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1. 发明申请

US20120285223A1 METHOD FOR DETERMINING EQUIVALENT THERMAL CONDITIONS BETWEEN LIQUID CHROMATOGRAPHY SYSTEMS 有权
标题翻译：用于确定液相色谱系统之间等效热条件的方法
公开(公告)号：US20120285223A1
公开(公告)日：2012-11-15
申请号：US13519712
申请日：2011-01-21
申请人： Richard W. Andrews , Peyton C. Beals
发明人： Richard W. Andrews , Peyton C. Beals
IPC分类号： G01N30/02
CPC分类号： G01N30/04 , B01D15/424 , G01N30/8672 , G01N2030/047 , G01N2030/3007
摘要： Described is a method of transferring a chromatographic method between liquid chromatography (LC) systems. The method is based on a determination of an isoretention temperature at which two solutes co-elute. The method enables separations to be performed using different LC systems with reproducible and equivalent results. For example, the method allows for a chromatography method developed for HPLC to be more readily transferred to a UPLC system and for a chromatography method developed for a UPLC system to be more readily transferred to a HPLC system. The method addresses LC systems having column ovens of different design in which the internal column temperatures are not equal although the operating temperatures of the column ovens may be accurately controlled to equal values. The retention behavior and resolution of different LC systems is caused to be substantially the same so that equivalent separation results are obtained.
摘要翻译：描述了在液相色谱（LC）系统之间转移色谱方法的方法。该方法基于两个溶质共洗脱的等离子体停留温度的测定。该方法可以使用具有可重现性和等效结果的不同液相色谱系统进行分离。例如，该方法允许为HPLC开发的色谱方法更容易转移到UPLC系统中，并且为UPLC系统开发的色谱方法更容易转移到HPLC系统。该方法解决了具有不同设计的列炉的LC系统，其中内部柱温度不相等，尽管柱式炉的操作温度可以被精确地控制为相等的值。导致不同LC系统的保持行为和分辨率基本相同，从而获得等效的分离结果。

2. 发明申请

US20120103075A1 Automated Dilution For Liquid Chromatography 有权
标题翻译：液相色谱自动稀释
公开(公告)号：US20120103075A1
公开(公告)日：2012-05-03
申请号：US13146683
申请日：2010-02-17
申请人： Sylvain Cormier , Richard W. Andrews , Robert Tacconi , Craig H. Dobbs
发明人： Sylvain Cormier , Richard W. Andrews , Robert Tacconi , Craig H. Dobbs
IPC分类号： G01N30/20
CPC分类号： F04B13/02 , F04B23/06 , G01N1/38 , G01N1/40 , G01N30/20
摘要： Described are a method and system for diluting a sample in a liquid chromatography system. A sample flowing at a first flow rate is combined for a predetermined time with a diluent flowing at a second flow rate to generate a volume of diluted sample. The diluted sample has a dilution ratio determined according to the two flow rates. A portion of the volume is loaded into a sample loop of an injection valve and subsequently injected into a mobile phase flowing to a chromatography column. The method eliminates the need to have a technician available to perform dilutions or to transfer the sample to a remote location for dilution. Advantageously, manufacturing or processing downtime to perform the dilution is not required and the amount of sample flowing to waste is reduced.
摘要翻译：描述了用于在液相色谱系统中稀释样品的方法和系统。将以第一流速流动的样品与以第二流量流动的稀释剂组合预定时间以产生一定体积的稀释样品。稀释样品根据两种流速测定稀释倍数。将体积的一部分装载到注射阀的样品环中，随后注入流动到色谱柱的流动相中。该方法不需要技术人员可以进行稀释或将样品转移到远程位置进行稀释。有利地，不需要制造或处理进行稀释的停机时间，并且减少流向废物的样品量。

3. 发明授权

US07754075B2 Backflow prevention for high pressure gradient systems 有权
标题翻译：高压梯度系统防回流
公开(公告)号：US07754075B2
公开(公告)日：2010-07-13
申请号：US12113253
申请日：2008-05-01
申请人： Hal Richardson , Richard W. Andrews
发明人： Hal Richardson , Richard W. Andrews
IPC分类号： B01D15/08
CPC分类号： G01N30/32 , G01N30/10 , G01N30/36 , G01N2030/322 , G01N2030/328 , Y10T137/7838 , Y10T137/87684 , G01N30/34
摘要： Gradient performance with high pressure gradient solvent delivery system is optimized by approximation of infinite stroke volume of high pressure pumps by the addition of pulse dampening with backflow prevention to each high pressure pump. The backflow prevention adds sufficient minimum flow resistance, thereby enhancing the performance of the pulse dampening over a wider range of flow rates resulting in consistent gradient performance.
摘要翻译：使用高压梯度溶剂输送系统的梯度性能通过对每个高压泵添加具有防回流的脉冲阻尼来近似高压泵的无限冲程体积来优化。防回流增加了足够的最小流阻，从而在更宽的流量范围内增强了脉冲阻尼的性能，从而达到了一致的梯度性能。

4. 发明授权

US09551329B2 Automated dilution for liquid chromatography 有权
标题翻译：自动稀释液相色谱
公开(公告)号：US09551329B2
公开(公告)日：2017-01-24
申请号：US13146683
申请日：2010-02-17
申请人： Sylvain Cormier , Richard W. Andrews , Robert Tacconi , Craig H. Dobbs
发明人： Sylvain Cormier , Richard W. Andrews , Robert Tacconi , Craig H. Dobbs
IPC分类号： F04B13/02 , G01N1/38 , G01N1/40 , G01N30/20
CPC分类号： F04B13/02 , F04B23/06 , G01N1/38 , G01N1/40 , G01N30/20
摘要： Described are a method and system for diluting a sample in a liquid chromatography system. A sample flowing at a first flow rate is combined for a predetermined time with a diluent flowing at a second flow rate to generate a volume of diluted sample. The diluted sample has a dilution ratio determined according to the two flow rates. A portion of the volume is loaded into a sample loop of an injection valve and subsequently injected into a mobile phase flowing to a chromatography column. The method eliminates the need to have a technician available to perform dilutions or to transfer the sample to a remote location for dilution. Advantageously, manufacturing or processing downtime to perform the dilution is not required and the amount of sample flowing to waste is reduced.
摘要翻译：描述了用于在液相色谱系统中稀释样品的方法和系统。将以第一流速流动的样品与以第二流量流动的稀释剂组合预定时间以产生一定体积的稀释样品。稀释样品根据两种流速测定稀释倍数。将体积的一部分装载到注射阀的样品环中，随后注入流动到色谱柱的流动相中。该方法不需要技术人员可以进行稀释或将样品转移到远程位置进行稀释。有利地，不需要制造或处理进行稀释的停机时间，并且减少流向废物的样品量。

5. 发明授权

US09086424B2 Method for determining equivalent thermal conditions between liquid chromatography systems 有权
标题翻译：确定液相色谱系统之间等效热条件的方法
公开(公告)号：US09086424B2
公开(公告)日：2015-07-21
申请号：US13519712
申请日：2011-01-21
申请人： Richard W. Andrews , Peyton C. Beals
发明人： Richard W. Andrews , Peyton C. Beals
IPC分类号： G01N30/02 , G01N30/86 , B01D15/42 , G01N30/30
CPC分类号： G01N30/04 , B01D15/424 , G01N30/8672 , G01N2030/047 , G01N2030/3007
摘要： Described is a method of transferring a chromatographic method between liquid chromatography (LC) systems. The method is based on a determination of an isoretention temperature at which two solutes co-elute. The method enables separations to be performed using different LC systems with reproducible and equivalent results. For example, the method allows for a chromatography method developed for HPLC to be more readily transferred to a UPLC system and for a chromatography method developed for a UPLC system to be more readily transferred to a HPLC system. The method addresses LC systems having column ovens of different design in which the internal column temperatures are not equal although the operating temperatures of the column ovens may be accurately controlled to equal values. The retention behavior and resolution of different LC systems is caused to be substantially the same so that equivalent separation results are obtained.
摘要翻译：描述了在液相色谱（LC）系统之间转移色谱方法的方法。该方法基于两个溶质共洗脱的等离子体停留温度的测定。该方法可以使用具有可重现性和等效结果的不同液相色谱系统进行分离。例如，该方法允许为HPLC开发的色谱方法更容易转移到UPLC系统中，并且为UPLC系统开发的色谱方法更容易转移到HPLC系统。该方法解决了具有不同设计的列炉的LC系统，其中内部柱温度不相等，尽管柱式炉的操作温度可以被精确地控制为相等的值。导致不同LC系统的保持行为和分辨率基本相同，从而获得等效的分离结果。

6. 发明申请

US20090211978A1 Passive column pre-heater with sample band spreading reduction feature 有权
标题翻译：被动柱预热器带有采样带扩散减少功能
公开(公告)号：US20090211978A1
公开(公告)日：2009-08-27
申请号：US11631730
申请日：2005-08-05
申请人： Edward J. Ognibene , Joseph A. Kareh , Uwe D. Neue , Theodore D. Ciolkosz , Richard W. Andrews , Marc Lemelin , Peyton C. Beals
发明人： Edward J. Ognibene , Joseph A. Kareh , Uwe D. Neue , Theodore D. Ciolkosz , Richard W. Andrews , Marc Lemelin , Peyton C. Beals
IPC分类号： B01D15/08
CPC分类号： B01D15/161 , B01D15/12 , B01D15/20 , G01N30/30 , G01N2030/3046
摘要： Disclosed is a chromatographic system and method which includes a passive pre-heater assembly. In the inventive system and method a fluid mixture is supplied from an injector to the pre-heater assembly and then to a chromatographic column having an active heating source. The pre-heater assembly includes a convoluted tube with first and second ends and a fluid passage extending centrally therebetween, first and second end fittings attached respectively to the first and second ends of the convoluted tube, and a thermally conductive film attached to an outer surface of the convoluted tube. The first end fitting is adapted for fluidly connecting the first end of the convoluted tube to the injector and the second end fitting is adapted for fluidly connecting the second end of the convoluted tube to the chromatographic column. The thermally conductive film conveys heat from an active heating source of a chromatographic column to the convoluted tube when the pre-heater assembly is positioned adjacent to the active heating source. The central fluid passage in the convoluted tube has a series of bends which function to create a secondary fluid flow field that is substantially orthogonal to a primary flow field established when fluid is traversing the fluid passage in the tube.
摘要翻译：公开了一种包括无源预热器组件的色谱系统和方法。在本发明的系统和方法中，将流体混合物从注射器供应到预热器组件，然后到具有主动加热源的色谱柱。预热器组件包括具有第一和第二端的回旋管和在其间中间延伸的流体通道，分别连接到回旋管的第一和第二端的第一和第二端配件以及附接到外表面的导热膜的回旋管。第一端配件适于将回旋管的第一端流体连接到注射器，并且第二端配件适于将回旋管的第二端流体连接到色谱柱。当预热器组件邻近主动加热源定位时，导热膜将热量从色谱柱的活性加热源传送到回旋管。回旋管中的中心流体通道具有一系列弯曲，其功能是产生与流体横穿管中的流体通道所建立的主流场大致正交的次级流体流场。

7. 发明授权

US07396469B2 Backflow prevention for high pressure gradient systems 有权
标题翻译：高压梯度系统防回流
公开(公告)号：US07396469B2
公开(公告)日：2008-07-08
申请号：US10911111
申请日：2004-08-04
申请人： Richard W. Andrews , Hal Richardson
发明人： Richard W. Andrews , Hal Richardson
IPC分类号： B01D15/08
CPC分类号： G01N30/32 , G01N30/10 , G01N30/36 , G01N2030/322 , G01N2030/328 , Y10T137/7838 , Y10T137/87684 , G01N30/34
摘要： Gradient performance with high pressure gradient solvent delivery system is optimized by approximation of infinite stroke volume of high pressure pumps by the addition of pulse dampening with backflow prevention to each high pressure pump. The backflow prevention adds sufficient minimum flow resistance, thereby enhancing the performance of the pulse dampening over a wider range of flow rates resulting in consistent gradient performance.
摘要翻译：使用高压梯度溶剂输送系统的梯度性能通过对每个高压泵添加具有防回流的脉冲阻尼来近似高压泵的无限冲程体积来优化。防回流增加了足够的最小流阻，从而在更宽的流量范围内增强了脉冲阻尼的性能，从而达到了一致的梯度性能。

8. 发明授权

US06780315B2 Backflow prevention for high pressure gradient systems 失效
标题翻译：高压梯度系统防回流
公开(公告)号：US06780315B2
公开(公告)日：2004-08-24
申请号：US10314725
申请日：2002-12-09
申请人： Hal Richardson , Richard W. Andrews
发明人： Hal Richardson , Richard W. Andrews
IPC分类号： B01D1508
CPC分类号： G01N30/32 , G01N30/10 , G01N30/36 , G01N2030/322 , G01N2030/328 , Y10T137/7838 , Y10T137/87684 , G01N30/34
摘要： Gradient performance with high pressure gradient solvent delivery system is optimized by approximation of infinite stroke volume of high pressure pumps by the addition of pulse dampening with backflow prevention to each high pressure pump. The backflow prevention adds sufficient minimum flow resistance, thereby enhancing the performance of the pulse dampening over a wider range of flow rates resulting in consistent gradient performance.
摘要翻译：使用高压梯度溶剂输送系统的梯度性能通过对每个高压泵添加具有防回流的脉冲阻尼来近似高压泵的无限冲程体积来优化。防回流增加了足够的最小流阻，从而在更宽的流量范围内增强了脉冲阻尼的性能，从而达到了一致的梯度性能。

9. 发明授权

US08956534B2 Passive column pre-heater with sample band spreading reduction feature 有权
公开(公告)号：US08956534B2
公开(公告)日：2015-02-17
申请号：US11631730
申请日：2005-08-05
申请人： Edward J. Ognibene , Joseph A. Kareh , Uwe D. Neue , Theodore D. Ciolkosz , Richard W. Andrews , Marc Lemelin , Peyton C. Beals
发明人： Edward J. Ognibene , Joseph A. Kareh , Uwe D. Neue , Theodore D. Ciolkosz , Richard W. Andrews , Marc Lemelin , Peyton C. Beals
IPC分类号： G01N30/30 , B01D15/20 , B01D15/12 , B01D15/16
CPC分类号： B01D15/161 , B01D15/12 , B01D15/20 , G01N30/30 , G01N2030/3046
摘要： Disclosed is a chromatographic system and method which includes a passive pre-heater assembly. In the inventive system and method a fluid mixture is supplied from an injector to the pre-heater assembly and then to a chromatographic column having an active heating source. The pre-heater assembly includes a convoluted tube with first and second ends and a fluid passage extending centrally therebetween, first and second end fittings attached respectively to the first and second ends of the convoluted tube, and a thermally conductive film attached to an outer surface of the convoluted tube. The first end fitting is adapted for fluidly connecting the first end of the convoluted tube to the injector and the second end fitting is adapted for fluidly connecting the second end of the convoluted tube to the chromatographic column. The thermally conductive film conveys heat from an active heating source of a chromatographic column to the convoluted tube when the pre-heater assembly is positioned adjacent to the active heating source. The central fluid passage in the convoluted tube has a series of bends which function to create a secondary fluid flow field that is substantially orthogonal to a primary flow field established when fluid is traversing the fluid passage in the tube.

10. 发明申请

US20130206666A1 Process For Preparing Liquid Mixtures Of Known pH And Salt Concentration 有权
标题翻译：制备已知pH和盐浓度的液体混合物的方法
公开(公告)号：US20130206666A1
公开(公告)日：2013-08-15
申请号：US13695811
申请日：2011-05-24
申请人： Richard W. Andrews , John Heden , Michael Jackson , John Lamoureux , Guo-Zhong Li , Barry Sunray , Thomas E. Wheat
发明人： Richard W. Andrews , John Heden , Michael Jackson , John Lamoureux , Guo-Zhong Li , Barry Sunray , Thomas E. Wheat
IPC分类号： B01D15/16
CPC分类号： B01D15/16 , B01D15/168 , B01F15/04 , G01N30/34 , G05D11/02
摘要： A method of preparing a liquid mixture for use in a liquid chromatography system is provided. The mixture comprises one or more acids, one or more bases, one or more salts, and one or more solvents, and the method comprises the steps of: i) calculating pH and/or salt concentration at a particular time t from a user-determined gradient function; and ii) based on the values obtained in step (i), calculating percent acid, percent base, percent salt and percent solvent in the liquid mixture at time t. A liquid chromatography system incorporating such method is also provided.
摘要翻译：提供了制备用于液相色谱系统的液体混合物的方法。所述混合物包含一种或多种酸，一种或多种碱，一种或多种盐和一种或多种溶剂，并且所述方法包括以下步骤：i）从特定时间t计算pH和/或盐浓度，确定梯度函数; 和ii）基于步骤（i）中获得的值，在时间t计算液体混合物中的酸的百分数，碱的百分比，盐的百分比和溶剂的百分比。还提供了包含这种方法的液相色谱系统。

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