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1. 发明授权

US09492123B2 Molecular imaging apparatus and method 有权
标题翻译：分子成像装置及方法
公开(公告)号：US09492123B2
公开(公告)日：2016-11-15
申请号：US12302929
申请日：2007-05-24
申请人： Lingxiong Shao , Douglas B. McKnight
发明人： Lingxiong Shao , Douglas B. McKnight
IPC分类号： A61B6/03 , A61B5/00 , A61B6/00
CPC分类号： A61B6/03 , A61B5/0013 , A61B6/00
摘要： A nuclear imaging chain (100) includes a molecular agent (102), an acquisition system (104), a reconstruction system (106), a detection system (108), and a display system (110). The various components of the imaging chain are optimized according to desired optimization criteria. The optimized characteristics of the imaging chain (100) may include one or more an agent characteristic, an acquisition characteristic (127), a reconstruction characteristic (143), a detection characteristic (159), and a display characteristic.
摘要翻译：核成像链（100）包括分子试剂（102），采集系统（104），重建系统（106），检测系统（108）和显示系统（110）。成像链的各种组件根据期望的优化标准进行优化。成像链（100）的优化特征可以包括一个或多个代理特征，获取特征（127），重建特性（143），检测特性（159）和显示特性。

2. 发明申请

US20080226149A1 Motion Compensation in Functional Imaging 有权
标题翻译：功能成像中的运动补偿
公开(公告)号：US20080226149A1
公开(公告)日：2008-09-18
申请号：US11997410
申请日：2006-07-27
申请人： Hans-Aloys Wischmann , Lingxiong Shao , Angela Da Silva , Ingwer-Curt Carlsen , Carsten Meyer
发明人： Hans-Aloys Wischmann , Lingxiong Shao , Angela Da Silva , Ingwer-Curt Carlsen , Carsten Meyer
IPC分类号： G01T1/164 , A61B5/00
CPC分类号： A61B6/503 , A61B5/113 , A61B5/7289 , A61B6/037 , A61B6/5235 , A61B6/541 , A61B8/0883 , G06F19/00 , G06T7/20 , G06T11/005 , G06T2207/30004 , G06T2211/412
摘要： Medical images are collected in a plurality of cardiac and respiratory phases. The images are transformed into a series of respiratory compensated images with the plurality of cardiac phases, but all at a common respiration phase. The series of respiratory compensated images are transformed into one image at a selected cardiac phase and the common respiration phase. In some embodiments, a database of gated transform matrices is generated. The database may be based on specific patient information or on information generated from a pool of patients. The database may account for respiratory motion, cardiac contractile motion, other physiological motion, or combinations thereof. For a current image to be motion corrected, the transformation matrices collected in the database are used to estimate a current set of transformation matrices accounting for the motion in the current image, and a motion-compensated image is generated based on the current set of transform matrices.
摘要翻译：在多个心脏和呼吸相中收集医学图像。图像被转换成具有多个心脏相的一系列呼吸补偿图像，但都在共同的呼吸阶段。一系列呼吸补偿图像在选定的心脏相和共同的呼吸期转化为一个图像。在一些实施例中，生成门控变换矩阵的数据库。数据库可以基于具体的患者信息或从患者池产生的信息。数据库可以解释呼吸运动，心脏收缩运动，其他生理运动或其组合。对于要进行运动校正的当前图像，使用在数据库中收集的变换矩阵来估计当前图像中运动的当前转换矩阵，并且基于当前变换集合生成运动补偿图像矩阵。

3. 发明授权

US06403960B1 Correction for spatial variations of deadtime of a monolithic scintillator based detector in a medical imaging system 失效
标题翻译：校正基于单片闪烁体的检测器在医学成像系统中的死区时间的空间变化
公开(公告)号：US06403960B1
公开(公告)日：2002-06-11
申请号：US09302161
申请日：1999-04-29
申请人： Donald R. Wellnitz , Michael J. Petrillo , Lingxiong Shao
发明人： Donald R. Wellnitz , Michael J. Petrillo , Lingxiong Shao
IPC分类号： G01T1164
CPC分类号： G01T1/171
摘要： A nuclear medicine imaging system includes the capability to correct for the deadtime, including the capability to correct for spatial variations in deadtime across the imaging surface of a detector. The imaging system includes one or more radiation detectors, each using a large, monolithic scintillation crystal. Each detector has deadtime associated with it. A given detector is used to acquire an energy profile of a patient based on emission radiation. The detector includes a number of timing channels. The energy profile is used to select a zone influence map indicating the extent of spatial overlap in response between the various timing channels. Emission data of the patient is then acquired during an emission scan. During acquisition of the emission data, a rate meter assigned to each timing channel samples the number of counts associated with each timing channel to acquire deadtime data. A unique deadtime function is provided for each unique zone represented in the zone influence map, including each region of overlap. The deadtime data acquired from the rate meters are then applied to the deadtime functions to correct the emission data for deadtime on a pixel-by-pixel basis. An image is generated based on the deadtime-corrected data.
摘要翻译：核医学成像系统包括校正死时间的能力，包括校正跨越检测器的成像表面的死时间的空间变化的能力。成像系统包括一个或多个辐射检测器，每个使用大的单片闪烁晶体。每个检测器都有与之相关的死区。给定的检测器用于基于发射辐射来获取患者的能量分布。检测器包括多个定时通道。能量分布用于选择区域影响图，指示各种定时通道之间响应的空间重叠程度。然后在发射扫描期间获取患者的排放数据。在获取排放数据期间，分配给每个定时通道的速率计对与每个定时通道相关联的计数进行采样以获取死区数据。为区域影响图中表示的每个独特区域提供独特的死区功能，包括每个重叠区域。然后将从速率计获得的死区时间数据应用于死区时间功能，以逐个像素为基础校正死时间的发射数据。基于死时间校正数据生成图像。

4. 发明授权

US5998793A Method and apparatus for correcting for random coincidences in a nuclear medicine imaging system 失效
标题翻译：用于校正核医学成像系统中的随机巧合的方法和装置
公开(公告)号：US5998793A
公开(公告)日：1999-12-07
申请号：US62226
申请日：1998-04-17
申请人： Lingxiong Shao , David Coles
发明人： Lingxiong Shao , David Coles
IPC分类号： G01T1/164 , G01T1/20
CPC分类号： G01T1/1647
摘要： A method and apparatus for correcting for random coincidences in a gamma camera imaging system are provided, based on the distribution of the object to be imaged as well as the measured singles and coincidence rates. Gamma radiation emitted from the object is detected for multiple projection angles, including detection of a plurality of coincidence events, to generate an object profile. The singles rate and the coincidence rate are also measured for each of the projection angles. A randoms distribution representing random coincidences in the detected coincidence events is then determined, including computing a randoms profile as the convolution of the object profile and a Gaussian function. The determination of the randoms distribution further includes computing a randoms fraction for each of the projection angles based on the measured singles rate and the measured coincidence rate, and then computing the randoms distribution based on the randoms profile and the randoms fraction for each of the projection angles. The coincidence projection data are corrected based on the randoms distribution prior to generating emission images.
摘要翻译：基于待成像对象的分布以及测量的单个和一致率，提供了用于校正伽马相机成像系统中的随机重合的方法和装置。检测从对象发射的伽马辐射用于多个投影角度，包括检测多个重合事件，以产生对象轮廓。对于每个投影角度也测量单打速率和一致率。然后确定在检测到的重合事件中表示随机符合的随机分布，包括计算随机分布作为对象分布的卷积和高斯函数。随机分布的确定还包括基于所测量的单数率和测量的一致率来计算每个投影角度的随机分数，然后基于随机分布和每个投影的随机分数来计算随机分布角度。基于在产生发射图像之前的随机分布来校正重合投影数据。

5. 发明授权

US09123260B2 Receiver operating characteristic-based training 有权
标题翻译：接收机操作特性为基础的训练
公开(公告)号：US09123260B2
公开(公告)日：2015-09-01
申请号：US12675414
申请日：2008-08-26
申请人： Horace Hines , Lingxiong Shao , Zuo Zhao , Xiyun Song
发明人： Horace Hines , Lingxiong Shao , Zuo Zhao , Xiyun Song
IPC分类号： G09B23/28
CPC分类号： G09B23/286 , G06F19/00
摘要： A presentation component (118) presents information from one or more data source(s) (102) to an assessor for assessment. A receiver operating characteristic (ROC) analyzer 120 uses an ROC analysis technique to evaluate the performance of the assessor. A feedback component (126) provides feedback as to the assessor's performance. A data manipulator (114) facilitates manipulation of the presented data.
摘要翻译：呈现组件（118）将来自一个或多个数据源（102）的信息提供给评估者进行评估。接收机工作特性（ROC）分析器120使用ROC分析技术来评估评估者的性能。反馈组件（126）提供关于评估者绩效的反馈。数据操纵器（114）有助于对所呈现的数据的操纵。

6. 发明授权

US08411915B2 Motion compensation in functional imaging 有权
标题翻译：功能成像中的运动补偿
公开(公告)号：US08411915B2
公开(公告)日：2013-04-02
申请号：US11997410
申请日：2006-07-27
申请人： Hans-Aloys Wischmann , Lingxiong Shao , Angela Da Silva , Ingwer C. Carlsen , Carsten Meyer
发明人： Hans-Aloys Wischmann , Lingxiong Shao , Angela Da Silva , Ingwer C. Carlsen , Carsten Meyer
IPC分类号： G06K9/00
CPC分类号： A61B6/503 , A61B5/113 , A61B5/7289 , A61B6/037 , A61B6/5235 , A61B6/541 , A61B8/0883 , G06F19/00 , G06T7/20 , G06T11/005 , G06T2207/30004 , G06T2211/412
摘要： Medical images are collected in a plurality of cardiac and respiratory phases. The images are transformed into a series of respiratory compensated images with the plurality of cardiac phases, but all at a common respiration phase. The series of respiratory compensated images are transformed into one image at a selected cardiac phase and the common respiration phase. In some embodiments, a database of gated transform matrices is generated. The database may be based on specific patient information or on information generated from a pool of patients. The database may account for respiratory motion, cardiac contractile motion, other physiological motion, or combinations thereof. For a current image to be motion corrected, the transformation matrices collected in the database are used to estimate a current set of transformation matrices accounting for the motion in the current image, and a motion-compensated image is generated based on the current set of transform matrices.
摘要翻译：在多个心脏和呼吸相中收集医学图像。图像被转换成具有多个心脏相的一系列呼吸补偿图像，但都在共同的呼吸阶段。一系列呼吸补偿图像在选定的心脏相和共同的呼吸期转化为一个图像。在一些实施例中，生成门控变换矩阵的数据库。数据库可以基于具体的患者信息或从患者池产生的信息。数据库可以解释呼吸运动，心脏收缩运动，其他生理运动或其组合。对于要进行运动校正的当前图像，使用在数据库中收集的变换矩阵来估计当前图像中运动的当前转换矩阵，并且基于当前变换集合生成运动补偿图像矩阵。

7. 发明授权

US08208599B2 Iterative reconstruction with enhanced noise control filtering 有权
标题翻译：具有增强噪声控制滤波的迭代重建
公开(公告)号：US08208599B2
公开(公告)日：2012-06-26
申请号：US12067185
申请日：2006-08-21
申请人： Jinghan Ye , Lingxiong Shao , Zuo Zhao , Mary K. Durbin
发明人： Jinghan Ye , Lingxiong Shao , Zuo Zhao , Mary K. Durbin
IPC分类号： G06K9/00
CPC分类号： G01T1/2985 , A61B6/037 , G06T5/002 , G06T11/006 , G06T2207/10081 , G06T2207/10104 , G06T2207/10108 , G06T2207/30004 , G06T2211/424
摘要： An imaging system (10) comprises at least one radiation detector (20) disposed adjacent a subject receiving aperture (18) to detect radiation from a subject, receive the radiation and generate measured data. An image processor (38) iteratively reconstructs the detected radiation into image representations, in each reconstruction iteration the image processor (38) applies noise reduction algorithms to at least a difference between the measured data and a portion of a previous iteration image representation.
摘要翻译：成像系统（10）包括邻近对象接收孔（18）设置的至少一个辐射检测器（20），以检测来自对象的辐射，接收辐射并产生测量数据。图像处理器（38）将检测到的辐射重建成图像表示，在每个重建迭代中，图像处理器（38）将噪声降低算法应用于至少测量数据与先前迭代图像表示的一部分之间的差异。

8. 发明申请

US20100284598A1 IMAGE REGISTRATION ALIGNMENT METRIC 审中-公开
标题翻译：图像注册对齐度
公开(公告)号：US20100284598A1
公开(公告)日：2010-11-11
申请号：US12812045
申请日：2009-01-07
申请人： Zuo Zhao , Lingxiong Shao , Jinghan Ye , Xiyun Song
发明人： Zuo Zhao , Lingxiong Shao , Jinghan Ye , Xiyun Song
IPC分类号： G06K9/32 , G06K9/00
CPC分类号： G06T7/33 , G06T2207/10081 , G06T2207/10108 , G06T2207/30048
摘要： A method includes obtaining a combined data set that includes first and second imaging data sets. The first and second imaging data sets correspond to different imaging modalities. The method further includes determining a metric indicative of an alignment between the first and second imaging data sets in the combined data set. The method further includes presenting the metric in a human readable format.
摘要翻译：一种方法包括获得包括第一和第二成像数据集的组合数据集。第一和第二成像数据集对应于不同的成像模态。该方法还包括确定指示组合数据集中的第一和第二成像数据集之间的对准的度量。该方法还包括以人类可读格式呈现度量。

9. 发明申请

US20100278412A1 MULTI-SEGMENT RECONSTRUCTION 有权
标题翻译：多部门重建
公开(公告)号：US20100278412A1
公开(公告)日：2010-11-04
申请号：US12812040
申请日：2009-01-07
申请人： Xiyun Song , Zuo Zhao , Jinghan Ye , Lingxiong Shao
发明人： Xiyun Song , Zuo Zhao , Jinghan Ye , Lingxiong Shao
IPC分类号： G06T7/00
CPC分类号： G01T1/1642 , A61B6/037 , A61B6/5241 , G06T11/005
摘要： A medical imaging system includes a view transformation component (210) and a segment combiner (212). The transformation component (210) transforms projection data in each view of a plurality of individual segments, which each includes at least one view. The transformed projection data for substantially similar views across the plurality of individual segments have a common radius of rotation. The segment combiner (212) combines the transformed projection data to produce a single data set that includes the transformed projection data for each of the views of each of the plurality of individual segments.
摘要翻译：医疗成像系统包括视角变换组件（210）和段组合器（212）。转换组件（210）在多个单独的段的每个视图中转换投影数据，每个段各自包括至少一个视图。用于跨越多个单独段的基本类似视图的变换的投影数据具有公共的旋转半径。段组合器（212）组合变换的投影数据以产生单个数据集，其包括用于多个单独段中的每一个的每个视图的变换的投影数据。

10. 发明申请

US20070183642A1 ITERATIVE RECONSTRUCTION OF MULTIPLE-PEAK ISOTOPE IMAGES 有权
标题翻译：多峰同位素图像的迭代重建
公开(公告)号：US20070183642A1
公开(公告)日：2007-08-09
申请号：US11627087
申请日：2007-01-25
申请人： Jinghan Ye , Mary K. Durbin , Xiyun Song , Lingxiong Shao
发明人： Jinghan Ye , Mary K. Durbin , Xiyun Song , Lingxiong Shao
IPC分类号： G06K9/00
CPC分类号： G06T11/006 , G06T2211/408 , G06T2211/424
摘要： In an imaging method, estimated data is iteratively projected and backprojected. The iterative projecting and backprojecting includes projecting or backprojecting the estimated data along parallel paths each employing energy-dependent parameters appropriate for a different energy. During each iteration, the estimated data is adjusted based on comparison of the estimated data with measured data.
摘要翻译：在成像方法中，估计数据被迭代地投影并反向投影。迭代投影和反向投影包括沿着并行路径投影或反投影估计数据，每个并行路径采用适用于不同能量的能量相关参数。在每次迭代期间，基于估计数据与测量数据的比较来调整估计数据。

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