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1. 发明授权

US11510360B2 Fertilizer gradient energy system 有权
公开(公告)号：US11510360B2
公开(公告)日：2022-11-29
申请号：US16646328
申请日：2018-09-10
申请人： Oakland University
发明人： Jonathan Maisonneuve
IPC分类号： A01C23/04 , A01C21/00
摘要： A fertilizer gradient energy system includes a membrane module. A membrane module may include a first section and a second section. The first and second sections may be separated by a semipermeable membrane. A load may be connected to the membrane module. The first section may be configured to receive a concentrated fertilizer solution. The second section may be configured to receive a freshwater feed solution. In embodiments, a semipermeable membrane may be configured to facilitate pressure retarded osmosis of the freshwater feed solution from the first section to the second section to increase a fluid pressure in the second section. The semipermeable membrane may include an anion exchange membrane. The membrane module may include a third section. A cation exchange membrane may separate the first and third section. Anion and cation exchange membranes may facilitate reverse electrodialysis. Methods of capturing energy via a membrane module are also disclosed.

2. 发明授权

US10287616B2 Label free biosensors, gram-negative bacteria detection, and real-time and end point determination of antibiotic effects 有权
公开(公告)号：US10287616B2
公开(公告)日：2019-05-14
申请号：US14985988
申请日：2015-12-31
申请人： Oakland University
发明人： Xiangqun Zeng
IPC分类号： G01N33/48 , C12Q1/18 , G01N27/416
摘要： Real-time and end point determination of antibiotic effects are disclosed herein. In one example, a surface of a label free biosensor is exposed to a sample including a gram-negative bacteria. A frequency and/or a current of the biosensor is then allowed to reach a constant value. The surface of the biosensor is then exposed to an antibiotic. Using the biosensor, i) a frequency change versus time and a damping resistance versus time, or ii) a current versus voltage or the current versus time at a fixed potential, or iii) both i and ii are then measured. The frequency change versus time and the damping resistance versus time and/or the current versus voltage or the current versus time are correlated to determine an effect of the antibiotic on the gram-negative bacteria. Examples of the label free biosensors and methods for detecting gram-negative bacteria using the label free biosensors are also disclosed.

3. 发明授权

US10197552B2 Monitoring cell-to-cell interactions 有权
公开(公告)号：US10197552B2
公开(公告)日：2019-02-05
申请号：US14981076
申请日：2015-12-28
申请人： Oakland University
发明人： Xiangqun Zeng , Gerard Madlambayan , Liang Tan , Bahareh Pezeshkian , Abdul Rehman
IPC分类号： G01N29/02 , G01N33/483 , G01N29/42 , G01N29/036 , G01N29/44
摘要： In a method for monitoring cell-to-cell interactions, a quartz crystal microbalance surface is exposed to a medium including a first cell. The first cell is exposed to a sample including a suspect cell. The first cell is activated prior to or simultaneously with the first cell exposure. Frequency and motional resistance changes versus time are measured after each of: surface exposure to the medium, first cell activation prior to the exposure to the sample, and first cell exposure to the sample; or after each of: surface exposure to the medium and simultaneous first cell activation and sample exposure. From the frequency and motional resistance changes versus time, any of i) a level of adhesion of the suspect cell to the activated first cell, ii) a type of the suspect cell, iii) a behavior or activity of the suspect cell is determined, or iv) activation of the first cell is determined.

4. 发明申请

US20160202235A1 MONITORING CELL-TO-CELL INTERACTIONS 审中-公开
标题翻译：监测细胞间细胞相互作用
公开(公告)号：US20160202235A1
公开(公告)日：2016-07-14
申请号：US14981076
申请日：2015-12-28
申请人： Oakland University
发明人： Xiangqun Zeng , Gerard Madlambayan , Liang Tan , Bahareh Pezeshkian , Abdul Rehman
IPC分类号： G01N33/483 , G01N29/42
CPC分类号： G01N33/4833 , G01N29/022 , G01N29/036 , G01N29/42 , G01N29/4472 , G01N2291/0228 , G01N2291/02466 , G01N2291/0255 , G01N2291/0256 , G01N2291/0426
摘要： In a method for monitoring cell-to-cell interactions, a quartz crystal microbalance surface is exposed to a medium including a first cell. The first cell is exposed to a sample including a suspect cell. The first cell is activated prior to or simultaneously with the first cellexposure. Frequency and motional resistance changes versus time are measured after each of: surface exposure to the medium, first cell activation prior to the exposure to the sample, and first cell exposure to the sample; or after each of: surface exposure to the medium and simultaneous first cell activation and sample exposure. From the frequency and motional resistance changes versus time, any of i) a level of adhesion of the suspect cell to the activated first cell, ii) a type of the suspect cell, iii) a behavior or activity of the suspect cell is determined, or iv) activation of the first cell is determined.
摘要翻译：在用于监测细胞间细胞相互作用的方法中，将石英晶体微量平衡表面暴露于包括第一细胞的培养基。将第一个细胞暴露于包含可疑细胞的样品。第一个细胞在第一次曝光之前或同时被激活。在暴露于样品之前的表面暴露于介质，第一细胞活化和第一细胞暴露于样品之后，测量频率和运动电阻变化对时间的影响。或者之后：表面暴露于培养基和同时进行第一细胞活化和样品暴露。从频率和运动阻力变化对时间，i）可疑细胞与活化的第一细胞的粘附水平，ii）可疑细胞的类型，iii）确定可疑细胞的行为或活性，或iv）确定第一个细胞的活化。

5. 发明申请

US20230010503A1 FLUID MODULATOR, SYSTEM, AND METHOD 有权
公开(公告)号：US20230010503A1
公开(公告)日：2023-01-12
申请号：US17772621
申请日：2020-10-27
申请人： Oakland University
发明人： John V. Seeley
IPC分类号： G01N30/20 , G01N30/46
摘要： A fluid modulator includes a fluid manifold, fluid valve, and pressure/flow controller. The manifold may include a primary tee, exhaust tee, secondary tee, loop conduit, and joining tube. The valve may include a common port, normally-open output port connected to the secondary tee, and normally-closed output port connected to the primary tee. The controller may be configured to provide auxiliary fluid to the common port. In embodiments, the primary tee, exhaust tee, and secondary tee are configured with the primary tee and secondary tee situated at ends of the fluid manifold and the exhaust tee disposed therebetween. In other embodiments, the exhaust tee, the primary tee, and the secondary tee are distributed in a linear fashion with the exhaust tee and secondary tee situated at ends of the fluid manifold and the primary tee disposed therebetween. An embodiment with a single, unitary 5-port fluid manifold is also disclosed.

6. 发明授权

US11020786B2 System for controlling the restraining force applied to a panel during a drawing operation 有权
公开(公告)号：US11020786B2
公开(公告)日：2021-06-01
申请号：US16139953
申请日：2018-09-24
申请人： OAKLAND UNIVERSITY
发明人： Sergey F. Golovashchenko
IPC分类号： B21D24/10 , B23Q17/24 , B23Q17/00 , B21D22/22
摘要： A system and apparatus is disclosed for controlling a restraining force applied to a panel. The apparatus includes a die, a binder supporting the panel against the die, and a punch used to draw the panel into the die. A restraining element is disposed on one of the die and the binder that engages a surface of the panel and applies a restraining force onto the panel. A strain gauge is disposed inside at least one of the die and the binder that engages a surface of the panel to measure the restraining force applied to the panel. The level of restraining force applied by the restraining element onto the panel is controlled based upon the restraining force measured by the strain gauge.

7. 发明授权

US10907957B2 Method of measuring localized strains in sheet metal stampings 有权
公开(公告)号：US10907957B2
公开(公告)日：2021-02-02
申请号：US15980954
申请日：2018-05-16
申请人： OAKLAND UNIVERSITY
发明人： Sergey F. Golovashchenko
IPC分类号： G01N21/84 , G01B11/16 , G06T7/62 , G06T7/00
摘要： A method for measuring localized stretching of a manufactured part or in a test sample of various materials to identify the fracture strain or strain distribution. The method begins by etching or printing a grid of a plurality of cells on a surface of a blank. Dots of paint are then applied to the surface of the blank that are measured in a pre-forming condition and identified as to the location of the dots relative to the grid. The blank is then formed into a formed part and the dots are measured in one or more cells in a post-forming condition. The size of the dots in the pre-forming condition is compared to the size of the dots in the post-forming condition to determine the extent of stretching in localized areas of the formed part. The method may be repeated for successive operations with different colored dots.

8. 发明授权

US10330463B2 Spatial phase-shift shearography system for non-destructive testing and strain measurement 有权
公开(公告)号：US10330463B2
公开(公告)日：2019-06-25
申请号：US15032577
申请日：2014-10-28
申请人： OAKLAND UNIVERSITY
发明人： Lianxiang Yang , Xin Xie , Nan Xu , Xu Chen
IPC分类号： G01B9/02 , G01L1/24 , G01B11/16 , G01N21/45 , G01N21/88
摘要： Embodiments of a shearography system may include light sources configured to produce beams of light to illuminate a test area. Each of the beams of light may include a different wavelength. A camera may be configured to obtain intensity information corresponding to reflections of the lights off of the test area. An optical shearing device may be disposed in an optical path between the light sources and the camera and the optical shearing device may be configured to provide a shearing angle.

9. 发明授权

US10322890B2 Sheet metal blank destacker 有权
公开(公告)号：US10322890B2
公开(公告)日：2019-06-18
申请号：US15786038
申请日：2017-10-17
申请人： OAKLAND UNIVERSITY
发明人： Sergey F. Golovashchenko , Yuriy V. Batygin
IPC分类号： B65G54/02 , B65G59/04 , B65H3/16 , B25J15/06 , B25J15/00 , B65G47/91 , B65G47/92
摘要： An apparatus for de-stacking sheet metal blanks uses electro-magnetic pulses to separate sheet metal blanks from a stack of blanks. A fixture supports an electromagnetic attraction device that includes one or more multi-turn electrical coils and one or more insulated metal screens. The coil is electrically connected to a bank of capacitors. The metal screen is disposed in an electrical insulation material and is retained by the fixture between the coil and the top blank of the stack of blanks. Suction cups perform the primary lifting function and are connected to a vacuum source. The suction cups may be supported by the same fixture or another associated fixture that cooperates with the coil and insulated screen.

10. 发明申请

US20180339913A1 Cerium Oxide Nanoparticle Compositions and Methods 审中-公开
公开(公告)号：US20180339913A1
公开(公告)日：2018-11-29
申请号：US15956468
申请日：2018-04-18
申请人： University of Central Florida Research Foundation Inc. , Oakland University
发明人： Sudipta SEAL , Swetha BARKAM , Amitava ADHIKARY
IPC分类号： C01F17/00 , A61K33/24 , A61K9/51
摘要： Cerium oxide nanoparticles (CNPs) have been proven to exhibit antioxidant properties attributed to its surface oxidation states (Ce4+ to Ce3+ and vice versa) mediated at the oxygen vacancies on the surface of CNPs. Different anions in precursor cerium salts were used to prepare CNPs resulting in disclosed CNPs with varying physicochemical properties such as dispersion stability, hydrodynamic size, and the signature surface chemistry. The antioxidant catalytic activity and oxidation potentials of different CNPs have been significantly altered with the change of anions in the precursor salts. For one, CNPs prepared using precursor salts containing NO3− and Cl− ions exhibited increased antioxidant activity than previously thought possible. The change in oxidation potentials of CNPs with the change in concentration of the nitrate and chloride ions indicates the disclosed CNP's have different surface chemistry and antioxidant properties. These compositions and methods of their synthesis are disclosed.

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