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1. 发明申请

US20210406414A1 COMPUTING INTERACTIONS OF SOURCES EMBEDDED IN THREE DIMENSIONAL LAYERED MEDIA 有权
公开(公告)号：US20210406414A1
公开(公告)日：2021-12-30
申请号：US17341596
申请日：2021-06-08
申请人： Southern Methodist University
发明人： Wei Cai , Bo Wang , Wenzhong Zhang
IPC分类号： G06F30/10 , G06F17/16
摘要： Systems and methods for computing interactions of charge sources embedded in three dimensional (3D) layered media. At least one of the methods includes decomposing the Green's function representing the potential caused by a charge source into a free space component and a plurality of reaction components; generating, for each reaction component of the plurality of reaction components, a multipole expansion (ME) operator and a multipole to local (M2L) translation operator; performing, for each reaction component of the plurality of reaction components, a convergence analysis of an ME of that reaction component; defining, for each reaction component, polarization charge sources based on the convergence analysis and combining the polarization charges sources with the charge sources; and computing, using a fast multipole method (FMM), interactions of the charge sources based on the polarization charge sources, the ME operators, and the M2L translation operators.

2. 发明申请

US20210255172A1 Sensor and Method for Detecting Target Molecules 有权
公开(公告)号：US20210255172A1
公开(公告)日：2021-08-19
申请号：US17171829
申请日：2021-02-09
申请人： Southern Methodist University
发明人： Ali Beskok , Anil Koklu , Jungchih Chiao
IPC分类号： G01N33/53 , G01N33/543 , B01L3/00 , G01N27/02 , G01N33/487
摘要： An apparatus and method for detecting one or more target molecules includes a hydrophobic substrate, and a sensor. The sensor includes two or more electrodes disposed on the hydrophobic substrate and separated from one another by a gap, a plurality of nanostructures formed on or within an upper surface of each electrode, a plurality of binding molecules attached to the plurality of nanostructures, wherein the plurality of binding molecules are configured to bind with the one or more target molecules, and wherein the upper surface of each electrode and the plurality of nanostructures are hydrophilic, and may further detect two or more analytes with two or more sensors that detect two or more different modalities, such as, electrical, optical fluorescence, optical resonance, magnetic detection, or acoustic waves.

3. 发明授权

US10898485B2 Inhibitors of multidrug resistance transporter p-glycoprotein 有权
公开(公告)号：US10898485B2
公开(公告)日：2021-01-26
申请号：US16715779
申请日：2019-12-16
申请人： Southern Methodist University
发明人： John G. Wise , Pia D. Vogel , Frances K. Brewer , Courtney A. Follit
IPC分类号： A61K31/5025 , A61K31/4525 , A61K31/4196 , A61K31/353 , A61P35/00 , A61K45/06
摘要： The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.

4. 发明申请

US20200281894A1 C5-SUBSTITUTED CARBAPENEM ANTIBIOTICS, COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHODS OF USE IN TREATMENT OF MYCOBACTERIUM TUBERCULOSIS AND NON-TUBERCULAR MYCOBACTERIA 审中-公开
公开(公告)号：US20200281894A1
公开(公告)日：2020-09-10
申请号：US16879892
申请日：2020-05-21
申请人： Southern Methodist University , University of Central Florida Research Foundation, Inc.
发明人： John D. Buynak , Noora M. S. A. Al-Kharji , Weirui Chai , Thu Q. Nguyen , Maha Alqurafi , Kyle Rohde , Rashmi Gupta
IPC分类号： A61K31/407 , C07D477/06 , C07D477/00 , A61K45/06 , C07D477/04 , C07D477/20
摘要： The present invention includes a composition, method of making and method of using a novel C5-substituted carbapenem antibiotic of formula 1: R1 is H or CH3 R2 is not H, and is CH3, or C1-C6 straight chain, or branched alkyl, or C3-C6 cycloalkyl group, or unsaturated alkenyl, including C═CH2; R3 is H, CH3, or a C1-C6 alkyl or cycloalkyl group, a heteroatom-substituted alkyl; and R4 is a C1 to C6 alkyl, or substituted alkyl group, especially including substituents which possess positive charge, or a hydroxyl group; or R4 is an SRa, where Ra is an unsubstituted C1 to C6 alkyl group, a substituted C1 to C6 alkyl group, or a functional group that is positively charged, or which bears a positive charge when in aqueous solution at pH 7; or R4 is a CH2ORb, where Rb=C1 to C6 alkyl or substituted alkyl groups, substituted or unsubstituted aryl, or a heteroaryl groups.

5. 发明授权

US10768339B1 Imaging hidden objects 有权
公开(公告)号：US10768339B1
公开(公告)日：2020-09-08
申请号：US15659517
申请日：2017-07-25
申请人： Southern Methodist University
发明人： Marc P. Christensen , Prasanna Rangarajan
IPC分类号： H04N5/30 , G01V8/20 , G06K9/20 , G03H1/04
摘要： The present disclosure describes an imaging system, method, and apparatus for identifying a latent image of a hidden object. A light source generates a first beam of narrow-band light and a second beam of narrow-band light that has temporal fluctuations correlated with the first beam. A frequency modulator shifts a temporal frequency of at least one of the first beam or the second beam. The first beam is directed towards a first scattering surface and the second beam is directed towards a second scattering surface. The first scattering surface scatters the first beam to a scattered light that illuminates a hidden object. The hidden object reflects at least a portion of the scattered light towards the second scattering surface, the reflected light interferes with the second beam and produces an interference pattern on the second scattering surface. A lock-in camera detects an irradiance of the interference pattern, monitors temporal variations of the irradiance caused by the temporal frequency shift introduced by the frequency modulator, and identifies a complex-valued light field that represents information of the hidden object based on the temporal variations of the irradiance.

6. 发明申请

US20200051241A1 IMAGE ANALYSIS USING MACHINE LEARNING AND HUMAN COMPUTATION 审中-公开
公开(公告)号：US20200051241A1
公开(公告)日：2020-02-13
申请号：US16538662
申请日：2019-08-12
申请人： Southern Methodist University , Retina Foundation of the Southwest
发明人： Corey Clark , Karl Csaky
IPC分类号： G06T7/00 , G06T7/11 , G06N20/00
摘要： Methods, systems, and computer readable media for analyzing an image using machine learning and human computation. A method for analyzing an image includes providing, via multiple instances of an interactive application for analysis of the image, multiple instances, respectively, of the image and receiving, via the interactive application, data from results of analyses of the image including multiple sets of user inputs from the analyses of the multiple instances of the image, respectively. The multiple sets of user inputs are from multiple users, respectively and the multiple users are associated with the multiple instances of the interactive application, respectively. The method further includes processing the received data to identify areas of interest within the image based on the multiple sets of user inputs and analyzing the image using a machine learning algorithm to identify structures in the image based on the identified areas of interest within the image.

7. 发明授权

US10523924B2 System and method for a three-dimensional optical switch display (OSD) device 有权
公开(公告)号：US10523924B2
公开(公告)日：2019-12-31
申请号：US15287906
申请日：2016-10-07
申请人： Southern Methodist University
发明人： Alexander R. Lippert , Shreya Patel
IPC分类号： H04N13/296 , G02B27/22 , H04N9/31 , H04N13/388
摘要： The present invention includes a system, apparatus and method for generating a three-dimensional image, the system comprising: a medium comprising a optical molecular switch molecule, wherein the optical molecular switch molecule has a non-fluorescent state and a fluorescent state, wherein at one wavelength of optical excitation the molecule has a first state, and at a second state the molecule fluoresces a second wavelength of excitation; and at least a first light source and a second light source into the medium, wherein light emitted by the at least first and second light sources are directed to contact the optical molecular switch molecule, e.g., scanning, weaving, diagonally or other pattern; wherein the optical molecular switch molecule is converted into a fluorescent “on state” by irradiation from the first light source, and the second light causes the optical molecular switch to emit light.

8. 发明申请

US20190301857A1 MICRO RESOLUTION IMAGING RANGE SENSOR SYSTEM 审中-公开
公开(公告)号：US20190301857A1
公开(公告)日：2019-10-03
申请号：US16367532
申请日：2019-03-28
申请人： Northwestern University , Southern Methodist University
发明人： Oliver Strider Cossairt , Fengqiang Li , Florian Willomitzer , Prasanna V. Rangarajan
IPC分类号： G01B11/24 , G01S17/89 , G01S17/02
摘要： A system configured to generate images includes one or more narrowband electromagnetic sources configured to emit a first radiation and a second radiation. The system also includes a detector configured to detect first reflected radiation off of an object and second reflected radiation off of the object, where the first reflected radiation results from the first radiation and the second reflected radiation results from the second radiation. The system further includes a processor operatively coupled to the detector and configured to generate an image of the object based at least in part on a first amplitude of the first reflected radiation and a second amplitude of the second reflected radiation. The processor is also configured to determine a depth profile of the object based at least in part on the first reflected radiation and the second reflected radiation detected by the detector.

9. 发明授权

US10418706B1 Circular polarized microstrip antenna using a single feed 有权
公开(公告)号：US10418706B1
公开(公告)日：2019-09-17
申请号：US15214123
申请日：2016-07-19
申请人： Southern Methodist University
发明人： Choon Sae Lee , Yang Fan
IPC分类号： H01Q9/04 , H01Q1/36
摘要： A microstrip antenna includes a dielectric substrate, a radiating plate, and a single feed connection. In these instances, the rectangular radiating plate is affixed to the dielectric substrate and having a center point, and the radiating patch defines a first aperture and a second aperture on opposite sides of the center point, each aperture having a center longitudinally aligned with the center point. The single feed connection is laterally offset from a point on a virtual line, wherein the virtual line is located between two opposite corners of the rectangular radiating patch and passes through the center point.

10. 发明申请

US20190216811A1 Inhibitors of Multidrug Resistance Transporter P-Glycoprotein 审中-公开
公开(公告)号：US20190216811A1
公开(公告)日：2019-07-18
申请号：US16366674
申请日：2019-03-27
申请人： Southern Methodist University
发明人： John G. Wise , Pia D. Vogel , Alexander R. Lippert , Amila K. Nanyakkara , Maha A. Aljowni
IPC分类号： A61K31/5025 , A61K31/353 , A61K31/4196 , A61P35/00 , A61K31/4525
CPC分类号： A61K31/5025 , A61K31/353 , A61K31/4196 , A61K31/4525 , A61K45/06 , A61P35/00
摘要： The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.

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