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1. 发明授权

US08463565B1 LED flashlight with battery life indicator 失效
标题翻译： LED手电筒，带电池寿命指示灯
公开(公告)号：US08463565B1
公开(公告)日：2013-06-11
申请号：US13336796
申请日：2011-12-23
申请人： Ralph Osterhout , Michael J. Keating , Antony Van der Mude
发明人： Ralph Osterhout , Michael J. Keating , Antony Van der Mude
IPC分类号： G01R31/36
CPC分类号： F21L4/005 , H01M10/443 , H02J7/0047
摘要： A flashlight includes a light powered by a battery, and a circuit having: a memory for storing a battery life information and voltage output information versus time for the battery to power the light, a controller operating a count down timer to accumulate an amount of time that the battery powers the light, a voltage measure circuit for monitoring the voltage output by the battery while the battery powers the light and supply the voltage output to the controller. The controller determines: a first remaining battery life by comparing the accumulated time to the battery life, a second remaining battery life by comparing the voltage output to the voltage output information, and the lesser of the first and second remaining battery lives. The flashlight includes a display for receiving a command from the controller to display the lesser of the first remaining battery life and the second remaining battery life.
摘要翻译：手电筒包括由电池供电的光，以及电路，具有：存储器，用于存储电池寿命信息和电压输出信息对电池供电的时间，控制器操作倒计时定时器以累积一定时间量电池为光源供电，一个电压测量电路，用于在电池供电并向控制器提供电压输出时监视电池输出的电压。所述控制器通过将所述累积时间与所述电池寿命进行比较来确定第一剩余电池寿命，通过将所述电压输出与所述电压输出信息进行比较来计算第二剩余电池寿命，以及所述第一和第二剩余电池寿命中的较小者。手电筒包括用于从控制器接收命令以显示第一剩余电池寿命和第二剩余电池寿命中的较小者的显示器。

2. 发明授权

US07816628B2 Heated garment 失效
标题翻译：加热服装
公开(公告)号：US07816628B2
公开(公告)日：2010-10-19
申请号：US11604182
申请日：2006-11-22
申请人： Juan Fernandez , Paul McGrath , Frank Cipolla , James Sabastian , Michael J. Keating
发明人： Juan Fernandez , Paul McGrath , Frank Cipolla , James Sabastian , Michael J. Keating
IPC分类号： H05B3/00 , H05B3/34
CPC分类号： H05B3/342 , A41D13/0051 , H05B2203/003 , H05B2203/014 , H05B2203/036
摘要： In an embodiment of the present invention, a garment includes a fabric having a channel, a heat conductive wire disposed in the channel, a power source coupled to the heat conductive wire and detachably attached to the garment, and a controller electrically coupled to the power source and detachably attached to the garment, wherein the controller is configured with a heat setting. In another embodiment of the present invention, a method of heating a garment includes providing a fabric, forming a channel, disposing a heat conductive wire within the channel, connecting the heat conductive wire with a power source, wherein the power source is a rechargeable battery, and adjusting the heating of the garment by operating the power source and the heat conductive wire using a controller.
摘要翻译：在本发明的一个实施例中，衣服包括具有通道的织物，设置在通道中的导热丝，耦合到导热丝并且可拆卸地附接到衣服的电源，以及电耦合到电源的控制器源和可拆卸地附接到衣服，其中控制器配置有热定形。在本发明的另一个实施例中，一种加热衣服的方法包括提供织物，形成通道，在通道内布置导热丝，将导热丝与电源连接，其中电源是可充电电池并且通过使用控制器操作电源和导热线来调节衣服的加热。

3. 发明授权

US07622306B2 Using plasma proteomic pattern for diagnosis, classification, prediction of response to therapy and clinical behavior, stratification of therapy, and monitoring disease in hematologic malignancies 有权
标题翻译：使用血浆蛋白质组学模式进行诊断，分类，对治疗反应的预测和临床行为，治疗分层和监测血液恶性肿瘤的疾病
公开(公告)号：US07622306B2
公开(公告)日：2009-11-24
申请号：US11110374
申请日：2005-04-20
申请人： Maher Albitar , Elihu H. Estey , Hagop M. Kantarjian , Francis J. Giles , Michael J. Keating
发明人： Maher Albitar , Elihu H. Estey , Hagop M. Kantarjian , Francis J. Giles , Michael J. Keating
IPC分类号： G01N24/00 , G01N1/00 , G01N1/10 , G01N33/48 , G01N33/00 , A61K49/00 , A01N61/00 , A61K31/00
CPC分类号： G01N33/6851 , G01N33/57426 , G01N33/6803 , G01N33/6848 , G01N2800/52 , Y10T436/24 , Y10T436/25 , Y10T436/25625
摘要： The present invention demonstrates that the diagnosis and prediction of clinical behavior in patients with hematologic malignancies, such as leukemia, can be accomplished by analysis of proteins present in a plasma sample. Thus, in particular embodiments the present invention uses plasma to create a diagnostic or prognostic protein profile of a hematologic malignancy comprising collecting plasma samples from a population of patients with hematologic malignancies; generating protein spectra from the plasma samples with or without fractionation; comparing the protein spectra with clinical data; and identifying protein markers in the plasma samples that correlate with the clinical data. Protein markers identified by this approach can then be used to create a protein profile that can be used to diagnose the hematologic malignancy or determine the prognosis of the hematologic malignancy. Potentially these specific proteins can be identified and targeted in the therapy of these malignancies.
摘要翻译：本发明表明，可以通过分析存在于血浆样品中的蛋白质来完成血液恶性肿瘤患者（例如白血病）的临床行为的诊断和预测。因此，在具体实施方案中，本发明使用血浆来产生血液恶性肿瘤的诊断或预后蛋白质谱，包括从具有血液恶性肿瘤的患者群体收集血浆样品; 产生具有或不具有分级分离的血浆样品的蛋白质光谱; 将蛋白质谱与临床资料进行比较; 并鉴定与临床数据相关的血浆样品中的蛋白质标记。然后可以使用通过该方法鉴定的蛋白质标记产生可用于诊断血液恶性肿瘤或确定血液恶性肿瘤的预后的蛋白质谱。潜在地，这些特异性蛋白质可以在这些恶性肿瘤的治疗中被鉴定和靶向。

4. 发明授权

US07309247B1 Cable interconnect 有权
标题翻译：电缆互连
公开(公告)号：US07309247B1
公开(公告)日：2007-12-18
申请号：US11438987
申请日：2006-05-23
申请人： Michael J. Keating
发明人： Michael J. Keating
IPC分类号： H01R13/52
CPC分类号： H01R13/5219 , H01R13/5202 , H01R13/6471 , H01R13/6477 , H01R13/6584 , H01R13/6597 , H01R24/40 , H01R2103/00
摘要： A connection device comprises first and second connectors. The first connector has a sleeve having axially extending slots at a distal end to define tines yieldable resiliently inward, and a resilient seal encircling the sleeve proximally of the slots. The second connector has a shroud dimensioned to receive the distal end of the first connector sleeve within the shroud and to engage the first connector resilient seal when the sleeve is fully received within the shroud.
摘要翻译：连接装置包括第一和第二连接器。第一连接器具有套筒，其在远端具有轴向延伸的狭槽，以限定可弹性地向内屈曲的齿，以及围绕狭槽的近侧环绕套筒的弹性密封件。第二连接器具有尺寸适于接纳护罩内的第一连接器套筒的远端并且当套筒完全容纳在护罩内时与第一连接器弹性密封件接合的护罩。

5. 发明授权

US06851453B2 Fluid dispense verification system 有权
标题翻译：流体分配验证系统
公开(公告)号：US06851453B2
公开(公告)日：2005-02-08
申请号：US10425615
申请日：2003-04-30
申请人： James H. Lipscomb , Anna Jurik , Bernard Katz , Michael J. Keating , Stone Klengler , John J. Kotlarik , Mieczyslaw Wroblewski
发明人： Larry Jurik
IPC分类号： G01F23/26 , G01N35/08 , G01N35/10 , F16L55/00 , B01L3/02 , F16L9/22 , G01F1/56
CPC分类号： G01N35/1009 , G01N35/1016 , G01N2035/1025 , Y10T137/8326
摘要： A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant mechanism for detecting fluid flow through the conduit.
摘要翻译：用于检测流体传送探针与流体表面的接触并用于检测通过探针的流体流动的传感器包括沿着探针的远侧末端上游的探针的流体流动路径设置的第一电极和纵向间隔开的第二电极，与第一电极电隔离并设置在探针的远端。振荡信号通过第一电极传输，信号的至少一部分通过第二电极被接收。通过由于探针的远端与流体表面接触或由于流体流过第一和第二电极之间的导管而导致的接收信号的变化，可以检测流体表面接触和流体流动。可以使用压力传感器来监测流体输送探针的流体导管内的内部流体压力，作为用于检测通过导管的流体流动的次要冗余机构。

6. 发明授权

US09244753B2 Redundant bus fault detection 有权
标题翻译：冗余总线故障检测
公开(公告)号：US09244753B2
公开(公告)日：2016-01-26
申请号：US13833021
申请日：2013-03-15
申请人： Michael J. Keating , Harald Schermann , Paul Richard Strelecki , Vincent Baroncini , Pablo Torres
发明人： Michael J. Keating , Harald Schermann , Paul Richard Strelecki , Vincent Baroncini , Pablo Torres
IPC分类号： G08B21/00 , G06F11/07 , G08B29/12 , G08B29/16 , G06F11/20 , G06F11/32
CPC分类号： G06F11/0757 , G06F11/0745 , G06F11/2007 , G06F11/325 , G06F11/327 , G08B29/123 , G08B29/16
摘要： A system and method for an approach of detecting faults in a redundant bus system based upon four timers.
摘要翻译：一种基于四个定时器检测冗余总线系统故障的方法的系统和方法。

7. 发明申请

US20140281752A1 REDUNDANT BUS FAULT DETECTION 有权
标题翻译：冗余总线故障检测
公开(公告)号：US20140281752A1
公开(公告)日：2014-09-18
申请号：US13833021
申请日：2013-03-15
申请人： Michael J. Keating , Harald Schermann , Paul Richard Strelecki , Vincent Baroncini , Pablo Torres
发明人： Michael J. Keating , Harald Schermann , Paul Richard Strelecki , Vincent Baroncini , Pablo Torres
IPC分类号： G06F11/07
CPC分类号： G06F11/0757 , G06F11/0745 , G06F11/2007 , G06F11/325 , G06F11/327 , G08B29/123 , G08B29/16
摘要： A system and method for an approach of detecting faults in a redundant bus system based upon four timers.
摘要翻译：一种基于四个定时器检测冗余总线系统故障的方法的系统和方法。

8. 发明授权

US08501423B2 Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using ELISA assays 有权
公开(公告)号：US08501423B2
公开(公告)日：2013-08-06
申请号：US13543560
申请日：2012-07-06
申请人： Maher Albitar , Michael J. Keating , Taghi Manshouri
发明人： Maher Albitar , Michael J. Keating , Taghi Manshouri
IPC分类号： G01N31/00 , G01N33/53
CPC分类号： G01N33/6872 , C07K16/2887 , C07K2317/24 , C07K2317/76 , G01N33/564 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/70596 , G01N2800/52 , Y10S424/81 , Y10S436/809 , Y10T436/106664 , Y10T436/107497
摘要： The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease.

9. 发明申请

US20120145891A1 Using Plasma Proteomic Pattern For Diagnosis, Classification, Prediction Of Response To Therapy And Clinical Behavior, Stratification Of Therapy, And Monitoring Disease In Hematologic Malignancies 有权
标题翻译：使用血浆蛋白质组学模式进行诊断，分类，治疗反应预测和临床行为，治疗分层和监测血液恶性肿瘤疾病
公开(公告)号：US20120145891A1
公开(公告)日：2012-06-14
申请号：US13325986
申请日：2011-12-14
申请人： Maher Albitar , Elihu H. Estey , Hagop M. Kantarjian , Francis J. Giles , Michael J. Keating
发明人： Maher Albitar , Elihu H. Estey , Hagop M. Kantarjian , Francis J. Giles , Michael J. Keating
IPC分类号： H01J49/26
CPC分类号： G01N33/6851 , G01N33/57426 , G01N33/6803 , G01N33/6848 , G01N2800/52 , Y10T436/24 , Y10T436/25 , Y10T436/25625
摘要： The present invention demonstrates that the diagnosis and prediction of clinical behavior in patients with hematologic malignancies, such as leukemia, can be accomplished by analysis of proteins present in a plasma sample. Thus, in particular embodiments the present invention uses plasma to create a diagnostic or prognostic protein profile of a hematologic malignancy comprising collecting plasma samples from a population of patients with hematologic malignancies; generating protein spectra from the plasma samples with or without fractionation; comparing the protein spectra with clinical data; and identifying protein markers in the plasma samples that correlate with the clinical data. Protein markers identified by this approach can then be used to create a protein profile that can be used to diagnose the hematologic malignancy or determine the prognosis of the hematologic malignancy. Potentially these specific proteins can be identified and targeted in the therapy of these malignancies.
摘要翻译：本发明表明，可以通过分析存在于血浆样品中的蛋白质来完成血液恶性肿瘤患者（例如白血病）的临床行为的诊断和预测。因此，在具体实施方案中，本发明使用血浆来产生血液恶性肿瘤的诊断或预后蛋白质谱，包括从具有血液恶性肿瘤的患者群体收集血浆样品; 产生具有或不具有分级分离的血浆样品的蛋白质光谱; 将蛋白质谱与临床资料进行比较; 并鉴定与临床数据相关的血浆样品中的蛋白质标记。然后可以使用通过该方法鉴定的蛋白质标记产生可用于诊断血液恶性肿瘤或确定血液恶性肿瘤的预后的蛋白质谱。潜在地，这些特异性蛋白质可以在这些恶性肿瘤的治疗中被鉴定和靶向。

10. 发明申请

US20120107846A1 MEASURING CIRCULATING THERAPEUTIC ANTIBODY, ANTIGEN AND ANTIGEN/ANTIBODY COMPLEXES USING ELISA ASSAYS 有权
标题翻译：使用ELISA测定法测量循环治疗抗体，抗原和抗原/抗体复合物
公开(公告)号：US20120107846A1
公开(公告)日：2012-05-03
申请号：US13349170
申请日：2012-01-12
申请人： Maher Albitar , Michael J. Keating , Taghi Manshouri
发明人： Maher Albitar , Michael J. Keating , Taghi Manshouri
IPC分类号： G01N33/566
CPC分类号： G01N33/6872 , C07K16/2887 , C07K2317/24 , C07K2317/76 , G01N33/564 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/70596 , G01N2800/52 , Y10S424/81 , Y10S436/809 , Y10T436/106664 , Y10T436/107497
摘要： The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease.
摘要翻译：本发明涉及免疫学和过度增殖性疾病的领域。更具体地，本发明涉及检测和监测治疗性抗体的方法：抗原复合物，可溶性抗原和可溶性治疗性抗体，其中患者已经历至少一种免疫治疗过程。此外，治疗性抗体：抗原复合物，可溶性抗原或可溶性治疗性抗体的水平可以被测量并用于分期或监测过度增殖性疾病。

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