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1. 发明申请

US20120264687A1 MODIFIED ERYTHROPOIETIN TO WHICH WATER-SOLUBLE LONG-CHAIN MOLECULE IS ADDED 审中-公开
标题翻译：添加了可溶性长链分子的改良的红细胞膜蛋白
公开(公告)号：US20120264687A1
公开(公告)日：2012-10-18
申请号：US13395534
申请日：2010-09-15
申请人： Nobutaka Tani , Toshihide Fujii , Hiroyuki Watanabe , Hirofumi Maeda
发明人： Nobutaka Tani , Toshihide Fujii , Hiroyuki Watanabe , Hirofumi Maeda
IPC分类号： A61K38/18 , A61P7/06
CPC分类号： A61K9/0019 , A61K38/1816 , A61K47/60
摘要： An object of the invention is to provide a pharmaceutical composition that contains erythropoietin as the active ingredient and has, when administered in humans and/or animals, a hematopoietic effect that lasts for not less than seven days. The invention provides a pharmaceutical composition containing, in an amount equal to not less than 50% of the total erythropoietin, erythropoietin to which two or more water-soluble long-chain molecules are added. The invention also provides a pharmaceutical composition containing erythropoietin to which a water-soluble long-chain molecule is added, wherein the water-soluble long-chain molecule has a molecular weight of not less than 30 kDa. The invention further provides a pharmaceutical composition containing erythropoietin to which a water-soluble long-chain molecule is added, wherein the water-soluble long-chain molecule has a branched chain.
摘要翻译：本发明的目的是提供一种含有促红细胞生成素作为活性成分并且在人和/或动物中施用时持续不少于7天的造血作用的药物组合物。本发明提供一种药物组合物，其含量等于不少于总促红细胞生成素的50％，红细胞生成素，其中加入了两种或更多种水溶性长链分子。本发明还提供含有促红细胞生成素的药物组合物，其中加入水溶性长链分子，其中水溶性长链分子的分子量不小于30kDa。本发明还提供含有促红细胞生成素的药物组合物，其中加入水溶性长链分子，其中所述水溶性长链分子具有支链。

2. 发明授权

US5302393A Method for inhibiting biological degradation of implantation polymeric material, inhibitor thereof and implantation polymeric material containing the inhibitor 失效
标题翻译：用于抑制植入聚合物材料的生物降解的方法，其抑制剂和含有抑制剂的植入聚合材料
公开(公告)号：US5302393A
公开(公告)日：1994-04-12
申请号：US910809
申请日：1992-07-09
申请人： Hiroshi Matsumoto , Kensuke Kondo , Kazuhiko Inoue , Nobutaka Tani
发明人： Hiroshi Matsumoto , Kensuke Kondo , Kazuhiko Inoue , Nobutaka Tani
IPC分类号： A61K31/505 , A61L17/00 , A61L27/50 , A61L29/14 , A61L33/00 , A61M39/00 , A61K31/74 , A61L27/00
CPC分类号： A61L27/505 , A61K31/505 , A61L17/005 , A61L29/143 , A61L33/0041 , A61L2300/204 , A61L2300/42 , Y10S623/92
摘要： A method for inhibiting decomposition and/or degradation of an implantation polymeric material in the living body, which comprises allowing dipyridamole and/or a salt or a derivative thereof as an active component to exist in the vicinity of an implantation polymeric material implanted in the living body; an inhibitor effective for inhibiting biological decomposition and/or degradation of a polymeric material implanted in the living body, which comprises dipyridamole and/or a salt or a derivative thereof as an active component; and an implantation polymeric material which contains dipyridamole and/or a salt or a derivative thereof as an active component.
摘要翻译：一种用于抑制活体中植入聚合物材料的分解和/或降解的方法，其包括使双嘧达莫和/或其盐或其衍生物作为活性成分存在于植入生物体内的植入聚合材料附近身体; 一种有效抑制植入生物体中的聚合材料的生物分解和/或降解的抑制剂，其包括双嘧达莫和/或其作为活性组分的盐或其衍生物; 以及含有双嘧达莫和/或其作为活性组分的盐或其衍生物的植入聚合材料。

3. 发明授权

US08695035B2 Information processing apparatus 有权
标题翻译：信息处理装置
公开(公告)号：US08695035B2
公开(公告)日：2014-04-08
申请号：US12703244
申请日：2010-02-10
申请人： Katsutoshi Sakao , Nobutaka Tani , Satoru Maeda
发明人： Katsutoshi Sakao , Nobutaka Tani , Satoru Maeda
IPC分类号： G06F3/00
CPC分类号： H04N21/4622 , H04N5/4401 , H04N5/445 , H04N5/44543 , H04N5/50 , H04N7/17318 , H04N21/2543 , H04N21/4312 , H04N21/4314 , H04N21/4316 , H04N21/4331 , H04N21/44222 , H04N21/47805 , H04N21/4782 , H04N21/482 , H04N21/4821 , H04N21/6125 , H04N21/6547
摘要： The present invention relates to an information processing apparatus with improved operatability. With the information processing apparatus in which the user is capable of watching a television program and connecting to the Internet, the index panel 1 shows channel buttons 2 to be operated to select a desired program, a site button 71 to be operated to make an access to site A available on the Internet and a site button 72 to be operated to make an access to site B on the Internet. The present invention allows the user to watch a television program and can be applied to an information processing apparatus such as a personal computer, which can be connected to the Internet.
摘要翻译：本发明涉及具有改进的可操作性的信息处理设备。利用用户能够观看电视节目并连接到因特网的信息处理设备，索引面板1示出要被操作以选择所需节目的频道按钮2，要被操作以进行访问的场所按钮71 到因特网上可用的站点A和要操作的站点按钮72以访问因特网上的站点B. 本发明允许用户观看电视节目并且可以应用于可以连接到因特网的诸如个人计算机的信息处理装置。

4. 发明授权

US07802281B1 Information providing apparatus and method, information receiving apparatus and method, lots-drawing system and method and medium 失效
标题翻译：信息提供装置和方法，信息接收装置和方法，绘图系统和方法和介质
公开(公告)号：US07802281B1
公开(公告)日：2010-09-21
申请号：US09572814
申请日：2000-05-17
申请人： Nobutaka Tani , Masahiro Tada , Hirotaka Sugiyama , Tadashi Saito
发明人： Nobutaka Tani , Masahiro Tada , Hirotaka Sugiyama , Tadashi Saito
IPC分类号： H04N7/10
CPC分类号： H04H20/30 , G06Q30/02 , G06Q50/00 , H04H60/68 , H04H60/91 , H04H60/94 , H04N7/088 , H04N21/4781
摘要： The invention makes it possible to draw lots for a present in real time in association with a broadcast program. A broadcasting station broadcasts information relating to lot for a present that is associated with a broadcast program by superimposing it on a video signal in vertical blanking intervals. The lot information is decoded by a decoder and viewed by a viewer on a TV receiver. When the viewer commands the decoder to enter the lot for the present, the decoder accesses a present call center and an automatic lots-drawing system draws lots. A drawing result is transmitted to the broadcasting station and announced during the broadcast of the program. A sponsor sends the present product to winner viewers based on winner data.
摘要翻译：本发明使得可以与广播节目相关联地实时绘制当前的作品。广播电台通过在垂直消隐间隔中将视频信号叠加在与广播节目相关联的节目中广播与批量有关的信息。批量信息由解码器解码并由观看者在电视接收机上观看。当观众命令解码器输入当前的批量时，解码器访问当前的呼叫中心，并且自动抽签系统抽签。绘图结果被传送到广播电台，并在播放节目期间宣布。赞助商根据获奖者数据将本产品发送给优胜者观众。

5. 发明授权

US07690014B2 Information processing apparatus 有权
标题翻译：信息处理装置
公开(公告)号：US07690014B2
公开(公告)日：2010-03-30
申请号：US10477724
申请日：2002-05-14
申请人： Katsutoshi Sakao , Nobutaka Tani , Satoru Maeda
发明人： Katsutoshi Sakao , Nobutaka Tani , Satoru Maeda
IPC分类号： G06F3/00
CPC分类号： H04N21/4622 , H04N5/4401 , H04N5/445 , H04N5/44543 , H04N5/50 , H04N7/17318 , H04N21/2543 , H04N21/4312 , H04N21/4314 , H04N21/4316 , H04N21/4331 , H04N21/44222 , H04N21/47805 , H04N21/4782 , H04N21/482 , H04N21/4821 , H04N21/6125 , H04N21/6547
摘要： An information processing apparatus with improved operatability in which the user is capable of watching a television program and connecting to the Internet. An index panel shows channel buttons operated to select a desired program, a first site button provides access to site A available on the Internet and a second site button provides access to site B on the Internet. The user is able to watch a television program and can have access to an information processing apparatus such as a personal computer, which can be connected to the Internet.
摘要翻译：一种信息处理装置，其具有用户能够观看电视节目并连接到因特网的可操作性。索引面板显示用于选择所需程序的频道按钮，第一站点按钮提供对因特网上可用的站点A的访问，而第二站点按钮提供对因特网上的站点B的访问。用户能够观看电视节目，并且可以访问可以连接到因特网的诸如个人计算机的信息处理装置。

6. 发明授权

US06387362B1 Adsorbent for bradykinin, method for eliminating the same by adsorption, and adsorber 失效
标题翻译：用于缓激肽的吸附剂，通过吸附除去其的方法和吸附剂
公开(公告)号：US06387362B1
公开(公告)日：2002-05-14
申请号：US09043537
申请日：1998-08-14
申请人： Fumiyasu Hirai , Nobutaka Tani , Takamune Yasuda , Takashi Asahi
发明人： Fumiyasu Hirai , Nobutaka Tani , Takamune Yasuda , Takashi Asahi
IPC分类号： A61K31795
CPC分类号： B01J20/26 , A61M1/3679
摘要： An adsorbent or bradykinin comprising styrene-divinylbenzene copolymer having sulfonic acid groups and a method for adsorbing and removing bradykinin comprising contacting the adsorbent with a fluid containing bradykinin are provided. An adsorber for adsorbing bradykinin in which the adsorbent is charged in a vessel having an inlet and an outlet for a fluid is also provided.
摘要翻译：提供了包含具有磺酸基的苯乙烯 - 二乙烯基苯共聚物的吸附剂或缓激肽以及吸收和去除缓激肽的方法，包括使吸附剂与含有缓激肽的流体接触。还提供了用于吸附缓冲激肽的吸附剂，其中将吸附剂装入具有流体入口和出口的容器中。

7. 发明授权

US5866387A Method for immobilizing ligand or compound having ligand bonded thereto 失效
标题翻译：固定具有配体键合的配体或化合物的方法
公开(公告)号：US5866387A
公开(公告)日：1999-02-02
申请号：US894782
申请日：1997-08-28
申请人： Eiji Ogino , Kazuo Suzuki , Nobutaka Tani
发明人： Eiji Ogino , Kazuo Suzuki , Nobutaka Tani
IPC分类号： B01J20/32 , C12N11/04 , C12N11/06 , C12N11/08 , G01N33/544
CPC分类号： B01J20/3274 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3251 , B01J20/3255 , Y10S530/814 , Y10S530/815 , Y10S530/816
摘要： There is provided a method for immobilizing a ligand by reacting a solvent-insoluble carrier having aldehyde group with a compound shown by the general formula: ##STR1## wherein X is --S-- or --O--, R.sup.1, R.sup.2 and R.sup.6 are the same or different, each of which is hydrogen atom or an alkyl group having 1 to 4 carbon atoms, R.sup.3 is hydrogen atom or a substituent wherein an atom adjacent to nitrogen atom shown in the above-mentioned general formula has no unsaturated bond, R.sup.4, R.sup.5 and R.sup.7 are arbitrary substituents; provided that only one partial chemical structure of HX--C--C--NHR.sup.3 wherein X and R.sup.3 are the same as defined above or HX--C--C--C--NHR.sup.3 wherein X and R.sup.3 are the same as defined above is contained in one compound described above by which, a ligand or a compound to which a ligand is bonded can react specifically and effectively with aldehyde group in a solvent-insoluble carrier at a prescribed position to form a stable bond.
摘要翻译： PCT No.PCT / JP96 / 00450 Sec。 371日期1997年8月28日 102（e）日期1997年8月28日PCT 1996年2月26日PCT公布。第WO96 / 26786号公报日期1996年6月9日提供了通过使具有醛基的溶剂不溶性载体与通式如下的化合物反应来固定配体的方法：其中X是-S-或-O-，R 1，R 2 R6相同或不同，分别为氢原子或碳原子数1〜4的烷基，R3为氢原子或上述通式所示的与氮原子相邻的原子没有不饱和基团的取代基键，R4，R5和R7是任意的取代基; 只要其中X和R 3与上述定义相同的HX-CC-NHR3的仅一部分化学结构或其中X和R 3与上述相同的HX-CCC-NHR 3包含在上述一种化合物中，其中a 配体或配体所结合的化合物可以在规定的位置上与溶剂不溶性载体中的醛基特异性和有效地反应以形成稳定的键。

8. 发明授权

US4721730A Adsorbent for .beta..sub.2 -microglobulin and immunoglobulin L-chain 失效
标题翻译：用于β2-微球蛋白和免疫球蛋白L链的吸附剂
公开(公告)号：US4721730A
公开(公告)日：1988-01-26
申请号：US55387
申请日：1987-05-29
申请人： Shigeo Furuyoshi , Eiji Ogino , Nobutaka Tani
发明人： Shigeo Furuyoshi , Eiji Ogino , Nobutaka Tani
IPC分类号： B01J20/28 , B01J20/32 , C08J9/36
CPC分类号： B01J20/28014 , B01J20/28047 , B01J20/28057 , B01J20/28078 , B01J20/3092 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3255 , B01J2220/58
摘要： An adsorbent for .beta..sub.2 -microglobulin and immunoglobulin L-chain suitable for use in an extracorporeal circulation treatment, which comprises a porous water-insoluble carrier and a compound immobilized onto said carrier, said compound satisfying that the value of log P, in which P is a partition coefficient in an octanol-water system, is not less than 2.5. The adsorbent is inexpensive, and efficiently adsorb and remove .beta..sub.2 -microglobulin and immunoglobulin L-chain contained in a body fluid.
摘要翻译：适用于体外循环治疗的β2-微球蛋白和免疫球蛋白L链的吸附剂，其包含多孔水不溶性载体和固定在所述载体上的化合物，所述化合物满足log P的值，其中P 是辛醇 - 水体系中的分配系数，不小于2.5。吸附剂便宜，有效地吸附和去除体液中所含的β2-微球蛋白和免疫球蛋白L链。

9. 发明授权

US4696670A Method and apparatus for treating blood constituents 失效
标题翻译：治疗血液成分的方法和装置
公开(公告)号：US4696670A
公开(公告)日：1987-09-29
申请号：US795663
申请日：1985-11-06
申请人： Michikazu Ohnishi , Nobutaka Tani
发明人： Michikazu Ohnishi , Nobutaka Tani
IPC分类号： A61M1/14 , A61M1/34 , A61M1/36 , A61M31/00
CPC分类号： A61M1/3472 , A61M1/3427 , A61M1/3606 , A61M1/3646 , A61M2202/0415 , A61M2202/046 , Y10S128/03
摘要： A method for treating circulatory fluid constituents with an apparatus which includes a first switching device which connects the upstream side of a first circulatory fluid treatment device with a flow of circulatory fluid from a source, and a second switching device which connects the downstream side of the first circulatory fluid treatment device with a destination of the circulatory fluid. Next, the second switching device maintains the flow of circulatory fluid to the destination from the downstream side of the first circulatory fluid treatment device, the upstream side of the first circulatory fluid treatment device is disconnected with the flow of circulatory fluid from the source, and further a third switching device connects the upstream side of a second circulatory fluid treatment device to the flow of a circulatory fluid from the source, and a fourth switching device connects the downstream side of the second circulatory fluid treatment device to communicate with the upstream side of the first circulatory fluid treatment device. Finally, the third switching device maintains the flow of circulatory fluid from the source into the upstream side of the second circulatory fluid treatment device, the downstream side of the first circulatory fluid treatment device is disconnected from sending the flow of circulatory fluid to the destination, and a fifth switching device connects the downstream side of the second circulatory fluid treatment device with the destination for the flow of circulatory fluid thereto.
摘要翻译：一种用于利用包括将第一循环流体处理装置的上游侧与来自源的循环流体流连接的第一开关装置的设备和用于连接第一循环流体处理装置的下游侧的第二开关装置的装置的方法，具有循环流体目的地的第一循环流体处理装置。接下来，第二切换装置将第一循环流体处理装置的下游侧的循环流体的流动维持到目的地，第一循环流体处理装置的上游侧与源的循环流体的流动断开，另外，第三开关装置将第二循环流体处理装置的上游侧连接到来自源的循环流体的流动，第四开关装置将第二循环流体处理装置的下游侧连接到第二循环流体处理装置的上游侧第一循环流体处理装置。最后，第三开关装置维持循环流体从源流入第二循环流体处理装置的上游侧，第一循环流体处理装置的下游侧与循环流体流向目的地分离，并且第五切换装置将第二循环流体处理装置的下游侧与循环流体流动的目的地连接。

10. 发明授权

US4654420A Lipoprotein adsorbent for use in extracorporeal circulation treatment and process for preparing thereof 失效
标题翻译：用于体外循环治疗的脂蛋白吸附剂及其制备方法
公开(公告)号：US4654420A
公开(公告)日：1987-03-31
申请号：US877089
申请日：1986-06-23
申请人： Shigeo Furuyoshi , Nobutaka Tani
发明人： Shigeo Furuyoshi , Nobutaka Tani
IPC分类号： A61M1/36 , B01J20/32 , C08G18/10
CPC分类号： A61M1/3687 , B01J20/24 , B01J20/261 , B01J20/262 , B01J20/265 , B01J20/267 , B01J20/28004 , B01J20/28016 , B01J20/28023 , B01J20/28033 , B01J20/28047 , B01J20/3085 , B01J20/3092 , B01J2220/4825 , B01J2220/58 , Y10S210/905
摘要： A lipoprotein adsorbent for use in extracorporeal circulation treatment which is made of a water-insoluble porous hard gel which has an exclusion limit value from 10.sup.6 to 10.sup.9 measured by using glubular proteins and comprises a polymer having hydroxy group in at least a part of the molecule, at least a part of hydroxy groups on the surface of said gel being converted to sulfates. By using the adsorbent of the present invention, LDL and VLDL can be selectively and effectively removed from the body fluids of the patient. Further, the adsorbent of the present invention can be prepared in a lower cost than the adsorbent based on the principle of the affinity chromatography, in which a relatively expensive ligand is employed.
摘要翻译：一种用于体外循环治疗的脂蛋白吸附剂，其由不溶于水的多孔硬凝胶制成，其具有通过使用胶质蛋白测量的106至109的排除极限值，并且包含在分子的至少一部分中具有羟基的聚合物，所述凝胶表面上的至少一部分羟基被转化为硫酸盐。通过使用本发明的吸附剂，LDL和VLDL可以被选择性地和有效地从患者体液中除去。此外，基于使用相对昂贵的配体的亲和层析原理，本发明的吸附剂可以以比吸附剂更低的成本来制备。

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