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1. 发明授权

US09685313B2 Combined mass-to-charge ratio and charge state selection in tandem mass spectrometry 有权
公开(公告)号：US09685313B2
公开(公告)日：2017-06-20
申请号：US12514972
申请日：2007-11-15
申请人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/00 , H01J49/42 , G01N27/62
CPC分类号： H01J49/4215 , G01N27/622 , H01J49/004 , H01J49/426
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer and an ion gate. A collision cell is arranged downstream of the ion gate. The operation of the ion mobility spectrometer and the ion gate are synchronised so that only ions having a particular mass to charge ratio and a desired charge state are onwardly transmitted to the collision cell.

2. 发明授权

US09607820B2 Ion mobility spectrometer with upstream devices at constant potential 有权
公开(公告)号：US09607820B2
公开(公告)日：2017-03-28
申请号：US12306162
申请日：2007-06-25
申请人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/42 , G01N27/62 , H01J49/00
CPC分类号： H01J49/429 , G01N27/622 , H01J49/0031 , H01J49/004
摘要： A mass spectrometer includes an ion mobility spectrometer or separator arranged upstream of a collision or fragmentation cell. Ions are separated according to their ion mobility within the ion mobility spectrometer or separator. The kinetic energy of the ions exiting the ion mobility spectrometer or separator is increased substantially linearly with time in order to optimize the fragmentation energy of ions as they enter the collision or fragmentation cell. During the time that the potential of the ion mobility spectrometer or separator is being varied, the potential of ion-optical components upstream of the ion mobility spectrometer or separator such as an ion source, ion guide, quadrupole mass filter, optional second collision or fragmentation cell and an ion trapping device are kept constant.

3. 发明授权

US09466472B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US09466472B2
公开(公告)日：2016-10-11
申请号：US11720520
申请日：2005-12-02
申请人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle
IPC分类号： H01J49/00 , H01J49/06
CPC分类号： H01J49/065
摘要： An ion guide is disclosed comprising one or more layers of intermediate planar, plate or mesh electrodes. A first array of first electrodes is provided on a upper surface and a second array of second electrodes is arranged on a lower surface. An ion guiding region is formed within the ion guide. One or more transient DC voltages or potentials are preferably applied to the first and second array of second electrodes in order to urge, propel, force or accelerate ions through or along the ion guide.
摘要翻译：公开了一种离子导向器，其包括一层或多层中间平面，板或网状电极。第一电极阵列设置在上表面上，第二电极阵列布置在下表面上。离子引导区域形成在离子导向器内。优选地将一个或多个瞬态DC电压或电位施加到第一和第二第二电极阵列，以促进，推进，强迫或加速离子通过或沿着离子导向器。

4. 发明授权

US09425035B2 Ion trap with spatially extended ion trapping region 有权
标题翻译：离子阱具有空间延伸的离子捕获区域
公开(公告)号：US09425035B2
公开(公告)日：2016-08-23
申请号：US14240586
申请日：2012-08-22
申请人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
发明人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/00 , H01J49/42 , H01J49/40
CPC分类号： H01J49/4285 , H01J49/0031 , H01J49/062 , H01J49/063 , H01J49/40 , H01J49/422
摘要： A mass or mass to charge ratio selective ion trap is disclosed which directs ions into a small ejection region. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC or RF voltage acts to confine ions in a second (x) direction. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. The profile of the quadratic DC potential well progressively varies along the second (x) direction.
摘要翻译：公开了将离子引导到小的喷射区域中的质量或质量比的选择性离子阱。 RF电压用于将离子限制在离子阱内的第一（y）方向。 DC或RF电压用于将离子限制在第二（x）方向。二次直流势阱用于将离子限制在离子阱内的第三（z）方向。二次直流电势的曲线沿着第二（x）方向逐渐变化。

5. 发明授权

US09281171B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US09281171B2
公开(公告)日：2016-03-08
申请号：US11721260
申请日：2005-12-08
申请人： Robert Harold Bateman , Kevin Giles , Jeffery Mark Brown , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Jeffery Mark Brown , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/40 , H01J49/06 , H01J49/00
CPC分类号： H01J49/062 , H01J49/004
摘要： A mass spectrometer is disclosed comprising a mass selective ion trap or mass analyzer arranged upstream of an ion guide. Ions are scanned out of the mass selective ion trap or mass analyzer and are received in one or more axial potential wells created or formed within the ion guide. One or more transient DC voltages or potentials are preferably applied to the ion guide in order to create a plurality of axial potential wells which are translated along the length of the ion guide. Ions are released in packets from the exit of the ion guide and are orthogonally acceleration into a drift or flight region of an orthogonal acceleration Time of Flight mass analyzer with a relatively high duty cycle.
摘要翻译：公开了一种质谱仪，其包括布置在离子导向器上游的质量选择性离子阱或质量分析器。离子从质量选择性离子阱或质量分析器扫描出来，并被接收在一个或多个在离子导向器内产生或形成的轴向势阱中。优选地将一个或多个瞬态DC电压或电位施加到离子导向器，以便产生沿离子导向件的长度平移的多个轴向势阱。离子从离子导向器的出口释放出来的离子，并且正交加速到相对较高占空比的正交加速时间飞行质量分析器的漂移或飞行区域。

6. 发明授权

US09082596B2 Method of single point internal lock-mobility correction 有权
标题翻译：单点内锁移动校正方法
公开(公告)号：US09082596B2
公开(公告)日：2015-07-14
申请号：US14123532
申请日：2012-06-01
申请人： Jeffery Mark Brown , Kevin Giles
发明人： Jeffery Mark Brown , Kevin Giles
IPC分类号： H01J49/40 , H01J49/02 , H01J49/00 , G01N27/62 , H01J49/26
CPC分类号： H01J49/0031 , G01N27/622 , H01J49/26
摘要： A method of mass spectrometry is disclosed comprising passing ions through an ion mobility spectrometer and acquiring first ion mobility drift time data. A calibration function is applied to the first ion mobility drift time data to determine a physico-chemical property (e.g. CCS) of the ions. Second ion mobility drift time data is then acquired and the calibration function is applied to the second ion mobility drift time data to determine the physico-chemical property of one or more known or reference ions. The calibration function is then adjusted.
摘要翻译：公开了一种质谱法，其包括使离子通过离子迁移谱仪并获得第一离子迁移率漂移时间数据。将校准功能应用于第一离子迁移率漂移时间数据以确定离子的物理化学性质（例如CCS）。然后获取第二离子迁移率漂移时间数据，并且将校准功能应用于第二离子迁移率漂移时间数据，以确定一种或多种已知或参考离子的物理化学性质。然后调整校准功能。

7. 发明授权

US09012840B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US09012840B2
公开(公告)日：2015-04-21
申请号：US11720771
申请日：2005-12-07
申请人： Robert Harold Bateman , Kevin Giles
发明人： Robert Harold Bateman , Kevin Giles
IPC分类号： H01J49/26 , H01J49/06 , G01N27/62 , H01J49/00
CPC分类号： H01J49/0045 , G01N27/622 , H01J49/004 , H01J49/022 , H01J49/062
摘要： A mass spectrometer is disclosed comprising a first quadrupole rod set mass filter, a collision cell, an ion mobility spectrometer or separator, an ion guide or collision cell arranged downstream of the ion mobility spectrometer or separator, a second quadrupole rod set mass filter and an ion detector.
摘要翻译：公开了一种质谱仪，其包括第一四极杆组质量过滤器，碰撞池，离子迁移谱仪或分离器，设置在离子迁移谱仪或分离器下游的离子导向器或碰撞元件，第二四极杆组质量过滤器和离子检测器

8. 发明申请

US20120056084A1 Apparatus Comprising an Ion Mobility Spectrometer 有权
标题翻译：包含离子迁移率光谱仪的装置
公开(公告)号：US20120056084A1
公开(公告)日：2012-03-08
申请号：US13297791
申请日：2011-11-16
申请人： Kevin Giles
发明人： Kevin Giles
IPC分类号： H01J49/40 , H01J49/00
CPC分类号： H01J49/0481 , G01N27/622 , H01J49/004 , H01J49/062
摘要： A mass spectrometer is disclosed comprising a first chamber and a second chamber. The second chamber is located downstream of the first chamber and an inter-chamber aperture is provided between the two chambers. An ion guide is located in the first chamber and an ion mobility spectrometer is located in the second chamber. Helium gas is provided to the first chamber. As ions are accelerated towards the ion mobility spectrometer from a relatively low pressure region they pass initially into the first chamber. The helium gas provided in the first chamber minimises ion fragmentation and ion discrimination effects as ions are accelerated into a relatively high pressure region. The ions are then transmitted by the ion guide and are subsequently transmitted to the ion mobility spectrometer located in the second chamber.
摘要翻译：公开了一种质谱仪，其包括第一室和第二室。第二室位于第一室的下游，并且在两个室之间设置室间孔。离子导向器位于第一室中，离子迁移谱仪位于第二室中。氦气被提供到第一室。当离子从相对低的压力区域向离子迁移谱仪加速时，它们最初通入第一室。当离子加速到相对高的压力区域时，设置在第一室中的氦气最小化离子碎片和离子鉴别效应。然后离子通过离子导向器传输并随后传输到位于第二室中的离子迁移谱仪。

9. 发明申请

US20100038530A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20100038530A1
公开(公告)日：2010-02-18
申请号：US11813221
申请日：2006-01-17
申请人： Kevin Giles , Martin Green , Jason Lee Wildgoose
发明人： Kevin Giles , Martin Green , Jason Lee Wildgoose
IPC分类号： H01J49/04 , H01J49/42
CPC分类号： H01J49/4235 , H01J49/4275
摘要： An ion guide or ion trap (1) is disclosed comprising a segmented linear ion guide or ion trap. Ions are confined radially within the ion guide or ion trap (1) by the application of an AC or RF voltage to the electrodes. A static potential well is maintained along at least a portion of the axial length of the ion guide or ion trap (1). A time varying homogeneous electric field is applied along at least a portion of the axial length of the ion guide or ion trap (1). The combination of the static axial potential well and the time varying axial homogeneous electric field causes ions to be ejected from the ion guide or ion trap (1) in a substantially non-resonant manner.
摘要翻译：公开了一种离子导向器或离子阱（1），其包括分段线性离子导向器或离子阱。通过向电极施加AC或RF电压，离子在径向上被限制在离子导向器或离子阱（1）内。沿离子导向器或离子阱（1）的轴向长度的至少一部分保持静电势阱。沿离子导向器或离子阱（1）的轴向长度的至少一部分施加时变均匀电场。静态轴向势阱和随时间变化的轴向均匀电场的组合导致离子以基本上非共振的方式从离子导向器或离子阱（1）喷出。

10. 发明申请

US20100032561A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20100032561A1
公开(公告)日：2010-02-11
申请号：US12518291
申请日：2007-12-12
申请人： Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/26
CPC分类号： G01N27/622 , G01N27/624 , H01J49/062 , H01J49/4235
摘要： A mass spectrometer is disclosed comprising a device (2) which is operable in a first mode of operation to separate ions temporally according to their ion mobility by applying a continuous axial electric field. The device (2) is also operable in a second mode of operation wherein ions are separated temporally according to the their mass to charge ratio by pulsing an applied axial electric field ON and OFF.
摘要翻译：公开了一种质谱仪，其包括可在第一操作模式中操作的装置（2），其通过施加连续轴向电场根据其离子迁移率暂时分离离子。装置（2）还可在第二操作模式中操作，其中通过脉冲施加的轴向电场ON和OFF，离子根据其质荷比逐时分离。

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