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1. 发明授权

US09061042B2 Composition for suppressing expression of target gene 有权
标题翻译：用于抑制靶基因表达的组合物
公开(公告)号：US09061042B2
公开(公告)日：2015-06-23
申请号：US13017562
申请日：2011-01-31
申请人： Nobuhiro Yagi , Junichi Enokizono
发明人： Nobuhiro Yagi , Junichi Enokizono
IPC分类号： C12N15/11 , A61K31/7105 , A61K9/00 , A61K9/127 , A61K31/712 , A61K31/713 , C12N15/113
CPC分类号： A61K31/7105 , A61K9/0019 , A61K9/1271 , A61K31/712 , A61K31/713 , C12N15/1135 , C12N2310/14 , Y10T436/143333
摘要： An object of the present invention is to provide a composition for suppressing expression of a target gene, and the like. A composition comprising an RNA-encapsulated liposome, wherein the RNA contains a sequence consisting of 15 to 30 contiguous bases of a target gene mRNA (hereinafter, sequence X) and a base sequence (hereinafter, complementary sequence X′) complementary to the sequence X, 1 to 90% of all sugars binding to the bases of the sequence X and the complementary sequence X′ being ribose substituted by a modifying group at 2′ position, and the lipid particle being capable of reaching a tissue or an organ containing an expression site of the target gene is provide.
摘要翻译：本发明的目的是提供抑制靶基因表达的组合物等。包含RNA包封的脂质体的组合物，其中所述RNA含有由靶基因mRNA（以下称为序列X）的15〜30个连续碱基和与序列X互补的碱基序列（以下称为互补序列X'）组成的序列，与所述序列X的碱基结合的所有糖的1至90％，并且所述互补序列X'是在2'位置被修饰基团取代的核糖，并且所述脂质颗粒能够到达包含表达的组织或器官提供靶基因的位点。

2. 发明申请

US20060179121A1 Control server, control terminal, control system, and recording medium storing control communication program 有权
标题翻译：控制服务器，控制终端，控制系统和存储控制通信程序的记录介质
公开(公告)号：US20060179121A1
公开(公告)日：2006-08-10
申请号：US11371026
申请日：2006-03-09
申请人： Kentaro Kegoya , Minoru Yoshida , Shunu Tanigawa , Satoshi Kato , Nobuhiro Yagi , Masao Saito , Masaaki Yamada
发明人： Kentaro Kegoya , Minoru Yoshida , Shunu Tanigawa , Satoshi Kato , Nobuhiro Yagi , Masao Saito , Masaaki Yamada
IPC分类号： G06F15/16
CPC分类号： H04L67/125 , G05B19/042 , G05B19/05 , G05B2219/24084 , G05B2219/31161 , G05B2219/31186 , G05B2219/31457 , H04L67/28 , H04L67/2823 , H04L69/08
摘要： Screen data is generated by a screen generating processor (74) of a control host computer (7) and transmitted to a programmable display apparatus (5). In accordance with the screen data, the programmable display apparatus (5) inquires a PLC (3) or the like about a state of a device (21), so as to update the display or transmit a control instruction depending on an input result. On the other hand, a control host computer (7) has a public server section (77) to transmit to a client apparatus (9) via the Internet an applet, which is generated by a compiler (76) compiling the screen data. The client apparatus (9) executes the applet to transmit to the public server section (77) an or the control instruction inquiry similar to those the programmable display apparatus (5) makes. In this way, the display is updated in accordance with a response. This realizes a control system, which allows a display content of the programmable display apparatus (5) to be remotely checked from a remote area remote from the programmable display apparatus (5), without newly generating a display screen.
摘要翻译：屏幕数据由控制主计算机（7）的画面生成处理器（74）产生并发送到可编程显示装置（5）。根据画面数据，可编程显示装置（5）向PLC（3）等询问设备（21）的状态，以根据输入结果更新显示或发送控制指令。另一方面，控制主计算机（7）具有公共服务器部（77），用于经由因特网向客户端装置（9）发送由编译器（76）生成的小应用程序。客户端装置（9）执行小程序以向公共服务器部分（77）发送或与可编程显示装置（5）相似的控制指令查询。以这种方式，根据响应更新显示。这实现了一种控制系统，其允许从远程可编程显示装置（5）的远程区域远程检查可编程显示装置（5）的显示内容，而不新生成显示屏幕。

3. 发明申请

US20120203023A1 Process For Preparing A Phenylalanine Derivative 审中-公开
标题翻译：制备苯丙氨酸衍生物的方法
公开(公告)号：US20120203023A1
公开(公告)日：2012-08-09
申请号：US13500148
申请日：2010-10-19
申请人： Joseph Paul Adams , Toru Kuroda , Hiroaki Matsumae , John Bryce Strachan , Nobuhiro Yagi
发明人： Joseph Paul Adams , Toru Kuroda , Hiroaki Matsumae , John Bryce Strachan , Nobuhiro Yagi
IPC分类号： C07C227/18 , C07C229/38
CPC分类号： C07C231/24 , C07C231/12 , C07C233/87
摘要： A novel process for the preparation of a phenylalanine derivative of formula (I):
摘要翻译：制备式（I）的苯丙氨酸衍生物的新方法：

4. 发明授权

US07953892B2 Control server, control terminal, control system, and recording medium storing control communication program 有权
公开(公告)号：US07953892B2
公开(公告)日：2011-05-31
申请号：US11371020
申请日：2006-03-09
申请人： Kentaro Kegoya , Minoru Yoshida , Shunu Tanigawa , Satoshi Kato , Nobuhiro Yagi , Masao Saito , Masaaki Yamada
发明人： Kentaro Kegoya , Minoru Yoshida , Shunu Tanigawa , Satoshi Kato , Nobuhiro Yagi , Masao Saito , Masaaki Yamada
IPC分类号： G06F15/16
CPC分类号： H04L67/125 , G05B19/042 , G05B19/05 , G05B2219/24084 , G05B2219/31161 , G05B2219/31186 , G05B2219/31457 , H04L67/28 , H04L67/2823 , H04L69/08
摘要： Screen data is generated by a screen generating processor (74) of a control host computer (7) and transmitted to a programmable display apparatus (5). In accordance with the screen data, the programmable display apparatus (5) inquires a PLC (3) or the like about a state of a device (21), so as to update the display or transmit a control instruction depending on an input result. On the other hand, a control host computer (7) has a public server section (77) to transmit to a client apparatus (9) via the Internet an applet, which is generated by a compiler (76) compiling the screen data. The client apparatus (9) executes the applet to transmit to the public server section (77) an or the control instruction inquiry similar to those the programmable display apparatus (5) makes. In this way, the display is updated in accordance with a response. This realizes a control system, which allows a display content of the programmable display apparatus (5) to be remotely checked from a remote area remote from the programmable display apparatus (5), without newly generating a display screen.

5. 发明授权

US07937496B2 Control server, control terminal, control system, and recording medium storing control communication program 有权
标题翻译：控制服务器，控制终端，控制系统和存储控制通信程序的记录介质
公开(公告)号：US07937496B2
公开(公告)日：2011-05-03
申请号：US11371026
申请日：2006-03-09
申请人： Kentaro Kegoya , Minoru Yoshida , Shunu Tanigawa , Satoshi Kato , Nobuhiro Yagi , Masao Saito , Masaaki Yamada
发明人： Kentaro Kegoya , Minoru Yoshida , Shunu Tanigawa , Satoshi Kato , Nobuhiro Yagi , Masao Saito , Masaaki Yamada
IPC分类号： G06F15/16
CPC分类号： H04L67/125 , G05B19/042 , G05B19/05 , G05B2219/24084 , G05B2219/31161 , G05B2219/31186 , G05B2219/31457 , H04L67/28 , H04L67/2823 , H04L69/08
摘要： Screen data is generated by a screen generating processor (74) of a control host computer (7) and transmitted to a programmable display apparatus (5). In accordance with the screen data, the programmable display apparatus (5) inquires a PLC (3) or the like about a state of a device (21), so as to update the display or transmit a control instruction depending on an input result. On the other hand, a control host computer (7) has a public server section (77) to transmit to a client apparatus (9) via the Internet an applet, which is generated by a compiler (76) compiling the screen data. The client apparatus (9) executes the applet to transmit to the public server section (77) an or the control instruction inquiry similar to those the programmable display apparatus (5) makes. In this way, the display is updated in accordance with a response. This realizes a control system, which allows a display content of the programmable display apparatus (5) to be remotely checked from a remote area remote from the programmable display apparatus (5), without newly generating a display screen.
摘要翻译：屏幕数据由控制主计算机（7）的画面生成处理器（74）产生并发送到可编程显示装置（5）。根据画面数据，可编程显示装置（5）向PLC（3）等询问设备（21）的状态，以根据输入结果更新显示或发送控制指令。另一方面，控制主计算机（7）具有公共服务器部（77），用于经由因特网向客户端装置（9）发送由编译器（76）生成的小应用程序。客户端装置（9）执行小程序以向公共服务器部分（77）发送或与可编程显示装置（5）相似的控制指令查询。以这种方式，根据响应更新显示。这实现了一种控制系统，其允许从远程可编程显示装置（5）的远程区域远程检查可编程显示装置（5）的显示内容，而不新生成显示屏幕。

6. 发明申请

US20090011003A1 Composition for Suppressing Expression of Target Gene 审中-公开
标题翻译：抑制靶基因表达的组成
公开(公告)号：US20090011003A1
公开(公告)日：2009-01-08
申请号：US11883168
申请日：2005-10-24
申请人： Masahiro Yamauchi , Tsuneaki Tottori , Atsushi Ishihara , Nobuhiro Yagi , Yasuki Kato
发明人： Masahiro Yamauchi , Tsuneaki Tottori , Atsushi Ishihara , Nobuhiro Yagi , Yasuki Kato
IPC分类号： A61K9/127 , A61K31/7105 , A61K48/00
CPC分类号： C12N15/1135 , A61K9/127 , A61K31/7105 , C12N2310/14
摘要： The present invention has its object to provide a composition for suppressing the expression of a target gene and the like, and provides a composition, comprising an RNA-encapsulated liposome which comprises complex particles comprising as constituent components a lead particle and an RNA comprising a sequence consisting of 15 to 30 contiguous nucleotides of a target gene mRNA and a sequence complementary to the sequence, and a lipid membrane for coating the complex particles, wherein constituent components of the lipid membrane can be solved in a polar organic solvent, and wherein the polar organic solvent can be contained in a liquid at such a concentration that the constituent components of the lipid membrane are dispersible and the complex particles are dispersible, and the like.
摘要翻译：本发明的目的是提供抑制靶基因表达等的组合物，提供包含RNA包封的脂质体的组合物，其包含作为铅粒子的构成成分的复合粒子和包含序列的RNA 由靶基因mRNA的15〜30个连续核苷酸和与该序列互补的序列构成，以及用于涂布复合粒子的脂质膜，其中脂质膜的构成成分可以在极性有机溶剂中溶解，其中极性有机溶剂可以以使得脂质膜的组成成分可分散并且复合颗粒可分散的浓度包含在液体中。

7. 发明申请

US20060190624A1 Control server, control terminal, control system, and recording medium storing control communication program 有权
公开(公告)号：US20060190624A1
公开(公告)日：2006-08-24
申请号：US11371020
申请日：2006-03-09
申请人： Kentaro Kegoya , Minoru Yoshida , Shunu Tanigawa , Satoshi Kato , Nobuhiro Yagi , Masao Saito , Masaaki Yamada
发明人： Kentaro Kegoya , Minoru Yoshida , Shunu Tanigawa , Satoshi Kato , Nobuhiro Yagi , Masao Saito , Masaaki Yamada
IPC分类号： G06F15/16
CPC分类号： H04L67/125 , G05B19/042 , G05B19/05 , G05B2219/24084 , G05B2219/31161 , G05B2219/31186 , G05B2219/31457 , H04L67/28 , H04L67/2823 , H04L69/08
摘要： Screen data is generated by a screen generating processor (74) of a control host computer (7) and transmitted to a programmable display apparatus (5). In accordance with the screen data, the programmable display apparatus (5) inquires a PLC (3) or the like about a state of a device (21), so as to update the display or transmit a control instruction depending on an input result. On the other hand, a control host computer (7) has a public server section (77) to transmit to a client apparatus (9) via the Internet an applet, which is generated by a compiler (76) compiling the screen data. The client apparatus (9) executes the applet to transmit to the public server section (77) an or the control instruction inquiry similar to those the programmable display apparatus (5) makes. In this way, the display is updated in accordance with a response. This realizes a control system, which allows a display content of the programmable display apparatus (5) to be remotely checked from a remote area remote from the programmable display apparatus (5), without newly generating a display screen.

8. 发明授权

US07467231B2 Control server, control terminal, control system, and recording medium storing control communication program 有权
标题翻译：控制服务器，控制终端，控制系统和存储控制通信程序的记录介质
公开(公告)号：US07467231B2
公开(公告)日：2008-12-16
申请号：US10221779
申请日：2001-03-15
申请人： Kentaro Kegoya , Minoru Yoshida , Shunu Tanigawa , Satoshi Kato , Nobuhiro Yagi , Masao Saito , Masaaki Yamada
发明人： Kentaro Kegoya , Minoru Yoshida , Shunu Tanigawa , Satoshi Kato , Nobuhiro Yagi , Masao Saito , Masaaki Yamada
IPC分类号： G06F15/16
CPC分类号： H04L67/125 , G05B19/042 , G05B19/05 , G05B2219/24084 , G05B2219/31161 , G05B2219/31186 , G05B2219/31457 , H04L67/28 , H04L67/2823 , H04L69/08
摘要： Screen data is generated by a screen generating processor (74) of a control host computer (7) and transmitted to a programmable display apparatus (5). In accordance with the screen data, the programmable display apparatus (5) inquires a PLC (3) or the like about a state of a device (21), so as to update the display or transmit a control instruction depending on an input result. On the other hand, a control host computer (7) has a public server section (77) to transmit to a client apparatus (9) via the Internet an applet, which is generated by a compiler (76) compiling the screen data. The client apparatus (9) executes the applet to transmit to the public server section (77) an or the control instruction inquiry similar to those the programmable display apparatus (5) makes. In this way, the display is updated in accordance with a response. This realizes a control system, which allows a display content of the programmable display apparatus (5) to be remotely checked from a remote area remote from the programmable display apparatus (5), without newly generating a display screen.
摘要翻译：屏幕数据由控制主计算机（7）的画面生成处理器（74）产生并发送到可编程显示装置（5）。根据画面数据，可编程显示装置（5）向PLC（3）等询问设备（21）的状态，以根据输入结果更新显示或发送控制指令。另一方面，控制主计算机（7）具有公共服务器部（77），用于经由因特网向客户端装置（9）发送由编译器（76）生成的小应用程序。客户端装置（9）执行小程序以向公共服务器部分（77）发送或与可编程显示装置（5）相似的控制指令查询。以这种方式，根据响应更新显示。这实现了一种控制系统，其允许从远程可编程显示装置（5）的远程区域远程检查可编程显示装置（5）的显示内容，而不新生成显示屏幕。

9. 发明申请

US20080226704A1 Method of Producing Coated Fine Particles 审中-公开
标题翻译：生产涂层微粒的方法
公开(公告)号：US20080226704A1
公开(公告)日：2008-09-18
申请号：US10593723
申请日：2005-03-23
申请人： Makoto Kigoshi , Nobuhiro Yagi , Yasuki Kato
发明人： Makoto Kigoshi , Nobuhiro Yagi , Yasuki Kato
IPC分类号： A61K9/127 , B05D7/00 , B32B5/16 , A61K9/50
CPC分类号： B01J13/02 , Y10T428/2989
摘要： The present invention provides a method of producing coated fine particles in which core fine particles is coated with a coating layer, which comprises the steps of preparing a liquid (liquid A) containing a polar organic solvent in which core fine particles are dispersed and a component constituting a coating layer is dissolved; preparing a liquid (liquid B) which is miscible with the liquid A and does not contain a polar organic solvent or contains a polar organic solvent in a ratio lower than that in the liquid A; and letting the liquid A flow from at least one inlet of a device for producing coated fine particles equipped with an in-line mixing means having two or more inlets and one or more outlet(s) and letting the liquid B flow from at least one remaining inlet to mix the liquids thereby coating the core fine particles with the coating layer.
摘要翻译：本发明提供一种制备其中芯细颗粒涂覆有涂层的涂覆微粒的方法，该方法包括以下步骤：制备包含其中分散芯细颗粒的极性有机溶剂的液体（液体A）和组分构成涂层溶解; 制备与液体A混溶并且不含极性有机溶剂或含有比液体A中的比例低的极性有机溶剂的液体（液体B）; 并且使液体A从用于生产包含具有两个或更多个入口和一个或多个出口的直列混合装置的涂覆微粒的装置的至少一个入口流出并使液体B从至少一个流出剩余的入口混合液体，从而涂覆核心微粒与涂层。

10. 发明申请

US20080171090A1 Method Of Producing Coated Fine Particles 审中-公开
标题翻译：生产涂层微粒的方法
公开(公告)号：US20080171090A1
公开(公告)日：2008-07-17
申请号：US11883165
申请日：2006-01-27
申请人： Nobuhiro Yagi , Takuya Tokuda , Masashi Nakakura , Yasuki Kato
发明人： Nobuhiro Yagi , Takuya Tokuda , Masashi Nakakura , Yasuki Kato
IPC分类号： A61K9/14 , A61J3/00 , A61P35/00 , A61P29/00 , B32B1/00
CPC分类号： A61K9/5123 , A61K9/1075 , A61K9/5192 , A61K31/7088 , B01J13/04 , Y10T428/2991
摘要： An object of the present invention is to provide a method for easily producing coated fine particles in which core fine particles are coated with a coating layer component, etc. There are provided a method of producing coated fine particles comprising core fine particles coated with a coating layer component, comprising the steps of dispersing the core fine particles and the coating layer component(s) in a liquid and the process of coating the core fine particles with the coating layer component, wherein the liquid contains a polar organic solvent in which the coating layer component(s) is soluble, and the concentration of the polar organic solvent is such that the core fine particles is not dissolved and the coating layer component(s) can be in the dispersed state in the liquid, and the like.
摘要翻译：本发明的目的是提供一种容易地生产其中芯细颗粒涂覆有涂层组分等的涂覆微粒的方法。提供了一种制备涂覆微粒的方法，其包括涂覆有涂层的芯细颗粒包括以下步骤：将芯细颗粒和涂层组分分散在液体中，以及用芯层细颗粒涂覆涂层组分的方法，其中液体含有极性有机溶剂，其中涂层层组分是可溶的，并且极性有机溶剂的浓度使得芯细颗粒不溶解，并且涂层组分可以在液体中处于分散状态等。

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