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1. 发明授权

US09484194B2 Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis 有权
标题翻译：通过频谱控制氢氘交换
公开(公告)号：US09484194B2
公开(公告)日：2016-11-01
申请号：US13885913
申请日：2011-11-16
申请人： Jeffery Mark Brown , Steven Derek Pringle , Keith Richardson
发明人： Jeffery Mark Brown , Steven Derek Pringle , Keith Richardson
IPC分类号： H01J49/00 , H01J49/06 , H01J49/26
CPC分类号： H01J49/0077 , H01J49/00 , H01J49/0031 , H01J49/0036 , H01J49/0054 , H01J49/0072 , H01J49/06 , H01J49/065 , H01J49/26
摘要： A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as Hydrogen-Deuterium exchange. A control system is arranged to automatically and repeatedly switch the reaction device back and forth between a first mode of operation and a second mode of operation, wherein in the first mode of operation at least some parent or precursor ions are caused to react within the reaction device and wherein in the second mode of operation substantially fewer or no parent or precursor ions are caused to react.
摘要翻译：公开了一种质谱仪，其包括用于分离离子的液相色谱装置。气相离子中性反应装置设置在下游以进行气相离子 - 中性反应如氢氘交换。控制系统被布置成在第一操作模式和第二操作模式之间来回自动重复地切换反应装置，其中在第一操作模式中，使至少一些母体或前体离子在反应中反应器件，并且其中在第二操作模式中基本上较少或没有使母体或前体离子发生反应。

2. 发明授权

US09136098B2 Ion guide coupled to MALDI ion source 有权
标题翻译：离子导轨耦合到MALDI离子源
公开(公告)号：US09136098B2
公开(公告)日：2015-09-15
申请号：US14130465
申请日：2012-07-06
申请人： Jason Lee Wildgoose , Steven Derek Pringle , Kevil Giles , Jeffery Mark Brown , Paul Murray , Daniel James Kenny
发明人： Jason Lee Wildgoose , Steven Derek Pringle , Kevil Giles , Jeffery Mark Brown , Paul Murray , Daniel James Kenny
IPC分类号： H01J49/40 , H01J49/10 , H01J49/06 , H01J49/00
CPC分类号： H01J49/10 , H01J49/0031 , H01J49/061 , H01J49/065 , H01J49/161
摘要： A pulsed ion source is disclosed wherein the ion source is energized one or more times to generate a first group of ions and a second group of ions. The first and second groups of ions are simultaneously transmitted through an ion guide whilst keeping the first and second groups of ions isolated from each other.
摘要翻译：公开了脉冲离子源，其中离子源被激发一次或多次以产生第一组离子和第二组离子。第一和第二组离子同时透过离子导向器同时保持第一和第二组离子彼此隔离。

3. 发明申请

US20150034814A1 MALDI Imaging and Ion Source 有权
标题翻译： MALDI成像和离子源
公开(公告)号：US20150034814A1
公开(公告)日：2015-02-05
申请号：US14130453
申请日：2012-07-06
申请人： Jeffery Mark Brown , Paul Murray , Daniel James Kenny
发明人： Jeffery Mark Brown , Paul Murray , Daniel James Kenny
IPC分类号： H01J49/16 , H01J49/06 , H01J49/26 , H01J49/04
CPC分类号： H01J49/062 , H01J49/0004 , H01J49/0463 , H01J49/065 , H01J49/164 , H01J49/26
摘要： An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length ≦300 mm. The laser beam is directed onto the target substrate at an angle θ with respect to the perpendicular to the target substrate, wherein θ≦3°. One or more ion guides receive ions released from the target substrate and onwardly transmit the ions along an ion path which substantially bypasses the lens and mirror.
摘要翻译：公开了一种用于质谱仪的离子源，其包括将激光束聚焦到目标衬底的上表面上的透镜和反射镜装置。镜头具有有效的焦距＆nlE; 300 mm。激光束以一定角度被引导到靶基底上; 相对于与靶基板的垂直度，其中＆amp; nlE; 3°。一个或多个离子导向器接收从目标衬底释放的离子，并沿基本上绕过透镜和反射镜的离子路径向上透射离子。

4. 发明申请

US20140191123A1 Ion Guide Coupled to MALDI Ion Source 有权
标题翻译：离子导向器与MALDI离子源耦合
公开(公告)号：US20140191123A1
公开(公告)日：2014-07-10
申请号：US14130465
申请日：2012-07-06
申请人： Jason Lee Wildgoose , Steven Derek Pringle , Kevil Giles , Jeffery Mark Brown , Paul Murray , Daniel James Kenny
发明人： Jason Lee Wildgoose , Steven Derek Pringle , Kevil Giles , Jeffery Mark Brown , Paul Murray , Daniel James Kenny
IPC分类号： H01J49/10 , H01J49/00
CPC分类号： H01J49/10 , H01J49/0031 , H01J49/061 , H01J49/065 , H01J49/161
摘要： A pulsed ion source is disclosed wherein the ion source is energised one or more times to generate a first group of ions and a second group of ions. The first and second groups of ions are simultaneously transmitted through an ion guide whilst keeping the first and second groups of ions isolated from each other.
摘要翻译：公开了脉冲离子源，其中离子源被激发一次或多次以产生第一组离子和第二组离子。第一和第二组离子同时透过离子导向器同时保持第一和第二组离子彼此隔离。

5. 发明申请

US20130256524A1 Mass Spectrometer With Beam Expander 有权
公开(公告)号：US20130256524A1
公开(公告)日：2013-10-03
申请号：US13702931
申请日：2011-06-07
申请人： Jeffery Mark Brown , Anthony James Gilbert , John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
发明人： Jeffery Mark Brown , Anthony James Gilbert , John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/40
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/0095 , H01J49/062 , H01J49/067 , H01J49/405
摘要： A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyser. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyser.

6. 发明申请

US20130206974A1 Mass Spectrometer Incorporating Hydrogen-Deuterium Exchange 有权
标题翻译：合成氢氘交换的质谱仪
公开(公告)号：US20130206974A1
公开(公告)日：2013-08-15
申请号：US13578397
申请日：2011-02-14
申请人： Jeffery Mark Brown
发明人： Jeffery Mark Brown
IPC分类号： H01J49/00 , H01J49/02
CPC分类号： H01J49/0031 , G01N27/622 , H01J49/0077 , H01J49/02
摘要： A mass spectrometer is disclosed comprising a hydrogen-deuterium exchange cell. Isomeric ions having different conformations but substantially similar ion mobilities can be differentiated by subjecting the ions to hydrogen-deuterium exchange. Two ions having similar ion mobilities can be differentiated more effectively if they have different surface conformations by determining the relative degree of hydrogen-deuterium exchange.
摘要翻译：公开了一种包含氢 - 氘交换电池的质谱仪。具有不同构象但基本上相似的离子迁移率的异构离子可以通过使离子进行氢氘交换来分化。具有相似离子迁移率的两个离子如果通过确定氢 - 氘交换的相对程度而具有不同的表面构象，可以更有效地区分。

7. 发明申请

US20130122599A1 Fragmentation Reagents For Mass Spectrometry 审中-公开
标题翻译：用于质谱的碎裂试剂
公开(公告)号：US20130122599A1
公开(公告)日：2013-05-16
申请号：US13522513
申请日：2011-01-31
申请人： Jeffery Mark Brown , Iain Campuzano , Darryl W. Brousmiche , Craig Dorschel , Jonathan Paul Williams , Steven Derek Pringle , Keith Richardson
发明人： Jeffery Mark Brown , Iain Campuzano , Darryl W. Brousmiche , Craig Dorschel , Jonathan Paul Williams , Steven Derek Pringle , Keith Richardson
IPC分类号： G01N33/68 , C07C205/06 , C07C47/55 , C07C255/51 , C07C47/54 , C07C205/44
摘要： A mass spectrometry electron transfer dissociation reagent comprising an unsaturated compound having a Frank Condon factor between 0.1 and 1.0 and an electron affinity having a positive value between 0.1 to 150 kJ/mol.
摘要翻译：一种质谱电子转移离解试剂，其包含Frank Condon因子在0.1至1.0之间的不饱和化合物和具有0.1至150kJ / mol的正值的电子亲和力。

8. 发明授权

US07199363B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07199363B2
公开(公告)日：2007-04-03
申请号：US10964791
申请日：2004-10-14
申请人： Robert Harold Bateman , Jeffery Mark Brown , Daniel James Kenny
发明人： Robert Harold Bateman , Jeffery Mark Brown , Daniel James Kenny
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/405 , H01J49/0031
摘要： A mass spectrometer is disclosed comprising an ion source 4, a field free or drift region 5 and an ion mirror 7 comprising a reflectron. Metastable parent ions which spontaneously fragment by Post Source Decay whilst passing through the field free or drift region 5 are arranged to enter the ion mirror 7 and be reflected by the reflectron towards an ion detector 8 when the reflectron is maintained at a certain voltage. The process is then repeated with the reflectron being maintained at a slightly lower voltage. Two related sets of time of flight or mass spectral data are obtained for the two different voltage settings of the reflectron. From the two data sets the different times of flight for the same species of fragment ion can be determined. The mass to charge ratio of the parent ion which fragmented to produce the particular species of fragment ion can then be determined from the times of flight of the fragment ions.
摘要翻译：公开了一种质谱仪，其包括离子源4，无场或漂移区5以及包括反射镜的离子镜7。当通过场自由或漂移区域5时通过后源衰变自发分裂的亚稳态亲本离子被布置成当反射器保持在一定电压时进入离子反射镜7并被反射器反射离子检测器8。然后重复该过程，其中反射器保持在稍低的电压。对于反射镜的两个不同的电压设置，获得两组相关的飞行时间或质谱数据。从两个数据集可以确定相同种类的碎片离子的不同飞行时间。然后可以从片段离子的飞行时间确定碎片化以产生特定种类的碎片离子的母体离子的质荷比。

9. 发明授权

US07053366B2 Desalting plate for MALDI mass spectrometry 有权
标题翻译：脱盐板用于MALDI质谱
公开(公告)号：US07053366B2
公开(公告)日：2006-05-30
申请号：US10478399
申请日：2002-05-24
申请人： Edouard S. P. Bouvier , Bruce J. Compton , Dominic O. Gostick , Jeffery Mark Brown
发明人： Edouard S. P. Bouvier , Bruce J. Compton , Dominic O. Gostick , Jeffery Mark Brown
IPC分类号： H01J37/20 , G01N1/28
CPC分类号： H01J49/0418 , G01N1/405 , Y10T436/24 , Y10T436/25
摘要： A novel Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) desalting sample support plate is described. The plate comprises a sample presentation surface, wherein the sample presentation surface comprises at least one receiving surface of an absorbent layer, wherein the absorbent layer retains selected molecules on the receiving surface. Methods for making and using the sample support plate in conventional and automated MALDI-MS are also described.
摘要翻译：描述了一种新型的矩阵辅助激光解吸/电离质谱（MALDI-MS）脱盐样品支撑板。所述板包括样品呈现表面，其中所述样品呈现表面包括吸收层的至少一个接收表面，其中所述吸收层将选定的分子保持在所述接收表面上。还描述了在常规和自动化的MALDI-MS中制备和使用样品支持板的方法。

10. 发明授权

US09293314B2 Photo-dissociation of proteins and peptides in a mass spectrometer 有权
标题翻译：蛋白质和肽在质谱仪中的光解离
公开(公告)号：US09293314B2
公开(公告)日：2016-03-22
申请号：US14130428
申请日：2012-07-06
申请人： Daniel James Kenny , Paul Murray , Keith Richardson , Kevin Giles , Jeffery Mark Brown
发明人： Daniel James Kenny , Paul Murray , Keith Richardson , Kevin Giles , Jeffery Mark Brown
IPC分类号： H01J49/06 , H01J49/00 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/42
CPC分类号： H01J49/0059 , G01N27/624 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/422 , H01J49/4245
摘要： A method of mass spectrometry is disclosed comprising automatically and repeatedly performing multiple cycles of operation, wherein a cycle of operation comprises the steps of: (i) mass analyzing first ions; (ii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions and mass analyzing the second ions; and (iii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions, fragmenting the second ions to form a plurality of third ions and mass analyzing the third ions.
摘要翻译：公开了一种自动重复执行多个操作循环的质谱法，其中操作循环包括以下步骤：（i）质量分析第一离子; （ii）将第一离子暴露于第一光离解装置以形成多个第二离子并质量分析第二离子; 和（iii）将第一离子暴露于第一光解离装置以形成多个第二离子，使第二离子碎裂以形成多个第三离子并大量分析第三离子。

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