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1. 发明授权

US09293314B2 Photo-dissociation of proteins and peptides in a mass spectrometer 有权
标题翻译：蛋白质和肽在质谱仪中的光解离
公开(公告)号：US09293314B2
公开(公告)日：2016-03-22
申请号：US14130428
申请日：2012-07-06
申请人： Daniel James Kenny , Paul Murray , Keith Richardson , Kevin Giles , Jeffery Mark Brown
发明人： Daniel James Kenny , Paul Murray , Keith Richardson , Kevin Giles , Jeffery Mark Brown
IPC分类号： H01J49/06 , H01J49/00 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/42
CPC分类号： H01J49/0059 , G01N27/624 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/422 , H01J49/4245
摘要： A method of mass spectrometry is disclosed comprising automatically and repeatedly performing multiple cycles of operation, wherein a cycle of operation comprises the steps of: (i) mass analyzing first ions; (ii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions and mass analyzing the second ions; and (iii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions, fragmenting the second ions to form a plurality of third ions and mass analyzing the third ions.
摘要翻译：公开了一种自动重复执行多个操作循环的质谱法，其中操作循环包括以下步骤：（i）质量分析第一离子; （ii）将第一离子暴露于第一光离解装置以形成多个第二离子并质量分析第二离子; 和（iii）将第一离子暴露于第一光解离装置以形成多个第二离子，使第二离子碎裂以形成多个第三离子并大量分析第三离子。

2. 发明授权

US07776839B2 Pharmaceutical compositions including alginates and methods of preparing and using same 失效
标题翻译：包括藻酸盐的药物组合物及其制备和使用方法
公开(公告)号：US07776839B2
公开(公告)日：2010-08-17
申请号：US10241048
申请日：2002-09-10
申请人： Raffaele Del Buono , Peter William Dettmar , Frank Chadwick Hampson , Ian Gordon Jolliffe , Paul Murray McPherson , Edvar Onsoyen , Massimo Pignatelli , Peter Edward Ross
发明人： Raffaele Del Buono , Peter William Dettmar , Frank Chadwick Hampson , Ian Gordon Jolliffe , Paul Murray McPherson , Edvar Onsoyen , Massimo Pignatelli , Peter Edward Ross
IPC分类号： A51K31/734
CPC分类号： A61K31/7012 , A61K31/734
摘要： A pharmaceutical composition is provided for use in the healing of cells containing about 0.0001 percent weight per volume (% w/v) to about 2% w/v of an alginic acid or a salt of alginic acid having a molecular weight in the range of greater than about 250,000 to about 1,000,000, provided that if the composition additionally contains an alginic acid or a salt of alginic acid having a molecular weight in the range of about 20,000 to about 250,000, it is present in an amount of less than 1% w/w. The use of the pharmaceutical composition for the healing cells in a mammal, preferably mucosal cells is also provided.
摘要翻译：提供了用于治疗细胞的药物组合物，其含有约0.0001重量％体积（％w / v）至约2％w / v的海藻酸或藻酸盐，其分子量范围为大于约250,000至约1,000,000，条件是如果组合物另外含有分子量在约20,000至约250,000范围内的藻酸或海藻酸盐，则其存在量小于1％w / w。还提供了用于哺乳动物，优选粘膜细胞中的愈合细胞的药物组合物的用途。

3. 发明申请

US20090268200A1 APPARATUS AND METHOD FOR OBTAINING SPECTRAL INFORMATION 有权
标题翻译：用于获取光谱信息的装置和方法
公开(公告)号：US20090268200A1
公开(公告)日：2009-10-29
申请号：US12302085
申请日：2007-05-23
申请人： David Rupert Klug , Paul Murray Donaldson
发明人： David Rupert Klug , Paul Murray Donaldson
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/658
摘要： A method of obtaining spectral information comprises initiating at least a first excitation at a first excitation frequency and a second excitation at a second frequency in a surface enhanced sample. The method further comprises varying one of said first and second excitation frequencies, detecting an output signal having an output signal strength and identifying an output signal peak. In addition the method includes correlating the identified output signal with the first and second excitation frequencies to obtain spectral information, in which the surface enhanced sample substrate is configured to enhance the field corresponding to at least one of the first and second excitation, or output fields initiated in this sample.
摘要翻译：获得光谱信息的方法包括在表面增强样本中以第一激发频率和第二频率的至少第一激发开始。该方法还包括改变所述第一和第二激励频率之一，检测具有输出信号强度并识别输出信号峰值的输出信号。此外，该方法包括将识别的输出信号与第一和第二激励频率相关联以获得频谱信息，其中表面增强采样基板被配置为增强对应于第一和第二激励或输出场中的至少一个的场在此样本中启动。

4. 发明申请

US20090197240A1 SYSTEMS AND METHODS FOR EX VIVO LUNG CARE 有权
标题翻译： EXVIVO LUNG CARE的系统和方法
公开(公告)号：US20090197240A1
公开(公告)日：2009-08-06
申请号：US12099715
申请日：2008-04-08
申请人： Robert Fishman , Robert Havener , Ihab Abdel Fattah , Anas Abdelazim , Scott Newell , Tom Bishop , Tamer Khayal , Stanley Kyi , Ron Taylor , Doug Harriott , Matthew De Remer , Paul Murray , John Sullivan , Mark Anderson , Richard Bringham , Michael Van Driel , Waleed Hassanein
发明人： Robert Fishman , Robert Havener , Ihab Abdel Fattah , Anas Abdelazim , Scott Newell , Tom Bishop , Tamer Khayal , Stanley Kyi , Ron Taylor , Doug Harriott , Matthew De Remer , Paul Murray , John Sullivan , Mark Anderson , Richard Bringham , Michael Van Driel , Waleed Hassanein
IPC分类号： A01N1/02 , A61B19/00
CPC分类号： A01N1/021 , A01N1/02 , A01N1/0247
摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
摘要翻译：维持，评估和提供肺外治疗的方法和系统。所述方法和系统包括将肺定位在离体灌注电路中; 循环灌注液通过肺，流体通过肺动脉界面进入肺，并使肺通过左心房界面; 并使通气气体通过气管界面通气。长时间维持肺包括使肺脏重新吸收一定体积的空气，并达到灌注流体和通气气体之间的平衡状态。评估肺的气体交换能力包括对灌注液进行脱氧，并测量通过用氧合气通气肺来再灌注灌注液所需的时间。

5. 发明授权

US07556706B2 Methods of manufacturing a product and container 有权
标题翻译：制造产品和容器的方法
公开(公告)号：US07556706B2
公开(公告)日：2009-07-07
申请号：US11398301
申请日：2006-04-04
申请人： Gary Wayne Yewdall , Jillian Louise Isabel Mahon , Paul Murray Malouf , Mark Simon Bayly , Peter Kinglsey Bayly
发明人： Gary Wayne Yewdall , Jillian Louise Isabel Mahon , Paul Murray Malouf , Mark Simon Bayly , Peter Kinglsey Bayly
IPC分类号： A61B17/06
CPC分类号： B65D43/0206 , A61F15/001 , B65D2543/00194 , B65D2543/00314 , B65D2543/0037 , B65D2543/00472 , B65D2543/00509 , B65D2543/00537 , B65D2543/00555 , B65D2543/00564 , B65D2543/00629 , B65D2543/00685 , B65D2543/0074 , B65D2543/00796 , B65D2543/0099
摘要： A container for a relatively brittle product, such as a haemostatic bandage, including a body and a lid for closing the container to hermetically seal the product therein. A sealing rim of the lid includes a layer of elastomeric material which sealingly engages with a sealing rim of the container body to provide a first, static, seal and a second, dynamic, seal. The elastomeric sealing material extends into the interior of the container beneath the lid to provide an elastomeric formation operative to engage an upper surface of the product within the container so as to apply a resilient bias thereto to hold a lower face of the product against the base of the container. The elastomeric formation thereby acts to inhibit substantial movement of the product within the container.
摘要翻译：用于相对脆性产品的容器，例如止血绷带，包括用于封闭容器的主体和盖子，以将产品密封在其中。盖的密封边缘包括与容器主体的密封边缘密封地接合以提供第一静态密封件和第二动态密封件的弹性体材料层。弹性体密封材料延伸到容器下面的容器内部，以提供可操作地与容器内的产品的上表面相接合的弹性体形式，以便向其施加弹性偏压以将产品的下表面抵靠基座的容器。弹性体形成因此用于抑制产品在容器内的显着移动。

6. 发明申请

US20070041336A1 Distributed tempero-spatial query service 有权
标题翻译：分布式温和空间查询服务
公开(公告)号：US20070041336A1
公开(公告)日：2007-02-22
申请号：US11191625
申请日：2005-07-28
申请人： Ming Wan , Paul Murray , Charles Erignac
发明人： Ming Wan , Paul Murray , Charles Erignac
IPC分类号： H04L12/28
CPC分类号： H04L29/12009 , H04L29/12047 , H04L61/15 , H04L67/1002 , H04L67/1008 , H04L67/104 , H04L67/1089
摘要： A distributed tempero-spatial query service uses a plurality of service agents each having an assigned area of responsibility. The service agents are organized into a spatial hierarchy based upon each service agent's area of responsibility. The spatial hierarchy is distributed and hosted on each of the service agents. The spatial hierarchy enables matching of requests from subscribing agents with publishing agents based upon spatial attributes. The spatial hierarchy is dynamically maintained in a distributed manner on each of the service agents. The service agents can be arranged into a tree-based spatial hierarchy having a limited depth.
摘要翻译：分布式温带空间查询服务使用多个服务代理，每个服务代理都具有分配的责任区域。服务代理基于每个服务代理的责任区域被组织成空间层级。在每个服务代理上分布和托管空间层次结构。空间层次结构使得能够基于空间属性来匹配订阅代理与发布代理的请求。在每个服务代理上以分布式的方式动态地维护空间层级。服务代理可以被布置成具有有限深度的基于树的空间层级。

7. 发明申请

US20050024094A1 Rotational frequency detector system 有权
标题翻译：旋转频率检测系统
公开(公告)号：US20050024094A1
公开(公告)日：2005-02-03
申请号：US10830664
申请日：2004-04-23
申请人： Declan Dalton , Lawrence DeVito , Mark Ferriss , Paul Murray
发明人： Declan Dalton , Lawrence DeVito , Mark Ferriss , Paul Murray
IPC分类号： H03D13/00 , H03L7/087 , H03L7/089 , H03L7/091 , H03L7/10 , H04L7/033 , H03D3/00
CPC分类号： H03D13/004 , H03L7/087 , H03L7/0891 , H03L7/091 , H03L7/10 , H04L7/033
摘要： A rotational frequency detector system including a rotational frequency detector responsive to a data signal and a clock signal. The rotational frequency detector is configured to compare the frequency of the clock signal to the frequency of the data signal to define frequency up and frequency down signals that adjust the frequency of the clock signal to be equal to the frequency of the data signal. A step control system is responsive to the rotational frequency detector and a step clock signal and is configured to define predetermined pulse widths for the frequency up and frequency down signals.
摘要翻译：一种旋转频率检测器系统，包括响应数据信号和时钟信号的旋转频率检测器。旋转频率检测器被配置为将时钟信号的频率与数据信号的频率进行比较，以定义将时钟信号的频率调整为等于数据信号的频率的上变频和下变频信号。步进控制系统响应于旋转频率检测器和步进时钟信号，并且被配置为为上变频信号和降频信号定义预定的脉冲宽度。

8. 发明申请

US20210264515A1 System and method for facilitating collateralized term transactions 有权
公开(公告)号：US20210264515A1
公开(公告)日：2021-08-26
申请号：US16799760
申请日：2020-02-24
申请人： Ari Pine , Paul Murray Sacks
发明人： Ari Pine , Paul Murray Sacks
IPC分类号： G06Q40/04 , G06Q40/02
摘要： A system and method for managing collateralized term transactions between two counterparties, employed by a third party, utilizing a novel margining process integrating escrow accounts and regularly rebalancing the notional amount of the transaction. The system and method allows far wider applicability to different forms of collateral and allows unfamiliar or lesser credit-worthy counterparties to transact.

9. 发明授权

US08510039B1 Methods and apparatus for three-dimensional localization and mapping 有权
标题翻译：三维定位和绘图的方法和装置
公开(公告)号：US08510039B1
公开(公告)日：2013-08-13
申请号：US12898412
申请日：2010-10-05
申请人： James J. Troy , Charles A. Erignac , Paul Murray
发明人： James J. Troy , Charles A. Erignac , Paul Murray
IPC分类号： G01S1/24
CPC分类号： G05D1/027 , G01C21/165 , G05D1/0251 , G05D1/0274
摘要： A system configured to enable three-dimensional localization and mapping is provided. The system includes a mobile device and a computing device. The mobile device includes an inertial measurement unit and a three-dimensional image capture device. The computing device includes a processor programmed to receive a first set of inertial measurement information from the inertial measurement unit, determine a first current position and orientation of the mobile device based on a defined position and orientation of the mobile device and the first set of inertial measurement information, receive three-dimensional image data of the environment from the three-dimensional image capture device, determine a second current position and orientation of the mobile device based on the received three-dimensional image data and the first current position and orientation of the mobile device, and generate a three-dimensional representation of an environment with respect to the second current position and orientation of the mobile device.
摘要翻译：提供了一种配置成实现三维定位和映射的系统。该系统包括移动设备和计算设备。移动设备包括惯性测量单元和三维图像捕获设备。计算设备包括被编程为从惯性测量单元接收第一组惯性测量信息的处理器，基于移动设备的定义的位置和取向以及第一组惯性来确定移动设备的第一当前位置和取向测量信息，从三维图像捕获装置接收环境的三维图像数据，基于接收到的三维图像数据和第一当前位置和取向来确定移动装置的第二当前位置和取向移动设备，并且相对于移动设备的第二当前位置和取向生成环境的三维表示。

10. 发明授权

US08420380B2 Systems and methods for ex vivo lung care 有权
标题翻译：离体肺部护理的系统和方法
公开(公告)号：US08420380B2
公开(公告)日：2013-04-16
申请号：US12099717
申请日：2008-04-08
申请人： Robert Fishman , Robert Havener , Ihab Abdel Fattah , Anas Abdelazim , Scott Newell , Tom Bishop , Tamer Khayal , Stanley Kyi , Ron Taylor , Doug Harriott , Matthew De Remer , Paul Murray , John Sullivan , Mark Anderson , Richard Bringham , Michael Van Driel , Waleed Hassanein
发明人： Robert Fishman , Robert Havener , Ihab Abdel Fattah , Anas Abdelazim , Scott Newell , Tom Bishop , Tamer Khayal , Stanley Kyi , Ron Taylor , Doug Harriott , Matthew De Remer , Paul Murray , John Sullivan , Mark Anderson , Richard Bringham , Michael Van Driel , Waleed Hassanein
IPC分类号： A01N1/02
CPC分类号： A01N1/021 , A01N1/02 , A01N1/0247
摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
摘要翻译：维持，评估和提供肺外治疗的方法和系统。所述方法和系统包括将肺定位在离体灌注电路中; 循环灌注液通过肺，流体通过肺动脉界面进入肺，并使肺通过左心房界面; 并使通气气体通过气管界面通气。长时间维持肺包括使肺脏重新吸收一定体积的空气，并达到灌注流体和通气气体之间的平衡状态。评估肺的气体交换能力包括对灌注液进行脱氧，并测量通过用氧合气通气肺来再灌注灌注液所需的时间。

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