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1. 发明授权

US08252790B2 Pyrazole-3-carboxamide derivative having 5-HT2B receptor antagonist activity 有权
标题翻译：具有5-HT2B受体拮抗剂活性的吡唑-3-甲酰胺衍生物
公开(公告)号：US08252790B2
公开(公告)日：2012-08-28
申请号：US13129916
申请日：2009-11-24
申请人： Tatsuya Yamagishi , Kiyoshi Kawamura , Tadashi Inoue , Yuji Shishido , Hiroaki Ito
发明人： Tatsuya Yamagishi , Kiyoshi Kawamura , Tadashi Inoue , Yuji Shishido , Hiroaki Ito
IPC分类号： A61K31/5375 , C07D413/02
CPC分类号： C07D487/04 , A61K31/415 , A61K31/4155 , A61K31/437 , A61K31/454 , A61K31/5377 , A61K31/553 , C07D231/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D409/04 , C07D413/14 , C07D417/04 , C07D471/04
摘要： Disclosed is a compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, which is useful as a selective antagonist of a 5-HT2B receptor. The compound and salt are useful for treatment or prevention of various diseases and conditions associated with a 5-HT2B receptor.
摘要翻译：公开了通式（I）表示的化合物或其药学上可接受的盐，其可用作5-HT 2B受体的选择性拮抗剂。该化合物和盐可用于治疗或预防与5-HT 2B受体相关的各种疾病和病症。

2. 发明申请

US20110152388A1 Multibranched polymer and method for producing the same 有权
标题翻译：多分支聚合物及其制造方法
公开(公告)号：US20110152388A1
公开(公告)日：2011-06-23
申请号：US12929659
申请日：2011-02-07
申请人： Takeshi Niitani , Kiyoshi Kawamura , Akihiro Shirai
发明人： Takeshi Niitani , Kiyoshi Kawamura , Akihiro Shirai
IPC分类号： C08J5/22 , C08F22/20 , C08F22/14 , C08F12/08 , C08F220/18 , C08F283/08
CPC分类号： C08F220/14 , C08F12/32 , C08F12/34 , C08F220/18 , H01M2/168 , H01M4/622 , H01M10/052 , H01M10/0565 , H01M2300/0082
摘要： A multibranched polymer represented by the following formula (I), and a method for producing the multibranched polymer: where A represents an organic group having 3 or more branched chains, Xa represents a linking group containing any atom of Groups 14 to 16 in the Periodic Table, Y represents a functional group having a structure capable of having an active halogen atom, Q represents an arm moiety having a repeating unit derived from a polymerizable unsaturated bond, m1 represents any integer of 1 to the number of branched chains of A, m2 represents the number of branched chains of A, n1 represents an integer of 0 or 1 or more, and Ra represents an organic group that is not associated with the polymerization reaction.
摘要翻译：由下式（I）表示的多分支聚合物和多分支聚合物的制备方法：其中A表示具有3个以上支链的有机基团，Xa表示在周期表中含有第14〜16族的任何原子的连接基团表中，Y表示具有能够具有活性卤素原子的结构的官能团，Q表示具有源自聚合性不饱和键的重复单元的臂部分，m1表示与A的支链数的任意整数1，m 2 表示A的支链数，n1表示0或1以上的整数，Ra表示与聚合反应无关的有机基团。

3. 发明授权

US07919570B2 Multibranched polymer and method for producing the same 有权
标题翻译：多分支聚合物及其制造方法
公开(公告)号：US07919570B2
公开(公告)日：2011-04-05
申请号：US11573635
申请日：2005-08-11
申请人： Takeshi Niitani , Kiyoshi Kawamura , Akihiro Shirai
发明人： Takeshi Niitani , Kiyoshi Kawamura , Akihiro Shirai
IPC分类号： C08F116/12
CPC分类号： C08F220/14 , C08F12/32 , C08F12/34 , C08F220/18 , H01M2/168 , H01M4/622 , H01M10/052 , H01M10/0565 , H01M2300/0082
摘要： The present invention provides a multibranched polymer represented by the following formula (I), and a method for producing the multibranched polymer: wherein A represents an organic group having 3 or more branched chains, Xa represents a linking group containing any atom of Groups 14 to 16 in the Periodic Table, Y represents a functional group having a structure capable of having an active halogen atom, Q represents an arm moiety having a repeating unit derived from a polymerizable unsaturated bond, m1 represents any integer of 1 to the number of branched chains of A, m2 represents the number of branched chains of A, n1 represents an integer of 0 or 1 or more, and Ra represents an organic group which is not associated with the polymerization reaction.
摘要翻译：本发明提供由下式（I）表示的多分支聚合物及其制造方法：其中，A表示具有3个以上支链的有机基团，Xa表示含有第14〜 16中，Y表示具有能够具有活性卤素原子的结构的官能团，Q表示具有源自聚合性不饱和键的重复单元的臂部，m1表示与支链数相同的1的整数的A，m 2表示A的支链数，n1表示0或1以上的整数，Ra表示与聚合反应无关的有机基团。

4. 发明申请

US20080255113A1 Quinolonecarboxylic Acid Compounds Having 5-Ht4 Receptor Agonistic Activity 失效
标题翻译：具有5-Ht4受体激活活性的喹诺酮羧酸化合物
公开(公告)号：US20080255113A1
公开(公告)日：2008-10-16
申请号：US10595948
申请日：2004-11-10
申请人： Tomoki Kato , Kiyoshi Kawamura , Mikio Morita , Chikara Uchida
发明人： Tomoki Kato , Kiyoshi Kawamura , Mikio Morita , Chikara Uchida
IPC分类号： A61K31/5377 , C07D405/14 , A61K31/4709 , C07D401/12 , C07D401/14 , C07D413/14
CPC分类号： C04B35/632 , C07D401/12 , C07D401/14 , C07D405/14
摘要： This invention provides a compound of the formula (I): wherein Het represents a heterocyclic group having one nitrogen atom, to which B binds directly, and from 4 to 7 carbon atoms, and said heterocyclic group being unsubstituted or substituted by 1 to 4 substituents independently selected from the group consisting of substituents α1; A represents an alkylene group having from 1 to 4 carbon atoms; B represents a covalent bond or an alkylene group having from 1 to 5 carbon atoms; R1 represents an isopropyl group, a n-propyl group or a cyclopentyl group; R2 represents a methyl group, a fluorine atom or a chlorine atom; R3 independently represents (i) an oxo group, a hydroxy group, an amino group, an alkylamino group or a carboxyl group; (ii) a cycloalkyl group having from 3 to 8 carbon atoms, and said cycloalkyl group being substituted by 1 to 5 substituents, or (iii) a heterocyclic group having from 3 to 8 atoms, and said heterocyclic group being unsubstituted or substituted by 1 to 5 substituents, and n is 1, 2 or 3, or a pharmaceutically acceptable salts thereof. These compounds have 5-HT4 receptor agonistic activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans.
摘要翻译：本发明提供式（I）化合物：其中Het表示具有一个氮原子的杂环基团，B直接与该碳原子结合，并且具有4至7个碳原子，所述杂环基团未被取代或被1至4个取代基取代独立地选自取代基α1， A表示具有1至4个碳原子的亚烷基; B表示共价键或具有1至5个碳原子的亚烷基; R 1表示异丙基，正丙基或环戊基; R 2表示甲基，氟原子或氯原子; R 3独立地表示（i）氧代基，羟基，氨基，烷基氨基或羧基; （ii）具有3至8个碳原子的环烷基，所述环烷基被1至5个取代基取代，或（iii）具有3至8个原子的杂环基，所述杂环基未被取代或被1 至5个取代基，n为1,2或3，或其药学上可接受的盐。这些化合物具有5-HT 4受体激动活性，因此可用于治疗哺乳动物，特别是人类的胃食管反流病，非溃疡性消化不良，功能性消化不良，肠易激综合征等。

5. 发明授权

US06660917B2 Keyboard musical instrument having fall board formed with clearance for fingers 有权
公开(公告)号：US06660917B2
公开(公告)日：2003-12-09
申请号：US10099747
申请日：2002-03-14
申请人： Motoomi Goto , Kiyoshi Kawamura
发明人： Motoomi Goto , Kiyoshi Kawamura
IPC分类号： G10C302
CPC分类号： G10C3/02
摘要： A grand piano has a keyboard placed on a key bed, and the keyboard is covered with a fall board after completion of practice on the keyboard, wherein a recess is formed in the fall board in such a manner as to offer a clearance to fingers on the black keys so that, even if the pianist straightens his or her fingers on the land portion before moving them to other keys, the nails are never hit against the inner surface of the fall board.

6. 发明授权

US06603008B1 Sulfamoylheleroaryl pyrazole compounds as anti-inflammatory/analgesic agents 失效
标题翻译：磺酰基杂芳基吡唑化合物作为抗炎/止痛剂
公开(公告)号：US06603008B1
公开(公告)日：2003-08-05
申请号：US09723661
申请日：2000-11-28
申请人： Kazuo Ando , Kiyoshi Kawamura
发明人： Kazuo Ando , Kiyoshi Kawamura
IPC分类号： C07D40104
CPC分类号： C07D405/14 , C07D413/14 , C07D417/14
摘要： This invention relates to a compound of the formula: or a pharmaceutically acceptable salt thereof, wherein A and R1 are each an optionally substituted 5 to 6-membered heteroaryl, wherein the heteroaryl is optionally fused to a carbocyclic ring or 5 to 6-heteroaryl; R2 is NH2; R3 and R4 are each hydrogen, halo, (C1-C4)alkyl optionally substituted with halo and the like; and X1 to X4 are each hydrogen, halo, hydroxy, (C1-C4)alkyl optionally substituted with halo and the like. These compounds have COX-2 inhibiting activity and thus useful for treating or preventing inflammation or other COX-2 related diseases.
摘要翻译：本发明涉及下式的化合物或其药学上可接受的盐，其中A和R 1各自为任选取代的5至6元杂芳基，其中杂芳基任选地与碳环或5至6-杂芳基稠合; R2是NH2; R 3和R 4各自为氢，卤素，任选被卤素取代的（C 1 -C 4）烷基等; 且X 1至X 4各自为氢，卤素，羟基，任选被卤素取代的（C 1 -C 4）烷基等。这些化合物具有COX-2抑制活性，因此可用于治疗或预防炎症或其他COX-2相关疾病。

7. 发明授权

US06275747B1 Microcomputer and its access speed control method 有权
标题翻译：微电脑及其访问速度控制方法
公开(公告)号：US06275747B1
公开(公告)日：2001-08-14
申请号：US09191377
申请日：1998-11-13
申请人： Takao Wada , Yuzo Ishibashi , Kiyoshi Kawamura , Yoshikatsu Kuroda
发明人： Takao Wada , Yuzo Ishibashi , Kiyoshi Kawamura , Yoshikatsu Kuroda
IPC分类号： G05B2100
CPC分类号： G06F11/00
摘要： A microcomputer usable for a long period of time even when disposed in a high dose radiation-exposed environment, and its access speed control method are provided. According to the microcomputer and the method, the total dose of radiation that the microcomputer receives is determined on the basis of detection signals from a radiation detecting element. Based on the determined total dose of radiation, and table data preset by tests and stored into a memory unit, a CPU controls an access speed. Moreover, the CPU, and the memory unit and a circuit interface unit that access the CPU are integrated on a single chip (ASIC) These units on the same chip are deteriorated and changed in the same direction, without fail, on exposure to radiation.
摘要翻译：即使设置在高剂量的曝光环境下也能够长时间使用的微型计算机及其存取速度控制方法。根据微型计算机和方法，基于来自辐射检测元件的检测信号确定微机接收的辐射总剂量。基于确定的辐射总剂量和通过测试预设的表数据并存储到存储器单元中，CPU控制访问速度。此外，CPU，存储器单元和访问CPU的电路接口单元集成在单个芯片（ASIC）上。同一芯片上的这些单元在暴露于辐射的同时，在相同的方向上都会相同的方向劣化并改变。

8. 发明授权

US5990226A Aqueous resin composition and curing process 失效
标题翻译：水性树脂组合物和固化过程
公开(公告)号：US5990226A
公开(公告)日：1999-11-23
申请号：US4890
申请日：1993-01-21
申请人： Yoshihiro Arita , Kiyoshi Kawamura , Kenta Kanaida , Satoshi Yamada
发明人： Yoshihiro Arita , Kiyoshi Kawamura , Kenta Kanaida , Satoshi Yamada
IPC分类号： C08L101/02 , C08G81/00 , C08L101/00 , C09D133/06 , C09D167/00 , C09D179/02 , C09D201/02 , C09D201/08 , C08G63/00
CPC分类号： C09D133/064 , C09D167/00 , C09D179/02
摘要： There is provided an aqueous resin composition which does not cause coagulation, can be cured at low temperature, and, by this curing, forms a coating superior in mechanical strength, water resistance, solvent resistance and adhesion to various substrates. The aqueous resin composition of this invention comprises an oxazoline group-containing polymer (A), a carboxyl group-containing polymer (B), and an acidic compound-amine salt catalyst (C). The curing is carried out by a reaction between the oxazoline group-containing polymer (A) and the carboxyl group-containing polymer (B) in the presence of the acidic compound-amine salt catalyst (C).
摘要翻译：提供一种不引起凝结的水性树脂组合物，可以在低温下固化，并且通过该固化形成机械强度，耐水性，耐溶剂性和对各种基材的粘附性优异的涂层。本发明的含水树脂组合物含有含恶唑啉基的聚合物（A），含羧基的聚合物（B）和酸性化合物 - 胺盐催化剂（C）。在酸性化合物 - 胺盐催化剂（C）的存在下，通过含恶唑啉基的聚合物（A）和含羧基的聚合物（B）之间的反应进行固化。

9. 发明授权

US5608175A Keyboard musical instrument having regulable regulating buttons linked with hammer stopper 失效
标题翻译：键盘乐器具有与锤子止动器连接的调节调节钮
公开(公告)号：US5608175A
公开(公告)日：1997-03-04
申请号：US343370
申请日：1994-11-22
申请人： Kiyoshi Kawamura
发明人： Kiyoshi Kawamura
IPC分类号： G10C1/02 , G10C3/16 , G10C5/00 , G10D15/00
CPC分类号： G10C5/005
摘要： A keyboard musical instrument has an acoustic piano, an electronic sound generating system, a rotary stopper for preventing sets of strings from impacts of hammer heads and regulator for changing distances between regulating buttons and toes of jacks, and a link mechanism connects a pedal and both of the rotary stopper and the regulator so as to concurrently change the rotary stopper and the regulator between an acoustic sound mode and a silent mode.
摘要翻译：键盘乐器具有原声钢琴，电子声音产生系统，用于防止琴弦组撞击的旋转止动器和用于改变调节按钮和千斤顶脚趾之间的距离的调节器，以及连接机构将踏板和两者连接起来以便在声音模式和静音模式之间同时改变旋转止动器和调节器。

10. 发明授权

US5594188A Keyboard musical instrument having key action mechanisms movable to and from strings 失效
标题翻译：键盘乐器具有可从琴弦移出的键动作机构
公开(公告)号：US5594188A
公开(公告)日：1997-01-14
申请号：US123294
申请日：1993-09-17
申请人： Kiyoshi Kawamura , Taroh Muramatsu , Masahiro Wada , Nobuo Sugiyama , Shinya Koseki
发明人： Kiyoshi Kawamura , Taroh Muramatsu , Masahiro Wada , Nobuo Sugiyama , Shinya Koseki
IPC分类号： G10C1/00 , G10C3/12 , G10C3/16 , G10C5/00 , G10D15/00
CPC分类号： G10C5/005
摘要： A keyboard musical instrument allowing a player to perform using acoustic piano tones or electronic sounds is provided. The keyboard is movable between various positions, such as between a raised and a lowered position. In an electronic sound mode, the keyboard is lowered so as to increase a gap between hammer assemblies and associated strings. In this mode, each hammer assembly rebounds on a stopper when a corresponding key is selected, thereby giving a desirable piano touch.
摘要翻译：提供允许玩家使用声学钢琴音调或电子声音执行的键盘乐器。键盘可在各种位置之间移动，例如在升高和降低位置之间。在电子声音模式中，键盘被降低以便增加琴弦组件和相关琴弦之间的间隙。在这种模式中，当选择对应的键时，每个琴槌组件在制动器上弹回，从而给出期望的钢琴触感。

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