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1. 发明授权

US6063360A Free radicals comprising benzodithiole derivatives 失效
标题翻译：包含苯并二硫杂衍生物的自由基
公开(公告)号：US6063360A
公开(公告)日：2000-05-16
申请号：US036021
申请日：1998-03-06
申请人： Sven Andersson , Finn Radner , Anna Rydbeck , Rolf Servin , Lars-Goran Wistrand , Mikkel Thaning
发明人： Sven Andersson , Finn Radner , Anna Rydbeck , Rolf Servin , Lars-Goran Wistrand , Mikkel Thaning
IPC分类号： A61K49/20 , C07B60/00 , C07D493/04 , C07D495/04 , C07D497/04 , C07D519/00 , G01R33/28 , G01R33/62 , A61K49/00 , C07D339/06
CPC分类号： C07D493/04 , A61K49/20 , C07B61/02 , C07D495/04 , C07D497/04 , G01R33/5601 , G01R33/62 , G01R33/281
摘要： The present invention relates to certain novel triaryl methyl free radicals and their use as image enhancing agents in magnetic resonance imaging (MRI) as well as to contrast media containing such radicals and to the use of such radicals and their non-radical precursors in the manufacture of MRI contrast media.
摘要翻译：本发明涉及某些新的三芳基甲基自由基及其在磁共振成像（MRI）中的图像增强剂的用途以及含有这种自由基的造影剂以及在制造中使用这种自由基及其非自由基前体的MRI造影剂。

2. 发明授权

US5827501A Use of free radicals in ESR and ESREMR imaging 失效
标题翻译：在ESR和ESREMR成像中使用自由基
公开(公告)号：US5827501A
公开(公告)日：1998-10-27
申请号：US477568
申请日：1995-06-07
申请人： Mikkel J.o slashed.rgensen , Frode Rise , Sven Andersson , Torsten Almen , Arne Aabye , Lars-Goran Wistrand , H.ang.kan Wikstrom , Klaes Golman , Rolf Servin , Peter Michelsen
发明人： Mikkel J.o slashed.rgensen , Frode Rise , Sven Andersson , Torsten Almen , Arne Aabye , Lars-Goran Wistrand , H.ang.kan Wikstrom , Klaes Golman , Rolf Servin , Peter Michelsen
IPC分类号： A61K49/00 , A61K49/20 , C07B60/00 , C07C1/20 , C07C15/16 , C07D213/06 , C07D213/30 , C07D333/08 , C07D333/16 , C07D333/38 , C07D409/06 , C07D493/04 , C07D495/04 , C07D497/04 , C07D519/00 , G01R33/28 , A61K49/04
CPC分类号： C07D409/06 , A61K49/20 , C07D333/16 , C07D333/38 , C07D493/04 , C07D495/04
摘要： The present invention relates to a method of generating an electron spin resonance enhanced magnetic resonance image of a sample which comprises introducing into the sample a magnetic resonance signal enhancing amount of a free radical and generating an enhanced electron spin resonance image of the sample. The method comprises using as the free radical an inert triarylmethyl free radical, wherein each aryl moiety of said triarylmethyl radical, which may be identical or different, comprises an optionally substituted 6-membered carbocyclic or thienyl ring. The invention also relates to the use of trityls in ESR imaging.
摘要翻译：本发明涉及一种产生样品的电子自旋共振增强磁共振图像的方法，该方法包括向样品中引入磁共振信号增强量的自由基并产生样品的增强的电子自旋共振图像。该方法包括使用惰性三芳基甲基自由基，其中所述三芳基甲基的每个芳基部分可以相同或不同，包含任选取代的6元碳环或噻吩基环。本发明还涉及三联体在ESR成像中的应用。

3. 发明授权

US5728370A Free Radicals 失效
标题翻译：自由基
公开(公告)号：US5728370A
公开(公告)日：1998-03-17
申请号：US467273
申请日：1995-06-06
申请人： Sven Andersson , Finn Radner , Anna Rydbeck , Rolf Servin , Lars-Goran Wistrand
发明人： Sven Andersson , Finn Radner , Anna Rydbeck , Rolf Servin , Lars-Goran Wistrand
IPC分类号： C07D493/04 , A61K31/58 , A61K49/00 , A61K49/20 , C07B60/00 , C07D495/04 , C07D497/04 , C07D497/22 , C07D519/00 , C07F7/08 , C07D339/06
CPC分类号： A61K49/20 , C07B61/02 , C07D493/04 , C07D495/04 , C07D497/04 , C07D519/00 , C07F7/0814
摘要： The present invention relates to certain novel triaryl methyl free radicals and their use as image enhancing agents in magnetic resonance imaging (MRI) as well as to contrast media containing such radicals and to the use of such radicals and their non-radical precursors in the manufacture of MRI contrast media.
摘要翻译：本发明涉及某些新的三芳基甲基自由基及其在磁共振成像（MRI）中的图像增强剂的用途以及含有这种自由基的造影剂以及在制造中使用这种自由基及其非自由基前体的MRI造影剂。

4. 发明申请

US20100190967A1 Method of Dynamic Nuclear Polarisation (DNP) and Compounds and Compositions for Use in the Method 有权
标题翻译：方法中使用的动态核极化（DNP）和化合物和组合物的方法
公开(公告)号：US20100190967A1
公开(公告)日：2010-07-29
申请号：US12376810
申请日：2007-08-29
申请人： Christian Gloegaard , Rolf Servin , Mikkel Thaning
发明人： Christian Gloegaard , Rolf Servin , Mikkel Thaning
IPC分类号： C07F5/00 , C07C59/19 , C07D257/02
CPC分类号： C07D257/02 , A61K49/10 , A61K49/106 , A61K49/20
摘要： The invention relates to an improved method of dynamic nuclear polarisation (DNP) of carboxylic acids and to compounds and compositions for use in the method.
摘要翻译：本发明涉及一种改进的羧酸动态核极化（DNP）和用于该方法的化合物和组合物的方法。

5. 发明授权

US07372274B2 Methods and devices configured for dissolving hyperpolarised solid material with a solvent within a cryostat for NMR analyses 有权
标题翻译：配置用于将超极化固体物质溶解在低温恒温器内用于NMR分析的方法和装置
公开(公告)号：US07372274B2
公开(公告)日：2008-05-13
申请号：US10415968
申请日：2001-11-02
申请人： Jan Henrik Ardenkjaer-Larsen , Oskar H. E. Axelsson , Klaes Koppel Golman , Georg Hansson , Haukur Johannesson , Rolf Servin , Mikkel Thaning , Lennart Hansson
发明人： Jan Henrik Ardenkjaer-Larsen , Oskar H. E. Axelsson , Klaes Koppel Golman , Georg Hansson , Haukur Johannesson , Rolf Servin , Mikkel Thaning , Lennart Hansson
IPC分类号： G01V3/00 , A61B5/055
CPC分类号： G01R33/282 , G01N1/44 , G01R33/307 , G01R33/5601 , G01R33/62
摘要： The present invention relates to devices and method for dissolving solid polarised material while retaining a high level of polarisation. In an embodiment of the present invention a material is polarised in a strong magnetic field in a cryostat 2 and then brought into solution while still inside the cryostat 2.
摘要翻译：本发明涉及用于溶解固体极化材料同时保持高水平偏振的装置和方法。在本发明的一个实施例中，材料在低温恒温器2中的强磁场中极化，然后在仍然在低温恒温器2内部的同时进入溶液中。

6. 发明申请

US20080061781A1 Multidimensional Nmr Spectroscopy of A Hyperpolarized Sample 有权
标题翻译：超极化样品的多维Nmr光谱
公开(公告)号：US20080061781A1
公开(公告)日：2008-03-13
申请号：US10553381
申请日：2004-04-13
申请人： Rolf Servin , Jan Henrik Ardenkjaer-Larsen , Haukur Johannesson , Maurice Goldman , Jan Wolber
发明人： Rolf Servin , Jan Henrik Ardenkjaer-Larsen , Haukur Johannesson , Maurice Goldman , Jan Wolber
IPC分类号： G01R33/46
CPC分类号： G01R33/4633 , G01R33/62
摘要： The present invention relates to methods of performing Nuclear Magnetic Resonance (NMR) spectroscopy adapted for a hyperpolarized sample. The methods comprise the steps of hyperpolarizing a sample using DNP, wherein at least a portion of the NMR active nuclei receives hyperpolarization; performing NMR spectroscopy on the sample with the use of sequences of rf-pulses, wherein the pulse sequences comprises at least two rf-pulses, either on the same nuclei or on different nuclei, and wherein the pulse sequence is adapted for a hyperpolarized sample; and analysing at least two of the NMR spectra to obtain a characterization of the sample, or to obtain an interim result to be used in the NMR spectroscopy step.
摘要翻译：本发明涉及适用于超极化样品的核磁共振（NMR）光谱的方法。所述方法包括使用DNP超极化样品的步骤，其中至少一部分NMR活性核接受超极化; 使用rf脉冲序列对样本进行NMR光谱分析，其中所述脉冲序列包括在同一核上或不同核上的至少两个rf脉冲，并且其中所述脉冲序列适用于超极化样品; 并分析至少两个NMR光谱以获得样品的表征，或获得在NMR光谱步骤中使用的中间结果。

7. 发明授权

US5530140A Free radicals 失效
标题翻译：自由基
公开(公告)号：US5530140A
公开(公告)日：1996-06-25
申请号：US220522
申请日：1994-03-31
申请人： Sven Andersson , Finn Radner , Anna Rydbeek , Rolf Servin , Lars-Goran Wistrand
发明人： Sven Andersson , Finn Radner , Anna Rydbeek , Rolf Servin , Lars-Goran Wistrand
IPC分类号： A61K49/20 , C07B60/00 , C07D493/04 , C07D495/04 , C07D497/04 , C07D519/00 , A61K49/00
CPC分类号： C07D493/04 , A61K49/20 , C07B61/02 , C07D495/04 , C07D497/04
摘要： The invention provides novel persistent free radicals useful in Overhauser MRI being triarylmethyl radicals having as at least one aryl group a group of formula ##STR1## (wherein each X which may be the same or different is an oxygen or sulphur atom or a group CO or S(O).sub.n, (where n is 1 to 3) with the proviso that at least one group X is a sulphur atom or a S(O).sub.n group; R.sup.1 is a hydrogen atom or group of formula --M, --XM, --X--Ar.sup.2, or --Ar.sup.2 where M is a water solubilizing group, and Ar.sup.2 represents a 5-10 membered aromatic ring optionally substituted by a water solubilizing group M; and each of the groups R.sup.7, which may be the same or different, is a hydrogen atom, or a hydrocarbon group or a water solubilizing group M, or two groups R.sup.7 together with the atom to which they are bound represent a carbonyl group or a 5 to 8 membered cycloalkylidene, mono- or di-oxacycloalkylidene, mono- or di-azacycloalkylidene or mono- or di-thiacycloalkylidene group optionally with the ring attachment carbon replaced by a silicon atom, and R.sup.7 where it is other than hydrogen, is optionally substituted by a hydroxyl group, an optionally alkoxylated, optionally hydroxylated acyloxy or alkyl group or a water solubilizing group M)). The novel radicals have good stability, long relaxation times and good relaxivity.
摘要翻译：本发明提供了在Overhauser MRI中有用的新型持久性自由基，其具有作为至少一个芳基的基团为具有下式的基团的三芳基甲基（其中可以相同或不同的X是氧或硫原子或基团CO或S（O）n，（其中n为1至3），条件是至少一个基团X为硫原子或S（O）n基团; R 1为氢原子或式-M ，-XM，-X-Ar2或-Ar2，其中M是水溶性基团，Ar2表示任选被水增溶基团M取代的5-10元芳香环;并且各基团R7可以是相同或不同的是氢原子，或烃基或水溶性基团M，或两个R 7与它们所连接的原子一起代表羰基或5-8元环亚烷基，单 - 或二 - 单环或二氮杂环亚烷基或任选具有环连接c的单 - 或二 - 芳烃被硅原子取代，并且其中不是氢的R 7任选被羟基取代，任选烷氧基化，任选羟基化的酰氧基或烷基或水溶性基团M））。新型自由基具有良好的稳定性，较长的松弛时间和良好的松弛性。

8. 发明申请

US20060171891A1 Nmr-based methods for detecting ligands, where the ligand or target are hyperpolarized and the nmr-spectrum is compared with a reference spectrum of the ligand or target 有权
标题翻译：用于检测配体的基于Nmr的方法，其中配体或靶是超极化的，并且将nmr光谱与配体或靶的参考光谱进行比较
公开(公告)号：US20060171891A1
公开(公告)日：2006-08-03
申请号：US10537235
申请日：2003-11-27
申请人： Jan-Henrik Ardenkjaer-Larsen , Herbert Baumann , Graham Cotton , Klaes Golman , Mark Howard , Mathilde Lerche , Rolf Servin , Mikkel Thaning , Jan Wolber
发明人： Jan-Henrik Ardenkjaer-Larsen , Herbert Baumann , Graham Cotton , Klaes Golman , Mark Howard , Mathilde Lerche , Rolf Servin , Mikkel Thaning , Jan Wolber
IPC分类号： A61B5/055
CPC分类号： G01R33/465 , G01N24/08 , G01N24/088 , G01R33/282 , G01R33/62
摘要： The invention relates to NMR-based methods comprising hyperpolarised ligands or targets for use in NMR-based assays.
摘要翻译：本发明涉及包含用于基于NMR的测定中使用的超极化配体或靶的基于NMR的方法。

9. 发明申请

US20050233470A1 Methods and compound mixtures for determining protein activity using nmr spectroscopy 审中-公开
标题翻译：使用nmr光谱法测定蛋白质活性的方法和化合物混合物
公开(公告)号：US20050233470A1
公开(公告)日：2005-10-20
申请号：US10511960
申请日：2003-04-15
申请人： Bill Clark , Klaes Golman , Mathilde Lerche , Mike Looker , Mike O'Sullivan , Albie Santos , Rolf Servin , Mikkel Thaning , Jan-Henrik Ardenkjaer-Larsen
发明人： Bill Clark , Klaes Golman , Mathilde Lerche , Mike Looker , Mike O'Sullivan , Albie Santos , Rolf Servin , Mikkel Thaning , Jan-Henrik Ardenkjaer-Larsen
IPC分类号： G01R33/465 , C12Q1/00 , C12Q1/26 , C12Q1/48 , G01N20060101 , G01N24/00 , G01N24/08 , G01R33/28
CPC分类号： G01N24/088 , G01R33/282 , G01R33/465 , Y10T436/24
摘要： The invention relates to methods for determining protein activity using NMR spectroscopy. The present invention provides a method for determining protein activity in vivo using probe compounds and enhancing the nuclear polarisation of NMR active nuclei present in the probe compounds (hereinafter termed “hyperpolarisation”) prior to NMR analysis. The invention also provides mixtures of probe compounds for the above-mentioned method.
摘要翻译：本发明涉及使用NMR光谱测定蛋白质活性的方法。本发明提供了在NMR分析之前使用探针化合物和增强存在于探针化合物中的NMR活性核（以下称为“超极化”）的核偏振来测定体内蛋白质活性的方法。本发明还提供了用于上述方法的探针化合物的混合物。

10. 发明授权

US08273874B2 Method of dynamic nuclear polarisation (DNP) and compounds and compositions for use in the method 有权
标题翻译：动态核极化方法（DNP）以及用于该方法的化合物和组合物
公开(公告)号：US08273874B2
公开(公告)日：2012-09-25
申请号：US12376810
申请日：2007-08-29
申请人： Christian Gloegaard , Rolf Servin , Mikkel Thaning
发明人： Christian Gloegaard , Rolf Servin , Mikkel Thaning
IPC分类号： A61B5/00 , C07B47/00
CPC分类号： C07D257/02 , A61K49/10 , A61K49/106 , A61K49/20
摘要： The invention relates to an improved method of dynamic nuclear polarisation (DNP) of carboxylic acids and to compounds and compositions for use in the method.
摘要翻译：本发明涉及一种改进的羧酸动态核极化（DNP）和用于该方法的化合物和组合物的方法。

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