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1. 发明申请

US20220223399A1 MULTIPLE GAS FLOW IONIZER 有权
公开(公告)号：US20220223399A1
公开(公告)日：2022-07-14
申请号：US17403033
申请日：2021-08-16
申请人： Frenny Kaushal , Gholamreza Javahery , Lisa Cousins , Charles Jolliffe
发明人： Frenny Kaushal , Gholamreza Javahery , Lisa Cousins , Charles Jolliffe
IPC分类号： H01J49/16 , H01J49/42 , H01J49/06
摘要： An ionizer includes a probe having multiple coaxially aligned conduits. The conduits may carry liquids, and nebulizing and heating gases at various flow rates and temperatures, for generation of ions from a liquid source. An outermost conduit defines an entrainment region that transports and entrains ions in a gas for a defined distance along the length of the conduits. In embodiments, various voltages may be applied to the multiple conduits to aid in ionization and to guide ions. Depending on the voltages applied to the multiple conduits and electrodes, the ionizer can act as an electrospray, APCI, or APPI source. Further, the ionizer may include a source of photons or a source of corona ionization. Formed ions may be provided to a downstream mass analyser.

2. 发明申请

US20140197333A1 MASS ANALYSER INTERFACE 有权
标题翻译：质量分析仪界面
公开(公告)号：US20140197333A1
公开(公告)日：2014-07-17
申请号：US13740985
申请日：2013-01-14
申请人： Charles Jolliffe , Lisa Cousins , Gholamreza Javahery
发明人： Charles Jolliffe , Lisa Cousins , Gholamreza Javahery
IPC分类号： H01J49/04
CPC分类号： H01J49/044 , H01J49/062
摘要： A mass analyzer includes a desolvation chamber into which an upstream gas is injected to provide a counter-flow to said downstream flow in the chamber. The counter-flow may slow the downstream flow of solvated ionized particles in the chamber, while allowing lighter desolvated ions to travel toward an outlet aperture of the desolvation chamber.
摘要翻译：质量分析器包括去溶剂化室，注入上游气体以向腔室中的所述下游流动提供逆流。逆流可以减缓腔室中溶剂化的离子化颗粒的下游流动，同时允许较轻的去溶剂离子朝向去溶剂化室的出口孔行进。

3. 发明授权

US08008619B2 High sensitivity mass spectrometer interface for multiple ion sources 有权
标题翻译：用于多个离子源的高灵敏度质谱仪界面
公开(公告)号：US08008619B2
公开(公告)日：2011-08-30
申请号：US12656701
申请日：2010-02-12
申请人： Charles Jolliffe , Gholamreza Javahery , Lisa Cousins , Ilia Tomski
发明人： Charles Jolliffe , Gholamreza Javahery , Lisa Cousins , Ilia Tomski
IPC分类号： H01J49/26 , H01J49/10
CPC分类号： G01N30/7233 , H01J49/04 , H01J49/067 , H01J49/107
摘要： An interface for mass spectrometers. The interface uses non coaxial sampling pathways of the analyte ion beam prior to entering the entrance of a mass spectrometer for decreasing chemical background, and can be done in such a way as to permit multiple sprayers, increasing sample throughput and sensitivity for LC/MS (liquid chromatography/MS). The interface includes an ion source having an exit from which a beam of analyte ions are emitted, a curtain plate and an aperture in the curtain plate member, an orifice plate having an orifice therein. The orifice plate is being spaced from the curtain plate member defining a flow passageway therebetween, and the aperture in the orifice plate is aligned with a sample entrance to a first vacuum stage of a mass spectrometer maintained substantially lower than atmospheric pressure. The aperture in the curtain plate member is non coaxially aligned with the orifice in the orifice plate and the interface includes a gas flow mechanism for directing a counter flow gas into the flow passageway.
摘要翻译：质谱仪界面。在进入质谱仪入口以减少化学背景之前，界面使用分析物离子束的非同轴取样路径，并且可以以允许多个喷雾器，增加LC / MS的样品通量和灵敏度的方式进行液相色谱/质谱）。该界面包括离子源，其具有从其分离的离子束射出的出口，帘板和帘板构件中的孔，其中具有孔口的孔板。孔板与限定其间的流动通道的帘板构件间隔开，并且孔板中的孔与进入维持在基本上低于大气压的质谱仪的第一真空级的样品入口对准。帘板构件中的孔与孔板中的孔不同轴地对准，并且界面包括用于将逆流气体引导到流动通道中的气流机构。

4. 发明申请

US20110133079A1 MASS SPECTROMETER ION GUIDE PROVIDING AXIAL FIELD, AND METHOD 审中-公开
标题翻译：提供轴向场的质谱仪离子导管及方法
公开(公告)号：US20110133079A1
公开(公告)日：2011-06-09
申请号：US12958797
申请日：2010-12-02
申请人： Lisa Cousins , Gholamreza Javahery , Ilia Tomski
发明人： Lisa Cousins , Gholamreza Javahery , Ilia Tomski
IPC分类号： H01J3/30 , H01J49/28
CPC分类号： H01J49/063
摘要： An ion guide includes a plurality of rods, arranged about an axis that extends lengthwise from one end to the other of the guide. The rods guide ions in a guide region along and about the axis. A conductive casing surrounds the rods. The casing and the rods are geometrically arranged to produce an axial electric field along the axis. Specifically, the geometry is such that a first constant applied DC voltage (UDC), applied to the rods, and a second constant applied DC voltage (UCASE) applied to the casing, produce a voltage gradient between said casing and said axis that has a different magnitude at different positions along said axis.
摘要翻译：离子导向器包括多个杆，其围绕从引导件的一端到另一端纵向延伸的轴线布置。杆沿引导区域沿轴线引导离子。导电套管围绕着棒。壳体和杆几何地布置成沿轴线产生轴向电场。具体地，几何形状使得施加到杆的第一恒定施加的DC电压（UDC）和施加到壳体的第二恒定施加的DC电压（UCASE）在所述壳体和所述轴线之间产生电压梯度，所述电压梯度具有沿着所述轴的不同位置处的不同大小。

5. 发明申请

US20100252729A1 METHOD AND APPARATUS FOR DETECTING POSITIVELY CHARGED AND NEGATIVELY CHARGED IONIZED PARTICLES 审中-公开
标题翻译：用于检测正确充电和负电荷离子化颗粒的方法和装置
公开(公告)号：US20100252729A1
公开(公告)日：2010-10-07
申请号：US12762783
申请日：2010-04-19
申请人： Charles JOLLIFFE , Lisa Cousins , Gholamreza Javahery
发明人： Charles JOLLIFFE , Lisa Cousins , Gholamreza Javahery
IPC分类号： H01J49/02
CPC分类号： H01J49/025 , H01J49/0095
摘要： An ion detector includes collision surfaces for converting both positively and negatively charged ions into emitted secondary electrons. Secondary electrons may be detected using an electron detector, than may, for example include an electron multiplier. Conveniently, secondary electrons (or electrons emitted by the multiplier) may be detected using an electron pulse counter.
摘要翻译：离子检测器包括用于将正电荷和带负电荷的离子转换成发射的二次电子的碰撞表面。可以使用电子检测器检测二次电子，例如可以包括电子倍增器。方便地，可以使用电子脉冲计数器检测二次电子（或乘法器发射的电子）。

6. 发明申请

US20080265154A1 MASS SPECTROMETER ION GUIDE PROVIDING AXIAL FIELD, AND METHOD 有权
标题翻译：提供轴向场的质谱仪离子导管及方法
公开(公告)号：US20080265154A1
公开(公告)日：2008-10-30
申请号：US11742203
申请日：2007-04-30
申请人： Lisa Cousins , Gholamreza Javahery , Ilia Tomski
发明人： Lisa Cousins , Gholamreza Javahery , Ilia Tomski
IPC分类号： H01J49/04
CPC分类号： H01J49/063
摘要： An ion guide includes a plurality of rods, arranged about an axis that extends lengthwise from one end to the other of the guide. The rods guide ions in a guide region along and about the axis. A conductive casing surrounds the rods. The casing and the rods are geometrically arranged to produce an axial electric field along the axis. Specifically, the geometry is such that a first constant applied DC voltage (UDC), applied to the rods, and a second constant applied DC voltage (UCASE) applied to the casing, produce a voltage gradient between said casing and said axis that has a different magnitude at different positions along said axis.
摘要翻译：离子导向器包括多个杆，其围绕从引导件的一端到另一端纵向延伸的轴线布置。杆沿引导区域沿轴线引导离子。导电套管围绕着棒。壳体和杆几何地布置成沿轴线产生轴向电场。特别地，几何形状使得施加到杆上的第一恒定施加的DC电压（U SUB DC）和施加到杆的第二恒定施加的DC电压（U> CASE ）施加到所述壳体在所述壳体和所述轴线之间产生在所述轴线的不同位置处具有不同大小的电压梯度。

7. 发明申请

US20080258052A1 MASS SPECTROMETER INTERFACE 有权
标题翻译：质谱仪界面
公开(公告)号：US20080258052A1
公开(公告)日：2008-10-23
申请号：US12163030
申请日：2008-06-27
申请人： Charles Jolliffe , Gholamreza Javahery , Lisa Cousins
发明人： Charles Jolliffe , Gholamreza Javahery , Lisa Cousins
IPC分类号： H01J49/28
CPC分类号： H01J49/0422 , H01J49/04 , H01J49/044 , H01J49/0468 , H01J49/06 , H01J49/26 , Y10T436/24
摘要： A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.
摘要翻译：公开了具有改进的灵敏度和降低的化学背景的质谱仪界面。质谱仪界面提供改进的去溶剂化学选择性和离子迁移。部分溶剂化离子的流动沿曲折路径输送到流动扰动区域，其中离子和中性分子碰撞和混合。热能被施加到扰动区域以促进至少一些离子化颗粒从任何附着的杂质的释放，从而增加流动中具有特征m / z比的离子化颗粒的浓度。还可以进行分子反应和低压离子化方法以选择性去除或增强特定的离子。

8. 发明申请

US20070164213A1 Concentrating mass spectrometer ion guide, spectrometer and method 有权
标题翻译：浓缩质谱仪离子导子，光谱仪和方法
公开(公告)号：US20070164213A1
公开(公告)日：2007-07-19
申请号：US11331153
申请日：2006-01-13
申请人： Gholamreza Javahery , Lisa Cousins , Charles Jolliffe , Ilia Tomski
发明人： Gholamreza Javahery , Lisa Cousins , Charles Jolliffe , Ilia Tomski
IPC分类号： H01J49/42
CPC分类号： H01J49/066
摘要： An ion guide includes multiple stages. An electric field within each stage guides ions along a guide axis. Within each stage, amplitude and frequency, and resolving potential of the electric field may be independently varied. The geometry of the rods maintains a similarly shaped field from stage to stage, allowing efficient guidance of the ions along the axis. In particular, each rod segment of the ith of stage has a cross sectional radius ri, and a central axis located a distance Ri+ri from the guide axis. The ratio ri/Ri and is substantially constant along the guide axis, thereby preserving the shape of the field.
摘要翻译：离子导向器包括多个阶段。每个阶段内的电场沿引导轴引导离子。在每个阶段内，可以独立地改变振幅和频率以及电场的分辨能力。杆的几何形状保持了从阶段到阶段的类似形状的场，允许离子沿轴线的有效引导。特别地，台阶i的每个棒段具有横截面半径r 1，并且中心轴位于距离R i + r 从引导轴。比率r＆lt; i＆gt; / i＆lt; i＆gt;并且沿着引导轴线基本上是恒定的，从而保持场的形状。

9. 发明授权

US07034292B1 Mass spectrometry with segmented RF multiple ion guides in various pressure regions 有权
公开(公告)号：US07034292B1
公开(公告)日：2006-04-25
申请号：US10448495
申请日：2003-05-30
申请人： Craig M. Whitehouse , David G. Welkie , Gholamreza Javahery , Lisa Cousins
发明人： Craig M. Whitehouse , David G. Welkie , Gholamreza Javahery , Lisa Cousins
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/4225 , H01J49/004 , H01J49/063
摘要： A mass spectrometer is configured with individual multipole ion guides, configured in an assembly in alignment along a common centerline wherein at least a portion of at least one multipole ion guide mounted in the assembly resides in a vacuum region with higher background pressure, and the other portion resides in a vacuum region with lower background pressure. Said multipole ion guides are operated in mass to charge selection and ion fragmentation modes, in either a high or low pressure region, said region being selected according to the optimum pressure or pressure gradient for the function performed. The diameter, lengths and applied frequencies and phases on these contiguous ion guides may be the same or may differ. A variety of MS and MS/MSn analysis functions can be achieved using a series of contiguous multipole ion guides operating in either higher background vacuum pressures, or along pressure gradients in the region where the pressure drops from high to low pressure, or in low pressure regions. Individual sets of RF, +/−DC and resonant frequency waveform voltage supplies provide potentials to the rods of each multipole ion guide allowing the operation of ion transmission, ion trapping, mass to charge selection and ion fragmentation functions independently in each ion guide. The presence of background pressure maintained sufficiently high to cause ion to neutral gas collisions along a portion of each multiple ion guide linear assembly allows the conducting of Collisional Induced Dissociation (CID) fragmentation of ions by axially accelerating ions from one multipole ion guide into an adjacent ion guide. Alternatively ions can be fragmented in one or more multipole ion guides using resonant frequency excitation CID. A multiple multipole ion guide assembly can be configured as the primary mass analyzer in single or triple quadrupole mass analyzers with or without mass selective axial ejection. Alternatively, the multiple multipole ion guide linear assembly can be configured as part of a hybrid Time-Of-Flight, Magnetic Sector, Ion Trap or Fourier Transform mass analyzer.

10. 发明授权

US5565679A Method and apparatus for plasma mass analysis with reduced space charge effects 失效
标题翻译：用于等离子体质量分析的方法和装置，具有减小的空间电荷效应
公开(公告)号：US5565679A
公开(公告)日：1996-10-15
申请号：US338221
申请日：1994-11-09
申请人： Scott D. Tanner , Donald J. Douglas , Lisa Cousins
发明人： Scott D. Tanner , Donald J. Douglas , Lisa Cousins
IPC分类号： G01N27/62 , H01J49/04 , H01J49/10 , B01D59/44 , H01J49/00
CPC分类号： H01J49/067 , H01J49/044 , H01J49/105
摘要： A method of analyzing an analyte contained in a plasma, in inductively coupled plasma mass spectrometry (ICP-MS). A sample of the plasma is drawn through an orifice in a sampler, then skimmed in a skimmer orifice, and the skimmed sample is directed at supersonic velocity onto a blunt reducer having a small orifice therein, forming a shock wave on the reducer. Gas in the shock wave is sampled through an offset aperture in the reducer into a vacuum chamber containing ion optics and a mass spectrometer. This reduces space charge effects, thus reducing mass bias and also reducing the mass dependency of matrix effects. Since the region between the skimmer and the reducer can operate at about 0.1 Torr, which is the same pressure as that produced by the roughing pump which backs the high vacuum pump for the vacuum chamber, a single common pump can be used for both purposes, thus reducing the hardware needed. In a simplified version, the skimmer can be replaced by a small beam blocking finger which extends across a line of sight between the sampler and reducer orifices and occludes the reducer orifice from the sampler orifice.
摘要翻译：在电感耦合等离子体质谱（ICP-MS）中分析包含在等离子体中的分析物的方法。等离子体的样品通过采样器中的孔被抽吸，然后在分离器孔口中被撇去，并将脱脂样品以超声速度引导到具有小孔口的钝化还原剂上，在还原剂上形成冲击波。冲击波中的气体通过减速器中的偏移孔被采样到包含离子光学器件和质谱仪的真空室中。这减少了空间电荷效应，从而减少了质量偏差并且还降低了矩阵效应的质量依赖性。由于撇渣器和减速器之间的区域可以在大约0.1托的范围内工作，这是与用于真空室的高真空泵背对的粗抽泵产生的压力相同的压力，因此可以使用单个公共泵用于两个目的，从而减少所需的硬件。在简化版本中，撇渣器可以由小梁阻挡手指代替，该手指延伸穿过取样器和减速器孔之间的视线并且从采样器孔口封闭减速器孔口。

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