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1. 发明授权

US06500147B2 Flexible catheter 有权
标题翻译：柔性导管
公开(公告)号：US06500147B2
公开(公告)日：2002-12-31
申请号：US09253591
申请日：1999-02-22
申请人： Samuel L. Omaleki , Isaac J. Kim , Jefferey C. Bleam , Juan T. Domingo , Andres D. Tomas , Celso J. Bagaoisan
发明人： Samuel L. Omaleki , Isaac J. Kim , Jefferey C. Bleam , Juan T. Domingo , Andres D. Tomas , Celso J. Bagaoisan
IPC分类号： A61M2900
CPC分类号： A61M25/104 , A61M25/0054 , A61M25/09 , A61M25/09033 , A61M2025/0098 , A61M2025/09008 , A61M2025/09183 , A61M2025/1079 , A61M2025/1093
摘要： A balloon catheter having improved flexibility in and about its distal end is provided. The flexibility of the catheter is determined in part by improving the properties of a wire or catheter located within the area where the balloon is mounted. In one aspect of the present invention, connecting wires extend through the balloon from the distal end of a catheter body to the proximal end of a core wire. The core wire extends distally away from the connecting wires and the catheter body. In another aspect of the present invention, a core wire is provided having a proximal end extending within the balloon into the catheter tubular body but is not mounted therein. This allows the proximal end of the core wire to “float” within the tubular body, such that when the catheter is advanced through the vasculature of a patient, the core wire may move longitudinally within the tubular body. In another aspect of the present invention, the balloon is mounted over a tubular body which is configured to give the catheter longitudinal flexibility.
摘要翻译：提供了具有在其远端中及其远端具有改进的柔性的球囊导管。导管的灵活性部分地通过改进位于安装气球的区域内的线或导管的性质来确定。在本发明的一个方面，连接线从导管主体的远端延伸穿过球囊到芯线的近端。芯线远离连接线和导管主体延伸。在本发明的另一方面，提供了一种芯线，其具有在气囊内延伸到导管管状体中但未安装在其中的近端。这允许芯线的近端在管状体内“漂浮”，使得当导管前进通过患者的脉管系统时，芯线可以在管状体内纵向移动。在本发明的另一方面，气囊被安装在管状体上，该管状体被配置成给予导管的纵向柔性。

2. 发明授权

US06190332B1 Core wire with shapeable tip 失效
标题翻译：具有可塑尖端的芯线
公开(公告)号：US06190332B1
公开(公告)日：2001-02-20
申请号：US09026357
申请日：1998-02-19
申请人： Ketan P. Muni , Sivette Lam , Juan T. Domingo , Gholam-Reza Zadno-Azizi , Samuel Omaleki , Isaac J. Kim , Celso J. Bagaoisan
发明人： Ketan P. Muni , Sivette Lam , Juan T. Domingo , Gholam-Reza Zadno-Azizi , Samuel Omaleki , Isaac J. Kim , Celso J. Bagaoisan
IPC分类号： A61B500
CPC分类号： C22F1/006 , A61M25/09 , A61M2025/09175 , A61M2025/1093
摘要： The present invention provides an improved core wire for use in a medical catheter. In one aspect, the invention provides a core wire with a shapeable tip and method of manufacturing the same. A core wire previously made superelastic is subject to additional processing to remove its superelasticity thereby allowing the material to be shapeable to aid in advancing the core wire through a blood vessel or other body cavities. In another aspect of the present invention, a method is provided for securing the core wire to the distal end of an elongated catheter tubular body. The tubular body is mechanically crimped onto the core wire to secure the core wire in place. This crimping method has been found to increase the strength of the bond between the core wire and the catheter tube so that greater pull force is required to break the core wire off from the catheter.
摘要翻译：本发明提供一种用于医疗导管的改进的芯线。一方面，本发明提供一种具有可成形尖端的芯线及其制造方法。预先制成超弹性的芯线经受额外的处理以去除其超弹性，从而允许材料可成型以帮助将芯线推进通过血管或其它体腔。在本发明的另一方面，提供了一种用于将芯线固定到细长导管管体的远端的方法。将管状体机械地压接在芯线上以将芯线固定到位。已经发现这种卷曲方法增加了芯线和导管之间的结合强度，使得需要更大的拉力来将芯线从导管断开。

3. 发明授权

US06468230B2 Core wire with shapeable tip 失效
公开(公告)号：US06468230B2
公开(公告)日：2002-10-22
申请号：US10035706
申请日：2001-12-21
申请人： Ketan P. Muni , Sivette Lam , Juan T. Domingo , Gholam-Reza Zadno-Azizi
发明人： Ketan P. Muni , Sivette Lam , Juan T. Domingo , Gholam-Reza Zadno-Azizi
IPC分类号： A61B500
CPC分类号： C22F1/006 , A61M25/09 , A61M2025/09175 , A61M2025/1093
摘要： The present invention provides an improved core wire for use in a medical catheter. In one aspect, the invention provides a core wire with a shapeable tip and method of using the same. A core wire previously made superelastic is subject to additional processing to remove its superelasticity thereby allowing the material to be shapeable to aid in advancing the core wire through a blood vessel or other body cavities. In another aspect of the present invention, a method is provided for securing the core wire to the distal end of an elongated catheter tubular body. The tubular body is mechanically crimped onto the core wire to secure the core wire in place. This crimping method has been found to increase the strength of the bond between the core wire and the catheter tube so that greater pull force is required to break the core wire off from the catheter.

4. 发明授权

US06319229B1 Balloon catheter and method of manufacture 失效
标题翻译：球囊导管及制造方法
公开(公告)号：US06319229B1
公开(公告)日：2001-11-20
申请号：US09432990
申请日：1999-11-03
申请人： Isaac J. Kim , Juan T. Domingo , Celso J. Bagaoisan
发明人： Isaac J. Kim , Juan T. Domingo , Celso J. Bagaoisan
IPC分类号： A61M2900
CPC分类号： A61M25/1029 , A61M25/0009 , A61M25/1034 , B29C55/04
摘要： Disclosed herein is a compliant catheter balloon with an improved elastic response and reduced longitudinal expansion, and a method of forming the same. The balloon comprises a SEBS block copolymer, which is longitudinally pre-stretched during the balloon manufacture process. In order to control the working length of a balloon on a catheter, at least one adhesive stop is provided on the catheter which prevents adhesive from wicking into the working length of the balloon. Preferably, a pair of thermoset tubings with an outer diameter size close to the size of the inner diameter of the balloon are inserted on the distal portion of the catheter. After the proper placement of the balloon, the adhesive is applied at the balloon's proximal and distal ends. As the adhesive wicks to the balloon, the thermoset tubings will eventually stop the adhesive to prevent further wicking of adhesive into the balloon's working length. In another aspect of the present invention, there is provided a method of manufacturing a balloon catheter to improve centering of the balloon on the catheter. After a balloon tubing is stretched, the stretched tubing is clamped to a fixture and stabilized at about 100° C. for 15 minutes. This stabilization step ensures that a balloon mounted on a catheter will inflate in a uniform manner.
摘要翻译：本文公开了一种具有改进的弹性响应和减小的纵向膨胀的柔顺导管气囊及其形成方法。气球包含SEBS嵌段共聚物，其在球囊制造过程中被纵向预拉伸。为了控制导管上的气球的工作长度，在导管上提供至少一个粘合阻挡件，其防止粘合剂吸入气球的工作长度。优选地，具有接近球囊内径尺寸的外径尺寸的一对热固管插入导管的远端部分。在适当放置气囊之后，将粘合剂施加在气囊的近端和远端。当粘合剂吸入气球时，热固性管将最终停止粘合剂，以防止粘合剂进一步吸入气囊的工作长度。在本发明的另一方面，提供一种制造球囊导管以改善球囊在导管上的对中的方法。在气囊管被拉伸之后，将拉伸的管道夹紧到夹具上并在约100℃下稳定15分钟。该稳定步骤确保安装在导管上的气囊将以均匀的方式充气。

5. 发明授权

US06375629B1 Core wire with shapeable tip 有权
标题翻译：具有可塑尖端的芯线
公开(公告)号：US06375629B1
公开(公告)日：2002-04-23
申请号：US09690588
申请日：2000-10-17
申请人： Ketan P. Muni , Sivette Lam , Juan T. Domingo , Gholam-Reza Zadno-Azizi , Samuel Omaleki , Isaac J. Kim , Celso J. Bagaoisan
发明人： Ketan P. Muni , Sivette Lam , Juan T. Domingo , Gholam-Reza Zadno-Azizi , Samuel Omaleki , Isaac J. Kim , Celso J. Bagaoisan
IPC分类号： A61B500
CPC分类号： C22F1/006 , A61M25/09 , A61M2025/09175 , A61M2025/1093
摘要： The present invention provides an improved core wire for use in a medical catheter. In one aspect, the invention provides a core wire with a shapeable tip and method of manufacturing the same. A core wire previously made superelastic is subject to additional processing to remove its superelasticity thereby allowing the material to be shapeable to aid in advancing the core wire through a blood vessel or other body cavities. In another aspect of the present invention, a method is provided for securing the core wire to the distal end of an elongated catheter tubular body. The tubular body is mechanically crimped onto the core wire to secure the core wire in place. This crimping method has been found to increase the strength of the bond between the core wire and the catheter tube so that greater pull force is required to break the core wire off from the catheter.
摘要翻译：本发明提供一种用于医疗导管的改进的芯线。一方面，本发明提供一种具有可成形尖端的芯线及其制造方法。预先制成超弹性的芯线经受额外的处理以去除其超弹性，从而允许材料可成型以帮助将芯线推进通过血管或其它体腔。在本发明的另一方面，提供了一种用于将芯线固定到细长导管管体的远端的方法。将管状体机械地压接在芯线上以将芯线固定到位。已经发现这种卷曲方法增加了芯线和导管之间的结合强度，使得需要更大的拉力来将芯线从导管断开。

6. 发明授权

US06355016B1 Catheter core wire 有权
标题翻译：导管芯线
公开(公告)号：US06355016B1
公开(公告)日：2002-03-12
申请号：US09253971
申请日：1999-02-22
申请人： Celso J. Bagaoisan , Ketan P. Muni , Gholam-Reza Zadno-Azizi , Sivette Lam , Juan T. Domingo , Isaac J. Kim , Samuel L. Omaleki , Jefferey C. Bleam
发明人： Celso J. Bagaoisan , Ketan P. Muni , Gholam-Reza Zadno-Azizi , Sivette Lam , Juan T. Domingo , Isaac J. Kim , Samuel L. Omaleki , Jefferey C. Bleam
IPC分类号： A61M2900
CPC分类号： A61M25/104 , A61M25/09 , A61M25/09033 , A61M2025/09175 , A61M2025/1093 , C22F1/006
摘要： Disclosed herein is an improved core wire for use in a medical catheter. In one aspect, a tapering core wire is incorporated into the distal end of a catheter. The catheter has a tubular body. Both ends of an inflatable balloon are mounted to the tubular body. The core wire extends from the distal end of the tubular body. In one embodiment, substantially all of the taper of the core wire occurs in the extending portion of the core wire over a length of at least 15 mm but no more than 60 mm. In another aspect, a core wire with a shapeable tip and method of manufacturing the same are provided. A core wire previously made superelastic is subject to additional processing to remove its superelasticity thereby allowing the material to be shapeable to aid in advancing the core wire through a blood vessel or other body cavities. In another aspect of the present invention, a method is provided for securing the core wire to the distal end of an elongated catheter tubular body. The tubular body is mechanically crimped onto the core wire to secure the core wire in place. This crimping method has been found to increase the strength of the bond between the core wire and the catheter tube so that greater pull force is required to break the core wire off from the catheter.
摘要翻译：本文公开了一种用于医疗导管的改进的芯线。在一个方面，锥形芯线被并入导管的远端。导管具有管状体。可充气气囊的两端安装在管状体上。芯线从管状体的远端延伸。在一个实施例中，芯线的基本上所有的锥形在芯线的延伸部分中发生长度至少为15mm但不大于60mm。另一方面，提供了具有可成形尖端的芯线及其制造方法。预先制成超弹性的芯线经受额外的处理以去除其超弹性，从而允许材料可成型以帮助将芯线推进通过血管或其它体腔。在本发明的另一方面，提供了一种用于将芯线固定到细长导管管体的远端的方法。将管状体机械地压接在芯线上以将芯线固定到位。已经发现这种卷曲方法增加了芯线和导管之间的结合强度，使得需要更大的拉力来将芯线从导管断开。

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