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    • 4. 发明申请
    • THERMALLY CROSS-LINKABLE PHOTO-HYDROLYZABLE INKJET PRINTABLE POLYMERS FOR MICROFLUIDIC CHANNELS
    • 用于微流控通道的热交联型可热缩水性可喷涂聚合物
    • US20140072777A1
    • 2014-03-13
    • US13611135
    • 2012-09-12
    • Dylan J. BodayJoseph KuczynskiRobert E. Meyer, III
    • Dylan J. BodayJoseph KuczynskiRobert E. Meyer, III
    • B05D3/06B05C11/00B05C5/02B32B33/00C09D11/10
    • B33Y10/00B29C64/112B33Y30/00B33Y50/02B33Y70/00C09D4/06C09D11/106C09D11/30C09D133/14Y10T428/24802
    • Thermally cross-linkable photo-hydrolyzable inkjet printable polymers are used to print microfluidic channels layer-by-layer on a substrate. In one embodiment, for each layer, an inkjet head deposits droplets of a mixture of hydrophobic polymer and cross-linking agent in a pattern lying outside a two-dimensional layout of the channels, and another inkjet head deposits droplets of a mixture of poly(tetrahydropyranyl methacrylate) PTHPMA (or another hydrophobic polymer which hydrolyzes to form a hydrophilic material), cross-linking agent, and a photoacid generator (PAG) in a pattern lying inside the two-dimensional layout of the channels. After all layers are printed, flood exposure of the entire substrate to UV radiation releases acid from the PAG which hydrolyzes PTHPMA to form hydrophilic poly(methacrylic acid) PMAA, thereby rendering the PTHPMA regions hydrophilic. The layers of these now-hydrophilic patterned regions together define the microfluidic channels. The cross-linking agent (e.g., triallyl isocyanurate TAIC) forms covalent cross-links between the two polymer phases.
    • 可热交联的光可水解可喷墨印刷聚合物用于在基材上逐层印刷微流体通道。 在一个实施方案中,对于每个层,喷墨头以疏水聚合物和交联剂的混合物的液滴以位于通道的二维布局之外的图案沉积,另一个喷墨头沉积聚 甲基丙烯酸四氢吡喃酯)PTHPMA(或水解形成亲水材料的另一种疏水性聚合物),交联剂和光致酸产生剂(PAG),其位于通道的二维布局内。 在印刷所有层之后,将整个基材暴露于紫外线辐射下,从PAG中释放酸,从而水解PTHPMA以形成亲水性聚(甲基丙烯酸)PMAA,从而使PTHPMA区亲水。 这些现在亲水的图案化区域的层一起限定了微流体通道。 交联剂(例如三烯丙基异氰脲酸酯TAIC)在两个聚合物相之间形成共价交联。
    • 8. 发明授权
    • Inkjet printing of microfluidic channels
    • 喷墨打印微流体通道
    • US08491083B2
    • 2013-07-23
    • US12913214
    • 2010-10-27
    • Dylan J. BodayJoseph KuczynskiRobert E. Meyer, III
    • Dylan J. BodayJoseph KuczynskiRobert E. Meyer, III
    • B41J29/38B41J2/015
    • B29C64/112B29L2031/756B33Y10/00B33Y30/00B33Y40/00B33Y50/02B33Y70/00B33Y80/00
    • A mechanism for fabricating microfluidic channels uses a three-dimensional inkjet printing unit to print the channels layer-by-layer on a substrate. In one embodiment, for each layer, an inkjet head deposits droplets of a hydrophobic material on a surface the substrate in a pattern lying outside a two-dimensional layout of the channels, and another inkjet head deposits droplets of a mixture of poly(tetrahydropyranyl methacrylate) PTHPMA (or another hydrophobic material which hydrolyzes to form a hydrophilic material) and a photoacid generator (PAG) on the surface of the substrate in a pattern lying inside the two-dimensional layout of the channels. After all layers are printed, flood exposure of the entire substrate to UV radiation releases acid from the PAG which hydrolyzes PTHPMA to form hydrophilic poly(methacrylic acid) PMMA, thereby rendering the PTHPMA regions hydrophilic. The layers of these now-hydrophilic patterned regions together define the microfluidic channels.
    • 用于制造微流体通道的机构使用三维喷墨印刷单元在衬底上逐层印刷通道。 在一个实施方案中,对于每个层,喷墨头以位于通道的二维布局之外的图案将衬底上的疏水材料的液滴沉积在基板上,而另一个喷墨头将聚(四氢吡喃甲基丙烯酸酯 )PTHPMA(或水解形成亲水材料的另一种疏水性材料)和光致酸产生剂(PAG)以位于通道的二维布局内的图案在基材表面上。 在印刷所有层之后,将整个基底暴露于UV辐射从PAG释放酸,其水解PTHPMA以形成亲水性聚(甲基丙烯酸)PMMA,从而使PTHPMA区亲水。 这些现在亲水的图案化区域的层一起限定了微流体通道。