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1. 发明授权

US08017654B2 Combination cancer therapy with bis(thiohydrazide) amide compounds 有权
标题翻译：联合癌症治疗与双（硫代酰肼）酰胺化合物
公开(公告)号：US08017654B2
公开(公告)日：2011-09-13
申请号：US11918357
申请日：2006-04-13
申请人： Thomas A. Dahl , Matthew McLeod
发明人： Thomas A. Dahl , Matthew McLeod
IPC分类号： A01N37/18 , A61K31/16 , C07D305/00 , C07D407/00 , C07D493/00 , C07C241/00 , C07C243/00 , C07C249/00 , C07C251/00
CPC分类号： A61K45/06 , A61K31/16 , A61K31/165 , A61K31/337 , A61K2300/00
摘要： A method of treating a subject with cancer includes the step of co-administering to the subject over three to five weeks, a taxane in an amount of between about 243 μmol/m2 to 315 μmol/m2 (e.g., equivalent to paclitaxel in about 210-270 mg/m2); and a bis(thiohydrazide amide) in an amount between about 1473 μmol/m2 and about 1722 μmol/m2 (e.g., Compound (1) in about 590-690 mg/m2). The bis(thiohydrazide amide) is represented by Structural Formula (I), Y is a covalent bond or an optionally substituted straight chained hydrocarbyl group, or, Y, taken together with both >C=Z groups to which it is bonded, is an optionally substituted aromatic group. R1-R4 are independently —H, an optionally substituted aliphatic group, an optionally substituted aryl group, or R1 and R3 taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2 and R4 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. R7-R8 are independently —H, an optionally substituted aliphatic group, or an optionally substituted aryl group. Z is O or S.
摘要翻译：用癌症治疗受试者的方法包括在三至五周内共同给予受试者的步骤，量为约243μmol/ m 3至315μmol/ m 2的紫杉烷（例如，相当于约210的紫杉醇 -270 mg / m2）; 和约1473μmol/ m 2与约1722μmol/ m 2之间的量的二（硫代酰肼）酰胺（例如化合物（1），约590-690mg / m 2）。双（硫代酰肼）由结构式（I）表示，Y为共价键或任选取代的直链烃基，或Y与它们所键合的两个> C = Z基团一起为任选取代的芳族基团。 R 1 -R 4独立地是-H，任选取代的脂族基团，任选取代的芳基，或者R 1和R 3与它们所键合的碳原子和氮原子一起，和/或R 2和R 4与碳和与它们键合的氮原子形成任选地与芳环稠合的非芳族杂环。 R 7 -R 8独立地为-H，任选取代的脂族基团或任选取代的芳基。 Z是O或S.

2. 发明申请

US20140031275A1 METHODS OF ERADICATING BACTERIAL CELL POPULATIONS 审中-公开
标题翻译：消灭细菌群体的方法
公开(公告)号：US20140031275A1
公开(公告)日：2014-01-30
申请号：US14043362
申请日：2013-10-01
申请人： Kim LEWIS , Brian CONLON , Mark L. NELSON , Michael P. POLLASTRI , Thomas A. DAHL
发明人： Kim LEWIS , Brian CONLON , Mark L. NELSON , Michael P. POLLASTRI , Thomas A. DAHL
IPC分类号： A61K31/437 , A61K31/5377 , A61K31/343
CPC分类号： A61K31/437 , A61K31/343 , A61K31/5377 , A61K38/12 , A61K38/15 , A61K45/06 , C07K7/56 , A61K2300/00
摘要： Disclosed herein are methods and compositions for the eradication of bacterial infections. In particular, methods and compositions are disclosed for the eradication of persister and slow growing bacterial cell populations. In particular embodiments, the methods and compositions disclosed herein are useful for eradication of biofilms.
摘要翻译：本文公开了用于根除细菌感染的方法和组合物。特别地，公开了消除持久和缓慢生长的细菌细胞群体的方法和组合物。在具体实施方案中，本文公开的方法和组合物可用于根除生物膜。

3. 发明授权

US5308758A Method and apparatus for study of gas-phase and gas-borne agents 失效
标题翻译：气相和气体介质的研究方法和装置
公开(公告)号：US5308758A
公开(公告)日：1994-05-03
申请号：US959311
申请日：1992-10-09
申请人： Thomas A. Dahl
发明人： Thomas A. Dahl
IPC分类号： C12M1/04 , C12M3/06 , C12Q1/24
CPC分类号： C12M41/46
摘要： Method and apparatus for exposing biological materials to gas-phase or gas-borne agents, including the steps of providing a chamber for supporting said biological materials, said chamber including wicking means configured and arranged to hold said biological materials and provide said cells with a wetting medium while allowing said gas-phase or gas-borne agents to directly interact with said biological materials, humidifying said chamber to a humidity between 95% and 100%, inclusive, placing said biological materials in said chamber on said wicking means, exposing said biological materials in said chamber to one or more said gas-phase or gas-borne agents while maintaining said humidity between 95% and 100%, inclusive, and assessing the effect of said exposing on said biological materials.
摘要翻译：用于将生物材料暴露于气相或气体传播剂的方法和装置，包括提供用于支撑所述生物材料的室的步骤，所述室包括芯吸装置，其被配置和布置成保持所述生物材料并向所述细胞提供润湿培养基，同时允许所述气相或气体传播剂与所述生物材料直接相互作用，将所述室加湿至95％至100％之间的湿度，包括将所述生物材料置于所述室中的所述芯吸装置上，暴露所述生物将所述室中的物质与一种或多种所述气相或气体载体物质保持在一起，同时保持所述湿度在95％至100％之间，并评估所述暴露对所述生物材料的影响。

4. 发明申请

US20120232134A1 COMBINATION CANCER THERAPY WITH BIS(THIOHYDRAZIDE) AMIDE COMPOUNDS 审中-公开
标题翻译：与BIS（THOHOHDRAZIDE）AMIDE化合物联合治疗癌症
公开(公告)号：US20120232134A1
公开(公告)日：2012-09-13
申请号：US13230315
申请日：2011-09-12
申请人： Thomas A. Dahl , Matthew McLeod
发明人： Thomas A. Dahl , Matthew McLeod
IPC分类号： A61K31/337 , A61P35/00
CPC分类号： A61K45/06 , A61K31/16 , A61K31/165 , A61K31/337 , A61K2300/00
摘要： Disclosed is a method of treating a subject with cancer, the method comprising the step of co-administering to the subject over three to five weeks, a taxane in an amount of between about 243 μmol/m2 to 315 μmol/m2; and a bis(thiohydrazide amide) compound in an amount between about 1473 μmol/m2 and about 1722 μmol/m2.
摘要翻译：本发明公开了一种治疗患有癌症的受试者的方法，所述方法包括在三至五周内共同施用受试者的步骤，紫杉烷的量为约243μmol/ m 3至315μmol/ m 2; 和约1473μmol/ m 2和约1722μmol/ m 2之间的量的双（硫代酰肼酰胺）化合物。

5. 发明申请

US20090137682A1 Combination cancer therapy with bis(thiohydrazide) amide compounds 有权
标题翻译：联合癌症治疗与双（硫代酰肼）酰胺化合物
公开(公告)号：US20090137682A1
公开(公告)日：2009-05-28
申请号：US11918357
申请日：2006-04-13
申请人： Thomas A Dahl
发明人： Thomas A Dahl
IPC分类号： A61K31/165 , A61P35/00
CPC分类号： A61K45/06 , A61K31/16 , A61K31/165 , A61K31/337 , A61K2300/00
摘要： A method of treating a subject with cancer includes the step of co-administering to the subject over three to five weeks, a taxane in an amount of between about 243 μmol/m2 to 315 μmol/m2 (e.g., equivalent to paclitaxel in about 210-270 mg/m2); and a bis(thiohydrazide amide) in an amount between about 1473 μmol/m2 and about 1722 μmol/m2 (e.g., Compound (1) in about 590-690 mg/m2). The bis(thiohydrazide amide) is represented by Structural Formula (I), Y is a covalent bond or an optionally substituted straight chained hydrocarbyl group, or, Y, taken together with both >C=Z groups to which it is bonded, is an optionally substituted aromatic group. R1-R4 are independently —H, an optionally substituted aliphatic group, an optionally substituted aryl group, or R1 and R3 taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2 and R4 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. R7-R8 are independently —H, an optionally substituted aliphatic group, or an optionally substituted aryl group. Z is O or S.
摘要翻译：用癌症治疗受试者的方法包括在三至五周内共同施用受试者的步骤，量为约243mol / m 2至315mol / m 2的紫杉烷（例如，相当于约210的紫杉醇 -270 mg / m2）; 和约1473μmol/ m 2和约1722μmol/ m 2之间的量的二（硫代酰肼）酰胺（例如化合物（1），约590-690mg / m 2）。双（硫代酰肼）由结构式（I）表示，Y为共价键或任选取代的直链烃基，或Y与它们所键合的两个> C = Z基团一起为任选取代的芳族基团。 R 1 -R 4独立地是-H，任选取代的脂族基团，任选取代的芳基，或者R 1和R 3与它们所键合的碳原子和氮原子一起，和/或R 2和R 4与碳和与它们键合的氮原子形成任选地与芳环稠合的非芳族杂环。 R 7 -R 8独立地为-H，任选取代的脂族基团或任选取代的芳基。 Z是O或S.

6. 发明授权

US5530168A Process for the synthesis of a C.sub.2 + Aliphatic alcohol in a slurry reactor comprising an in-situ catalyst impregnation step 失效
标题翻译：在含有原位催化剂浸渍步骤的淤浆反应器中合成C2 +脂族醇的方法
公开(公告)号：US5530168A
公开(公告)日：1996-06-25
申请号：US317053
申请日：1994-10-03
申请人： Richard P. Underwood , Bernard A. Toseland , Thomas A. Dahl , Janet F. Hugo
发明人： Richard P. Underwood , Bernard A. Toseland , Thomas A. Dahl , Janet F. Hugo
IPC分类号： C07C29/154 , C07C27/20
CPC分类号： C07C29/154
摘要： A process is set forth for the synthesis of a C.sub.2 + aliphatic alcohol from hydrogen and carbon oxides in the presence of a copper-based catalyst which has been impregnated with an alkali metal compound. The process differs from the prior art in that the catalyst is impregnated with the alkali metal compound in the same slurry reactor which is used for reacting the hydrogen and carbon oxides. By contrast, in the prior art C.sub.2 + aliphatic alcohol synthesis, impregnation of the copper-based catalyst with the alkali metal compound is accomplished by a separate step in a separate vessel. By eliminating this separate step, the present invention realizes a savings in processing and equipment costs.
摘要翻译：阐述了在浸渍有碱金属化合物的铜基催化剂存在下，从氢和碳氧化物合成C2 +脂族醇的方法。该方法与现有技术的不同之处在于，催化剂在用于使氢和碳氧化物反应的同一浆料反应器中用碱金属化合物浸渍。相比之下，在现有技术的C2 +脂族醇合成中，用碱金属化合物浸渍铜基催化剂是通过分离的容器中的单独步骤完成的。通过消除这个单独的步骤，本发明实现了处理和设备成本的节省。

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