfer time. The sum of the Raman integration time and the parallel transfer time is less than the minimum time it takes to trigger luminescence from the sample.
摘要翻译：用于收集拉曼数据集而不发出发光光子的“污染”影响的系统和方法。使用帧传输CCD进行时间分辨数据采集，拉曼成像可以在没有光漂白样品的情况下进行。该系统可以包括光源，帧传送CCD，光学透镜和至少一个控制器。光源用多个光子照射样品以从样品产生散射的光子。帧传送CCD具有图像阵列和存储阵列。光学透镜收集散射的光子并将散射的光子引导到图像阵列。控制器将表示散射光子的拉曼数据集从图像阵列传送到存储阵列。帧传送CCD可以被配置为使得图像阵列在拉曼积分时间期间对散射的光子进行积分，并且控制器在平行传送时间期间将拉曼数据集从图像阵列传送到存储阵列。拉曼积分时间和平行传输时间的总和小于从样品触发发光所需的最小时间。

2. 发明授权

US07564546B2 Dynamic imaging of biological cells and other subjects 有权
标题翻译：生物细胞和其他科目的动态成像
公开(公告)号：US07564546B2
公开(公告)日：2009-07-21
申请号：US10556038
申请日：2005-06-30
申请人： John S. Maier , Patrick J. Treado , David Tuschel , Thomas C. Voigt
发明人： John S. Maier , Patrick J. Treado , David Tuschel , Thomas C. Voigt
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/6456 , G01J3/2803 , G01J3/32 , G01J3/36 , G01J3/44 , G01N21/359 , G01N21/6486 , G01N21/65 , G01N21/658 , G01N2021/656
摘要： The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.
摘要翻译：本发明涉及动态化学成像方法，包括细胞成像方法。该方法包括以基本上单色的光照亮电池的至少一部分，并且在多个离散时间评估从照射部分散射的拉曼偏移光。可以在每个离散时间处以多个拉曼位移（RS）值评估拉曼移位的光，并且可以将每个离散时间的RS值选择为预选择的分量的特征。如此获得的图像的拉曼光谱特征的多变量分析可以产生视场中部件的位置和化学特性。该信息可以与从视野获得的其他光谱数据（例如，可见显微镜图像）组合或覆盖。

3. 发明授权

US07471389B2 System and method for fiber array spectral translator based polymorph screening 有权
标题翻译：基于光纤阵列光谱变换器的多态性筛选系统与方法
公开(公告)号：US07471389B2
公开(公告)日：2008-12-30
申请号：US11682302
申请日：2007-03-05
申请人： David Tuschel , Patrick J. Treado , Matthew P. Nelson
发明人： David Tuschel , Patrick J. Treado , Matthew P. Nelson
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/0221 , G01J3/2823 , G01N21/474 , G01N21/6456 , G01N21/65 , G01N2021/6423 , G01N2021/6484 , G01N2201/08 , G01N2201/0833
摘要： The present disclosure describes methods and systems that combine Raman spectroscopy performed in a manner that utilizes one or more of widefield illumination, simultaneous multipoint Raman spectral acquisition, and spectral unmixing for the purpose of high throughput polymorph screening. Features of this methodology include: (a) high throughput polymorph screening to reduce crystal orientation effects on Raman spectra; (b) in-well multi-polymorph screening using increased statistical sampling; and (c) multipoint spectral sampling to enable spectral unmixing.
摘要翻译：本公开描述了组合拉曼光谱的方法和系统，其以利用一种或多种宽场照明，同时多点拉曼光谱采集和光谱解混合的方式进行，以进行高通量多晶型筛选。该方法的特点包括：（a）高通量多晶型筛选以减少对拉曼光谱的晶体取向效应; （b）使用增加的统计学抽样的井内多多态性筛选; 和（c）多点光谱采样以使光谱解混合。

4. 发明授权

US07394542B2 Method and apparatus for chemical imaging in a microfluidic circuit 有权
公开(公告)号：US07394542B2
公开(公告)日：2008-07-01
申请号：US10920320
申请日：2004-08-18
申请人： Thomas Voigt , David Tuschel
发明人： Thomas Voigt , David Tuschel
IPC分类号： G01J3/51 , G01N21/25 , G01N21/62 , G01N21/64 , G01N21/65
CPC分类号： G01N21/05 , B01L3/5027 , G01J3/0227 , G01J3/4406 , G01N21/03 , G01N21/31 , G01N21/3577 , G01N21/64 , G01N21/65 , G01N2021/0325 , G01N2021/0346 , G01N2021/651
摘要： The disclosure generally relates to a system for detecting a change in an attribute of a substance. The system may include a photon source for producing a first of a plurality of photons which interact with the substance while an attribute of the substance changes to produce a second plurality of photons. The system may also include a filter for receiving the collected photons and providing filtered photons; a photon detector for receiving the filtered photons and obtaining therefrom a spectrum of the substance; and a processor for detecting an aspect of the filtered photons wherein the aspect of the filtered photons is the function of the attribute of the substance.

5. 发明申请

US20070258089A1 Method and apparatus for chemical imaging in a microfluidic circuit 有权
标题翻译：用于在微流体电路中进行化学成像的方法和装置
公开(公告)号：US20070258089A1
公开(公告)日：2007-11-08
申请号：US11824878
申请日：2007-07-03
申请人： David Tuschel , Thomas Voigt
发明人： David Tuschel , Thomas Voigt
IPC分类号： G01J3/30
CPC分类号： G01N21/05 , B01L3/5027 , G01J3/0227 , G01J3/4406 , G01N21/03 , G01N21/31 , G01N21/3577 , G01N21/64 , G01N21/65 , G01N2021/0325 , G01N2021/0346 , G01N2021/651
摘要： The disclosure generally relates to a system for detecting a change in an attribute of a substance. The system may include a photon source for producing a first of a plurality of photons which interact with the substance while an attribute of the substance changes to produce a second plurality of photons. The system may also include a filter for receiving the collected photons and providing filtered photons; a photon detector for receiving the filtered photons and obtaining therefrom a spectrum of the substance; and a processor for detecting an aspect of the filtered photons wherein the aspect of the filtered photons is the function of the attribute of the substance.
摘要翻译：本发明一般涉及用于检测物质属性变化的系统。该系统可以包括用于产生与物质相互作用的多个光子中的第一个的光子源，同时物质的属性改变以产生第二多个光子。该系统还可以包括用于接收所收集的光子并提供经滤光的光子的滤光器; 光子检测器，用于接收经滤光的光子并从中获得物质的光谱; 以及用于检测滤光光子的方面的处理器，其中滤光光子的方面是物质属性的函数。

6. 发明申请

US20070221732A1 Method and apparatus for counterfeiting protection 审中-公开
公开(公告)号：US20070221732A1
公开(公告)日：2007-09-27
申请号：US11641666
申请日：2006-12-20
申请人： David Tuschel , Wesley Hutchison , Thomas Voigt
发明人： David Tuschel , Wesley Hutchison , Thomas Voigt
IPC分类号： G06K7/10 , B41M3/14 , B44F1/12
CPC分类号： G06K19/10 , G06K19/06037 , G09C5/00 , H04K1/00 , H04L9/321 , H04L9/3231 , H04L2209/60
摘要： The disclosure relates generally to methods and apparatus for protecting against counterfeit products and for methods and apparatus for providing counterfeiting protection for an object. In one embodiment, the method includes the steps of: (a) accessing an object including an identifying mark having a first portion and a second portion wherein said second portion includes an encrypted feature; (b) reading the first portion to thereby obtain a first set of information; (c) transmitting the first set of information to a remote location; (d) receiving from the remote location a second set of information; and (e) reading the second portion using the second set of information to thereby determine the authenticity of the object.

7. 发明申请

US20070152032A1 Method and apparatus for counterfeiting protection 审中-公开
公开(公告)号：US20070152032A1
公开(公告)日：2007-07-05
申请号：US11641667
申请日：2006-12-20
申请人： David Tuschel , Thomas C. Voigt
发明人： David Tuschel , Thomas C. Voigt
IPC分类号： G06F17/00
CPC分类号： G06K19/10
摘要： The disclosure relates generally to methods and apparatus for protecting against counterfeit products and for methods and apparatus for providing counterfeiting protection for an object. In one embodiment, the method includes the steps of: (a) accessing an object including an identifying mark having a first portion and a second portion wherein said second portion includes an encrypted feature; (b) reading the first portion to thereby obtain a first set of information; (c) transmitting the first set of information to a remote location; (d) receiving from the remote location a second set of information; and (e) reading the second portion using the second set of information to thereby determine the authenticity of the object.

8. 发明申请

US20070008525A1 Method for Raman imaging of semiconductor materials 审中-公开
标题翻译：半导体材料拉曼成像方法
公开(公告)号：US20070008525A1
公开(公告)日：2007-01-11
申请号：US11520348
申请日：2006-09-13
申请人： David Tuschel , Patrick Treado , Joseph Demuth
发明人： David Tuschel , Patrick Treado , Joseph Demuth
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01J3/28 , G01N21/274 , G01N21/6489 , G01N21/65
摘要： An ion implanted semiconductor surface is illuminated with a flood illumination of monochromatic radiation, and an image of the surface is taken using light which has been Raman scattered. The illumination and imaging system are calibrated by flood illuminating a uniformly Raman scattering surface.
摘要翻译：用单色辐射的泛光照射照射离子注入的半导体表面，并且使用已经被拉曼散射的光进行表面的图像。照明和成像系统通过泛光照射均匀的拉曼散射表面来校准。

9. 发明申请

US20060250613A1 Method and applications to enhance and image optical signals from biological objects 审中-公开
标题翻译：从生物对象增强和成像光信号的方法和应用
公开(公告)号：US20060250613A1
公开(公告)日：2006-11-09
申请号：US11404964
申请日：2006-04-14
申请人： Joseph Demuth , Patrick Treado , John Maier , David Tuschel
发明人： Joseph Demuth , Patrick Treado , John Maier , David Tuschel
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/32 , G01N21/658
摘要： A method and apparatus for imaging biological objects. A SERS surface is provided having enhancing structures uniformly distributed on the surface. The surface includes a two dimensional area of at least 5×105 nm. The enhancing structures may have a size, in at least one dimension of height, width and length, ranging from 100 nm to 1000 nm. A biological material is deposited on the SERS surface. The biological material on the SERS surface is illuminated using a monochromatic light source producing Raman scattered photons. The Raman scattered photons are filtered using a tunable filter into a plurality of predetermined wavelength bands. A two-dimensional array detector detects the filtered Raman scattered photons, in a spatially accurate manner. The results of filtering and detecting steps are combined to produce a plurality of spectrally resolved Raman images of the biological material.
摘要翻译：一种用于成像生物体的方法和装置。提供了具有均匀分布在表面上的增强结构的SERS表面。该表面包括至少5×10 5 nm的二维区域。增强结构可以在100nm至1000nm范围内的高度，宽度和长度的至少一个尺寸中具有尺寸。生物材料沉积在SERS表面上。使用产生拉曼散射光子的单色光源照射SERS表面上的生物材料。使用可调滤波器将拉曼散射光子滤波成多个预定波长带。二维阵列检测器以空间准确的方式检测经过滤波的拉曼散射光子。滤波和检测步骤的结果被组合以产生生物材料的多个光谱分辨的拉曼图像。

10. 发明申请

US20060170907A1 System for obtaining images in bright field and crossed polarization modes and chemical images in Raman, luminescence and absorption modes 有权
标题翻译：用于在拉曼，发光和吸收模式下在明场和交叉极化模式和化学图像中获得图像的系统
公开(公告)号：US20060170907A1
公开(公告)日：2006-08-03
申请号：US11393395
申请日：2006-03-30
申请人： David Tuschel
发明人： David Tuschel
IPC分类号： G01J3/44 , G01J3/30 , G01N21/65
CPC分类号： G01J3/44 , G01J3/10 , G01J3/1256 , G01J3/26 , G01J3/32 , G01N21/21 , G01N21/23 , G01N21/31 , G01N21/35 , G01N21/3563 , G01N21/359 , G01N21/6456 , G01N21/6458 , G01N21/65 , G01N2021/6471 , G01N2021/6493
摘要： An integrated system including one or more light sources, at least one processor, an optical lens, a two-dimensional tunable filter, one or more two-dimensional array of detection elements and instructions and a method using the integrated system. The system includes a plurality of modes: a Raman mode, an absorption mode, a luminescence mode, a crossed polarization mode, a crossed polarization absorption mode, bright field transmission or reflectance modes and a birefringence mode. The system includes instructions, executable by Sequential outputs from the two-dimensional array of detection elements is combined to generate a chemical image of the sample, wherein each of the sequential outputs from the first two-dimensional array of detection elements corresponds to spatially accurate wavelength-resolved images. The system is also used to detect dynamic changes in a sample over time by monitoring the sample using one or more of the modes.
摘要翻译：包括一个或多个光源的集成系统，至少一个处理器，光学透镜，二维可调滤波器，检测元件和指令的一个或多个二维阵列以及使用该集成系统的方法。该系统包括多种模式：拉曼模式，吸收模式，发光模式，交叉偏振模式，交叉偏振吸收模式，亮场透射或反射模式和双折射模式。该系统包括可由来自检测元件的二维阵列的顺序输出执行的指令，以组合以产生样本的化学图像，其中来自检测元件的第一二维阵列的每个顺序输出对应于空间上准确的波长解决的图像。该系统还用于通过使用一种或多种模式监测样品来随时间检测样品中的动态变化。

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