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1. 发明授权

US09060696B2 Implantable pressure transducer system optimized to correct environmental factors 有权
标题翻译：植入式压力传感器系统优化，以纠正环境因素
公开(公告)号：US09060696B2
公开(公告)日：2015-06-23
申请号：US11116138
申请日：2005-04-27
申请人： Neal L. Eigler , Brian M. Mann , James S. Whiting , Werner Hafelfinger
发明人： Neal L. Eigler , Brian M. Mann , James S. Whiting , Werner Hafelfinger
IPC分类号： A61B5/0215 , A61M25/04 , A61M25/02
CPC分类号： A61B5/6882 , A61B5/0215 , A61B5/042 , A61B5/6869 , A61B8/12 , A61B17/3468 , A61M25/0108 , A61M25/04 , A61M31/002 , A61M2025/0233 , A61N1/362 , A61N2001/0578
摘要： This invention relates generally to systems and methods for optimizing the performance and minimizing complications related to implanted sensors, such as pressure sensors, for the purposes of detecting, diagnosing and treating cardiovascular disease in a medical patient. Systems and methods for anchoring implanted sensors to various body structures is also provided.
摘要翻译：本发明一般涉及用于优化性能并最小化与诸如压力传感器的植入传感器有关的并发症的系统和方法，以便在医疗患者中检测，诊断和治疗心血管疾病。还提供了用于将植入的传感器锚定到各种身体结构的系统和方法。

2. 发明授权

US08303511B2 Implantable pressure transducer system optimized for reduced thrombosis effect 有权
标题翻译：植入式压力传感器系统优化减少血栓形成的作用
公开(公告)号：US08303511B2
公开(公告)日：2012-11-06
申请号：US11111691
申请日：2005-04-21
申请人： Neal L. Eigler , Brian M. Mann , James S. Whiting , Werner Hafelfinger
发明人： Neal L. Eigler , Brian M. Mann , James S. Whiting , Werner Hafelfinger
IPC分类号： A61B5/02 , A61B5/00 , A61M31/00
CPC分类号： A61B5/6882 , A61B5/0215 , A61B5/042 , A61B5/6869 , A61B8/12 , A61B17/3468 , A61M25/0108 , A61M25/04 , A61M31/002 , A61M2025/0233 , A61N1/362 , A61N2001/0578
摘要： This invention relates generally to systems and methods for optimizing the performance and minimizing complications related to implanted sensors, such as pressure sensors, for the purposes of detecting, diagnosing and treating cardiovascular disease in a medical patient. Systems and methods for anchoring implanted sensors to various body structures are also provided.
摘要翻译：本发明一般涉及用于优化性能并最小化与诸如压力传感器的植入传感器有关的并发症的系统和方法，以便在医疗患者中检测，诊断和治疗心血管疾病。还提供了用于将植入的传感器锚定到各种身体结构的系统和方法。

3. 发明授权

US08206435B2 Expandable medical device for delivery of beneficial agent 有权
标题翻译：可扩展医疗器械用于输送有益药剂
公开(公告)号：US08206435B2
公开(公告)日：2012-06-26
申请号：US12390542
申请日：2009-02-23
申请人： John F. Shanley , Neal L. Eigler , Kinam Park , Elazer R. Edelman
发明人： John F. Shanley , Neal L. Eigler , Kinam Park , Elazer R. Edelman
IPC分类号： A61F2/82 , A61F2/94
CPC分类号： A61L31/10 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2210/0004 , A61F2210/0076 , A61F2250/003 , A61F2250/0031 , A61F2250/0068 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/42 , A61L2300/602 , A61L2300/622
摘要： An expandable medical device has elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. At least one of the struts includes at least one opening extending at least partially through a thickness of the strut. A beneficial agent is loaded into the opening within the strut in layers to achieve desired temporal release kinetics of the agent. Alternatively, the beneficial agent is loaded in a shape which is configured to achieve the desired agent delivery profile. A wide variety of delivery profiles can be achieved including zero order, pulsatile, increasing, decrease, sinusoidal, and other delivery profiles.
摘要翻译：可扩张医疗装置具有连接在一起的细长支柱，以形成一个基本上圆柱形的装置，该装置可从具有第一直径的圆柱体扩展到具有第二直径的圆筒。支柱中的至少一个包括至少部分穿过支柱的厚度延伸的至少一个开口。将有益剂加载到支柱内的开口中以实现试剂的期望的释放动力学。或者，有益试剂被加载成被配置成实现所需试剂输送曲线的形状。可以实现各种各样的输送曲线，包括零级，脉冲，增加，减少，正弦和其他输送曲线。

4. 发明授权

US08172856B2 Methods and apparatus for atrioventricular valve repair 有权
标题翻译：房室瓣膜修复方法与装置
公开(公告)号：US08172856B2
公开(公告)日：2012-05-08
申请号：US10628880
申请日：2003-07-28
申请人： Neal L. Eigler , Matthew J. Price , Robert J. Siegel
发明人： Neal L. Eigler , Matthew J. Price , Robert J. Siegel
IPC分类号： A61B17/10 , A61B17/04
CPC分类号： A61B17/0469 , A61B17/0491 , A61B2017/00243 , A61B2017/00292 , A61B2017/003 , A61B2017/00783 , A61B2017/0472 , A61B2017/0608 , A61B2017/22038 , A61B2017/22069
摘要： Methods and devices are disclosed for minimally invasive procedures in the heart. In one application, a catheter is advanced from the left atrium through the mitral valve and along the left ventricular outflow tract to orient and stabilize the catheter and enable a procedure such as a “bow tie” repair of the mitral valve. Right heart procedures are also disclosed.
摘要翻译：公开了用于心脏中的微创手术的方法和装置。在一个应用中，导管从左心房通过二尖瓣并沿着左心室流出道前进，以定向和稳定导管，并且实现诸如二尖瓣的“弓领”修复之类的过程。右心脏手术也被公开。

5. 发明申请

US20120035590A1 SYSTEM AND METHOD FOR MANIPULATING INSERTION PATHWAYS FOR ACCESSING TARGET SITES 有权
标题翻译：用于操纵目标站点的插入路径的系统和方法
公开(公告)号：US20120035590A1
公开(公告)日：2012-02-09
申请号：US13248922
申请日：2011-09-29
申请人： James S. Whiting , Neal L. Eigler , Brian M. Mann , Werner Hafelfinger
发明人： James S. Whiting , Neal L. Eigler , Brian M. Mann , Werner Hafelfinger
IPC分类号： A61M25/09
CPC分类号： A61B17/3468 , A61B2017/00243 , A61M25/01 , A61M25/09 , A61M2025/0681 , A61N1/056
摘要： A method for accessing a target site in the body by transferring a guidewire from an initial insertion site on the body to a different insertion site on the body is provided. In one aspect, a method for transferring a medical device or component, such as a sensor lead, from an initial insertion site to another insertion site is also provided. A guidewire of sufficient length, pliancy and deformability to perform a transfer from one insertion site to another insertion site is provided. In one aspect, the guidewire comprises a removable core mandrel to increase rigidity, facilitate insertion and/or improve steerability. A kit or system, comprising introducers, guidewires and catheters for performing a guidewire or device transfer is also provided.
摘要翻译：提供了一种通过将导丝从身体上的初始插入位置传递到身体上的不同插入位置来访问身体中的目标部位的方法。一方面，还提供了用于将诸如传感器引线的医疗装置或部件从初始插入位置转移到另一插入位置的方法。提供了足够的长度，柔软度和变形性的导线，以执行从一个插入位点到另一个插入位点的转移。在一个方面，导丝包括可移除的芯心，以增加刚性，便于插入和/或提高可操纵性。还提供了一种套件或系统，其包括用于执行导丝或设备转移的导引器，导线和导管。

6. 发明授权

US08029470B2 Transmembrane access systems and methods 有权
标题翻译：跨膜进入系统和方法
公开(公告)号：US08029470B2
公开(公告)日：2011-10-04
申请号：US10956899
申请日：2004-09-30
申请人： James S. Whiting , Neal L. Eigler , John L. Wardle , Werner Hafelfinger , Brian Mann
发明人： James S. Whiting , Neal L. Eigler , John L. Wardle , Werner Hafelfinger , Brian Mann
IPC分类号： A61M5/178
CPC分类号： A61M25/0662 , A61M25/0041 , A61M2025/0681
摘要： Systems and methods for penetrating a tissue membrane to gain access to a target site are disclosed. In some examples, systems and methods for accessing the left atrium from the right atrium of a patient's heart are carried out by puncturing the intra-atrial septal wall. One embodiment provides a system for transseptal cardiac access that includes a stabilizer sheath having a side port, a shaped guiding catheter configured to exit the side port and a tissue penetration member disposed within and extendable from the distal end of the guide catheter. The tissue penetration member may be configured to penetrate tissue upon rotation and may be coupled to a distal portion of a torqueable shaft. In some embodiments, the stabilizer sheath and shaped guiding catheter may be moved relative to the patient's body structure and relative to each other so that a desired approach angle may be obtained for the tissue penetration member with respect to the target tissue.
摘要翻译：公开了渗透组织膜以获得进入目标部位的系统和方法。在一些实例中，通过穿刺房间隔壁来进行从患者心脏的右心房进入左心房的系统和方法。一个实施例提供了一种用于经心脏进入的系统，其包括具有侧端口的稳定器护套，被配置为离开侧端口的成形引导导管和设置在引导导管的远端内并且可从引导导管的远端延伸的组织穿透构件。组织穿透构件可以构造成在旋转时穿透组织并且可以联接到可扭转轴的远侧部分。在一些实施例中，稳定器护套和成形引导导管可以相对于患者的身体结构相对于彼此移动，使得组织穿透构件相对于目标组织可以获得期望的接近角。

7. 发明授权

US5822391A Coronary tracking display 失效
公开(公告)号：US5822391A
公开(公告)日：1998-10-13
申请号：US555673
申请日：1996-03-25
申请人： James S. Whiting , Neal L. Eigler
发明人： James S. Whiting , Neal L. Eigler
IPC分类号： A61B6/00 , A61M25/01 , G06T7/00 , G06T7/20 , H04N5/32 , H04N5/325 , H05G1/60 , H05G1/64
CPC分类号： A61B6/481 , A61B6/504 , G06T7/004 , G06T7/20 , G06T7/2033 , H04N5/3205 , H04N5/325 , H05G1/60 , G06T2207/30101
摘要： A method of displaying details of a coronary artery lesion in a cineangiogram, by adjusting each frame of the cineangiogram so that the lesion is continually displayed at a fixed location on a display. The remaining cardiac anatomy appears to move, in background, past a stationary arterial segment, thus making the displayed arterial segment easier to identify and to examine by medical personnel. Cineangiographic image frames are digitized and processed by a processor and the image frames are digitally shifted to place the arterial segment in substantially the same viewing location in each frame. Sequential image frames may be presented to the viewer as a stereoscopic pair, to produce pseudostereopsis. The arterial segment appears to the viewer in foreground, as if it was floating in front of the remaining cardiac anatomy. Image frames may be further processed to aid examination by medical personnel. The processor may make quantitative measurements of the cineangiogram and may display results of those measurements to aid review of the cineangiogram. Frames may be averaged to reduce quantum noise and to blur any structure noise; frames may be compared with prior cineangiograms to increase clarity or contrast. Coordinate adjustments for a cineangiogram may help guide therapeutic procedures, or may help enhance other imaging procedures such as fluoroscopy.

8. 发明申请

US20120310331A1 METHODS AND APPARATUS FOR ATRIOVENTRICULAR VALVE REPAIR 审中-公开
标题翻译：方法和装置用于血管内膜瓣修复
公开(公告)号：US20120310331A1
公开(公告)日：2012-12-06
申请号：US13441308
申请日：2012-04-06
申请人： Neal L. Eigler , Matthew J. Price , Robert J. Siegel
发明人： Neal L. Eigler , Matthew J. Price , Robert J. Siegel
IPC分类号： A61F2/24
CPC分类号： A61B17/0469 , A61B17/0491 , A61B2017/00243 , A61B2017/00292 , A61B2017/003 , A61B2017/00783 , A61B2017/0472 , A61B2017/0608 , A61B2017/22038 , A61B2017/22069
摘要： Methods and devices are disclosed for minimally invasive procedures in the heart. In one application, a catheter is advanced from the left atrium through the mitral valve and along the left ventricular outflow tract to orient and stabilize the catheter and enable a procedure such as a “bow tie” repair of the mitral valve. Right heart procedures are also disclosed.
摘要翻译：公开了用于心脏中的微创手术的方法和装置。在一个应用中，导管从左心房通过二尖瓣并沿着左心室流出道前进，以定向和稳定导管，并且实现诸如二尖瓣弓形修复的过程。右心脏手术也被公开。

9. 发明授权

US08202313B2 Expandable medical device with beneficial agent in openings 有权
标题翻译：具有开口的有益剂的可扩展医疗器械
公开(公告)号：US08202313B2
公开(公告)日：2012-06-19
申请号：US10849324
申请日：2004-05-19
申请人： John F. Shanley , Neal L. Eigler , Elazer R. Edelman
发明人： John F. Shanley , Neal L. Eigler , Elazer R. Edelman
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91558 , A61F2250/0004 , A61F2250/0068
摘要： An expandable medical device having a plurality of elongated struts, the plurality of elongated struts being joined together by ductile hinges to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. The plurality of struts and ductile hinges are arranged to improve the spatial distribution of the struts which is particularly important when delivering beneficial agents with the struts. The improved strut arrangement expands to a substantially parallelogram shape for improved beneficial agent distribution to the surrounding tissue. A beneficial agent may be loaded into openings within the struts or coated onto the struts for delivery to the tissue.
摘要翻译：一种具有多个细长支柱的可扩张医疗装置，所述多个细长支柱通过延性铰链连接在一起以形成可从具有第一直径的圆柱体膨胀至具有第二直径的圆柱体的基本上圆柱形的装置。多个支柱和延性铰链被布置成改善支柱的空间分布，这在用支柱输送有益试剂时是特别重要的。改进的支柱布置扩展到基本上平行四边形的形状，以改善对周围组织的有益剂分布。有益剂可以装载到支柱内的开口中或涂覆到支柱上以输送到组织。

10. 发明申请

US20110054405A1 HEMOSTASIS VALVE WITH IRIS SEAL 有权
标题翻译： HEMOSTASIS阀与IRIS密封
公开(公告)号：US20110054405A1
公开(公告)日：2011-03-03
申请号：US12552199
申请日：2009-09-01
申请人： James S. Whiting , Werner Hafelfinger , Neal L. Eigler , John L. Wardle
发明人： James S. Whiting , Werner Hafelfinger , Neal L. Eigler , John L. Wardle
IPC分类号： A61B17/34
CPC分类号： A61B17/3462 , A61B17/3439 , A61M39/0613
摘要： A hemostasis valve is disclosed herein. The hemostasis valve may include an inner bushing, a rotation sleeve, an elastomeric sleeve, and a biasing element. The rotation sleeve may extend about the inner bushing and be rotationally displaceable relative to the inner bushing. The elastomeric sleeve may include a first end operably coupled to the inner bushing, a second end operably coupled to the rotation sleeve, and an iris valve portion. Rotation of the rotation sleeve relative to the inner bushing may cause the iris valve to transition from an open state to a closed state. The biasing element may act between the rotation sleeve and inner bushing to bias the iris valve towards at least one of a closed state or an open state.
摘要翻译：本文公开了一种止血阀。止血阀可以包括内衬套，旋转套筒，弹性体套筒和偏置元件。旋转套筒可以围绕内衬套延伸并且可相对于内衬套旋转移位。弹性体套筒可以包括可操作地联接到内衬套的第一端，可操作地联接到旋转套筒的第二端和可变光阀部分。旋转套筒相对于内衬套的旋转可能导致虹膜阀从打开状态转换到关闭状态。偏置元件可以在旋转套筒和内衬套之间作用，以将虹膜阀朝向关闭状态或打开状态中的至少一个偏压。

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