专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09864028B2 PET-MRI apparatus 有权
公开(公告)号：US09864028B2
公开(公告)日：2018-01-09
申请号：US13873706
申请日：2013-04-30
申请人： NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES , TOSHIBA MEDICAL SYSTEMS CORPORATION
发明人： Iwao Kanno , Takayuki Obata , Taiga Yamaya , Kazuya Okamoto , Takuzo Takayama , Hitoshi Yamagata
IPC分类号： G01R33/422 , A61B5/055 , A61B6/03 , A61B6/00 , G01R33/48 , G01T1/16 , A61B5/00
CPC分类号： G01R33/422 , A61B5/0035 , A61B5/055 , A61B6/037 , A61B6/4417 , A61B6/5235 , A61B6/5247 , G01R33/481 , G01T1/1603
摘要： In a PET (Positron Emission Tomography)-MRI (Magnetic Resonance Imaging) apparatus of an embodiment, a transmitting radio frequency coil applies a radio frequency magnetic field on a subject placed in a static magnetic field. A detector is formed in a ring shape, disposed on a side adjacent to an outer circumference of the transmitting radio frequency coil, includes at least two PET detectors disposed with a space therebetween in an axial direction of a bore so as to interpose the magnetic field center of the static magnetic field therebetween, and detects gamma rays emitted from positron emitting radionuclides injected into the subject. Radio frequency shields are each formed in an approximately cylindrical shape, disposed between the transmitting radio frequency coil and the detector, and shield the radio frequency magnetic field generated by the transmitting radio frequency coil.

2. 发明授权

US09382303B2 Vaccine for treatment of tautopathy 有权
标题翻译：用于治疗tautopathy的疫苗
公开(公告)号：US09382303B2
公开(公告)日：2016-07-05
申请号：US14585922
申请日：2014-12-30
申请人： Kyoto University , National Institute of Radiological Sciences
发明人： Haruhisa Inoue , Hiroki Takeuchi , Ryosuke Takahashi , Makoto Higuchi , Bin Ji , Tetsuya Suhara
IPC分类号： A61K39/00 , A61K38/00 , A61K38/16 , C07K14/47
CPC分类号： C07K14/4711 , A61K39/0005 , A61K39/0007 , A61K2039/5256 , A61K2039/53 , C07K2319/02 , C12N2799/021
摘要： This invention relates to a vaccine for preventing or treating tautopathy, comprising a vector, as an active ingredient, comprising a nucleic acid encoding a mutant tau protein linked to a secretion signal sequence, wherein the vaccine is capable of inducing an antibody against an (optionally phospholylated) tau protein in a subject in a more sustained manner compared with a case where the mutant tau protein is administered directly.
摘要翻译：本发明涉及用于预防或治疗tau蛋白病的疫苗，其包含作为活性成分的载体，其包含编码与分泌信号序列连接的突变型tau蛋白的核酸，其中所述疫苗能够诱导针对（任选地磷酸化）tau蛋白在与直接施用突变型tau蛋白的情况相比更持续的方式。

3. 发明申请

US20160045625A1 [11C] AND [18F] LABELED 1,3-DIPHENYL-5-(PYRIMIDIN-2-YL)-PYRIDIN-2(1H)-ONE DERIVATIVES AND THEIR USE FOR PET IMAGING OF THE AMPA RECEPTOR 审中-公开
标题翻译： [11C]和[18F]标记的1,3-二苯基-5-（吡咯烷-2-基） - 吡啶-2（1H） - 酮衍生物及其用于PETA摄取的PET成像的用途
公开(公告)号：US20160045625A1
公开(公告)日：2016-02-18
申请号：US14780665
申请日：2014-04-02
申请人： EISAI R&D MANAGEMENT CO., LTD. , NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES
发明人： Norihito Oi , Noboru Yamamoto , Michiyuki Suzuki , Yosuke Nakatani , Tetsuya Suhara , Meiei Cho , Toshimitsu Fukumura , Makoto Higuchi , Takafumi Minamimoto , Jun Maeda , Masaki Tokunaga , Yuji Nagai
IPC分类号： A61K51/04 , C07D401/04
CPC分类号： A61K51/0459 , C07D401/04
摘要： A compound selected from the group consisting of compounds represented by the formulas below or pharmaceutically acceptable salt thereof is useful in PET imaging for AMPA receptor.
摘要翻译：选自由下式表示的化合物或其药学上可接受的盐的化合物可用于AMPA受体的PET成像。

4. 发明申请

US20150266937A1 VACCINE FOR TREATMENT OF TAUTOPATHY 有权
标题翻译：用于治疗胃肠病的疫苗
公开(公告)号：US20150266937A1
公开(公告)日：2015-09-24
申请号：US14585922
申请日：2014-12-30
申请人： Kyoto University , National Institute of Radiological Sciences
发明人： Haruhisa INOUE , Hiroki TAKEUCHI , Ryosuke TAKAHASHI , Makoto HIGUCHI , Bin JI , Tetsuya SUHARA
IPC分类号： C07K14/47 , A61K39/00
CPC分类号： C07K14/4711 , A61K39/0005 , A61K39/0007 , A61K2039/5256 , A61K2039/53 , C07K2319/02 , C12N2799/021
摘要： This invention relates to a vaccine for preventing or treating tautopathy, comprising a vector, as an active ingredient, comprising a nucleic acid encoding a mutant tau protein linked to a secretion signal sequence, wherein the vaccine is capable of inducing an antibody against an (optionally phospholylated) tau protein in a subject in a more sustained manner compared with a case where the mutant tau protein is administered directly.
摘要翻译：本发明涉及用于预防或治疗tau蛋白病的疫苗，其包含作为活性成分的载体，其包含编码与分泌信号序列连接的突变型tau蛋白的核酸，其中所述疫苗能够诱导针对（任选地磷酸化）tau蛋白在与直接施用突变型tau蛋白的情况相比更持续的方式。

5. 发明申请

US20140186260A1 RADIOPHARMACEUTICAL AND PHARMACEUTICAL KIT 审中-公开
标题翻译：放射医学和药物包装
公开(公告)号：US20140186260A1
公开(公告)日：2014-07-03
申请号：US14140209
申请日：2013-12-24
申请人： NIHON MEDI-PHYSICS CO., LTD. , NATIONAL CANCER CENTER , NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES
发明人： Yukie YOSHII , Hiroki Matsumoto , Mitsuyoshi Yoshimoto
IPC分类号： A61K51/04
CPC分类号： A61K51/0497 , A61K31/195 , A61K31/555 , A61K51/0478 , A61K2300/00
摘要： A radiopharmaceutical comprising combination of a particular radioactive dithiosemicarbazone copper complex, and a chelating agent comprising a multidentate ligand having a maximum dentate number of 2 or more to 4 or less.
摘要翻译：包括特定放射性二硫代缩氨基脲铜络合物的组合的放射性药物和包含最大齿数为2以上至4以下的多齿配体的螯合剂。

6. 发明申请

US20040178347A1 Radiation three-dimensional position detector 有权
标题翻译：辐射三维位置检测器
公开(公告)号：US20040178347A1
公开(公告)日：2004-09-16
申请号：US10786366
申请日：2004-02-26
申请人： NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES , SHIMADZU CORPORATION , HAMAMATSU PHOTONICS K.K.
发明人： Hideo Murayama , Naoko Inadama , Keishi Kitamura , Takaji Yamashita
IPC分类号： G01T001/20
CPC分类号： G01T1/2008 , G01T1/1644
摘要： The radiation three-dimensional position detector of the present invention comprises a scintillator unit (10), a light receiving element (20) and an operation section (30). The scintillator unit is disposed on the light incident plane of the light receiving element, wherein the scintillator unit is comprised of four layers of scintillator arrays, each layer being composed of scintillator cells arrayed in 8 rownull8 column matrix. The scintillator cell produces scintillation light corresponding to the radiation absorbed thereby. The optical characteristic of a partition material for separating neighboring scintillator cells, which faces at least one same side face is different between a scintillator cell Ck1,m,n included in one scintillator array layer (k1-th layer) and a scintillator cell Ck2,m,n included in the other scintillator array layer (k2-th layer).
摘要翻译：本发明的辐射三维位置检测器包括闪烁体单元（10），光接收元件（20）和操作部分（30）。闪烁体单元设置在光接收元件的光入射平面上，其中闪烁体单元由四层闪烁体阵列组成，每层由排列在8行8列矩阵中的闪烁体单元组成。闪烁体细胞产生对应于由此吸收的辐射的闪烁光。用于分离面向至少一个相同侧面的相邻闪烁体单元的分隔材料的光学特性在包括在一个闪烁体阵列层（第k1层）和闪烁体单元Ck2中的闪烁体单元Ck1，m，n之间是不同的， m，n包含在另一个闪烁体阵列层（第k2层）中。

7. 发明申请

US20160155228A1 MEDICAL IMAGE GENERATION APPARATUS, METHOD, AND PROGRAM 审中-公开
标题翻译：医学图像生成装置，方法和程序
公开(公告)号：US20160155228A1
公开(公告)日：2016-06-02
申请号：US14953224
申请日：2015-11-27
申请人： KABUSHIKI KAISHA TOSHIBA , National Institute of Radiological Sciences
发明人： Yukinobu SAKATA , Ryusuke HIRAI , Kyoka SUGIURA , Yasunori TAGUCHI , Tomoyuki TAKEGUCHI , Shinichiro MORI , Fumi MARUYAMA
IPC分类号： G06T7/00 , G06K9/46 , A61B6/00 , G06T11/00
CPC分类号： A61B6/5205 , A61B6/0421 , A61B6/0457 , A61B6/4266 , A61B6/4464 , A61B6/5223 , A61B6/5252 , A61B34/10 , A61B2034/107 , A61N5/1049 , A61N2005/1061 , A61N2005/1062 , G06K9/00208 , G06K9/2018 , G06K2209/05 , G06T7/11 , G06T7/194 , G06T11/008 , G06T2207/10081 , G06T2207/30196
摘要： A medical image generation apparatus includes: a three-dimensional image acquisition unit that acquires a three-dimensional image in which a space including a patient is captured; an imparting unit that imparts, to each of voxels constituting the three-dimensional image, a living-body likelihood coefficient indicating a likelihood of being a living-body region of the patient; an updating unit that updates a luminance value of the voxel in which the imparted living-body likelihood coefficient shows a given value, through predetermined processing; a virtual viewpoint setting unit that sets a virtual viewpoint for transforming the three-dimensional image into a two-dimensional radiation image; and a radiation image generation unit that calculates a luminance value of a pixel constituting the radiation image based on the luminance value of the voxel existing along a line connecting each of the corresponding pixels and the virtual viewpoint.
摘要翻译：一种医用图像生成装置，包括：三维图像获取单元，其获取包含患者的空间的三维图像; 赋予构成所述三维图像的体素的每个体素赋予表示患者的生物体区域的可能性的生物体似然系数的赋予单位; 更新单元，通过预定处理来更新所赋予的生物体似然系数显示给定值的体素的亮度值; 虚拟视点设置单元，其将用于将所述三维图像变换为二维辐射图像的虚拟视点; 以及放射线图像生成单元，其基于沿着连接各个像素和虚拟视点的线存在的体素的亮度值来计算构成放射线图像的像素的亮度值。

8. 发明申请

US20150299280A1 MEDICAL TREATMENT USE OF CELL-MEMBRANE-PERMEABLE FIBROBLAST GROWTH FACTOR 审中-公开
标题翻译：细胞膜渗透性成纤维细胞生长因子的医疗处理
公开(公告)号：US20150299280A1
公开(公告)日：2015-10-22
申请号：US14647634
申请日：2013-11-11
申请人： NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES
发明人： Fumiaki NAKAYAMA , Sachiko UMEDA , Takeshi YASUDA , Mayumi FUJITA , Takashi IMAI
IPC分类号： C07K14/50 , C07K14/705
CPC分类号： C07K14/50 , A61K38/00 , C07K14/501 , C07K14/503 , C07K14/705 , C07K2319/10
摘要： The present invention relates to a chimeric protein formed by fusing a CPP containing a CPP-C domain in any of an FGF11, FGF12, FGF13, and FGF14 to an FGF1 or an FGF2, or DNA molecules that contain DNA sequences coding the FGF1 or the FGF2 and DNA sequences coding a CPP-C or vectors containing these DNA sequences. These chimeric protein, DNA molecules, or vectors can be used for a medicine or a method of treatment effective to a tissue on which an expression of an FGFR is low or becomes low due to any cause, a medicine or a method of treatment that can further dynamize bioactivity of the FGF1 or the FGF2 via the FGFR, or a medicine or a method of treatment that protects a stem cell against an influence from radiation exposure, a chemotherapy, or a similar treatment.
摘要翻译：本发明涉及通过将含有FGF11，FGF12，FGF13和FGF14中的任一种中的CPP-C结构域的CPP融合到FGF1或FGF2而形成的嵌合蛋白，或含有编码FGF1或 FGF2和编码CPP-C的DNA序列或含有这些DNA序列的载体。这些嵌合蛋白质，DNA分子或载体可以用于药物或治疗方法，对于FGFR的表达低或由于任何原因，药物或治疗方法可能会降低的组织有效通过FGFR进一步动力FGF1或FGF2的生物活性，或通过保护干细胞免受辐射暴露，化疗或类似治疗影响的药物或治疗方法。

9. 发明申请

US20150117736A1 METHOD FOR GENERATING IMAGE FOR PET ATTENUATION CORRECTION FROM MR IMAGE AND COMPUTER PROGRAM 有权
标题翻译：用于从MR图像和计算机程序生成用于PET衰减校正的图像的方法
公开(公告)号：US20150117736A1
公开(公告)日：2015-04-30
申请号：US14385683
申请日：2013-03-28
申请人： NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES , SHIMADZU CORPORATION
发明人： Taiga Yamaya , Takayuki Obata , Mikio Suga , Hiroshi Kawaguchi , Yoshiyuki Yamakawa
IPC分类号： G06T11/00 , A61B5/00
CPC分类号： G06T11/005 , A61B5/0035 , A61B5/055 , A61B6/037 , A61B2576/026 , G01R33/481 , G01T1/1603 , G06T7/11 , G06T2207/10088 , G06T2207/10104 , G06T2207/30004
摘要： When an image for PET attenuation correction is generated from an MR image, the MR image captured by MRI is segmented into regions according to pixel values. In a region in which a radiation attenuation coefficient is considered to be uniform, a radiation attenuation correction value is determined by referring to an existing radiation attenuation correction value table. In a region including multiple tissues having different radiation attenuation coefficients, a radiation attenuation correction value is determined by referring to a standard image. In such a manner, an image for PET attenuation correction in which tissues having similar pixel values in the MR image but different attenuation coefficients for radiation can be distinguished and that can accommodate individual differences and an affected area such as a space occupying lesion (for example, a cancer, abscess, or the like) and an organic defect is generated.
摘要翻译：当从MR图像产生用于PET衰减校正的图像时，由MRI捕获的MR图像根据像素值被分割成区域。在辐射衰减系数被认为是均匀的区域中，通过参照现有的辐射衰减校正值表确定辐射衰减校正值。在包括具有不同辐射衰减系数的多个组织的区域中，通过参考标准图像来确定辐射衰减校正值。以这种方式，用于PET衰减校正的图像，其中可以区分在MR图像中具有相似像素值但是具有不同的辐射衰减系数的组织，并且可以适应个体差异和诸如空间占据病变的受影响区域（例如，，癌症，脓肿等），产生有机缺陷。

10. 发明申请

US20130324836A1 PET DEVICE, PET-MRI APPARATUS, AND IMAGE PROCESSING METHOD 审中-公开
标题翻译： PET装置，PET-MRI装置和图像处理方法
公开(公告)号：US20130324836A1
公开(公告)日：2013-12-05
申请号：US13938592
申请日：2013-07-10
申请人： National Institute of Radiological Sciences , Toshiba Medical Systems Corporation
发明人： Taiga YAMAYA , Takayuki Obata , Iwao Kanno , Takuzo Takayama , Hitoshi Yamagata , Kazuya Okamoto
IPC分类号： G01T1/164 , G01R33/48
CPC分类号： G01T1/164 , A61B6/037 , A61B6/4417 , A61B6/5229 , G01R33/4808 , G01R33/481 , G01T1/2985
摘要： In a PET device according to an embodiment, a first detector includes a plurality of first scintillators and detects gamma rays that are emitted from positron-emitting radionuclides that are injected into a subject. A second detector is provided on the outer circumferential side of the first detector, includes a plurality of second scintillators arranged in an arrangement surface density lower than that of the first scintillators, and detects gamma rays that have passed through the first detector. A counted information acquiring unit acquires, as first counted information and second counted information, the detection positions, energy values, and detection time regarding gamma rays detected by the first detector and the second detector. Based on the detection time contained in each of the first counted information and the second counted information, an energy value adder generate corrected counted information by summing the energy values contained in the first counted information and the second counted information.
摘要翻译：在根据实施例的PET装置中，第一检测器包括多个第一闪烁体并且检测从注射到对象中的正电子发射放射性核素发射的伽马射线。第二检测器设置在第一检测器的外圆周侧，包括以比第一闪烁体低的布置表面密度布置的多个第二闪烁体，并且检测已经通过第一检测器的伽马射线。计数信息获取单元获取由第一检测器和第二检测器检测的关于伽马射线的检测位置，能量值和检测时间作为第一计数信息和第二计数信息。基于包含在第一计数信息和第二计数信息中的检测时间，能量值加法器通过将包含在第一计数信息和第二计数信息中的能量值相加来生成校正的计数信息。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式