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    • 3. 发明授权
    • System and method for promoting selective tissue in-growth for an implantable medical device
    • 用于促进可植入医疗装置的选择性组织生长的系统和方法
    • US06704604B2
    • 2004-03-09
    • US09827103
    • 2001-04-05
    • Thomas M. SoukupStephen SundquistRoger DahlGregory A. Boser
    • Thomas M. SoukupStephen SundquistRoger DahlGregory A. Boser
    • A61N105
    • A61N1/0563A61N2001/0578
    • Disclosed is an improved system and method to selectively promote tissue in-growth on, or adjacent to, an implantable medical device. In one embodiment, at least one surface of the housing of a medical device is in contact with a first portion of a porous PTFE having a pore size adapted to prevent substantially all tissue in-growth. This first portion, or layer, of porous PTFE material is further in contact at predetermined locations with an additional porous PTFE layer having a pore size adapted to selectively promote tissue in-growth only at the predetermined locations. Each of the PTFE layers may be formed of porous PTFE tubing or tape. Alternatively, the two layers may comprise a single composite structure that has a more porous material exposed on a first surface, and a less porous, more dense, material on a second surface. Another embodiment of the invention involves forming the layers of PTFE into a removable member that is adjacent to at least one surface of the implantable medical device. The removable member may take the form of a sleeve that surrounds a portion of a the medical device and is adapted to remain in the body during an extraction process. For example, during the removal of a lead, the sleeve remains within the body and is capable of receiving a replacement lead, making it unnecessary to disturb tissue in-growth attached to the sleeve.
    • 公开了一种改进的系统和方法,用于选择性地促进在可植入医疗装置上或与植入式医疗装置相邻的组织生长。 在一个实施例中,医疗装置的壳体的至少一个表面与多孔PTFE的第一部分接触,孔的孔径适于防止基本上所有的组织生长。 多孔PTFE材料的该第一部分或多层进一步在预定位置处接触,另外的多孔PTFE层具有适于仅在预定位置选择性地促进组织生长的孔径。 每个PTFE层可以由多孔PTFE管或带形成。 或者,两层可以包括单个复合结构,其具有在第二表面上暴露在第一表面上的多孔材料和较少多孔,更致密的材料。 本发明的另一实施例涉及将PTFE层形成为与可植入医疗装置的至少一个表面相邻的可移除构件。 可移除构件可以采取围绕医疗装置的一部分的套筒的形式,并且适于在提取过程期间保持在身体中。 例如,在去除引线期间,套筒保持在主体内并且能够接收替换引线,使得不必干扰附着到套筒上的组织生长。
    • 4. 发明授权
    • System for anchoring mid-lead electrode on an endocardial catheter lead
    • 用于在心内膜导管引线上固定中间引线电极的系统
    • US6058332A
    • 2000-05-02
    • US113885
    • 1998-07-10
    • Roger Dahl
    • Roger Dahl
    • A61N1/05
    • A61N1/057
    • A system for passively anchoring mid-lead electrodes on an endocardial catheter lead includes at least one fibrosis-anchoring opening positioned along the exterior surface of the catheter lead body proximal or distal to the mid-lead electrodes for passively securing the catheter lead against the interior wall of the heart. Within the fibrosis-anchoring openings a suitable material is provided for anchoring the catheter lead body to the heart wall by fibrosis. Preferably, the fibrosis-anchoring openings comprise at least a pair of openings positioned only partially around the exterior of the catheter lead body at locations both proximal and distal to the mid-lead electrodes, with the catheter lead body between the fibrosis-anchoring openings being preformed to bias the mid-lead electrodes against the heart wall.
    • 用于在心内膜导管引线上被动地固定中间引线电极的系统包括至少一个纤维化锚定开口,沿着导管引线体的外表面位于中间引线电极的近端或远侧,用于被动地将导管引线固定在内部 心脏的墙壁 在纤维化锚定开口内,提供合适的材料用于通过纤维化将导管引线体锚固到心脏壁。 优选地,纤维化锚定开口包括至少一对开口,该对开口仅位于导联引线体的外部位于中间引线电极的近端和远端的位置处,导线引线主体位于纤维化锚定开口之间 预先将中间引线电极偏压抵靠心壁。
    • 7. 发明授权
    • System and method for placing a medical electrical lead
    • 放置医用电线的系统和方法
    • US06697677B2
    • 2004-02-24
    • US09826730
    • 2001-04-05
    • Roger DahlBrad D. PedersenDuane ZytkoviczKenneth C. Gardeski
    • Roger DahlBrad D. PedersenDuane ZytkoviczKenneth C. Gardeski
    • A61N105
    • A61N1/056A61N2001/0578A61N2001/058A61N2001/0585
    • An improved system and method that is capable of delivering multiple electrode assemblies to predetermined implant sites within a body is disclosed. The system includes an elongated member such as an introducer sheath. The introducer includes an elongated channel along at least a distal end portion of the introducer. The elongated channel opens to the exterior surface of the introducer through an elongated slot. One or more electrode assemblies may be retained within the elongated channel such that the leads exit the introducer via the elongated slot. The elongated introducer further includes a lumen that is in fluid communication with channel through openings, or gaps. The electrode assemblies are loaded within the channel at predetermined positions with respect to the openings. A distal end of a stiffening member such as a stylet may then be advanced within the lumen and through a selected one of the openings to engage an electrode assembly. The distal end of the stylet, along with the electrode assembly, is pushed in a distal direction within the channel until the electrode assembly exits the channel at a predetermined implant site. The stylet is then de-coupled from the electrode assembly, and the distal end is again retracted into the lumen. The distal end of the stiffening member may be re-directed into a different opening to engage a second electrode assembly. After the introducer is repositioned at a second implant site, the second electrode assembly may be deployed in a manner similar to that discussed above. The process may be repeated to deploy an array of electrodes. According to one aspect of the invention, the stylet distal end is canted to extend from the lumen of the introducer into the channel.
    • 公开了能够将多个电极组件递送到体内预定植入部位的改进的系统和方法。 该系统包括细长构件,例如导引器护套。 导引器包括沿导引器的至少远端部分的细长通道。 细长通道通过细长的槽向导引器的外表面开口。 一个或多个电极组件可以保持在细长通道内,使得引线经由细长槽离开导引器。 细长导引器还包括与通道通过开口或间隙流体连通的内腔。 电极组件相对于开口在预定位置处装载在通道内。 然后,诸如探针之类的加强构件的远端可以在内腔内并通过选定的一个开口进入以接合电极组件。 探针的远端与电极组件一起沿通道内的远端方向推动,直到电极组件在预定的植入部位离开通道。 然后将探针从电极组件脱耦合,并且远端再次缩回到内腔中。 加强构件的远端可以被重新引导到不同的开口中以接合第二电极组件。 在导引器在第二植入位置重新定位之后,第二电极组件可以以与上述相似的方式展开。 可以重复该过程以展开电极阵列。 根据本发明的一个方面,探针的远端倾斜以从导引器的内腔延伸到通道中。
    • 8. 发明授权
    • System for anchoring mid-lead electrode on an endocardial catheter lead
    • 用于在心内膜导管引线上固定中间引线电极的系统
    • US5782898A
    • 1998-07-21
    • US729900
    • 1996-10-15
    • Roger DahlDuane Zytkovicz
    • Roger DahlDuane Zytkovicz
    • A61N1/05
    • A61N1/057
    • A system for passively anchoring mid-lead electrodes on an endocardial catheter lead includes at least one fibrosis-anchoring opening positioned along the exterior surface of the catheter lead body proximal or distal to the mid-lead electrodes for passively securing the catheter lead against the interior wall of the heart. Within the fibrosis-anchoring openings a suitable material is provided for anchoring the catheter lead body to the heart wall by fibrosis. Preferably, the fibrosis-anchoring openings comprise at least a pair of openings positioned only partially around the exterior of the catheter lead body at locations both proximal and distal to the mid-lead electrodes, with the catheter lead body between the fibrosis-anchoring openings being pre-formed to bias the mid-lead electrodes against the heart wall.
    • 用于在心内膜导管引线上被动地固定中间引线电极的系统包括至少一个纤维化锚定开口,沿着导管引线体的外表面位于中间引线电极的近端或远端,用于被动地将导管引线固定在内部 心脏的墙壁 在纤维化锚定开口内,提供合适的材料用于通过纤维化将导管引线体锚固到心脏壁。 优选地,纤维化锚定开口包括至少一对开口,该对开口仅位于导联引线体的外部位于中间引线电极的近端和远端的位置处,导线引线主体位于纤维化锚定开口之间 预先形成以将中间引线电极偏压抵靠心壁。
    • 9. 发明授权
    • System and method for placing endocardial leads
    • 放置心内膜导管的系统和方法
    • US06934589B2
    • 2005-08-23
    • US09827108
    • 2001-04-05
    • Stephen SundquistArnold ThorntonRoger DahlDuane ZytkoviczKenneth C. Gardeski
    • Stephen SundquistArnold ThorntonRoger DahlDuane ZytkoviczKenneth C. Gardeski
    • A61N1/05A61N1/00
    • A61N1/056A61N2001/0578A61N2001/0585
    • An improved system and method for deploying medical electrical leads is disclosed. The system includes a guiding device such as a guidewire used to navigate the vascular system of a body. The guiding device includes a fixation member that can be deployed to maintain the guiding device at a desired location within the vascular system. The fixation member may be an inflatable device such as a balloon, or alternatively, may be an expandable device constructed of flexible fibers that has both an expanded and a contracted state. The system may further include a coupling member located adjacent to the guiding device. The coupling member may be a rail extending distally from a proximal end of the guiding device to a point proximal the fixation member. In an alternative embodiment of the invention, the coupling member is a channel included in the body of the guiding device adapted to slidably engage an electrode assembly. The coupling member is adapted to allow the electrode assembly to be slid to the distal end of the coupling member and deployed at a predetermined implant site. In one embodiment of the invention, the coupling member is movable with respect to the guiding device. This allows the coupling member to be re-positioned to multiple implant sites to deploy more than one electrode while the fixation mechanism remains stationary within a patient's vascular system. According to yet another aspect of the invention, the guiding device includes a lumen to delivery fluoro visible medium.
    • 公开了用于部署医疗电引线的改进的系统和方法。 该系统包括诸如用于导航身体的血管系统的导丝的引导装置。 引导装置包括可以部署以将引导装置保持在血管系统内的期望位置的固定构件。 固定构件可以是诸如气囊的可充气装置,或者可替代地,可以是由具有膨胀和收缩状态的柔性纤维构成的可扩张装置。 该系统还可以包括邻近引导装置定位的联接构件。 联接构件可以是从引导装置的近端向靠近固定构件的点向远侧延伸的轨道。 在本发明的替代实施例中,联接构件是包括在引导装置的主体中的通道,其适于可滑动地接合电极组件。 联接构件适于允许电极组件滑动到联接构件的远端并且在预定的植入位置展开。 在本发明的一个实施例中,联接构件可相对于引导装置移动。 这允许将联接构件重新定位到多个植入位置以展开多于一个电极,同时固定机构在患者的血管系统内保持静止。 根据本发明的另一方面,引导装置包括用于输送氟可见介质的内腔。