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1. 发明授权

US07696247B2 Lipid-based nitric oxide donors 有权
标题翻译：基于脂质的一氧化氮供体
公开(公告)号：US07696247B2
公开(公告)日：2010-04-13
申请号：US10885055
申请日：2004-07-06
申请人： Robert A. Herrmann , Wendy Naimark
发明人： Robert A. Herrmann , Wendy Naimark
IPC分类号： A61K31/20 , A01N33/26 , C07C205/00 , C07C207/00 , C07C241/00 , C07C243/00
CPC分类号： A61L29/16 , A61K45/06 , A61L15/44 , A61L31/16 , A61L2300/114 , A61L2300/416 , C07C243/42 , C07J41/0055 , Y10T436/104165
摘要： Novel nitric-oxide releasing lipid molecules are provided which comprise a lipid molecule selected from (a) phosphoglycerides, (b) lipids having a sphingosine base as a backbone, (c) monoacylglyerols, (d) diacylglycerols, (e) glycosylacylglycerols, and (f) sterol compounds of the formula: where R is a branched aliphatic chain of eight or more carbon atoms, wherein the lipid molecule is provided with a nitric-oxide containing group which comprises (a) a —S—N═O moiety, (b) a —O—N═O moiety, or (c) a a moiety. Also provided are methods of forming such nitric oxide releasing lipid molecules. Various pharmaceutical compositions, topical liquids and drug delivery systems comprising the nitric-oxide releasing lipid molecules are also described. Further provided are methods for therapeutically administering nitric oxide to patients, methods of treating or preventing various conditions, methods for promoting wound healing and methods of reducing the cells present in an atherosclerotic lesion, which methods utilize the nitric-oxide releasing lipid molecules.
摘要翻译：提供新的一氧化氮释放脂质分子，其包含选自（a）磷酸甘油酯，（b）具有鞘氨醇碱作为主链的脂质的脂质分子，（c）单酰基甘醇，（d）二酰基甘油，（e）糖基酰基甘油和（ f）下式的甾醇化合物：其中R是具有8个或更多个碳原子的支链脂族链，其中所述脂质分子具有含一氧化氮的基团，其包含（a）-S-N = O部分，（ b）-O-N = O部分，或（c）aa部分。还提供了形成这种一氧化氮释放脂质分子的方法。还描述了包含释放一氧化氮的脂质分子的各种药物组合物，局部液体和药物递送系统。还提供了向患者治疗性给予一氧化氮的方法，治疗或预防各种病症的方法，促进伤口愈合的方法以及减少存在于动脉粥样硬化病变中的细胞的方法，该方法利用释放一氧化氮的脂质分子。

2. 发明授权

US5965496A Fluorine-containing compounds and use thereof 失效
标题翻译：含氟化合物及其用途
公开(公告)号：US5965496A
公开(公告)日：1999-10-12
申请号：US817440
申请日：1997-05-23
申请人： Masayuki Yamana , Yoshitaka Honda
发明人： Masayuki Yamana , Yoshitaka Honda
IPC分类号： C07C243/00 , C07C243/22 , C07D211/94 , C07D257/08 , C10M105/56 , C10M105/64 , C10M105/70 , C10M107/44 , G11B5/71 , G11B5/725
CPC分类号： C10M105/64 , C07C243/00 , C07C243/22 , C07D211/94 , C07D257/08 , C10M105/56 , C10M105/70 , C10M107/44 , G11B5/71 , G11B5/725 , C10M2215/08 , C10M2215/082 , C10M2215/18 , C10M2215/202 , C10M2215/204 , C10M2215/22 , C10M2215/221 , C10M2215/225 , C10M2215/226 , C10M2215/28 , C10M2215/30 , C10M2217/00 , C10M2217/02 , C10M2217/04 , C10N2240/20 , C10N2240/201 , C10N2240/202 , C10N2240/203 , C10N2240/204 , C10N2240/205
摘要： A fluorine-containing polyether compound, a lubricant, and a magnetic recording medium comprising the lubricant.
摘要翻译： PCT No.PCT / JP95 / 02084 Sec。 371日期1997年5月23日 102（e）日期1997年5月23日PCT提交1995年10月12日PCT公布。公开号WO96 / 11905 日期：1996年4月25日A含氟聚醚化合物，润滑剂和含有润滑剂的磁记录介质。

3. 发明授权

US08952128B2 Somatostatin-dopamine chimeric analogs 有权
标题翻译：生长抑素 - 多巴胺嵌合类似物
公开(公告)号：US08952128B2
公开(公告)日：2015-02-10
申请号：US14068286
申请日：2013-10-31
申请人： Ipsen Pharma S.A.S.
发明人： Zheng Xin Dong , Yeelana Shen , Sun Hyuk Kim
IPC分类号： A61K38/00 , C07K14/655 , A61K38/31 , C07K7/56 , C07K7/06 , C07K7/08 , A61K39/00 , C07K7/23 , C07C243/00 , C07K5/02 , A61K38/08 , C07K7/64 , C07K11/00 , C07C215/52 , C07K19/00
CPC分类号： A61K47/64 , A61K38/00 , A61K38/31 , A61K47/55 , C07C215/52 , C07K14/655 , C07K19/00
摘要： The present invention relates to novel somatostatin-dopamine chimeric analogs and their therapeutic uses for the inhibition, prevention, and/or treatment of neoplasia, neuroendocrine tumors, Cushing's disease/syndrome, and other conditions.
摘要翻译：本发明涉及新的生长抑素 - 多巴胺嵌合类似物及其治疗用途，用于抑制，预防和/或治疗瘤形成，神经内分泌肿瘤，库兴氏病/综合征和其他病症。

4. 发明申请

US20130143933A1 TARGETED CORRECTION OF A GENETIC DEFECT IN CANCER THERAPY 审中-公开
标题翻译：癌症治疗遗传性缺陷的目标矫正
公开(公告)号：US20130143933A1
公开(公告)日：2013-06-06
申请号：US13673090
申请日：2012-11-09
申请人： TRT Pharma Inc.
发明人： Gérald BATIST , Jian Hui WU
IPC分类号： C07D213/81 , A61K31/4409 , C07C323/48 , C07C251/86 , C07C243/00 , A61K31/175 , C07D213/86
CPC分类号： C07D213/81 , A61K45/06 , C07C251/86 , C07C323/48 , C07C323/60
摘要： The present document describes a cancer mutation-selective chemosensitizer that comprise compounds for restoring association between mutated keap1 protein and Nrf2 protein, and inhibition of Nrf2 functions. The present document also describes composition of matter containing the compounds, as well as methods of medical treatment for treating diseases such as cancer with the compounds.
摘要翻译：本文件描述了癌症突变选择性化学敏感剂，其包含用于恢复突变的keap1蛋白和Nrf2蛋白之间的缔合的化合物和抑制Nrf2功能。本文件还描述了含有化合物的物质的组成，以及用化合物治疗诸如癌症的疾病的药物治疗方法。

5. 发明授权

US08362273B2 Process for preparing aminale and their use for preparing 1,3-disubstituted pyrazole compounds 有权
标题翻译：制备胺的方法及其用于制备1,3-二取代吡唑化合物的方法
公开(公告)号：US08362273B2
公开(公告)日：2013-01-29
申请号：US13504558
申请日：2010-10-28
申请人： Maximilian Dochnahl , Michael Keil , Roland Goetz
发明人： Maximilian Dochnahl , Michael Keil , Roland Goetz
IPC分类号： C07D231/10 , C07C241/00 , C07C243/00
CPC分类号： C07D231/14
摘要： Process for preparing aminale and their use for preparing 1,3-disubstituted pyrazole compounds.
摘要翻译：制备胺的方法及其用于制备1,3-二取代吡唑化合物的方法。

6. 发明授权

US08206692B2 Inhibition of sweat malodor 有权
标题翻译：抑制汗水恶臭
公开(公告)号：US08206692B2
公开(公告)日：2012-06-26
申请号：US11779462
申请日：2007-07-18
申请人： Christian Starkenmann , Anthony Clark , Myriam Troccaz , Yvan Niclass
发明人： Christian Starkenmann , Anthony Clark , Myriam Troccaz , Yvan Niclass
IPC分类号： C07C315/00 , C07C317/00 , C07C321/00 , C07C323/00 , C07C381/00 , C07C391/00 , C07C241/00 , C07C243/00 , C07C249/00 , C07C251/00 , C07C259/00 , C07C273/00 , C07C275/00 , C07C279/00 , C07C277/00 , C07C229/00
CPC分类号： C07K5/06026 , C07C237/12 , C07C237/16 , C07K5/0215 , C07K5/0606 , C07K5/06069 , C12Q1/025 , C12Q1/527 , G01N2500/00
摘要： The present invention relates to a method for screening compounds having the ability to prevent, treat or reduce malodor development on body surfaces. In particular, the method allows to efficiently screen for compound having the ability of preventing sweat malodor development caused by volatile sulfur compounds (VSCs). The present invention is based on the finding of the direct precursor of naturally VSCs, which is present in human sweat and which will be metabolized by Staphylococci to VSCs.
摘要翻译：本发明涉及一种筛选具有预防，治疗或减少身体表面恶臭发展能力的化合物的方法。特别地，该方法允许有效地筛选具有防止由挥发性硫化合物（VSC）引起的汗液恶臭发展的能力的化合物。本发明基于天然VSCs的直接前体的发现，其存在于人的汗液中，并且其将被葡萄球菌代谢为VSC。

7. 发明申请

US20100253213A1 LATENT CURING AGENTS, EPOXY RESIN COMPOSITIONS CONTAINING THE SAME, SEALING MATERIALS, AND ORGANIC EL DISPLAYS 有权
标题翻译：专利固化剂，含有它们的环氧树脂组合物，密封材料和有机EL显示器
公开(公告)号：US20100253213A1
公开(公告)日：2010-10-07
申请号：US12681271
申请日：2008-12-26
申请人： Hiroaki Tamatani , Mitsuaki Chida , Yugo Yamamoto , Yuichi Ito , Takashi Nakano , Naritoshi Yoshimura
发明人： Hiroaki Tamatani , Mitsuaki Chida , Yugo Yamamoto , Yuichi Ito , Takashi Nakano , Naritoshi Yoshimura
IPC分类号： H05B33/04 , C07C243/00 , C08L63/00
CPC分类号： C08L63/00 , C07C243/40 , C07C271/28 , C07D295/32 , C08G59/54 , H01L51/5246
摘要： The invention aims to provide latent curing agents which exert high low-temperature curing properties when used together with ionically polymerizable compounds and which exhibit high storage stability at room temperature. Latent curing agents for ionically polymerizable compounds which agents each contain a hydroxyl-free amine imide compound having an N—N bond energy of 100 to 210 kJ/mol as determined by B3LYP functional theory method.
摘要翻译：本发明旨在提供当与离子聚合性化合物一起使用时具有高低温固化性能的潜在性固化剂，并且在室温下表现出高的储存稳定性。用于离子可聚合化合物的潜在固化剂，其各自含有通过B3LYP功能理论方法测定的具有100至210kJ / mol的N-N键能量的无羟基胺酰亚胺化合物。

8. 发明授权

US07276631B2 Cyclopentylamine and cyclohexylamine derivatives as NK-1/SSRI antagonists 有权
标题翻译：环戊胺和环己胺衍生物作为NK-1 / SSRI拮抗剂
公开(公告)号：US07276631B2
公开(公告)日：2007-10-02
申请号：US11183700
申请日：2005-07-18
申请人： Yong-Jin Wu , Huan He
发明人： Yong-Jin Wu , Huan He
IPC分类号： C07C243/00 , A01N31/00
CPC分类号： C07C217/52 , C07C2601/02 , C07C2601/08 , C07C2601/14
摘要： The present disclosure relates to chemical compounds and their use in human therapy. A specific embodiment of the disclosure relates to compounds of Formula (I); or an isomer, a pharmaceutically acceptable salt or solvate thereof or a pharmaceutically acceptable formulation comprising said compounds are useful for the useful for the treatment or prevention of conditions mediated by tachykinins and/or selective inhibition of serotonin reuptake transporter protein. The compounds act as dual NK-1 antagonists and selective serotonin reuptake inhibitors.
摘要翻译：本公开涉及化学化合物及其在人类治疗中的用途。本公开的具体实施方案涉及式（I）的化合物; 或其异构体，药学上可接受的盐或溶剂合物或包含所述化合物的药学上可接受的制剂可用于治疗或预防由速激肽介导的病症和/或选择性抑制5-羟色胺再摄取转运蛋白。该化合物作为双重NK-1拮抗剂和选择性5-羟色胺再摄取抑制剂。

9. 发明申请

US20040039229A1 Method for recovery of nitramines from aluminized energetic materials 失效
标题翻译：从镀铝能量材料中回收硝胺的方法
公开(公告)号：US20040039229A1
公开(公告)日：2004-02-26
申请号：US10646419
申请日：2003-08-22
发明人： Kirstin F. Warner , Louis F. Cannizzo , Robert M. Hajik
IPC分类号： C07C243/00
CPC分类号： C07D257/02 , Y10S149/124
摘要： Nitramines are one of the more expensive and often the more plentiful ingredients found in energetic materials, such as solid rocket motor propellants, explosives, and pyrotechnics. By treating aluminized energetic material with an aqueous nitric acid solution containing not more than 55% by weight aqueous nitric acid at a weight ratio of aqueous nitric acid to energetic material of about 4:1 to about 6:1, most constituents of conventional aluminized energetic materials are digested into solution, with the exception of nitramines, which remain substantially insoluble in the aqueous nitric acid and can be recovered without requiring recrystallization of the nitramines. A mineral acid other than nitric acid, preferably hydrochloric acid, may be added to increase the rate of aluminum digestion. Treatment of the energetic material can be performed without volatile organic solvents, thus obviating ecological, cost, and safety concerns raised by the use of volatile organic solvents.
摘要翻译：硝胺是在高能材料中发现的更昂贵和经常更丰富的成分之一，例如固体火箭发动机推进剂，爆炸物和烟火。通过用含有不超过55重量％的硝酸水溶液的硝酸水溶液处理镀铝的能量材料，其中硝酸水溶液与高分子材料的重量比为约4:1至约6:1，常规镀铝能量材料被消化成溶液，除了硝酸铵基本上不溶于硝酸水溶液中，并且可以回收而不需要硝酸盐的重结晶。可以加入除硝酸之外的无机酸，优选盐酸以提高铝消化速率。高能材料的处理可以在没有挥发性有机溶剂的情况下进行，从而避免使用挥发性有机溶剂引起的生态，成本和安全问题。

10. 发明授权

US08865934B2 Method for preparing ramalin 有权
标题翻译：制备罗马林的方法
公开(公告)号：US08865934B2
公开(公告)日：2014-10-21
申请号：US13810145
申请日：2011-07-14
申请人： Joung Han Yim , Il Chan Kim , Sung Gu Lee , Dockyu Kim , Se Jong Han , Hyoung Seok Lee , Seung Jin Kim , Tai Kyoung Kim , Pil-Sung Kang , Heeyong Park , Ha Ju Park , Hye Yeon Koh , Mi Ra Park , Yu-Kyeong Park
发明人： Joung Han Yim , Il Chan Kim , Sung Gu Lee , Dockyu Kim , Se Jong Han , Hyoung Seok Lee , Seung Jin Kim , Tai Kyoung Kim , Pil-Sung Kang , Heeyong Park , Ha Ju Park , Hye Yeon Koh , Mi Ra Park , Yu-Kyeong Park
IPC分类号： C07C241/00 , C07C243/00 , C07C249/00 , C07C241/04
CPC分类号： C07C241/04 , C07C243/34
摘要： The present invention relates to a method for synthesizing ramalin, and more particularly to a method for synthesizing ramalin, which comprises allowing 2-hydrazinylphenol to react with L-glutamic acid having a protected carboxyl group at C-1 and a protected amino group at C-2, and a method for preventing decomposition of the ramalin. According to the present invention, ramalin having excellent antioxidant and anti-inflammatory activities can be synthesized in high yield, and thus can be produced in large amounts. In addition, ramalin can be stably maintained for a long period of time, and thus can be easily used for industrial purposes.
摘要翻译：本发明涉及一种合成马来林蛋白的方法，更具体地说，涉及一种合成马马拉林的方法，该方法包括使2-肼基苯酚与C-1具有保护的羧基的L-谷氨酸和C的保护的氨基反应 -2，以及防止马马林分解的方法。根据本发明，可以以高收率合成具有优异抗氧化和抗炎活性的马马林，因此可大量制造。另外，马马龙可以长期稳定地维持，因此可以容易地用于工业目的。

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