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1. 发明申请

US20220313986A1 SYSTEMS AND METHODS FOR VAGAL NERVE STIMULATION 有权
公开(公告)号：US20220313986A1
公开(公告)日：2022-10-06
申请号：US17843736
申请日：2022-06-17
申请人： Bruce J. Simon , Joseph P. Errico
发明人： Bruce J. Simon , Joseph P. Errico
IPC分类号： A61N1/05 , A61N1/36 , A61N1/04 , A61N2/00
摘要： Devices, systems and methods are disclosed for electrical stimulation of the vagus nerve to treat or prevent disorders in a patient. The methods comprise transmitting impulses of energy to the vagus nerve according to a treatment paradigm. The treatment paradigm may include generating and transmitting the electrical impulse as a single dose from about 30 seconds to about 5 minutes. The treatment paradigm may comprise a treatment session of 2 to 4 times within an hour time period and/or as a single dose from 2 to 5 times during a day.

2. 发明授权

US09126050B2 Non-invasive vagus nerve stimulation devices and methods to treat or avert atrial fibrillation 有权
标题翻译：非侵入性迷走神经刺激装置和治疗或避免房颤的方法
公开(公告)号：US09126050B2
公开(公告)日：2015-09-08
申请号：US13736096
申请日：2013-01-08
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36 , A61N1/362
CPC分类号： A61N1/3625 , A61N1/36014 , A61N1/36053 , A61N1/36114 , A61N1/36171 , A61N1/36178 , A61N1/362
摘要： Energy is transmitted noninvasively to a patient using electrode-based stimulation devices or magnetic stimulation devices that are designed to non-invasively stimulate nerves selectively. The devices produce impulses that are used to treat atrial fibrillation, by stimulating a vagus nerve of a patient. The devices are also used to forecast the imminent onset of atrial fibrillation and then avert it by stimulating a vagus nerve.
摘要翻译：使用基于电极的刺激装置或设计成非侵入性地刺激神经的磁刺激装置将能量非侵入地传播给患者。该装置通过刺激患者的迷走神经产生用于治疗房颤的脉冲。这些装置也用于预测心房颤动即将发生，然后通过刺激迷走神经来避免。

3. 发明申请

US20150105412A1 COMBINATION THERAPY WITH MDM2 AND EFGR INHIBITORS 有权
标题翻译：与MDM2和EFGR抑制剂组合治疗
公开(公告)号：US20150105412A1
公开(公告)日：2015-04-16
申请号：US14571770
申请日：2014-12-16
申请人： Joseph P. Errico
发明人： Joseph P. Errico , Benjamin Mugrage , Ignatius Turchi , Matthew Sills , Jane Ong , John Allocco , Pam Wines , Margarita Bastos
IPC分类号： A61K31/517 , C07D409/06 , A61K31/4709
CPC分类号： C07D401/12 , A61K31/4709 , A61K31/517 , A61K39/3955 , C07D409/06 , C07K16/44
摘要： Provided is a method of treating a proliferative disease, condition, or disorder in a subject by administering a combination of an inhibitor of p53 and MDM2 binding and an EGFR inhibitor. Various embodiments of the disclosed methods provide a synergistic anti-proliferative or anti-apoptotic effect compared to administration of one agent alone.
摘要翻译：提供了通过施用p53和MDM2结合的抑制剂与EGFR抑制剂的组合来治疗受试者的增殖性疾病，病症或病症的方法。与单独施用一种试剂相比，所公开方法的各种实施方案提供协同的抗增殖或抗凋亡作用。

4. 发明授权

US08983628B2 Non-invasive vagal nerve stimulation to treat disorders 有权
标题翻译：非侵入性迷走神经刺激治疗疾病
公开(公告)号：US08983628B2
公开(公告)日：2015-03-17
申请号：US13603781
申请日：2012-09-05
申请人： Bruce Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/18 , A61N1/36 , A61N1/40 , A61N2/00 , A61N1/04 , A61N2/02 , A61B5/08
CPC分类号： A61N1/36014 , A61B5/08 , A61B5/082 , A61N1/0456 , A61N1/3601 , A61N1/40 , A61N2/006 , A61N2/008 , A61N2/02
摘要： Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
摘要翻译：公开了用于治疗主要或至少部分地由脑中的神经递质不平衡驱动的各种疾病和病症的装置，系统和方法，例如哮喘，COPD，抑郁症，焦虑症，癫痫，纤维肌痛等。本发明涉及使用能量源，该能量源包括磁性和/或电能非侵入性或非常接近所选择的神经以暂时刺激，阻断和/或调节选定神经中的信号，使得激活神经通路以释放患者大脑中的抑制性神经递质。

5. 发明授权

US08940047B2 Intervertebral spacer device having recessed notch pairs for manipulation using a surgical tool 有权
公开(公告)号：US08940047B2
公开(公告)日：2015-01-27
申请号：US12321562
申请日：2009-01-22
申请人： Joseph P. Errico , Michael W. Dudasik , Rafail Zubok
发明人： Joseph P. Errico , Michael W. Dudasik , Rafail Zubok
IPC分类号： A61F2/44 , A61B17/58 , A61B17/02 , A61F2/46 , A61F2/30
CPC分类号： A61F2/4425 , A61B17/025 , A61B2017/0256 , A61F2/30742 , A61F2/30767 , A61F2/442 , A61F2/446 , A61F2/4611 , A61F2/4684 , A61F2002/30171 , A61F2002/30187 , A61F2002/302 , A61F2002/30331 , A61F2002/30365 , A61F2002/30378 , A61F2002/30433 , A61F2002/30441 , A61F2002/30443 , A61F2002/30444 , A61F2002/30446 , A61F2002/30451 , A61F2002/30454 , A61F2002/30492 , A61F2002/30502 , A61F2002/30507 , A61F2002/30518 , A61F2002/30528 , A61F2002/30538 , A61F2002/30563 , A61F2002/30565 , A61F2002/30571 , A61F2002/30594 , A61F2002/30604 , A61F2002/30649 , A61F2002/30769 , A61F2002/30772 , A61F2002/30774 , A61F2002/30785 , A61F2002/30841 , A61F2002/30909 , A61F2002/3092 , A61F2002/30975 , A61F2002/443 , A61F2002/4619 , A61F2002/4627 , A61F2002/4628 , A61F2220/0025 , A61F2220/0033 , A61F2220/0041 , A61F2220/0058 , A61F2230/0034 , A61F2230/005 , A61F2230/0065 , A61F2250/0006 , A61F2310/00017 , A61F2310/00023 , A61F2310/00365
摘要： Instrumentation for implanting an artificial intervertebral disc includes static trials and a dynamic trial for determining the appropriate size of disc to be implanted, static trial holders for manipulating the static trials, inserter/impactors for inserting and removing the static trials and for inserting the artificial intervertebral discs, repositioners/extractors for repositioning and extracting the static trials or the artificial intervertebral discs, and a leveler for setting the proper position of the artificial intervertebral disc. Methods for using the same are also disclosed. Features for artificial intervertebral discs and intervertebral spacer devices useful for manipulation by the instrumentation are also disclosed.

6. 发明授权

US08918178B2 Non-invasive vagal nerve stimulation to treat disorders 有权
标题翻译：非侵入性迷走神经刺激治疗疾病
公开(公告)号：US08918178B2
公开(公告)日：2014-12-23
申请号：US13603799
申请日：2012-09-05
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/34 , A61N1/40 , A61N1/36 , A61N2/00 , A61N2/02 , A61B5/00
CPC分类号： A61N1/3601 , A61B5/4836 , A61N1/36014 , A61N1/40 , A61N2/006 , A61N2/008 , A61N2/02
摘要： Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
摘要翻译：公开了用于治疗主要或至少部分地由脑中的神经递质不平衡驱动的多种疾病和病症的装置，系统和方法，例如哮喘，COPD，抑郁症，焦虑症，癫痫，纤维肌痛等。本发明涉及使用能量源，该能量源包括磁性和/或电能非侵入性或非常接近所选择的神经以暂时刺激，阻断和/或调节选定神经中的信号，使得激活神经通路以释放患者大脑中的抑制性神经递质。

7. 发明授权

US08858564B2 Wedge plate inserter/impactor and related methods for use in implanting an artificial intervertebral disc 有权
标题翻译：楔形板插入器/冲击器以及用于植入人造椎间盘的相关方法
公开(公告)号：US08858564B2
公开(公告)日：2014-10-14
申请号：US10784645
申请日：2004-02-23
申请人： Joseph P. Errico , Michael W. Dudasik , Rafail Zubok
发明人： Joseph P. Errico , Michael W. Dudasik , Rafail Zubok
IPC分类号： A61B17/56 , A61B17/70 , A61F2/44 , A61B17/02 , A61F2/46 , A61F2/30
CPC分类号： A61F2/442 , A61B2017/0256 , A61F2/30742 , A61F2/30767 , A61F2/4425 , A61F2/446 , A61F2/4611 , A61F2/4684 , A61F2002/30171 , A61F2002/30187 , A61F2002/302 , A61F2002/30331 , A61F2002/30365 , A61F2002/30378 , A61F2002/30433 , A61F2002/30441 , A61F2002/30443 , A61F2002/30444 , A61F2002/30446 , A61F2002/30451 , A61F2002/30454 , A61F2002/30492 , A61F2002/30502 , A61F2002/30507 , A61F2002/30518 , A61F2002/30528 , A61F2002/30538 , A61F2002/30563 , A61F2002/30565 , A61F2002/30571 , A61F2002/30594 , A61F2002/30604 , A61F2002/30616 , A61F2002/30649 , A61F2002/30662 , A61F2002/30769 , A61F2002/30772 , A61F2002/30774 , A61F2002/30785 , A61F2002/30841 , A61F2002/30909 , A61F2002/3092 , A61F2002/30975 , A61F2002/443 , A61F2002/4619 , A61F2002/4627 , A61F2002/4628 , A61F2220/0025 , A61F2220/0033 , A61F2220/0041 , A61F2220/0058 , A61F2230/0034 , A61F2230/005 , A61F2230/0065 , A61F2250/0006 , A61F2310/00017 , A61F2310/00023 , A61F2310/00365
摘要： A wedge plate inserter/impactor instrument is provided primarily for holding, inserting, repositioning, removing, impacting, extracting, and otherwise manipulating an artificial intervertebral disc having features suitable for being manipulated thereby. A spring-loaded holding pin of the instrument can be used to engage a corresponding hole on the disc and confront the angled surfaces of the disc to enable the holding and manipulation of the disc. A forward wedge extension of the inserter/impactor has upper and lower surfaces that engage inwardly facing surfaces of the disc to hold the baseplates of the disc at a preferred lordosis angle with respect to one another. The instrument can engage the disc from a variety of surgical approach angles.
摘要翻译：提供楔形板插入器/冲击器主要用于保持，插入，重新定位，移除，冲击，提取和以其他方式操纵具有适于被操纵的特征的人造椎间盘。可以使用仪器的弹簧加载的固定销来接合盘上的对应的孔并且面对盘的成角度的表面以实现盘的保持和操纵。插入器/冲击器的向前楔形延伸部具有与盘的面向内的表面接合的上表面和下表面，以将盘的基板相对于彼此保持在优选的前凸角度。该仪器可以从各种手术进近角度接合椎间盘。

8. 发明授权

US08843210B2 Non-invasive vagal nerve stimulation to treat disorders 有权
公开(公告)号：US08843210B2
公开(公告)日：2014-09-23
申请号：US13603852
申请日：2012-09-05
申请人： Bruce Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36 , A61N1/40 , A61B5/00 , A61N2/00 , A61N2/02
CPC分类号： A61N1/3601 , A61B5/4836 , A61N1/36014 , A61N1/40 , A61N2/006 , A61N2/008 , A61N2/02
摘要： Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.

9. 发明授权

US08676330B2 Electrical and magnetic stimulators used to treat migraine/sinus headache and comorbid disorders 有权
标题翻译：用于治疗偏头痛/窦性头痛和并发症的电磁刺激剂
公开(公告)号：US08676330B2
公开(公告)日：2014-03-18
申请号：US13109250
申请日：2011-05-17
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36
CPC分类号： A61N1/36021 , A61N1/0456 , A61N1/36075 , A61N1/40 , A61N2/006 , A61N2/008 , A61N2/02
摘要： Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache. The disclosed methods may also be used to treat other disorders that may be co-morbid with migraine headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.
摘要翻译：公开了非侵入性电神经刺激装置和磁刺激装置，以及使用由这种装置非侵入性地输送的能量来治疗医学病症的方法。这些疾病包括偏头痛和其他原发性头痛，例如丛集性头痛，包括类似于免疫介导的反应（“窦”头痛）的窦性症状，而不管这些症状是否由与头痛并发的过敏引起。所公开的方法还可以用于治疗可能与偏头痛如焦虑症一起并发的其它疾病。在所公开的方法的优选实施例中，患者的迷走神经中的一个或两个被非侵入性地刺激。在其它实施方案中，刺激部分交感神经系统和/或肾上腺。

10. 发明授权

US08612004B2 Electrical stimulation treatment of hypotension 有权
公开(公告)号：US08612004B2
公开(公告)日：2013-12-17
申请号：US13537547
申请日：2012-06-29
申请人： Joseph P. Errico , Bruce J. Simon , Steven Mendez
发明人： Joseph P. Errico , Bruce J. Simon , Steven Mendez
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/0456 , A61N1/05 , A61N1/0517 , A61N1/0519 , A61N1/36014 , A61N1/36053 , A61N1/36117 , A61N1/36153 , A61N1/36171 , A61N1/36175
摘要： The present invention includes methods and devices for treating hypotension, such as in cases of shock, including septic shock, anaphylactic shock and hypovolemia. The method includes the step of applying at least one electrical impulse to at least one selected region of a parasympathetic nervous system of the patient. The electrical impulse is sufficient to modulate one or more nerves of the parasympathetic nervous system to increase the ratio of blood pressure to heart rate and relieve the condition and/or extend the patient's life.

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