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1. 发明公开

US20230235337A1 CIRCULAR RNA PLATFORMS, USES THEREOF, AND THEIR MANUFACTURING PROCESSES FROM ENGINEERED DNA 审中-公开
公开(公告)号：US20230235337A1
公开(公告)日：2023-07-27
申请号：US18054431
申请日：2022-11-10
申请人： Martin Williams , SYTE.BIO INC.
发明人： Martin Williams
IPC分类号： C12N15/64 , C12P21/02 , C12N9/22
CPC分类号： C12N15/64 , C12N9/22 , C12P21/02
摘要： The present invention relates to circular RNA platforms, their manufacturing processes from an engineered parental circular covalently closed synthetic plasmid DNA and, uses thereof. Novel engineered circular covalently closed plasmids comprising sequences capable of aiding in RNA circularization either autonomously or when processed with an engineered ligase are provided. The circular RNA platforms of the current invention have improved stability and increased half-life, display exceptional and stable protein production, while avoiding doublestranded intramolecular self-pairing RNA segments.

2. 发明申请

US20110090325A1 SYSTEM AND METHOD FOR EXAMINING AN OBJECT 有权
标题翻译：用于检查对象的系统和方法
公开(公告)号：US20110090325A1
公开(公告)日：2011-04-21
申请号：US12757000
申请日：2010-04-08
申请人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leutenegger , Erica Martin-Williams , Antonio Lopez
发明人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leutenegger , Erica Martin-Williams , Antonio Lopez
IPC分类号： H04N7/18 , G06K9/00
CPC分类号： G01N21/6408 , A61B5/0042 , A61B5/0261 , A61B5/14546 , A61B5/1455 , A61B5/14553 , A61B2018/00446 , A61B2576/026 , G01N21/4795 , G01N21/6428 , G01N21/6456 , G01N2021/6482 , G06T7/0012 , G06T2207/30016
摘要： In a system and a method for examining an object containing a fluid liquid, the object is illuminated with measuring light and images are temporarily shortly subsequently recorded. The images are evaluated per pixel to determine perfusion data from a high frequency portion above 1 kHz and to determine further information about properties of the object from a low frequency portion below 100 Hz, such as a degree of oxygenation of hemoglobin, a concentration of hemoglobin or a concentration of ICG. This information determined by evaluation is displayed in a form of an image in superposition with a white light image of the object.
摘要翻译：在用于检查包含流体液体的物体的系统和方法中，用测量光照射物体，并且临时不久后记录图像。每像素评估图像以确定来自高于1kHz的高频部分的灌注数据，并且从低于100Hz的低频部分确定关于对象的属性的进一步信息，诸如血红蛋白的氧合程度，血红蛋白浓度或ICG的浓度。由评估确定的信息以与对象的白光图像重叠的图像的形式显示。

3. 发明申请

US20110063720A1 Optical amplifiers using switched filter devices 失效
标题翻译：使用开关滤波器的光放大器
公开(公告)号：US20110063720A1
公开(公告)日：2011-03-17
申请号：US12584919
申请日：2009-09-15
申请人： Christopher Lin , Ming Cai , Martin Williams
发明人： Christopher Lin , Ming Cai , Martin Williams
IPC分类号： H01S3/00
CPC分类号： H01S3/06754 , G02B26/023 , H01S3/10023 , H01S3/1608 , H04B10/2941
摘要： Described are Gain Flattening Filters (GFFs) implemented using mechanical translating assemblies to move selected thin film Gain Attenuating Filters (GAFs), and combinations of selected GAFs, into or out of the output path from an optical amplifier. The GAFs may be used singly, or in combinations that synthesize many target filter characteristics. The GFF is primarily adapted for WDM systems operating with a wavelength range of approximately 1520 nm to 1620 nm. Several embodiments are shown for effectively combining different GAFs to provide multiple GFF curves.
摘要翻译：描述的是使用机械平移组件实现的增益扁平滤波器（GFF），其将所选择的薄膜增益衰减滤波器（GAF）以及所选择的GAF的组合移动到光放大器的输出路径中或外。 GAF可以单独使用，也可以合成许多目标滤光片特性。 GFF主要适用于波长范围约为1520 nm至1620 nm的WDM系统。示出了几个实施例用于有效地组合不同的GAF以提供多个GFF曲线。

4. 发明申请

US20090269058A1 System and Method for Self-Generation of Reference Signals 审中-公开
标题翻译：参考信号自发的系统和方法
公开(公告)号：US20090269058A1
公开(公告)日：2009-10-29
申请号：US12111051
申请日：2008-04-28
申请人： Mark Summa , Martin Williams , Christopher Lin
发明人： Mark Summa , Martin Williams , Christopher Lin
IPC分类号： H04B10/08
CPC分类号： H04B10/0795
摘要： One embodiment of the present invention sets forth a technique for determining properties of optical links using the amplified spontaneous emission (ASE) of integrated amplifiers. To calibrate the system, existing amplifiers in the nodes of the system can be operated in an ASE mode. A bypass switch at the mid-stage of each amplifier routes the ASE from the amplifier's first stage into one or more signal processing components, creating reference signals. Subsequently, the bypass switch routes the reference signals back into the mid-stage of the amplifier. After propagating through a link to the next node in the system, the optical parameters of the reference signals are measured and used to determine properties of the link, such as chromatic dispersion and attenuation. Tunable devices within the two nodes connected by the link may be set to compensate for specific properties of the link, thereby improving the quality of transmitted signals.
摘要翻译：本发明的一个实施例提出了一种使用放大的放大自发发射（ASE）来确定光链路性质的技术。要校准系统，系统节点中的现有放大器可以在ASE模式下运行。每个放大器中段的旁路开关将ASE从放大器的第一级传送到一个或多个信号处理组件，创建参考信号。随后，旁路开关将参考信号路由到放大器的中间阶段。在通过链路传播到系统中的下一个节点之后，测量参考信号的光学参数并用于确定链路的属性，例如色散和衰减。可以设置通过链路连接的两个节点内的可调谐设备来补偿链路的特定属性，从而提高发送信号的质量。

5. 发明申请

US20090188191A1 Panelization Method and System 有权
标题翻译：面板化方法与系统
公开(公告)号：US20090188191A1
公开(公告)日：2009-07-30
申请号：US12019138
申请日：2008-01-24
申请人： Martin Williams , Bill R. Lindley, II
发明人： Martin Williams , Bill R. Lindley, II
IPC分类号： E04B5/17 , E04C3/29 , E04G21/14
CPC分类号： E04C3/293 , E04B5/19
摘要： A prefabrication system having a floor component and a frame component. In particular, the floor component includes a deck member, which can be made of deck sections, profiles, or panels. For example, the deck member can be made of continuous panels that cover the desired width and length of the floor component. Alternatively, the deck member can be made of preassembled sections that are combined in juxtaposed relation to form the desired width and length. The frame component includes opposing horizontal support channels that are attached to opposing vertical columns, respectfully.
摘要翻译：一种具有底板部件和框架部件的预制系统。特别地，地板部件包括甲板部件，该甲板部件可由甲板部分，轮廓或面板制成。例如，甲板构件可以由覆盖地板构件的期望宽度和长度的连续面板制成。或者，甲板构件可以由预先组装的部分制成，它们以并列关系组合以形成期望的宽度和长度。框架部件包括相对的相对的水平支撑通道，其相对于相对的垂直列附接。

6. 发明申请

US20090054788A1 METHOD AND APPARATUS FOR DISPLAYING A FIELD OF A BRAIN OF A PATIENT AND NAVIGATION SYSTEM FOR BRAIN SURGERY 审中-公开
标题翻译：用于显示用于脑外科手术的患者和导航系统的脑区域的方法和装置
公开(公告)号：US20090054788A1
公开(公告)日：2009-02-26
申请号：US12104919
申请日：2008-04-17
申请人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leuteneger , Erica Martin-Williams , Antonio Lopez
发明人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leuteneger , Erica Martin-Williams , Antonio Lopez
IPC分类号： A61B5/00 , G06K9/00 , A61B18/14
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/0261 , A61B5/4064 , A61B34/20 , A61B90/10 , A61B90/14 , A61B90/36 , A61B2017/00061 , A61B2017/00066 , A61B2034/105 , A61B2034/107 , A61B2034/2055 , A61B2034/2065 , A61B2090/365 , A61B2090/373
摘要： A method and an apparatus for displaying a part of a brain of a patient is described. Laser-Doppler-images are acquired before and after a stimulation. The laser-Doppler-images include information about a blood motion or about a perfusion at the acquired part. Then, the blood motion images acquired before and after the stimulation are compared to identify areas in the brain of the patient which are related to the stimulation.
摘要翻译：描述了用于显示患者的脑的一部分的方法和装置。在刺激之前和之后获取激光多普勒图像。激光多普勒图像包括关于血液运动或所获取部分的灌注的信息。然后，比较刺激之前和之后获取的血液运动图像，以识别与刺激相关的患者脑部区域。

7. 发明申请

US20080176828A1 Treating melanoma with BIS(THIOHYDRAZIDE AMIDES) 审中-公开
标题翻译：用BIS（THIOHYDRAZIDE AMIDES）治疗黑色素瘤
公开(公告)号：US20080176828A1
公开(公告)日：2008-07-24
申请号：US11894261
申请日：2007-08-20
申请人： Martin Williams , Matthew McLeod , Keizo Koya
发明人： Martin Williams , Matthew McLeod , Keizo Koya
IPC分类号： A61K31/397 , A61K31/165 , A61P35/00
CPC分类号： A61K31/16 , A61K31/337 , A61K2300/00
摘要： Disclosed herein are methods of preventing or delaying the recurrence of melanoma in a subject with bis(thio-hydrazide amides) represented by a formula selected from Structural Formulas (I)-(IX) or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these bis(thio-hydrazide amides) and compositions comprising these bis(thiohydrazide)amides and one or more anti-cancer agent.
摘要翻译：本文公开的是用选自结构式（I） - （IX）或其药学上可接受的盐的式（II）表示的双（硫代酰肼）酰胺）来预防或延迟受试者黑素瘤复发的方法，包含这些双硫代酰肼）和包含这些双（硫代酰肼）酰胺和一种或多种抗癌剂的组合物。

8. 发明申请

US20070286020A1 Heads-up Navigation for Seismic Data Acquisition 审中-公开
标题翻译：地震数据采集头顶导航
公开(公告)号：US20070286020A1
公开(公告)日：2007-12-13
申请号：US11760078
申请日：2007-06-08
申请人： Andrew Bull , Craig Williamson , Martin Williams , Scott Hoenmans
发明人： Andrew Bull , Craig Williamson , Martin Williams , Scott Hoenmans
IPC分类号： G01V1/00
CPC分类号： G01V1/003 , G01V1/22
摘要： A method and system for acquiring seismic data from a seismic survey plan is provided. A survey area is selected in which the seismic data will be acquired. A coordinate for at least one point of interest within the survey area is determined and input into a portable navigation device. A navigation solution is determined between a GPS-determined location of the portable navigation device and the determined coordinate and thereupon presented in a human cognizable media. A seismic device may be positioned at the determined coordinate to insonify a subterranean formation with seismic energy or for detecting reflected seismic energy. Data may be periodically entered into and retrieved from the portable navigation device by an in-field operator. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.
摘要翻译：提供了一种从地震勘测计划中获取地震数据的方法和系统。选择其中将获取地震数据的勘测区域。测量区域内至少一个兴趣点的坐标被确定并输入到便携式导航设备中。在GPS确定的便携式导航装置的位置和所确定的坐标之间确定导航解决方案，并且随后呈现在人类可认可的媒体中。地震装置可以被放置在确定的坐标处，以使地下地层与地震能量进行增强或用于检测反射的地震能量。数据可以由现场操作员周期性地输入并从便携式导航装置检索。要强调的是，该摘要被提供以符合要求摘要的规则，这将允许搜索者或其他读者快速确定技术公开的主题。提交它的理解是，它不会用于解释或限制权利要求的范围或含义。

9. 发明授权

US09764954B2 Particulate materials, composites comprising them, preparation and uses thereof 有权
公开(公告)号：US09764954B2
公开(公告)日：2017-09-19
申请号：US13992201
申请日：2011-12-08
申请人： Ian Walters , Martin Williams
发明人： Ian Walters , Martin Williams
IPC分类号： B01J2/12 , C01B31/02 , B01J19/08 , B82Y30/00 , C09C1/44 , H05H1/24 , C01B31/04 , B82Y40/00
CPC分类号： C01B32/225 , B01J19/088 , B01J2219/0809 , B01J2219/0818 , B01J2219/083 , B01J2219/0841 , B01J2219/0847 , B01J2219/0869 , B01J2219/0886 , B82Y30/00 , B82Y40/00 , C01B32/168 , C01B32/174 , C01P2002/84 , C01P2004/03 , C01P2004/62 , C01P2004/64 , C01P2006/60 , C09C1/44 , H05H1/2406 , H05H2001/2431 , Y10T428/2982
摘要： Methods of processing particulate carbon material, such as graphic particles or agglomerates of carbon nanoparticles such as CNTs are provided. The starting material is agitated in a treatment vessel in the presence of low-pressure (glow) plasma generated between electrodes. The material is agitated in the presence of conductive contact bodies such as metal balls, on the surface of which plasma glow is present and amongst which the material to be treated moves. The methods effectively deagglomerate nanoparticles, and exfoliate graphitic material to produce very thin graphitic sheets showing graphene-type characteristics. The resulting nanomaterials used by dispersal in composite materials, e.g. conductive polymeric composites for electric or electronic articles and devices. The particle surfaces can be functionalized by choosing appropriate gas in which to form the plasma.

10. 发明授权

US09066686B2 Functional optical coherent imaging 有权
标题翻译：功能光学相干成像
公开(公告)号：US09066686B2
公开(公告)日：2015-06-30
申请号：US13057593
申请日：2008-07-10
申请人： Theo Lasser , Dimitri Van De Ville , Erica Martin-Williams , Marcel Leutenegger , Iwan Maerki , Michael Friedrich , Martin Villiger
发明人： Theo Lasser , Dimitri Van De Ville , Erica Martin-Williams , Marcel Leutenegger , Iwan Maerki , Michael Friedrich , Martin Villiger
IPC分类号： H04N5/228 , A61B3/12 , A61B5/00 , H04N9/47 , H04N7/18 , H04N5/253 , A61B3/10
CPC分类号： A61B5/0066 , A61B3/102 , A61B3/1233 , A61B5/0048 , A61B5/0059 , A61B5/02028 , A61B5/413 , A61B5/7203 , A61B5/726 , A61B5/7278 , A61B5/742
摘要： The present invention relates to a functional optical coherent imaging (fOCI) platform comprising at least one active camera unit (ACU) comprising a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOD. Further the invention relates to a process for acquiring stimuli activated subject data comprising the steps of aligning a body function unit at a subject and monitoring pre-selected body function; selecting a stimulus or stimuli; imaging a body area of interest; exerting one or a series of stimuli on the subject; imaging the body area of interest synchronous with said stimuli and the preselected body functions; and transferring said synchronized image, stimuli and body function data to a statistical analysis unit (SAU) and performing calculations to generate results pertaining to body functions.
摘要翻译：功能性光学相干成像（fOCI）平台本发明涉及包括至少一个包括相干和/或部分相干光源的有源相机单元（ACU）的功能性光学相干成像（fOCI）平台，以及用于对感兴趣的所选择的身体区域进行频谱滤波和成像的装置; 用于预处理从ACU接收的数据的图像处理单元（IPU）; 向受试者传送刺激的至少一个刺激单元（STU）; 至少一个身体功能参考测量单元（BFMU）; 中央时钟和处理单元（CCU），与ACU，IPU，STU的互连，用于从IPU收集预处理的数据，以同步方式从BFMU的STU主体功能参考数据的刺激; 后处理单位（统计分析单位，SAU）; 另外本发明涉及一种用于获取刺激激活的被摄体数据的处理，包括以下步骤：对准对象的身体功能单元并监视预先选择的身体功能;选择刺激或刺激;对身体区域进行成像对所述受试者施加一个或一系列刺激;对与所述刺激和预选身体功能同步的感兴趣体部成像;将所述同步图像，刺激和身体功能数据传送到统计分析单元（SAU）和执行计算以生成与身体功能相关的结果。

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