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1. 发明申请

US20180330477A1 SYSTEMS AND METHODS FOR ANALYZING PATHOLOGIES UTILIZING QUANTITATIVE IMAGING 审中-公开
公开(公告)号：US20180330477A1
公开(公告)日：2018-11-15
申请号：US15874474
申请日：2018-01-18
申请人： David S. Paik , Andrew J. Buckler , Kjell Johnson , Xiaonan Ma , Keith A. Moulton
发明人： David S. Paik , Andrew J. Buckler , Kjell Johnson , Xiaonan Ma , Keith A. Moulton
IPC分类号： G06T5/00 , G06T7/136 , G06T7/11 , G06T7/194 , G06T7/00 , G06K9/46
摘要： The present disclosure provides for improved image analysis via novel deblurring and segmentation techniques of image data. These techniques advantageously account for and incorporate segmentation of biological analytes into a deblurring process for an image. Thus, the deblurring of the image may advantageously be optimized for enabling identification and quantitative analysis of one or more biological analytes based on underlying biological models for those analytes. The techniques described herein provide for significant improvements in the image deblurring and segmentation process which reduces signal noise and improves the accuracy of the image. In particular, the system and methods described herein advantageously utilize unique optimization and tissue characteristics image models which are informed by the underlying biology being analyzed, (for example by a biological model for the analytes). This provides for targeted deblurring and segmentation which is optimized for the applied image analytics.

2. 发明授权

US06321158B1 Integrated routing/mapping information 失效
标题翻译：集成路由/映射信息
公开(公告)号：US06321158B1
公开(公告)日：2001-11-20
申请号：US09144836
申请日：1998-08-31
申请人： David M. DeLorme , Keith A. Gray , Gordon Autry , Keith A. Moulton
发明人： David M. DeLorme , Keith A. Gray , Gordon Autry , Keith A. Moulton
IPC分类号： G01C2130
CPC分类号： G06Q10/02 , G01C21/26 , G01C21/3476 , G01C21/36 , G01C21/3679 , G06Q10/047 , G08G1/0969 , G09B29/106
摘要： An Integrated Routing/Mapping Information System (IRMIS) links desktop personal computer cartographic applications to one or more handheld organizer, personal digital assistant (PDA) or “palmtop” devices. Such devices may be optionally equipped with, or connected to, portable Global Positioning System (GPS) or equivalent position sensing device. Desktop application facilitates user selection of areas, starts, stops, destinations, maps and/or point and/or route information. It optionally includes supplemental online information, preferably for transfer to the PDA or equivalent device. Users' options include route information, area, and route maps. Maps and related route information are configured with differential detail and levels of magnitude. Used in the field, in conjunction with GPS receiver, the PDA device is configured to display directions, text and map formats, the user's current position, heading, speed, elevation, and so forth. Audible signals identifying the next turn along the user's planned route are also provided. The user can pan across maps and zoom between two or more map scales, levels of detail, or magnitudes. The IRMIS also provides for “automatic zooming,” e.g., to show greater detail or closer detail as the user approaches a destination, or to larger scale and lower resolution to show the user's overall planned route between points of interest. The IRMIS also enables the user to mark or record specific locations and/or log actual travel routes, using GPS position information. These annotated location marks and/or “breadcrumb” or GPS log data can be saved, uploaded, displayed, or otherwise processed on the user's desktop geographic information or cartographic system. The IRMIS application and data may be distributed online and/or in tangible media in limited and advanced manipulation formats.
摘要翻译：综合路由/映射信息系统（IRMIS）将桌面个人计算机制图应用程序链接到一个或多个手持组织者，个人数字助理（PDA）或“掌上电脑”设备。这样的设备可以可选地配备有或连接到便携式全球定位系统（GPS）或等同位置感测装置。桌面应用程序便于用户选择区域，启动，停止，目的地，地图和/或点和/或路线信息。它可选地包括补充的在线信息，优选地用于传送到PDA或等效设备。用户的选项包括路线信息，区域和路线图。地图和相关路线信息配置有差异细节和幅度。在本领域中，与GPS接收机一起使用，PDA设备被配置为显示方向，文本和地图格式，用户的当前位置，航向，速度，高程等。还提供了识别沿用户计划路线的下一回合的声音信号。用户可以跨地图平移，并在两个或多个地图尺度，细节级别或幅度之间缩放。 IRMIS还提供“自动缩放”，例如，当用户接近目的地时显示更多的细节或更详细的细节，或者提供更大规模和更低的分辨率，以显示用户在兴趣点之间的总体计划路线。 IRMIS还允许用户使用GPS位置信息来标记或记录特定位置和/或记录实际行驶路线。这些注释的位置标记和/或“导航痕迹”或GPS记录数据可以在用户的桌面地理信息或制图系统上保存，上传，显示或以其他方式处理。 IRMIS应用程序和数据可以在有限和高级的操作格式中在线和/或有形媒体分发。

3. 发明授权

US10176408B2 Systems and methods for analyzing pathologies utilizing quantitative imaging 有权
公开(公告)号：US10176408B2
公开(公告)日：2019-01-08
申请号：US14959732
申请日：2015-12-04
申请人： David S. Paik , Andrew J. Buckler , Kjell Johnson , Xiaonan Ma , Keith A. Moulton
发明人： David S. Paik , Andrew J. Buckler , Kjell Johnson , Xiaonan Ma , Keith A. Moulton
IPC分类号： G06K9/00 , G06K9/62
摘要： Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.

4. 发明申请

US20170046839A1 SYSTEMS AND METHODS FOR ANALYZING PATHOLOGIES UTILIZING QUANTITATIVE IMAGING 审中-公开
标题翻译：使用定量成像分析病理学的系统和方法
公开(公告)号：US20170046839A1
公开(公告)日：2017-02-16
申请号：US14959732
申请日：2015-12-04
申请人： David S. Paik , Andrew J. Buckler , Kjell Johnson , Xiaonan Ma , Keith A. Moulton
发明人： David S. Paik , Andrew J. Buckler , Kjell Johnson , Xiaonan Ma , Keith A. Moulton
IPC分类号： G06T7/00
CPC分类号： G06K9/6296 , A61B6/032 , A61B6/504 , G06K9/00147
摘要： Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.
摘要翻译：本文介绍了利用定量成像分析病变的系统和方法。有利地，本公开的系统和方法利用分层分析框架，其从成像数据识别和定量生物学特性/分析物，然后基于量化的生物学特性/分析物来鉴定和表征一种或多种病理学。使用成像检查潜在生物学作为评估病理学的中介的这种分层方法提供了许多分析和处理优势，其优于被配置为直接确定和表征基础成像数据的病理学的系统和方法。

5. 发明申请

US20170046484A1 METHODS AND SYSTEMS FOR REPRESENTING, STORING, AND ACCESSING COMPUTABLE MEDICAL IMAGING-DERIVED QUANTITIES 审中-公开
标题翻译：用于表示，存储和访问可计算的医学成像衍生数量的方法和系统
公开(公告)号：US20170046484A1
公开(公告)日：2017-02-16
申请号：US15237249
申请日：2016-08-15
申请人： Andrew J. Buckler , Keith A. Moulton , Mary Buckler , Larry Martell , David S. Paik , Xiaonan Ma , Samantha St. Pierre
发明人： Andrew J. Buckler , Keith A. Moulton , Mary Buckler , Larry Martell , David S. Paik , Xiaonan Ma , Samantha St. Pierre
IPC分类号： G06F19/00 , G06F17/30 , G06F21/62
摘要： Methods and systems for making image-derived information available by performing analyses with semantic annotations accessible using semantic web technology for personalized medicine and discovery science are disclosed. Individual cases are identified according to an identification scheme. Targets for image analysis for each case are characterized in order to support tracking of a given anatomy, suspected pathology, confirmed pathology, or medical intervention at one or more timepoints. Access information to one or more medical images of each target at each one of the one or more timepoints is provided and stored. One or more levels of image-derived analysis is obtained and stored, the image derived analysis including at least one of imaging features, measured quantities, phenotypic descriptions, or predictions relative to said one case. A semantic search ability accesses across stored data items, for imaging or non-imaging associated data, according to concepts in an ontology according to relationships, without requiring the queries to be defined beforehand. By accessing predetermined data services, queries from the knowledge base are formed in order to collect data sets. The data sets can be used to test a hypothesis, the hypothesis related to supporting tracking of the given anatomy, the suspected pathology, the confirmed pathology, or the medical intervention.
摘要翻译：公开了通过使用可用于个性化医学和发现科学的语义网技术访问的语义注释进行分析来制作图像衍生信息的方法和系统。根据识别方案识别个案。每个病例的图像分析目标的特征在于支持在一个或多个时间点跟踪给定的解剖结构，疑似病理学，确认的病理学或医学干预。提供并存储在一个或多个时间点中的每一个处访问每个目标的一个或多个医学图像的信息。获得并存储图像衍生分析的一个或多个级别，所述图像衍生分析包括相对于所述一种情况的成像特征，测量量，表型描述或预测中的至少一种。根据关系，根据本体的概念，语义搜索能力跨存储的数据项访问，用于成像或非成像相关联的数据，而不需要事先定义查询。通过访问预定的数据服务，形成来自知识库的查询以便收集数据集。数据集可用于测试假设，与支持跟踪给定解剖结构相关的假设，可疑病理学，确诊病理学或医学干预。

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