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    • 3. 发明授权
    • Method for staging cancer progression by AFM
    • 通过AFM分期癌症进展的方法
    • US08756711B2
    • 2014-06-17
    • US13992743
    • 2011-12-12
    • Marija PlodinecRoderick LimMarko Loparic
    • Marija PlodinecRoderick LimMarko Loparic
    • G01Q60/00
    • G01N33/4833G01N2001/2873G01N2800/7028G01Q60/366G01Q60/38
    • The present invention relates to a method for classifying a tissue biopsy sample obtained from a tumor, comprising determining a plurality of stiffness values for said sample by measuring a plurality of points on the sample with a spatial resolution of at least 100 μm and assigning the sample to a probability of malignancy. A sample showing a unimodal stiffness distribution is assigned to a high probability of being non-malignant, and a sample showing an at least bimodal stiffness distribution is assigned to a high probability of being malignant, wherein said stiffness distribution is characterized by a first peak exhibiting an at least two-fold higher stiffness value than a second peak. The present invention further relates to a system for classifying a tumor tissue biopsy sample.
    • 本发明涉及一种用于分类从肿瘤获得的组织活检样品的方法,包括通过以至少100μm的空间分辨率测量样品上的多个点来确定所述样品的多个刚度值,并分配样品 以恶性肿瘤的概率。 显示单峰刚度分布的样本被赋予非恶性的高概率,并且显示至少双峰刚度分布的样本被赋予恶性的高概率,其中所述刚度分布的特征在于第一峰显示 比第二个峰高至少两倍的刚度值。 本发明还涉及用于分类肿瘤组织活组织检查样品的系统。
    • 4. 发明申请
    • Fluid Delivery for Scanning Probe Microscopy
    • 流体输送用于扫描探针显微镜
    • US20140082776A1
    • 2014-03-20
    • US13904892
    • 2013-05-29
    • Victor B. Kley
    • Victor B. Kley
    • G01Q60/00
    • G01Q60/00B82Y35/00B82Y99/00G01Q30/12G01Q30/14G01Q80/00Y10S977/849Y10S977/856Y10S977/902Y10T29/53
    • A gas (or fluid) is introduced around an SPM probe or nanotool™ to control chemical activity e.g., oxygen to promote oxidation, argon to inhibit oxidation or clean dry air (CDA) to inhibit moisture to control static charging due to the action of the probe or nanotools and to provide vacuum at and around the tip and substrate area. Electrical current can be produced for use with active electronic devices on, in or near the body of the device. In addition by use of a fluid like water, certain oils, and other liquids in conjunction with specific tip structure either electric discharge machining can be used at the tip area on the tip itself (in conjunction with a form structure on the work piece) or on a work piece beneath the tip to shape, polish and remove material at very small scales (10 microns to 1 nm or less).
    • 在SPM探针或nanotool™周围引入气体(或流体)以控制化学活性,例如氧气以促进氧化,氩气抑制氧化或清洁干燥空气(CDA)以抑制湿气以控制由于 探针或纳米工具,并在尖端和基底区域周围提供真空。 可以产生电流,用于与设备的主体中,外部或附近的有源电子设备一起使用。 此外,通过使用像水一样的流体,某些油和其他液体结合特定的尖端结构,可以在尖端本身的尖端区域(结合工件上的形式结构)或 在尖端下方的工件上以非常小的尺度(10微米至1纳米或更小)成型,抛光和去除材料。
    • 6. 发明授权
    • Tomographic atom probe comprising an electro-optical generator of high-voltage electrical pulses
    • 断层原子探针包括高电压电脉冲的电光发生器
    • US08276210B2
    • 2012-09-25
    • US13130520
    • 2009-10-13
    • François VurpillotAlain Bostel
    • François VurpillotAlain Bostel
    • G01Q60/00
    • H03K3/42H01J49/168H03K3/537
    • A tomographic atom probe uses electrical pulses applied to an electrode in order to carry out evaporation of the sample being analyzed. In order to produce these electrical pulses, the tomographic atom probe comprises a high-voltage generator connected to an electrode by an electrical connection comprising a chip of semiconductor material. The probe also comprises a light source which can be controlled in order to generate light pulses which are applied to the semiconductor chip. Throughout the illumination, the chip is rendered conductive, which puts the high-voltage generator and the electrode in electrical contact so that a potential step is applied to the latter. The probe also comprises means for applying a voltage step of opposite amplitude to the previous step at the end of a time interval Δt0, so that the electrode finally receives a voltage pulse of duration Δt0.
    • 断层原子探针使用施加到电极的电脉冲,以便进行正在分析的样品的蒸发。 为了产生这些电脉冲,断层原子探针包括通过包括半导体材料芯片的电连接器连接到电极的高压发生器。 探头还包括可以被控制以产生施加到半导体芯片的光脉冲的光源。 在整个照明过程中,芯片导通,使高电压发生器和电极电接触,从而对其施加电势。 该探头还包括用于在时间间隔&Dgr; t0结束时向前一步骤施加相反幅度的电压步骤的装置,使得电极最终接收持续时间&Dgr; t0的电压脉冲。
    • 8. 发明申请
    • PREAMPLIFYING CANTILEVER AND APPLICATIONS THEREOF
    • 预制CAN LE。。。。。。。。
    • US20100017923A1
    • 2010-01-21
    • US12472183
    • 2009-05-26
    • Bede PittengerKumar VirwaniBenedikt Zeyen
    • Bede PittengerKumar VirwaniBenedikt Zeyen
    • G01Q60/00
    • G01Q60/38G01Q60/32
    • Aspects of the invention are directed to piezoresponse force analysis of a material. A stimulus signal including a first frequency component is applied to a contact point on the material such that the stimulus signal actuates a portion of the material to experience a motion as a result of a piezoelectric effect. A resonant device is coupled to the contact point such that the resonant device experiences a resonant motion at the first frequency component in response to the motion of the material, the resonant motion having a greater displacement than a displacement of the motion of the material, and is substantially unaffected by mechanical properties of the material at the contact point. The resonant motion of the resonant device is detected and processed to produce a measurement representing the piezoresponse of the material at the contact point.
    • 本发明的方面涉及材料的压力响应力分析。 包括第一频率分量的激励信号被施加到材料上的接触点,使得激励信号致动材料的一部分以经受作为压电效应的结果的运动。 谐振装置耦合到接触点,使得谐振装置响应于材料的运动而在第一频率分量处经历谐振运动,谐振运动具有比材料运动的位移更大的位移,以及 基本上不受材料在接触点的机械性能的影响。 检测和处理谐振装置的谐振运动,以产生表示材料在接触点的压力响应的测量。
    • 10. 发明授权
    • Method of determining of true nonlinearity of scan along a selected direction X or Y in scan microscope
    • 在扫描显微镜中沿选定方向X或Y扫描的真实非线性的确定方法
    • US06978215B2
    • 2005-12-20
    • US09945527
    • 2001-09-04
    • Arkady Nikitin
    • Arkady Nikitin
    • G01Q40/02G01Q60/00G02B21/00H01J37/28G01D18/00
    • H01J37/28G01Q40/00G02B21/002G02B21/004H01J2237/2816H01J2237/2826
    • This invention allows the scan nonlinearity of different type of scanning microscopes to be measured, including: optical, confocal, scanning electron and scanning probe microscopes. The scan nonlinearity of the scanning type measuring microscopes can be considerable source of errors in precise measurements of the Critical Dimension—CDs. The invention allows scanning measuring microscopes to be certified for scan nonlinearity; this invention can be used for the monitoring, adjustment and/or alignment of these type instruments. The high reliability of scan nonlinearity determination is achieved with the use of a pair of offset images of a calibration structure and consequent computer analysis of the signal differences. In addition to scan nonlinearity of a scanning measuring microscope being determined this proposed invention allows determination of heterogeneity of the pitch values intrinsic to any test-objects with periodic structure used as calibration references.
    • 本发明允许测量不同类型的扫描显微镜的扫描非线性,包括:光学,共焦,扫描电子和扫描探针显微镜。 扫描型测量显微镜的扫描非线性可能是精确测量临界尺寸CD的重大错误来源。 本发明允许扫描测量显微镜被认证为扫描非线性; 本发明可用于监测,调整和/或对准这些类型的仪器。 通过使用校准结构的一对偏移图像和信号差异的计算机分析来实现扫描非线性确定的高可靠性。 除了正在确定的扫描测量显微镜的扫描非线性之外,本发明允许确定用作校准参考的具有周期性结构的任何测试对象固有的间距值的异质性。