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    • 9. 发明申请
    • Linker molecules for selective metallisation of nucleic acids and their uses
    • 用于核酸选择性金属化的接头分子及其用途
    • US20060246482A1
    • 2006-11-02
    • US11365656
    • 2006-03-02
    • William FordJurina WesselsAkio Yasuda
    • William FordJurina WesselsAkio Yasuda
    • C12Q1/68G06F19/00C07H21/04
    • B82Y30/00B82Y5/00C07C235/74C07C237/20C07C323/60C07H21/00
    • The present invention is related to the linker molecules comprising one or more nucleic acid binding group and one or more nanoparticle binding group which are connected covalently by a spacer group. The problem underlying the present invention is to provide methods for the controlled and selective metallisation of nucleic acids, the production of nanowires which may be used, e. g., in the formation of electronic networks and circuits allowing a high density arrangement, and the components of devices that may be incorporated in such networks and circuits. This problem is solved by a linker molecule which comprises one or more nucleic acid binding group(s) and one or more nanoparticle binding group(s) which are connected covalently by a spacer group. Such linkers can be used for the manufacture of nucleic acid/linker conjugates, nanoparticle/linker conjugates, and nanoparticle/linker/nucleic acid composites and further nanowires, electronic networks, electronic circuits and junctions comprising said nanowires.
    • 本发明涉及包含由间隔基团共价连接的一个或多个核酸结合基团和一个或多个纳米粒子结合基团的连接体分子。 本发明的潜在问题是提供核酸的受控和选择性金属化的方法,可以使用的纳米线的生产, 例如,形成允许高密度布置的电子网络和电路,以及可以并入这种网络和电路中的设备的组件。 该问题通过包含一个或多个核酸结合基团和由间隔基团共价连接的一个或多个纳米粒子结合基团的连接分子来解决。 这样的接头可以用于制造核酸/接头缀合物,纳米颗粒/连接体缀合物和纳米颗粒/连接体/核酸复合物,以及纳米线,电子网络,电子电路和包含所述纳米线的结。