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1. 发明授权

US08756711B2 Method for staging cancer progression by AFM 有权
标题翻译：通过AFM分期癌症进展的方法
公开(公告)号：US08756711B2
公开(公告)日：2014-06-17
申请号：US13992743
申请日：2011-12-12
申请人： Marija Plodinec , Roderick Lim , Marko Loparic
发明人： Marija Plodinec , Roderick Lim , Marko Loparic
IPC分类号： G01Q60/00
CPC分类号： G01N33/4833 , G01N2001/2873 , G01N2800/7028 , G01Q60/366 , G01Q60/38
摘要： The present invention relates to a method for classifying a tissue biopsy sample obtained from a tumor, comprising determining a plurality of stiffness values for said sample by measuring a plurality of points on the sample with a spatial resolution of at least 100 μm and assigning the sample to a probability of malignancy. A sample showing a unimodal stiffness distribution is assigned to a high probability of being non-malignant, and a sample showing an at least bimodal stiffness distribution is assigned to a high probability of being malignant, wherein said stiffness distribution is characterized by a first peak exhibiting an at least two-fold higher stiffness value than a second peak. The present invention further relates to a system for classifying a tumor tissue biopsy sample.
摘要翻译：本发明涉及一种用于分类从肿瘤获得的组织活检样品的方法，包括通过以至少100μm的空间分辨率测量样品上的多个点来确定所述样品的多个刚度值，并分配样品以恶性肿瘤的概率。显示单峰刚度分布的样本被赋予非恶性的高概率，并且显示至少双峰刚度分布的样本被赋予恶性的高概率，其中所述刚度分布的特征在于第一峰显示比第二个峰高至少两倍的刚度值。本发明还涉及用于分类肿瘤组织活组织检查样品的系统。

2. 发明申请

US20140007309A1 METHOD FOR STAGING CANCER PROGRESSION BY AFM 有权
标题翻译：用AFM进行癌症进展的方法
公开(公告)号：US20140007309A1
公开(公告)日：2014-01-02
申请号：US13992743
申请日：2011-12-12
申请人： Marija Plodinec , Roderick Lim , Marko Loparic
发明人： Marija Plodinec , Roderick Lim , Marko Loparic
IPC分类号： G01N33/483 , G01Q60/38
CPC分类号： G01N33/4833 , G01N2001/2873 , G01N2800/7028 , G01Q60/366 , G01Q60/38
摘要： The present invention relates to a method for classifying a tissue biopsy sample obtained from a tumour, comprising determining a plurality of stiffness values for said sample by measuring a plurality of points on the sample with a spatial resolution of at least 100 μm and assigning the sample to a probability of malignancy. A sample showing a unimodal stiffness distribution is assigned to a high probability of being non-malignant, and a sample showing an at least bimodal stiffness distribution is assigned to a high probability of being malignant, wherein said stiffness distribution is characterized by a first peak exhibiting an at least two-fold higher stiffness value than a second peak. The present invention further relates to a system for classifying a tumour tissue biopsy sample.
摘要翻译：本发明涉及一种用于分类从肿瘤获得的组织活组织检查样品的方法，包括通过以至少100μm的空间分辨率测量样品上的多个点来确定所述样品的多个刚度值，并分配样品以恶性肿瘤的概率。显示单峰刚度分布的样本被赋予非恶性的高概率，并且显示至少双峰刚度分布的样本被赋予恶性的高概率，其中所述刚度分布的特征在于第一峰显示比第二个峰高至少两倍的刚度值。本发明还涉及用于分类肿瘤组织活组织检查样品的系统。

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