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1. 发明授权

US09169210B2 Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex 有权
公开(公告)号：US09169210B2
公开(公告)日：2015-10-27
申请号：US13603965
申请日：2012-09-05
申请人： Robert Eugene Hormann , David W. Potter , Orestes Chortyk , Colin M. Tice , Glenn Richard Carlson , Andrew Meyer , Thomas R. Opie
发明人： Robert Eugene Hormann , David W. Potter , Orestes Chortyk , Colin M. Tice , Glenn Richard Carlson , Andrew Meyer , Thomas R. Opie
IPC分类号： C07C243/38 , C07D213/63 , C07D213/87 , C07C243/24 , C07C251/08 , C07C251/38 , C07C255/66 , C07C281/10 , C07C309/59 , C07C317/44 , C07C317/46 , C07D209/42 , C07D213/81 , C07D213/82 , C07D231/14 , C07D231/56 , C07D235/06 , C07D237/24 , C07D239/52 , C07D241/24 , C07D271/12 , C07D317/68 , C07D319/18 , C07D405/12 , C07C243/18
CPC分类号： C07C241/04 , A61K31/166 , A61K31/222 , A61K31/357 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/455 , A61K31/4965 , C07C243/18 , C07C243/24 , C07C243/38 , C07C251/08 , C07C251/38 , C07C255/66 , C07C281/10 , C07C309/59 , C07C315/02 , C07C317/44 , C07C317/46 , C07D209/42 , C07D213/81 , C07D213/82 , C07D213/86 , C07D213/87 , C07D231/14 , C07D231/56 , C07D235/06 , C07D235/24 , C07D237/24 , C07D239/52 , C07D241/24 , C07D271/12 , C07D317/68 , C07D319/08 , C07D319/18 , C07D319/20 , C07D405/12 , C12N9/0069 , C12N15/635 , C12P21/00 , Y02A50/471
摘要： The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.

2. 发明授权

US08748125B2 Diacylhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex 有权
标题翻译：二酰基肼配体，用于通过蜕皮激素受体复合物调节哺乳动物系统中外源基因的表达
公开(公告)号：US08748125B2
公开(公告)日：2014-06-10
申请号：US11838044
申请日：2007-08-13
申请人： Robert Eugene Hormann , Colin M. Tice , Orestes Chortyk , Howard Smith , Thomas Meteyer
发明人： Robert Eugene Hormann , Colin M. Tice , Orestes Chortyk , Howard Smith , Thomas Meteyer
IPC分类号： C12P21/06 , C12P21/04 , C12N5/07 , C12N5/071 , C12N5/00 , C12N15/00 , C07H21/02 , C07H21/04
CPC分类号： C07C243/38 , C07D213/87 , C07D311/58 , C07D311/66 , C07D319/20 , C07F7/1896 , C12N9/0069 , C12N15/85 , C12N2830/002
摘要： The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
摘要翻译：本发明涉及用于基于核受体的诱导型基因表达系统的非甾体配体，以及调节外源基因表达的方法，其中蜕皮激素受体复合物包含：DNA结合结构域; 配体结合域; 反式激活域并且配体与包含以下的DNA构建体接触：外源基因和应答元件; 其中外源基因处于响应元件的控制之下，并且在配体存在下DNA结合结构域与响应元件的结合导致基因的激活或抑制。

3. 发明授权

US08168426B2 Multiple inducible gene regulation system 有权
标题翻译：多重诱导型基因调控系统
公开(公告)号：US08168426B2
公开(公告)日：2012-05-01
申请号：US12707599
申请日：2010-02-17
申请人： Tarlochan Singh Dhadialla , Dean Ervin Cress , Glenn Richard Carlson , Robert Eugene Hormann , Subba Reddy Palli , Arthur John Kudla , Ronald Phillip Herzig, Jr. , Mohan Philip
发明人： Tarlochan Singh Dhadialla , Dean Ervin Cress , Glenn Richard Carlson , Robert Eugene Hormann , Subba Reddy Palli , Arthur John Kudla , Ronald Phillip Herzig, Jr. , Mohan Philip
IPC分类号： C12N5/00 , C12N15/00 , C12N5/07 , C12N5/10 , C12N5/071 , C12N5/02 , C12N1/00 , C12P21/06 , C07H21/04
CPC分类号： C12N15/635 , A01K2217/05 , A61K48/00 , C07K14/721 , C07K2319/00 , C12N15/70 , C12N15/74 , C12N15/80 , C12N15/81 , C12N15/8217 , C12N15/8238 , C12N15/8241 , C12N15/85 , C12N15/861 , G01N33/6845
摘要： The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions within cells to simultaneously control the quantitative expression of multiple genes.
摘要翻译：本发明涉及生物技术或遗传工程领域。更具体地，本发明涉及在细胞内起作用以同时控制多个基因的定量表达的多重诱导型基因调控系统。

4. 发明申请

US20120046322A1 Bioavailable Diacylhydrazine Ligands for Modulating the Expression of Exogenous Genes via an Ecdysone Receptor Complex 有权
标题翻译：用于通过蜕皮激素受体复合物调节外源基因表达的生物可利用的二酰基肼配体
公开(公告)号：US20120046322A1
公开(公告)日：2012-02-23
申请号：US13243210
申请日：2011-09-23
申请人： Robert Eugene HORMANN , David W. Potter , Orestes Chortyk , Colin M. Tice , Glenn Richard Carlson , Andrew Meyer , Thomas R. Opie
发明人： Robert Eugene HORMANN , David W. Potter , Orestes Chortyk , Colin M. Tice , Glenn Richard Carlson , Andrew Meyer , Thomas R. Opie
IPC分类号： A61K31/166 , C07D319/18 , C07D213/87 , A61K31/357 , A61K31/455 , A61P3/10 , A61P31/00 , A61P23/00 , A61P7/02 , A61P33/02 , A61P19/02 , A61P9/00 , C07C243/18 , A61P29/00
CPC分类号： C07C241/04 , A61K31/166 , A61K31/222 , A61K31/357 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/455 , A61K31/4965 , C07C243/18 , C07C243/24 , C07C243/38 , C07C251/08 , C07C251/38 , C07C255/66 , C07C281/10 , C07C309/59 , C07C315/02 , C07C317/44 , C07C317/46 , C07D209/42 , C07D213/81 , C07D213/82 , C07D213/86 , C07D213/87 , C07D231/14 , C07D231/56 , C07D235/06 , C07D235/24 , C07D237/24 , C07D239/52 , C07D241/24 , C07D271/12 , C07D317/68 , C07D319/08 , C07D319/18 , C07D319/20 , C07D405/12 , C12N9/0069 , C12N15/635 , C12P21/00 , Y02A50/471
摘要： The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
摘要翻译：本发明涉及用于基于核受体的诱导型基因表达系统的非甾体配体，以及调节外源基因表达的方法，其中蜕皮激素受体复合物包含：DNA结合结构域; 配体结合域; 反式激活域并且配体与DNA构建体接触，所述DNA构建体包含：外源基因和应答元件; 其中外源基因处于响应元件的控制之下，并且在配体存在下DNA结合结构域与响应元件的结合导致基因的激活或抑制。

5. 发明申请

US20080255210A1 OXADIAZOLINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX 审中-公开
标题翻译：用于通过ECDYSONE受体复合物调节外源基因表达的OXADIAZOLINE LIGANDS
公开(公告)号：US20080255210A1
公开(公告)日：2008-10-16
申请号：US11838095
申请日：2007-08-13
申请人： Robert Eugene Hormann , Orestes Chortyk , Dat Phat Le
发明人： Robert Eugene Hormann , Orestes Chortyk , Dat Phat Le
IPC分类号： A61K31/4245 , C07D271/07 , C12N5/02 , C12P21/06
CPC分类号： C07D271/06 , C07D413/12
摘要： The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
摘要翻译：本发明涉及用于基于核受体的诱导型基因表达系统的非甾体配体，以及调节外源基因表达的方法，其中蜕皮激素受体复合物包含：DNA结合结构域; 配体结合域; 反式激活域并且配体与包含以下的DNA构建体接触：外源基因和应答元件; 其中外源基因处于响应元件的控制之下，并且在配体存在下DNA结合结构域与响应元件的结合导致基因的激活或抑制。

6. 发明授权

US5780652A Process for chroman carboxylates 失效
标题翻译：苯并二氢吡喃羧酸盐的工艺
公开(公告)号：US5780652A
公开(公告)日：1998-07-14
申请号：US890251
申请日：1997-07-09
申请人： Robert Eugene Hormann
发明人： Robert Eugene Hormann
IPC分类号： C07C69/757 , C07D311/58 , C07D311/74
CPC分类号： C07C69/757 , C07D311/58 , C07D311/74
摘要： This invention relates to an improved process for the preparation of 5-methylchroman-6-carboxylic acid, a useful intermediate in the preparation of chroman-containing diacylhydrazines which are useful as insecticides, by reacting a Hagemann's ester with a propargyl derivative in the presence of a base and a solvent to produce a propargyl ether, rearranging the propargyl ether by application of heat with a suitable catalyst being present, with or without a solvent, to produce a cyclic ether type compound and isomerizing the cyclic ether type compound with a catalyst in a suitable solvent to produce a chroman ester. The propargyl ethers and the cyclic ether type compounds produced by the process of the present invention are new.
摘要翻译：本发明涉及一种制备5-甲基苯并二氢吡喃-6-羧酸的改进方法，该5-甲基苯并二氢吡喃-6-羧酸是制备可用作杀虫剂的含色马酰二酰肼的有用中间体，可通过使Hagemann酯与炔丙基衍生物在碱和溶剂以产生炔丙基醚，通过在存在或不含有溶剂的情况下用合适的催化剂进行加热来重排丙炔醚，以产生环醚型化合物并用催化剂异构化环醚型化合物合适的溶剂以产生苯并二氢吡喃酯。通过本发明方法制备的炔丙醚和环醚型化合物是新的。

7. 发明授权

US08669072B2 Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex 有权
标题翻译：用于通过蜕皮激素受体复合物调节外源基因表达的恶二唑啉配体
公开(公告)号：US08669072B2
公开(公告)日：2014-03-11
申请号：US11838090
申请日：2007-08-13
申请人： Robert Eugene Hormann , Orestes Chortyk , Dat Phat Le
发明人： Robert Eugene Hormann , Orestes Chortyk , Dat Phat Le
IPC分类号： C12P21/02
CPC分类号： C07D271/06 , C07D413/12
摘要： The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
摘要翻译：本发明涉及用于基于核受体的诱导型基因表达系统的非甾体配体，以及调节外源基因表达的方法，其中蜕皮激素受体复合物包含：DNA结合结构域; 配体结合域; 反式激活域并且配体与包含以下的DNA构建体接触：外源基因和应答元件; 其中外源基因处于响应元件的控制之下，并且在配体存在下DNA结合结构域与响应元件的结合导致基因的激活或抑制。

8. 发明授权

US08105825B2 Multiple inducible gene regulation system 有权
公开(公告)号：US08105825B2
公开(公告)日：2012-01-31
申请号：US09965697
申请日：2001-09-27
申请人： Tarlochan Singh Dhadialla , Dean Ervin Cress , Glenn Richard Carlson , Robert Eugene Hormann , Subba Reddy Palli , Arthur John Kudla , Ronald Phillip Herzig, Jr. , Mohan Philip
发明人： Tarlochan Singh Dhadialla , Dean Ervin Cress , Glenn Richard Carlson , Robert Eugene Hormann , Subba Reddy Palli , Arthur John Kudla , Ronald Phillip Herzig, Jr. , Mohan Philip
IPC分类号： C12N5/00 , C12N15/00 , C12N5/07 , C12N5/10 , C12N5/071 , C12N5/02 , C12N1/00 , C12P21/06 , C07H21/04 , C07K1/00
CPC分类号： C12N15/635 , A01K2217/05 , A61K48/00 , C07K14/721 , C07K2319/00 , C12N15/70 , C12N15/74 , C12N15/80 , C12N15/81 , C12N15/8217 , C12N15/8238 , C12N15/8241 , C12N15/85 , C12N15/861 , G01N33/6845
摘要： The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions within cells to simultaneously control the quantitative expression of multiple genes.

9. 发明授权

US07563928B2 Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex 有权
标题翻译：生物可利用的二酰肼配体，用于通过蜕皮激素受体复合物调节外源基因的表达
公开(公告)号：US07563928B2
公开(公告)日：2009-07-21
申请号：US11841568
申请日：2007-08-20
申请人： Robert Eugene Hormann , David W. Potter , Orestes Chortyk , Colin M. Tice , Glenn Richard Carlson , Andrew Meyer , Thomas R. Opie
发明人： Robert Eugene Hormann , David W. Potter , Orestes Chortyk , Colin M. Tice , Glenn Richard Carlson , Andrew Meyer , Thomas R. Opie
IPC分类号： C01C243/32 , A61K31/16
CPC分类号： C07C241/04 , A61K31/166 , A61K31/222 , A61K31/357 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/455 , A61K31/4965 , C07C243/18 , C07C243/24 , C07C243/38 , C07C251/08 , C07C251/38 , C07C255/66 , C07C281/10 , C07C309/59 , C07C315/02 , C07C317/44 , C07C317/46 , C07D209/42 , C07D213/81 , C07D213/82 , C07D213/86 , C07D213/87 , C07D231/14 , C07D231/56 , C07D235/06 , C07D235/24 , C07D237/24 , C07D239/52 , C07D241/24 , C07D271/12 , C07D317/68 , C07D319/08 , C07D319/18 , C07D319/20 , C07D405/12 , C12N9/0069 , C12N15/635 , C12P21/00 , Y02A50/471
摘要： The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
摘要翻译：本发明涉及用于基于核受体的诱导型基因表达系统的非甾体配体，以及调节外源基因表达的方法，其中蜕皮激素受体复合物包含：DNA结合结构域; 配体结合域; 反式激活域并且配体与包含以下的DNA构建体接触：外源基因和应答元件; 其中外源基因处于响应元件的控制之下，并且在配体存在下DNA结合结构域与响应元件的结合导致基因的激活或抑制。

10. 发明申请

US20090149514A1 OXADIAZOLINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX 有权
标题翻译：用于通过ECDYSONE受体复合物调节外源基因表达的OXADIAZOLINE LIGANDS
公开(公告)号：US20090149514A1
公开(公告)日：2009-06-11
申请号：US11935255
申请日：2007-11-05
申请人： Robert Eugene HORMANN , Orestes Chortyk , Dat Phat Le
发明人： Robert Eugene HORMANN , Orestes Chortyk , Dat Phat Le
IPC分类号： A61K31/4245 , C12N5/10 , C12P21/00 , A61P35/00
CPC分类号： C07D271/06 , C07D413/12
摘要： The present invention relates to methods to use non-steroidal ligands in nuclear receptor-based inducible gene expression system to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
摘要翻译：本发明涉及在基于核受体的诱导型基因表达系统中使用非甾体配体以调节外源基因表达的方法，其中蜕皮激素受体复合物包含：DNA结合结构域; 配体结合域; 反式激活域并且配体与包含以下的DNA构建体接触：外源基因和应答元件; 其中外源基因处于响应元件的控制之下，并且在配体存在下DNA结合结构域与响应元件的结合导致基因的激活或抑制。

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