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1. 发明授权

US08956534B2 Passive column pre-heater with sample band spreading reduction feature 有权
公开(公告)号：US08956534B2
公开(公告)日：2015-02-17
申请号：US11631730
申请日：2005-08-05
申请人： Edward J. Ognibene , Joseph A. Kareh , Uwe D. Neue , Theodore D. Ciolkosz , Richard W. Andrews , Marc Lemelin , Peyton C. Beals
发明人： Edward J. Ognibene , Joseph A. Kareh , Uwe D. Neue , Theodore D. Ciolkosz , Richard W. Andrews , Marc Lemelin , Peyton C. Beals
IPC分类号： G01N30/30 , B01D15/20 , B01D15/12 , B01D15/16
CPC分类号： B01D15/161 , B01D15/12 , B01D15/20 , G01N30/30 , G01N2030/3046
摘要： Disclosed is a chromatographic system and method which includes a passive pre-heater assembly. In the inventive system and method a fluid mixture is supplied from an injector to the pre-heater assembly and then to a chromatographic column having an active heating source. The pre-heater assembly includes a convoluted tube with first and second ends and a fluid passage extending centrally therebetween, first and second end fittings attached respectively to the first and second ends of the convoluted tube, and a thermally conductive film attached to an outer surface of the convoluted tube. The first end fitting is adapted for fluidly connecting the first end of the convoluted tube to the injector and the second end fitting is adapted for fluidly connecting the second end of the convoluted tube to the chromatographic column. The thermally conductive film conveys heat from an active heating source of a chromatographic column to the convoluted tube when the pre-heater assembly is positioned adjacent to the active heating source. The central fluid passage in the convoluted tube has a series of bends which function to create a secondary fluid flow field that is substantially orthogonal to a primary flow field established when fluid is traversing the fluid passage in the tube.

2. 发明申请

US20090211978A1 Passive column pre-heater with sample band spreading reduction feature 有权
标题翻译：被动柱预热器带有采样带扩散减少功能
公开(公告)号：US20090211978A1
公开(公告)日：2009-08-27
申请号：US11631730
申请日：2005-08-05
申请人： Edward J. Ognibene , Joseph A. Kareh , Uwe D. Neue , Theodore D. Ciolkosz , Richard W. Andrews , Marc Lemelin , Peyton C. Beals
发明人： Edward J. Ognibene , Joseph A. Kareh , Uwe D. Neue , Theodore D. Ciolkosz , Richard W. Andrews , Marc Lemelin , Peyton C. Beals
IPC分类号： B01D15/08
CPC分类号： B01D15/161 , B01D15/12 , B01D15/20 , G01N30/30 , G01N2030/3046
摘要： Disclosed is a chromatographic system and method which includes a passive pre-heater assembly. In the inventive system and method a fluid mixture is supplied from an injector to the pre-heater assembly and then to a chromatographic column having an active heating source. The pre-heater assembly includes a convoluted tube with first and second ends and a fluid passage extending centrally therebetween, first and second end fittings attached respectively to the first and second ends of the convoluted tube, and a thermally conductive film attached to an outer surface of the convoluted tube. The first end fitting is adapted for fluidly connecting the first end of the convoluted tube to the injector and the second end fitting is adapted for fluidly connecting the second end of the convoluted tube to the chromatographic column. The thermally conductive film conveys heat from an active heating source of a chromatographic column to the convoluted tube when the pre-heater assembly is positioned adjacent to the active heating source. The central fluid passage in the convoluted tube has a series of bends which function to create a secondary fluid flow field that is substantially orthogonal to a primary flow field established when fluid is traversing the fluid passage in the tube.
摘要翻译：公开了一种包括无源预热器组件的色谱系统和方法。在本发明的系统和方法中，将流体混合物从注射器供应到预热器组件，然后到具有主动加热源的色谱柱。预热器组件包括具有第一和第二端的回旋管和在其间中间延伸的流体通道，分别连接到回旋管的第一和第二端的第一和第二端配件以及附接到外表面的导热膜的回旋管。第一端配件适于将回旋管的第一端流体连接到注射器，并且第二端配件适于将回旋管的第二端流体连接到色谱柱。当预热器组件邻近主动加热源定位时，导热膜将热量从色谱柱的活性加热源传送到回旋管。回旋管中的中心流体通道具有一系列弯曲，其功能是产生与流体横穿管中的流体通道所建立的主流场大致正交的次级流体流场。

3. 发明授权

US10788504B2 Apparatus for controlling sample position in a liquid chromatography system 有权
公开(公告)号：US10788504B2
公开(公告)日：2020-09-29
申请号：US13520194
申请日：2011-01-11
申请人： Joshua A. Burnett , James E. Usowicz , Marc Lemelin
发明人： Joshua A. Burnett , James E. Usowicz , Marc Lemelin
IPC分类号： G01N35/02 , G01N35/04 , B01D15/08
摘要： Described is an apparatus for controlling a position of a sample in a liquid chromatography system. The apparatus includes a rotary drive mechanism, a stepper motor and a rotational coupling system such as a drive belt and pulley system. The rotational coupling system transfers the rotational motion of a motor shaft to a shaft of the rotary drive mechanism. Advantageously, the stepper motor is remote to the sample compartment for improved safety in the event that volatile gas accumulates within the sample compartment. The rotary drive mechanism can be configured in a small form factor and can provide highly stable rotation of an attached sample tray to accommodate the requirements of compact liquid chromatography systems. In addition, leakage from inside the sample compartment to the ambient environment is substantially reduced or eliminated, resulting in better thermal control of the sample compartment.

4. 发明授权

US09075035B2 Injection port needle support and washing 有权
标题翻译：注射口针支撑和洗涤
公开(公告)号：US09075035B2
公开(公告)日：2015-07-07
申请号：US13520610
申请日：2011-01-10
申请人： James E. Usowicz , Tony A. Lin , Joshua A. Burnett , Marc Lemelin
发明人： James E. Usowicz , Tony A. Lin , Joshua A. Burnett , Marc Lemelin
IPC分类号： G01N1/02 , G01N30/18 , G01N35/10
CPC分类号： G01N30/18 , G01N35/1004 , G01N35/1009 , G01N35/1097 , G01N2030/185
摘要： Described are techniques for use with an injection port. The injection port includes a needle support structure configured to accommodate a needle containing a sample aspirated therein. The injection port includes a needle seal having a first surface thereof in contact with a second surface of a tip of the needle. A seal is formed when the first surface contacts the second surface and a sufficient force is applied to the needle.
摘要翻译：描述了与注射口一起使用的技术。注射口包括针支撑结构，其构造成容纳包含吸入其中的样品的针。注射口包括针密封件，其针头的第一表面与针尖的第二表面相接触。当第一表面接触第二表面并且向针施加足够的力时形成密封。

5. 发明申请

US20130112604A1 Valve For High Pressure Analytical System 审中-公开
标题翻译：高压分析系统阀
公开(公告)号：US20130112604A1
公开(公告)日：2013-05-09
申请号：US13695823
申请日：2011-06-14
申请人： Russell L. Keene , Marc Lemelin
发明人： Russell L. Keene , Marc Lemelin
IPC分类号： F16K3/08 , B01D15/08
CPC分类号： F16K3/08 , B01D15/08 , F16K11/0743 , G01N30/20 , G01N35/1097 , G01N2030/202
摘要： A high pressure valve, comprising a stator having a stator sealing surface with at least one stator port and a rotor having a rotor sealing surface with at least one rotor port or channel. The rotor is movable with respect to the stator to selectively move the rotor port or channel into and/or out of alignment with the stator port thereby to open and/or close the valve. The stator port is provided by a passage with a first part that extends perpendicularly from the stator sealing surface and a second part that extends from the first part in a direction that is other than perpendicular from the stator sealing surface.
摘要翻译：一种高压阀，包括具有至少一个定子端口的定子密封表面的定子和具有至少一个转子端口或通道的转子密封表面的转子。转子可相对于定子移动以选择性地将转子端口或通道移动到定子端口中和/或不与定子端口对准，从而打开和/或关闭阀门。定子端口由具有从定子密封表面垂直延伸的第一部分的通道提供，第二部分从除了垂直于定子密封表面的方向从第一部分延伸。

6. 发明申请

US20130019699A1 INJECTION PORT NEEDLE SUPPORT AND WASHING 有权
标题翻译：注射口针头支撑和洗涤
公开(公告)号：US20130019699A1
公开(公告)日：2013-01-24
申请号：US13520610
申请日：2011-01-10
申请人： James E. Usowicz , Tony A. Lin , Joshua A. Burnett , Marc Lemelin
发明人： James E. Usowicz , Tony A. Lin , Joshua A. Burnett , Marc Lemelin
IPC分类号： G01N1/00
CPC分类号： G01N30/18 , G01N35/1004 , G01N35/1009 , G01N35/1097 , G01N2030/185
摘要： Described are techniques for use with an injection port. The injection port includes a needle support structure configured to accommodate a needle containing a sample aspirated therein. The injection port includes a needle seal having a first surface thereof in contact with a second surface of a tip of the needle. A seal is formed when the first surface contacts the second surface and a sufficient force is applied to the needle.
摘要翻译：描述了与注射口一起使用的技术。注射口包括针支撑结构，其构造成容纳包含吸入其中的样品的针。注射口包括针密封件，其针头的第一表面与针尖的第二表面相接触。当第一表面接触第二表面并且向针施加足够的力时形成密封。

7. 发明授权

US09028780B2 Compound sample needle for liquid chromatograph 有权
标题翻译：用于液相色谱的复合样品针
公开(公告)号：US09028780B2
公开(公告)日：2015-05-12
申请号：US13519687
申请日：2011-01-11
申请人： John Auclair , James E. Usowicz , Tony A. Lin , Marc Lemelin , Robert A. Jencks , Kenneth R. Plant
发明人： John Auclair , James E. Usowicz , Tony A. Lin , Marc Lemelin , Robert A. Jencks , Kenneth R. Plant
IPC分类号： G01N1/10 , G01N30/18 , B01L3/00 , G01N30/36 , G01N30/24 , G01N30/60
CPC分类号： G01N30/18 , B01L3/561 , B01L3/563 , B01L2200/026 , G01N1/10 , G01N30/24 , G01N30/36 , G01N30/6039
摘要： Described is a compound sample needle for a liquid chromatography system. In one embodiment, the compound sample needle includes a rigid needle having a coupling end with a face and a counterbore. The compound sample needle also includes a flexible tubing having an outer surface and a coupling end disposed in the counterbore of the rigid needle. The coupling end of the flexible tubing has a face adjacent to a base of the counterbore. The coupling ends of the rigid needle and flexible tubing are secured to each other by a weld formed along a circumference of the outer surface and the face of the rigid needle. A rigid sleeve protects the welded joint. The compound sample needle is suitable for injection into the high pressure mobile phase of ultra performance liquid chromatography systems.
摘要翻译：描述了用于液相色谱系统的复合样品针。在一个实施例中，复合样品针包括刚性针，其具有带有面和联轴器的连接端。复合样品针还包括柔性管，其具有设置在刚性针的沉孔中的外表面和联接端。柔性管的联接端具有邻近沉孔的底部的面。刚性针和柔性管的联接端通过沿着外表面的圆周和刚性针的表面形成的焊接彼此固定。刚性套筒保护焊接接头。复合样品针适用于高效液相色谱系统的高压流动相。

8. 发明申请

US20130008237A1 NEEDLE SEAL FORCE SENSOR 有权
标题翻译：针式密封传感器
公开(公告)号：US20130008237A1
公开(公告)日：2013-01-10
申请号：US13520605
申请日：2011-01-10
申请人： James E. Usowicz , Tony A. Lin , Joshua A. Burnett , Marc Lemelin
发明人： James E. Usowicz , Tony A. Lin , Joshua A. Burnett , Marc Lemelin
IPC分类号： G01N30/00
CPC分类号： G01N30/16 , G01L1/00 , G01L5/0038 , G01N30/24 , G01N35/1011 , G01N2030/185
摘要： Described are techniques for force sensing. A computing device is configured to have a desired force setting. A first vertical position of a needle is determined using the computer device. A control signal is sent from the computing device to a positioning device. In response to the control signal, the needle is positioned at the first vertical position. When in the first vertical position, surfaces of a tip of the needle are in contact with surfaces of an opening of a sealing member and positioning the needle causes application of a force at surfaces of the opening in contact with surfaces of the tip of the needle. In response to application of the force, a spring is compressed a distance that is proportional to the force. The force is measured using a force sensor.
摘要翻译：描述了用于力感测的技术。计算设备被配置为具有期望的力设置。使用计算机设备确定针的第一垂直位置。控制信号从计算设备发送到定位设备。响应于控制信号，针位于第一垂直位置。当在第一垂直位置时，针的尖端的表面与密封构件的开口的表面接触，并且定位针使得在开口的表面处施加力以与针的尖端的表面接触。响应于施加力，弹簧被压缩与力成比例的距离。使用力传感器测量力。

9. 发明授权

US08997587B2 Needle seal force sensor 有权
标题翻译：针密封力传感器
公开(公告)号：US08997587B2
公开(公告)日：2015-04-07
申请号：US13520605
申请日：2011-01-10
申请人： James E. Usowicz , Tony A. Lin , Joshua A. Burnett , Marc Lemelin
发明人： James E. Usowicz , Tony A. Lin , Joshua A. Burnett , Marc Lemelin
IPC分类号： G01L5/00 , G01N30/16 , G01N35/10 , G01N30/18 , G01L1/00 , G01N30/24
CPC分类号： G01N30/16 , G01L1/00 , G01L5/0038 , G01N30/24 , G01N35/1011 , G01N2030/185
摘要： Described are techniques for force sensing. A computing device is configured to have a desired force setting. A first vertical position of a needle is determined using the computer device. A control signal is sent from the computing device to a positioning device. In response to the control signal, the needle is positioned at the first vertical position. When in the first vertical position, surfaces of a tip of the needle are in contact with surfaces of an opening of a sealing member and positioning the needle causes application of a force at surfaces of the opening in contact with surfaces of the tip of the needle. In response to application of the force, a spring is compressed a distance that is proportional to the force. The force is measured using a force sensor.
摘要翻译：描述了用于力感测的技术。计算设备被配置为具有期望的力设置。使用计算机设备确定针的第一垂直位置。控制信号从计算设备发送到定位设备。响应于控制信号，针位于第一垂直位置。当在第一垂直位置时，针的尖端的表面与密封构件的开口的表面接触，并且定位针使得在开口的表面处施加力以与针的尖端的表面接触。响应于施加力，弹簧被压缩与力成比例的距离。使用力传感器测量力。

10. 发明申请

US20120328486A1 COMPOUND SAMPLE NEEDLE FOR LIQUID CHROMATOGRAPH 有权
标题翻译：化合物样品用于液相色谱
公开(公告)号：US20120328486A1
公开(公告)日：2012-12-27
申请号：US13519687
申请日：2011-01-11
申请人： John Auclair , James E. Usowicz , Tony A. Lin , Marc Lemelin , Robert A. Jencks , Kenneth R. Plant
发明人： John Auclair , James E. Usowicz , Tony A. Lin , Marc Lemelin , Robert A. Jencks , Kenneth R. Plant
IPC分类号： G01N1/10
CPC分类号： G01N30/18 , B01L3/561 , B01L3/563 , B01L2200/026 , G01N1/10 , G01N30/24 , G01N30/36 , G01N30/6039
摘要： Described is a compound sample needle for a liquid chromatography system. In one embodiment, the compound sample needle includes a rigid needle having a coupling end with a face and a counterbore. The compound sample needle also includes a flexible tubing having an outer surface and a coupling end disposed in the counterbore of the rigid needle. The coupling end of the flexible tubing has a face adjacent to a base of the counterbore. The coupling ends of the rigid needle and flexible tubing are secured to each other by a weld formed along a circumference of the outer surface and the face of the rigid needle. A rigid sleeve protects the welded joint. The compound sample needle is suitable for injection into the high pressure mobile phase of ultra performance liquid chromatography systems.
摘要翻译：描述了用于液相色谱系统的复合样品针。在一个实施例中，复合样品针包括刚性针，其具有带有面和联轴器的连接端。复合样品针还包括柔性管，其具有设置在刚性针的沉孔中的外表面和联接端。柔性管的联接端具有邻近沉孔的底部的面。刚性针和柔性管的联接端通过沿着外表面的圆周和刚性针的表面形成的焊接彼此固定。刚性套筒保护焊接接头。复合样品针适用于高效液相色谱系统的高压流动相。

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