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1. 发明申请

US20180267124A1 MAGNETIC RESONANCE IMAGING APPARATUS AND MAGNETIC RESONANCE IMAGING METHOD 审中-公开
公开(公告)号：US20180267124A1
公开(公告)日：2018-09-20
申请号：US15541533
申请日：2016-01-19
申请人： HITACHI, LTD.
发明人： Yasuhiro KAMADA , Yoshiyuki KUNUGI
IPC分类号： G01R33/561 , A61B5/055 , G01R33/54 , G01R33/48 , G01R33/46
CPC分类号： G01R33/5611 , A61B5/055 , G01R33/4633 , G01R33/482 , G01R33/4822 , G01R33/543 , G01R33/546
摘要： In an imaging method using k space low-frequency region data including a lot of useful information, in order to obtain an image with high quality without increasing measurement time by measuring a minimum required region in proper quantities, according to the present invention, pre-measurement is performed prior to main measurement, a rough shape of k space low-frequency region data is measured with respect to each signal reception channel, so as to be set as k space characteristics, and a range measured as a k space low-frequency region is specified in the measurement. The specified result is reflected in an imaging sequence, and thus k space low-frequency region data including useful information which can be used for a process is appropriately collected.

2. 发明申请

US20180164290A1 NMR-BASED METABOLITE SCREENING PLATFORM 审中-公开
公开(公告)号：US20180164290A1
公开(公告)日：2018-06-14
申请号：US15469973
申请日：2017-03-27
申请人： Children's Medical Center Corporation , President and Fellows of Harvard College
发明人： Elizabeth M. O'Day , Judy Lieberman , Gerhard Wagner
IPC分类号： G01N33/50 , G01R33/465 , G01R33/46 , G01N24/08
CPC分类号： G01N33/5011 , A61B5/055 , G01N24/08 , G01N33/5005 , G01N33/5038 , G01N2458/15 , G01N2500/10 , G01N2570/00 , G01R33/4633 , G01R33/465
摘要： Methods that enable one to specifically measure the metabolic product of a particular molecule in relatively few cells, e.g. primary cells, are described. The methods involve optionally preloading cells with labeled substrate (e.g. labeled by 13C, 15N, or 31P). The methods allow for easy identification of metabolites that are differentially generated in cells of different phenotypes. The new methods for unbiased multi-dimensional NMR screening and rapid and efficient analysis of the NMR screening identify differentially expressed metabolites in different cell or tissue types. Analysis of the differentially expressed metabolites can present unique druggable targets to which small molecule therapeutics can be designed.

3. 发明申请

US20180045715A1 STRUCTURE AND FUNCTION OF THE SALICYCLIC ACID BINDING SITES ON HUMAN HMGB1 AND METHODS OF USE THEREOF FOR THE RATIONAL DESIGN OF BOTH SALICYCLIC ACID DERIVATIVES AND OTHER AGENTS THAT ALTER ANIMAL AND PLANT HMGBS ACTIVITIES 审中-公开
公开(公告)号：US20180045715A1
公开(公告)日：2018-02-15
申请号：US15551448
申请日：2016-02-12
申请人： Boyce Thompson Institute for Plant Research, Inc. , RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , Ospedale San Raffaele
发明人： Daniel F. Klessig , Sang-Wook Park , Hyong Woo Choi , Frank C. Schroeder , Gaetano T. Montelione , Keith Hamilton , Swapna Gurla , Fei Song , Marco E. Bianchi
IPC分类号： G01N33/50 , G01N24/08 , G01R33/46 , C07K14/52 , A61K36/31 , A61K31/19 , A61K49/14 , G01N33/566 , A61K38/17
CPC分类号： G01N33/5097 , A61K31/19 , A61K36/31 , A61K38/177 , A61K49/14 , C07K14/52 , G01N24/088 , G01N33/566 , G01R33/4633
摘要： Compositions and methods for identifying agents which 1) mimic salicyclic acid binding to human, animal and plant high mobility group box proteins or 2) alter activities of these HMGBs by binding in or around their salicyclic acid-binding sites and agents so identified are disclosed.

4. 发明申请

US20180011990A1 METHOD AND SYSTEM FOR IDENTIFICATION OF METABOLITES 审中-公开
公开(公告)号：US20180011990A1
公开(公告)日：2018-01-11
申请号：US15642143
申请日：2017-07-05
申请人： UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
发明人： Hunter N.B. Moseley , William J. Carreer , Joshua Mitchell , Robert M. Flight
IPC分类号： G06F19/00 , G01N33/50 , A61B5/055 , G01N33/68 , G01R33/46 , G01R33/465 , H01J49/26 , G06F19/10
CPC分类号： G16C20/20 , A61B5/055 , G01N24/08 , G01N33/5038 , G01N33/6848 , G01R33/4633 , G01R33/465 , G16B40/10 , G16B99/00 , H01J49/0036 , H01J49/26
摘要： A method and system is provided for mass spectrometry for identification of a specific elemental formula for an unknown compound which includes but is not limited to a metabolite. The method includes calculating a natural abundance probability (NAP) of a given isotopologue for isotopes of non-labelling elements of an unknown compound. Molecular fragments for a subset of isotopes identified using the NAP are created and sorted into a requisite cache data structure to be subsequently searched. Peaks from raw spectrum data from mass spectrometry for an unknown compound. Sample-specific peaks of the unknown compound from various spectral artifacts in ultra-high resolution Fourier transform mass spectra are separated. A set of possible isotope-resolved molecular formula (IMF) are created by iteratively searching the molecular fragment caches and combining with additional isotopes and then statistically filtering the results based on NAP and mass-to-charge (m/2) matching probabilities. An unknown compound is identified and its corresponding elemental molecular formula (EMF) from statistically-significant caches of isotopologues with compatible IMFs.

5. 发明授权

US09720128B2 Rotating frame pulsed nuclear magnetic resonance spectroscopy 有权
公开(公告)号：US09720128B2
公开(公告)日：2017-08-01
申请号：US13768965
申请日：2013-02-15
申请人： SCHLUMBERGER TECHNOLOGY CORPORATION
发明人： Ravinath Kausik Kadayam Viswanathan , Lukasz Zielinski , Martin D. Hürlimann
IPC分类号： G01V3/00 , G01V3/32 , G01R33/46 , G01N24/08 , G01R33/44
CPC分类号： G01V3/32 , G01N24/081 , G01R33/448 , G01R33/4633
摘要： An NMR method and apparatus for analyzing a sample of interest applies a static magnetic field together with RF pulses of oscillating magnetic field across a sample volume that encompasses the sample of interest. The RF pulses are defined by a pulse sequence that includes a plurality of measurement segments configured to characterize a plurality of relaxation parameters related to relaxation of nuclear magnetization of the sample of interest. Signals induced by the RF pulses are detected in order to derive the relaxation parameters. The measurement segments of the pulse sequence include at least one first-type measurement segment configured to characterize relaxation of spin-lattice interaction between nuclei of the sample of interest in a rotating frame (T1ρ) at a predefined frequency. The T1ρ parameter can be measured in conjunction with the measurement of other relaxation and/or diffusion parameters as part of multidimensional NMR experiments.

6. 发明申请

US20160061986A1 Formation Property Characteristic Determination Methods 审中-公开
标题翻译：形成性质特征确定方法
公开(公告)号：US20160061986A1
公开(公告)日：2016-03-03
申请号：US14470052
申请日：2014-08-27
申请人： Schlumberger Technology Corporation
发明人： Vivek Anand , Vikas Jain
IPC分类号： G01V3/32 , G01V3/38
CPC分类号： G01V3/32 , G01N24/081 , G01R33/448 , G01R33/4633 , G01V3/38
摘要： A method for analyzing at least one characteristic of a geological formation may include obtaining measured data for the geological formation based upon a logging tool, and minimizing an objective function representing at least an Lp norm of model parameters and an error between the measured data and predicted data for the objective function, wherein p is not equal to 2. The method may further include determining the at least one characteristic of the geological formation based upon the minimization of the objective function.
摘要翻译：用于分析地质构造的至少一个特征的方法可以包括基于测井工具获得用于地质构造的测量数据，并且最小化表示模型参数的至少Lp范数的目标函数和测量数据与预测的误差之间的误差用于目标函数的数据，其中p不等于2.该方法还可以包括基于目标函数的最小化来确定地质构造的至少一个特征。

7. 发明申请

US20160041243A1 Two-Dimensional Semi-LASER Correlation Spectroscopy with Well-Maintained Cross Peaks 审中-公开
标题翻译：二维半激光相关光谱与维护十字峰
公开(公告)号：US20160041243A1
公开(公告)日：2016-02-11
申请号：US14782474
申请日：2014-04-04
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人： Shaolin YANG
IPC分类号： G01R33/483 , G01R33/485 , G01R33/46
CPC分类号： G01R33/4833 , G01R33/4633 , G01R33/485
摘要： A sLASER-first-COSY sequence is disclosed. After a delay time, Δ1, from application of a first 90° radio frequency (RF) pulse, a first pair of adiabatic full-passage (AFP) pulses are applied to an object in a MRI scanner. The first 90° RF pulse is a non-adiabatic slice-selective 90° RF pulse and the first pair of AFP pulses is separated by an inter-pulse time interval, Δ2. A second pair of AFP pulses, separated by the time Δ2, is then applied, followed by a second 90° RF pulse. The second 90° RF pulse is a non-adiabatic non-slice-selective 90° RF pulse. MR signal is acquired after an echo time (TE) from application of the excitation RF pulse. The present method may achieve intended full magnetization transfer between a coupled spin pair of a metabolite and maintain metabolite cross peak intensity of a coupled spin pair of a metabolite in the object.
摘要翻译：公开了sLASER-first-COZY序列。在延迟时间之后，由于应用第一个90°射频（RF）脉冲，第一对绝热全通道（AFP）脉冲被施加到MRI扫描仪中的一个物体上。第一个90°RF脉冲是非绝热切片选择性90°RF脉冲，第一对AFP脉冲由脉冲间隔间隔＆Dgr; 2分隔开。然后施加第二对AFP脉冲，分开时间＆Dgr; 2，然后施加第二个90°RF脉冲。第二个90°RF脉冲是非绝热的非切片选择性90°RF脉冲。在应用激励RF脉冲的回波时间（TE）之后获取MR信号。本方法可以实现代谢物的偶联自旋对之间的期望的全部磁化转移，并维持物体中代谢物的偶联自旋对的代谢物交叉峰强度。

8. 发明授权

US08963546B2 Method for NMR spectroscopy 有权
标题翻译： NMR光谱法
公开(公告)号：US08963546B2
公开(公告)日：2015-02-24
申请号：US13402897
申请日：2012-02-23
申请人： Simone Ulzega , Veronika Vitzthum , Geoffrey Bodenhausen , Marc Anthony Caporini
发明人： Simone Ulzega , Veronika Vitzthum , Geoffrey Bodenhausen , Marc Anthony Caporini
IPC分类号： G01V3/00 , G01R33/46
CPC分类号： G01R33/4641 , G01R33/4616 , G01R33/4633
摘要： A method for performing magnetic resonance spectroscopy on solid samples containing nuclei of interest with spin quantum number I subjects the sample to a static magnetic field. The sample is spun at the magic angle and broad-band excitation of transverse magnetization of the nuclei of interest is effected by applying a first train of rotor-synchronized rf-pulses, having a carrier frequency, to the nuclei of interest with a pulse duration 0.1 μs 1. Uniform excitation of a great number of spinning sidebands or families of sidebands that arise from large first-order quadrupole or hyperfine interactions is enabled and signal intensity is thereby improved.
摘要翻译：在具有自旋量子数I的感兴趣的核的固体样品上进行磁共振光谱的方法将样品置于静态磁场中。样品以魔角旋转，通过将具有载波频率的转子同步rf脉冲的第一列施加到具有脉冲持续时间的感兴趣的核，实现感兴趣的核的横向磁化的宽带激发 0.1μs<τp<2μs，第一列rf脉冲包括在转子周期τrot延伸的k·n个脉冲，每转子周期τrot具有n个脉冲，其中n是整数n> 1。使大量一阶四极杆或超精细相互作用产生的大量旋转边带或边带族的均匀激发成为可能，从而提高信号强度。

9. 发明授权

US08773126B2 Nuclear magnetic resonance measuring method using an isotope-labeled compound 有权
标题翻译：使用同位素标记化合物的核磁共振测量方法
公开(公告)号：US08773126B2
公开(公告)日：2014-07-08
申请号：US12676239
申请日：2008-09-08
申请人： Katsuaki Kuge , Kimihiro Yoshimura , Fumio Yamauchi , Tetsuya Yano , Masahiro Shirakawa , Yasuhiro Aoyama
发明人： Katsuaki Kuge , Kimihiro Yoshimura , Fumio Yamauchi , Tetsuya Yano , Masahiro Shirakawa , Yasuhiro Aoyama
IPC分类号： G01V3/00 , G01R33/485 , G01R33/46 , G01R33/483 , G01R33/56
CPC分类号： G01R33/485 , G01R33/4608 , G01R33/4633 , G01R33/4833 , G01R33/5605 , G01R33/5607
摘要： The present invention provides a method for measuring nuclear magnetic resonance that employs a compound in which a plurality of nuclei is labeled with isotopes as a probe agent, highly selectively and highly sensitively obtains a nuclear magnetic resonance signal of the above described probe agent, and can attach a spatial positional information to the above described nuclear magnetic resonance signal, and an apparatus therefore.
摘要翻译：本发明提供一种测定核磁共振的方法，其使用多个核被同位素标记的化合物作为探针剂，高度选择性且高度灵敏地获得上述探针剂的核磁共振信号，并且可以将空间位置信息附加到上述核磁共振信号，因此装置。

10. 发明申请

US20110267052A1 BROADBAND DECOUPLING PULSE TRAIN WITH INTERLEAVED PAUSES FOR MAGNETIC RESONANCE SPECTROSCOPY 有权
标题翻译：用于磁共振光谱的宽带放大器的宽带解码脉冲串
公开(公告)号：US20110267052A1
公开(公告)日：2011-11-03
申请号：US13141089
申请日：2009-11-23
申请人： Thomas S. Cull , William McLemore
发明人： Thomas S. Cull , William McLemore
IPC分类号： G01R33/44
CPC分类号： G01R33/4608 , G01N24/088 , G01R33/3614 , G01R33/4633 , G01R33/4836
摘要： A magnetic resonance apparatus (10) includes a magnet (18) that generates a static magnetic field, e.g., 7T, a resonance excitation system (26, 30, 32) induces resonance in an observed nuclear species such as 13C or 31P. A decoupling delay generator (48) introduces pauses between adjacent pulses of a decoupling pulse train configured to decouple a coupled species such as 1H. An RF amplifier (32, 44) whose energy shortage capacity would be exceeded by the pulse train without the pauses amplifies the pulse train with the pauses. The pauses are sufficiently short that decoupling and Nuclear Overhauser Effect enhancement are not adversely affected, but long enough to provide recovery time to the RF amplifier, e.g., 0.2 msec.
摘要翻译：磁共振装置（10）包括产生静态磁场（例如7T）的磁体（18），共振激发系统（26,30,32）在观察到的核物质如13C或31P中引起共振。解耦延迟发生器（48）引入解耦脉冲串的相邻脉冲之间的暂停，其被配置为使耦合的物质例如1H去耦。一个RF放大器（32,44），其能量短缺容量将被脉冲串超过，而不会暂停，脉冲串将随着暂停放大。暂停时间足够短，使得去耦和核超越效应增强不会受到不利影响，但长度足以为RF放大器提供恢复时间，例如0.2毫秒。

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