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1. 发明授权

US08652406B2 Blood processing unit with modified flow path 有权
标题翻译：血液处理单元具有改进的流路
公开(公告)号：US08652406B2
公开(公告)日：2014-02-18
申请号：US13753638
申请日：2013-01-30
申请人： Sorin Group Italia S.r.l. , Politecnico di Milano
发明人： Stefano Reggiani , Gianfranco Beniamino Fiore , Alberto Redaelli , Christian Baiotto
IPC分类号： A61M1/36
CPC分类号： A61M1/1698 , A61M1/32 , A61M1/3627 , A61M1/3666 , A61M1/3667 , A61M2206/10 , A61M2206/14 , A61M2206/16 , A61M2206/18 , A61M2206/20 , B01D63/02 , B01D2313/08 , B01D2313/19 , B01D2313/32 , B01D2313/38 , F28D7/103 , F28D7/1623 , F28D21/0015 , F28D2021/005 , F28F13/06 , F28F21/06 , F28F21/062 , F28F2260/00 , Y10S128/03 , Y10S261/28
摘要： A blood processing apparatus includes a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger is configured to impart a radial component to blow flow through the heat exchanger and/or gas exchanger. In some instances, the heat exchanger is configured to cause blood flow to follow a spiral flow path.
摘要翻译：血液处理装置包括热交换器和气体交换器。热交换器和气体交换器中的至少一个构造成赋予径向分量以吹动通过热交换器和/或气体交换器的流动。在一些情况下，热交换器被配置成引起血流遵循螺旋流动路径。

2. 发明申请

US20130142696A1 BLOOD PROCESSING UNIT WITH MODIFIED FLOW PATH 有权
标题翻译：血液加工单元改造流程
公开(公告)号：US20130142696A1
公开(公告)日：2013-06-06
申请号：US13753638
申请日：2013-01-30
申请人： Sorin Group Italia S.r.I. , Politecnico di Milano
发明人： Stefano Reggiani , Gianfranco Beniamino Fiore , Alberto Redaelli , Christian Baiotto
IPC分类号： A61M1/16
CPC分类号： A61M1/1698 , A61M1/32 , A61M1/3627 , A61M1/3666 , A61M1/3667 , A61M2206/10 , A61M2206/14 , A61M2206/16 , A61M2206/18 , A61M2206/20 , B01D63/02 , B01D2313/08 , B01D2313/19 , B01D2313/32 , B01D2313/38 , F28D7/103 , F28D7/1623 , F28D21/0015 , F28D2021/005 , F28F13/06 , F28F21/06 , F28F21/062 , F28F2260/00 , Y10S128/03 , Y10S261/28
摘要： A blood processing apparatus may include a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger may be configured to impart a radial component to blow flow through the heat exchanger and/or gas exchanger. The heat exchanger may be configured to cause blood flow to follow a spiral flow path.
摘要翻译：血液处理装置可以包括热交换器和气体交换器。热交换器和气体交换器中的至少一个可以被配置成赋予径向分量以吹动通过热交换器和/或气体交换器。热交换器可以被配置为使血液流动遵循螺旋流动路径。

3. 发明授权

US08409502B2 Methods, apparatuses, and applications for compliant membrane blood gas exchangers 有权
标题翻译：用于顺应性膜血气换气器的方法，装置和应用
公开(公告)号：US08409502B2
公开(公告)日：2013-04-02
申请号：US11211115
申请日：2005-08-24
申请人： Robert N. Schaap , Barry Bagley
发明人： J D Mortensen , Robert N. Schaap , Barry Bagley
IPC分类号： A61M1/00 , A61M37/00
CPC分类号： A61M1/16 , A61M1/1625 , A61M1/1698 , Y10S128/03 , Y10S261/28
摘要： A compliant blood gas exchanger is provided including a housing having a first end cap, a second end cap, and an elastomeric sidewall or sleeve extending there between forming a chamber. A hollow fiber assembly is disposed in the chamber. The hollow fiber assembly has a first mounting collar, a second mounting collar and a plurality of hollow fibers disposed there between. The first end cap is disposed in communication with the first mounting collar and the second end cap is disposed in communication with the second mounting collar. The end caps are connected to a gas inlet and a gas outlet. The chamber is in communication with a blood inlet and a blood outlet. The elastomeric sidewall is responsive to internal and external pressures affecting the chamber. The first chamber can also be placed adjacent to a second chamber and both chambers placed within a rigid outer housing. Thus, a dual-chamber pulsatile blood gas exchanger can be provided. That is, the second chamber may be in connection with a pump mechanism or vacuum mechanism such that the chamber creates a pulsatile flow within the first chamber.
摘要翻译：提供了一种兼容的血液气体交换器，其包括具有第一端盖，第二端盖和在其之间延伸形成腔室的弹性体侧壁或套管的壳体。中空纤维组件设置在腔室中。中空纤维组件具有第一安装套环，第二安装环和布置在其间的多个中空纤维。第一端盖设置成与第一安装轴环连通，并且第二端盖设置成与第二安装轴环连通。端盖连接到气体入口和气体出口。腔室与血液入口和血液出口连通。弹性体侧壁响应影响腔室的内部和外部压力。第一室也可以放置在第二室附近，并且两个室都放置在刚性外壳内。因此，可以提供双室脉动血液换气器。也就是说，第二室可以与泵机构或真空机构连接，使得室在第一室内产生脉动流。

4. 发明授权

US07285105B2 Automatic dialyzer and dialyzing method 有权
标题翻译：自动透析器和透析法
公开(公告)号：US07285105B2
公开(公告)日：2007-10-23
申请号：US10311391
申请日：2001-06-14
申请人： Sung-Teh Kim , Masahiro Taoka , Tieko Yamamoto , Kunihiko Yamanaka , Katunori Masaoka
发明人： Sung-Teh Kim , Masahiro Taoka , Tieko Yamamoto , Kunihiko Yamanaka , Katunori Masaoka
IPC分类号： A61M37/00 , B01D11/00 , C02F1/44 , C02F9/00 , A61M1/16
CPC分类号： A61M1/16 , A61M1/1645 , A61M1/3427 , A61M1/3465 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3649 , Y10S128/03
摘要： An automatic dialyzer for purifying blood brought into contact with a dialysate via a semi-impermeable membrane. The dialyzer includes at least a blood circulating system and a dialysate supply/discharge system, wherein the blood line of the blood circulating system is connected to an overflow line having a reversibly-rotatable blood pump, a blood chamber, and an open/close device for overflowing of liquid from the blood chamber to the outside of the blood line. Liquid supply means is provided to a first bypass line and/or a second bypass line for supplying liquid in both forward and reverse directions to enable regulation of the supply amount of the dialysate for water removing/liquid replenishing. The supply speed of the liquid supply device and the supply speed of the blood pump are regulatable in conjunction with each other. Also provided is a dialyzing method using the automatic dialyzer.
摘要翻译：一种自动透析器，用于净化通过半透膜与透析液接触的血液。所述透析器至少包括血液循环系统和透析液供给/排出系统，其中，所述血液循环系统的血液管线连接到具有可逆转的血液泵，血液室和开闭装置的溢流管线用于使液体从血液室溢出到血液管线外部。液体供给装置设置在第一旁路管线和/或第二旁路管路中，用于在向前和向后两个方向上供应液体，以便能够调节用于除水/液体补充的透析液的供应量。液体供给装置的供给速度和血液泵的供给速度相互配合。还提供了使用自动透析器的透析方法。

5. 发明申请

US20070098593A1 Hemostatic system and components for extracorporeal circuit 审中-公开
标题翻译：止血系统和体外循环组件
公开(公告)号：US20070098593A1
公开(公告)日：2007-05-03
申请号：US11593720
申请日：2006-11-07
申请人： Daniel Ericson , Eric Thor , William Haworth
发明人： Daniel Ericson , Eric Thor , William Haworth
IPC分类号： A61M1/00
CPC分类号： A61M1/367 , A61M1/3609 , A61M1/3666 , A61M1/3672 , A61M1/3673 , A61M1/3675 , A61M2202/0478 , B01D2325/16 , Y10S128/03
摘要： A method and system for use in the course of extracorporeal blood flow, e.g., cardiopulmonary bypass, dialysis, and angioplasty procedures, in order to reduce or minimize inflammation, excessive bleeding, and other undesirable side effects. The system can include one or more automated blood parameter sensor modules and one or more blood parameter regulating modules. The system is particularly well suited to monitor and/or regulate blood parameters that include blood analytes (e.g., biomolecules, drugs or metabolites) as well as blood functions (e.g., clotting time, fibrinolytic activity, immune response). The system is particularly well suited for use in the management of clotting (e.g., heparin/protamine) and bleeding (e.g., aprotinin).
摘要翻译：用于体外血流过程中使用的方法和系统，例如体外循环，透析和血管成形术程序，以减少或最小化炎症，过度出血以及其它不希望的副作用。该系统可以包括一个或多个自动血液参数传感器模块和一个或多个血液参数调节模块。该系统特别适合于监测和/或调节包括血液分析物（例如生物分子，药物或代谢物）以及血液功能（例如，凝血时间，纤维蛋白溶解活性，免疫应答）的血液参数。该系统特别适用于治疗凝血（例如肝素/鱼精蛋白）和出血（例如抑肽酶）。

6. 发明授权

US06974434B2 Methods and devices for maintaining cardiopulmonary bypass and arresting a patient's heart 失效
标题翻译：用于维持心肺旁路并阻止患者心脏的方法和装置
公开(公告)号：US06974434B2
公开(公告)日：2005-12-13
申请号：US10193627
申请日：2002-07-11
申请人： Craig P. Roberts , John M. Toomasian , Sylvia W. Fan
发明人： Craig P. Roberts , John M. Toomasian , Sylvia W. Fan
IPC分类号： A61M1/36 , A61M25/00 , A61M37/00 , A61M1/14
CPC分类号： A61M25/0021 , A61M1/3667 , A61M25/0032 , A61M25/007 , A61M2025/0004 , A61M2025/0031 , A61M2205/12 , A61M2210/125 , Y10S128/03
摘要： An endovascular system for arresting a patient's heart and maintaining the patient on cardiopulmonary bypass. A venous cannula, venting catheter and an aortic occlusion device are all coupled together so that the blood drawn into each of these catheters may be fed to a pump. A manifold has valves which control flows through the venous cannula, venting catheter and aortic occlusion device. A blood storage element is also provided so that the amount of blood in the perfusion circuit may be varied if necessary. The blood storage element is preferably positioned in parallel with the pump so that the pump may be used to add and remove blood to and from the blood storage element.
摘要翻译：用于阻止患者心脏并维持患者体外循环的血管内系统。静脉插管，通气导管和主动脉闭塞装置都联接在一起，使得吸入这些导管中的每一个的血液可以被供给到泵。歧管具有控制流经静脉插管，通气导管和主动脉闭塞装置的阀。还提供血液存储元件，使得如果需要，可以改变灌注回路中的血液量。血液存储元件优选地与泵平行定位，使得泵可以用于向血液存储元件添加血液并从血液存储元件移除血液。

7. 发明授权

US06773426B2 Soft shell venous reservoir with improved air handling 失效
标题翻译：软壳静脉储层，改善空气处理
公开(公告)号：US06773426B2
公开(公告)日：2004-08-10
申请号：US09795782
申请日：2001-02-28
申请人： Yehuda Tamari
发明人： Yehuda Tamari
IPC分类号： A61B1900
CPC分类号： A61M1/3621 , A61M1/3627 , A61M1/3667 , Y10S128/03
摘要： Venous reservoirs are interposed between the patient and the arterial pump and serve to remove air bubbles and provide compliance that accommodates variations in the volume of blood circulating in the extracorporeal circuit during cardiopulmonary bypass (CPB). The invention is a reservoir that incorporates automated means to remove air bubbles from the venous line prior to the blood entering the arterial blood pump. In form, the reservoir includes means that handle foam prior to the blood entering the blood pump. In another form, the invention provides means that improve air removal in a soft shell venous reservoir. These features are applicable to CPB circuits using gravity drainage or vacuum assisted venous drainage.
摘要翻译：在患者和动脉泵之间插入静脉储库，用于去除气泡并提供适应性，以适应体外循环（CPB）期间在体外循环中循环的血液体积的变化。本发明是一种储存器，其包括在血液进入动脉血泵之前从静脉血管中除去气泡的自动装置。在形式上，储存器包括在血液进入血液泵之前处理泡沫的装置。在另一种形式中，本发明提供了改善软壳静脉储库中的空气去除的手段。这些功能适用于使用重力引流或真空辅助静脉引流的CPB电路。

8. 发明申请

US20030215356A1 Method of blood oxygenation 失效
公开(公告)号：US20030215356A1
公开(公告)日：2003-11-20
申请号：US10384301
申请日：2003-03-07
发明人： William R. Patterson , Stephen E. Myrick , Vincent Divino JR. , Jeffrey L. Creech , Mark S. Buhr
IPC分类号： A61M001/14 , A61M037/00
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758 , Y10S128/03 , Y10S261/28
摘要： An apparatus and method for blood oxygenation is provided, advantageously comprising an extracorporeal circuit for the preparation and delivery of hyperoxic or hyperbaric blood. In one embodiment, an apparatus for gas-supersaturating fluids, e.g., physiologic saline, includes a chamber having a first inlet to receive the fluid; a second inlet to receive a gas, e.g., oxygen, from a gas supply that maintains pressure within the chamber at a predetermined level, advantageously about 600 p.s.i.; and an outlet advantageously coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet advantageously creates within the chamber fine droplets of fluid into which gas diffuses to create the gas-supersaturated fluid, which collects within the chamber below the atomizer nozzle for removal via the outlet. The removed gas-supersaturated fluid mixes with blood provided by a blood pump, the mixing occurring within a liquid-to-liquid oxygenation assembly including a pressurizable chamber having inlets for the gas-supersaturated fluid and blood, the inlets advantageously arranged to create a vortical or cyclonic fluid flow within the chamber to promote mixing. The mixed fluid exits the chamber via an outlet for delivery to a patient (e.g., sub-selective delivery) or other site via a catheter, infusion guidewire, or other interventional fluid delivery device, the mixed fluid advantageously comprising blood having increased oxygen levels, i.e., oxygenated blood. Alternatively, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen, advantageously provided at a pressure greater than atmospheric, diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site. Advantageously, the oxygenated blood is delivered at a target pO2 greater than about 760 mm Hg and is delivered from the liquid-to-liquid oxygenation assembly or membrane oxygenator via a fluid conduit having an approximate pressure drop greater than the target pO2.

9. 发明申请

US20030194348A1 Apparatus for blood oxygenation 有权
公开(公告)号：US20030194348A1
公开(公告)日：2003-10-16
申请号：US10424031
申请日：2003-04-25
发明人： Vincent Divino JR. , Jeffrey L. Creech , William R. Patterson , Stephen E. Myrick
IPC分类号： A61M001/14 , A61M037/00
CPC分类号： A61M1/3621 , A61M1/1678 , A61M1/1698 , A61M1/32 , A61M1/325 , A61M1/3603 , A61M1/361 , A61M1/3612 , A61M1/3613 , A61M1/3626 , A61M25/0028 , A61M25/0029 , A61M2025/0031 , A61M2025/0036 , A61M2025/0037 , A61M2025/004 , A61M2202/0476 , C01B13/02 , Y10S128/03 , Y10S261/28 , A61M2202/0007
摘要： An apparatus and method for blood oxygenation is provided, advantageously comprising an extracorporeal circuit for the preparation and delivery of hyperoxic or hyperbaric blood. In one embodiment, an apparatus for gas-supersaturating fluids, e.g., physiologic saline, includes a chamber having a first inlet to receive the fluid; a second inlet to receive a gas, e.g., oxygen, from a gas supply that maintains pressure within the chamber at a predetermined level, advantageously about 600 p.s.i.; and an outlet advantageously coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet advantageously creates within the chamber fine droplets of fluid into which gas diffuses to create the gas-supersaturated fluid, which collects within the chamber below the atomizer nozzle for removal via the outlet. The removed gas-supersaturated fluid mixes with blood provided by a blood pump, the mixing occurring within a liquid-to-liquid oxygenation assembly including a pressurizable chamber having inlets for the gas-supersaturated fluid and blood, the inlets advantageously arranged to create a vortical or cyclonic fluid flow within the chamber to promote mixing. The mixed fluid exits the chamber via an outlet for delivery to a patient (e.g., sub-selective delivery) or other site via a catheter, infusion guidewire, or other interventional fluid delivery device, the mixed fluid advantageously comprising blood having increased oxygen levels, i.e., oxygenated blood. Alternately, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen, advantageously provided at a pressure greater than atmospheric, diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site. Advantageously, the oxygenated blood is delivered at a target pO2 greater than about 760 mm Hg and is delivered from the liquid-to-liquid oxygenation assembly or membrane oxygenator via a fluid conduit having an approximate pressure drop greater than the target pO2.

10. 发明申请

US20030163077A1 Automatic dialyzer and dialyzing method 有权
标题翻译：自动透析器和透析法
公开(公告)号：US20030163077A1
公开(公告)日：2003-08-28
申请号：US10311391
申请日：2003-03-11
发明人： Sung-Teh Kim , Masahiro Taoka , Tieko Yamamoto , Kunihiko Yamanaka , Katunori Masaoka
IPC分类号： A61M037/00
CPC分类号： A61M1/16 , A61M1/1645 , A61M1/3427 , A61M1/3465 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3649 , Y10S128/03
摘要： An automatic dialyzer for purifying blood brought into contact with a dialysate via a semi-impermeable membrane, comprising at least a blood circulating system and a dialysate supply/discharge system, characterized in that the blood line of the blood circulating system is connected to an overflow line having a reversibly-rotatable blood pump and also having a blood chamber and an open/close means for overflowing of liquid from the blood chamber to the outside of the blood line, and liquid supply means, for supplying liquid in both forward and reverse directions and being able to regulate the supply amount of the dialysate for water removing/liquid replenishing, are provided to a first bypass line and/or a second bypass line, the supply speed of the liquid supply means and the supply speed of the blood pump being regulatable in conjunction with each other; and a dialyzing method using the automatic dialyzer.
摘要翻译：一种自动透析器，用于净化经由半不透液膜与透析液接触的血液，其至少包括血液循环系统和透析液供给/排出系统，其特征在于，所述血液循环系统的血液线连接到溢出物线，其具有可逆旋转的血液泵，并且还具有血液腔和用于使血液从血液室溢出到血液管外部的打开/关闭装置;以及液体供应装置，用于在前后方向上供应液体并且能够调节用于除水/液体补充的透析液的供给量，设置在第一旁通管线和/或第二旁通管路上，液体供给装置的供给速度和血液泵的供给速度为相互配合; 以及使用自动透析器的透析方法。

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