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1. 发明授权

US08926605B2 Systems and methods for radiometrically measuring temperature during tissue ablation 有权
标题翻译：组织消融期间放射测量温度的系统和方法
公开(公告)号：US08926605B2
公开(公告)日：2015-01-06
申请号：US13368112
申请日：2012-02-07
申请人： John McCarthy , Timothy J. Lenihan , Eric R. Kanowsky , Robert C. Allison
发明人： John McCarthy , Timothy J. Lenihan , Eric R. Kanowsky , Robert C. Allison
IPC分类号： A61B18/04
CPC分类号： A61B18/1492 , A61B5/015 , A61B5/0402 , A61B18/02 , A61B18/12 , A61B18/1206 , A61B18/1815 , A61B2017/0007 , A61B2018/00029 , A61B2018/00351 , A61B2018/00577 , A61B2018/00648 , A61B2018/00678 , A61B2018/00708 , A61B2018/00714 , A61B2018/00791 , A61B2018/00797 , A61B2018/00821 , A61B2018/00898 , A61B2018/1861 , A61B2218/002 , A61N7/022
摘要： The present invention provides systems and methods for radiometrically measuring temperature during ablation. An interface module includes a processor; a first input/output (I/O) port configured to receive digital radiometer and thermocouple signals from an integrated catheter tip (ICT) that includes a radiometer; a second I/O port configured to receive ablative energy from an electrosurgical generator; a temperature display; a patient relay in communication with the first and second I/O ports and the processor; and a computer-readable medium storing radiometer and thermocouple operation parameters and instructions for causing the processor to: calculate a temperature adjacent to the ICT based on the radiometer and thermocouple signals and the operation parameters, causing the temperature display to display the calculated temperature, and closing the patient relay so as to pass ablative energy received on the second I/O port to the first I/O port.
摘要翻译：本发明提供了消融期间用于放射学测量温度的系统和方法。接口模块包括处理器; 配置为从包括辐射计的集成导管尖端（ICT）接收数字辐射计和热电偶信号的第一输入/输出（I / O）端口; 配置为从电外科发生器接收消融能量的第二I / O端口; 温度显示; 与所述第一和第二I / O端口和所述处理器通信的患者继电器; 以及存储辐射计和热电偶操作参数和指令的计算机可读介质，用于使处理器：基于辐射计和热电偶信号和操作参数计算与ICT相邻的温度，使温度显示显示计算出的温度;以及关闭患者继电器以便将在第二I / O端口上接收的烧蚀能量传递到第一I / O端口。

2. 发明申请

US20090312754A1 METHOD AND APPARATUS FOR MEASURING CATHETER CONTACT FORCE DURING A MEDICAL PROCEDURE 有权
标题翻译：在医疗过程中测量导管接触力的方法和装置
公开(公告)号：US20090312754A1
公开(公告)日：2009-12-17
申请号：US12483407
申请日：2009-06-12
申请人： Timothy J. Lenihan , Robert C. Allison , Kenneth L. Carr , Peter Van der Sluis
发明人： Timothy J. Lenihan , Robert C. Allison , Kenneth L. Carr , Peter Van der Sluis
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/10 , A61B18/18 , A61B90/06 , A61B2017/00084 , A61B2017/00243 , A61B2018/00023 , A61B2018/00642 , A61B2018/00791 , A61B2090/065
摘要： A method for measuring the contact force exerted on tissue by a probe for heating the tissue and containing an antenna which is connected to a radiometer whose output reading indicates the temperature at depth of the tissue contacted by the probe comprises displaying the output reading of the radiometer, applying sufficient power to the probe to heat the tissue to a selected first temperature that is not lethal to the tissue, moving the probe into contact with the tissue, observing the increase in the displayed temperature reading that occurs when the probe contacts the tissue, and advancing the probe toward the tissue until the displayed temperature reading reaches a value corresponding to a selected tissue contact force. After the probe position in the tissue has stabilized, the applied power to the probe may be increased to heat the tissue to a selected second temperature that is lethal to tissue for a sufficient time to ablate the tissue followed by lowering the tissue heating to a sub-lethal temperature. Apparatus for practicing the method is also disclosed.
摘要翻译：一种用于测量由用于加热组织的探针施加在组织上的接触力并包含连接到辐射计的天线的方法，该辐射计的输出读数表示与探头接触的组织的深度处的温度，包括显示辐射计的输出读数向探头施加足够的功率以将组织加热到对组织不致死的选定的第一温度，使探针与组织接触，观察当探针接触组织时发生的显示温度读数的增加，并且将探针推向组织直到显示的温度读数达到对应于所选择的组织接触力的值。在组织中的探针位置已经稳定之后，可以增加对探针的施加的功率，以将组织加热到对组织致死的选定的第二温度足够的时间以消融组织，随后将组织加热降低到亚致死温度。还公开了用于实施该方法的装置。

3. 发明授权

US5683382A Microwave antenna catheter 失效
标题翻译：微波天线导管
公开(公告)号：US5683382A
公开(公告)日：1997-11-04
申请号：US440716
申请日：1995-05-15
申请人： Timothy J. Lenihan , Kenneth L. Carr , Mark Guetersloh
发明人： Timothy J. Lenihan , Kenneth L. Carr , Mark Guetersloh
IPC分类号： A61N5/02 , A61B18/18
CPC分类号： A61B18/18 , A61B18/1815
摘要： A helical antenna, which is matched to the desired microwave frequency of 915 MHz, comprises a helix having a linear length which is in the range of 74 to 112 mm or a non-zero integer multiple thereof, and which delivers microwave energy in an optimal heating pattern with little reflected power.
摘要翻译：与期望的915MHz的微波频率匹配的螺旋天线包括具有在74至112mm范围内的线性长度或其非零整数倍的螺旋线，并将微波能量传递到最佳加热模式反射功率很小。

4. 发明授权

US08954161B2 Systems and methods for radiometrically measuring temperature and detecting tissue contact prior to and during tissue ablation 有权
标题翻译：在组织消融之前和期间，用于放射学测量温度和检测组织接触的系统和方法
公开(公告)号：US08954161B2
公开(公告)日：2015-02-10
申请号：US13486889
申请日：2012-06-01
申请人： John F. McCarthy , Timothy J. Lenihan , Eric R. Kanowsky , Robert C. Allison
发明人： John F. McCarthy , Timothy J. Lenihan , Eric R. Kanowsky , Robert C. Allison
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B5/01 , A61B5/0422 , A61B5/1405 , A61B5/150022 , A61B5/6852 , A61B5/6886 , A61B5/7405 , A61B18/12 , A61B18/1233 , A61B2017/00057 , A61B2017/0007 , A61B2018/00351 , A61B2018/00577 , A61B2018/00642 , A61B2018/0066 , A61B2018/00672 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00791 , A61B2018/00821 , A61B2018/00898 , A61B2018/0212 , A61B2018/1467 , A61B2018/1861 , A61B2090/065
摘要： The present invention provides systems and methods for radiometrically measuring temperature and detecting tissue contact during ablation. An interface module includes a first input/output (I/O) port for receiving radiometer and thermocouple signals from an integrated catheter tip (ICT) that includes a radiometer; a second I/O port for receiving ablative energy from an electrosurgical generator; a temperature display; a patient relay; a computer-readable medium storing radiometer and thermocouple parameters and instructions for causing the processor to: calculate a temperature adjacent to the ICT based on the radiometer and thermocouple signals and the parameters; causing the temperature display to display the calculated temperature; closing the patient relay to pass ablative energy from the second to the first I/O port; determining whether the ICT is in contact with tissue based on the radiometer signal. An output device indicates whether the ICT is determined to be in contact with the tissue.
摘要翻译：本发明提供了用于放射学测量温度和检测消融期间的组织接触的系统和方法。接口模块包括用于从包括辐射计的集成导管尖端（ICT）接收辐射计和热电偶信号的第一输入/输出（I / O）端口; 用于从电外科发生器接收烧蚀能量的第二I / O端口; 温度显示; 病人接力存储用于使处理器基于辐射计和热电偶信号和参数计算与ICT相邻的温度的辐射计和热电偶参数和指令的计算机可读介质; 使温度显示显示计算出的温度; 关闭患者继电器以将烧蚀能量从第二I / O端口传递到第一I / O端口; 基于辐射计信号确定ICT是否与组织接触。输出设备指示ICT是否被确定为与组织接触。

5. 发明授权

US08206380B2 Method and apparatus for measuring catheter contact force during a medical procedure 有权
标题翻译：用于在医疗过程中测量导管接触力的方法和装置
公开(公告)号：US08206380B2
公开(公告)日：2012-06-26
申请号：US12483407
申请日：2009-06-12
申请人： Timothy J. Lenihan , Robert C. Allison , Kenneth L. Carr , Peter Van der Sluis
发明人： Timothy J. Lenihan , Robert C. Allison , Kenneth L. Carr , Peter Van der Sluis
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/10 , A61B18/18 , A61B90/06 , A61B2017/00084 , A61B2017/00243 , A61B2018/00023 , A61B2018/00642 , A61B2018/00791 , A61B2090/065
摘要： A method for measuring the contact force exerted on tissue by a probe for heating the tissue and containing an antenna which is connected to a radiometer whose output reading indicates the temperature at depth of the tissue contacted by the probe comprises displaying the output reading of the radiometer, applying sufficient power to the probe to heat the tissue to a selected first temperature that is not lethal to the tissue, moving the probe into contact with the tissue, observing the increase in the displayed temperature reading that occurs when the probe contacts the tissue, and advancing the probe toward the tissue until the displayed temperature reading reaches a value corresponding to a selected tissue contact force. After the probe position in the tissue has stabilized, the applied power to the probe may be increased to heat the tissue to a selected second temperature that is lethal to tissue for a sufficient time to ablate the tissue followed by lowering the tissue heating to a sub-lethal temperature. Apparatus for practicing the method is also disclosed.
摘要翻译：一种用于测量由用于加热组织的探针施加在组织上的接触力并包含连接到辐射计的天线的方法，该辐射计的输出读数表示与探头接触的组织的深度处的温度，包括显示辐射计的输出读数向探头施加足够的功率以将组织加热到对组织不致死的选定的第一温度，使探针与组织接触，观察当探针接触组织时发生的显示温度读数的增加，并且将探针推向组织直到显示的温度读数达到对应于所选择的组织接触力的值。在组织中的探针位置已经稳定之后，可以增加对探针的施加的功率，以将组织加热到对组织致死的选定的第二温度足够的时间以消融组织，随后将组织加热降低到亚致死温度。还公开了用于实施该方法的装置。

6. 发明授权

US5676653A Kink-resistant steerable catheter assembly 失效
标题翻译：抗扭转导管组件
公开(公告)号：US5676653A
公开(公告)日：1997-10-14
申请号：US619912
申请日：1996-03-20
申请人： Kevin Taylor , Philip F. Latzgo , Timothy J. Lenihan
发明人： Kevin Taylor , Philip F. Latzgo , Timothy J. Lenihan
IPC分类号： A61M25/00 , A61M25/01 , A61M25/092 , A61M37/00
CPC分类号： A61M25/0144 , A61M25/0147 , A61M2025/0036 , A61M2025/0037 , A61M2025/004 , A61M2025/015 , A61M25/0032 , A61M25/0074 , A61M25/008 , A61M25/0082
摘要： A kink-resistant steerable catheter assembly suitable for microwave ablation includes a handle, a catheter and a steering control. The catheter has (a) a flexible, torque-transmitting and axially incompressible proximal or body portion terminating in a proximal end attached to the handle, and (b) a flexible and axially compressible distal or tip portion terminating in a distal end. A coaxial cable is disposed in and extends through a large aperture in the catheter proximal portion, and a coaxial cable extension is generally centrally disposed in, substantially fills, and snugly extends through a large lumen in the catheter distal portion to reduce kinking. The control is disposed in and actuatable from the handle, for placing tension on one of a pair of steering wires while relaxing tension on the other of the pair of steering wires, thereby to bend the distal end of the coaxial cable extension toward the tensed one of the steering wires.
摘要翻译：适用于微波消融的抗扭转导管组件包括手柄，导管和转向控制装置。导管具有（a）柔性的，扭矩传递的和轴向不可压缩的近端或主体部分，其终止于附接到手柄的近端，以及（b）终止于远端的柔性且可轴向压缩的远端或尖端部分。同轴电缆设置在导管近端部分中并穿过导管近端部分中的大孔，并且同轴电缆延伸部通常居中设置在基本上填充并且紧密地延伸穿过导管远端部分中的大腔，以减少扭结。控制装置设置在手柄中并可从手柄驱动，用于在一对操纵线之一上张紧张力，同时放松一对转向线中的另一个上的张力，从而使同轴电缆延伸部的远端朝向张紧的一个的转向线。

7. 发明申请

US20130324993A1 SYSTEMS AND METHODS FOR RADIOMETRICALLY MEASURING TEMPERATURE AND DETECTING TISSUE CONTACT PRIOR TO AND DURING TISSUE ABLATION 有权
标题翻译：用于放射性测量温度的系统和方法，并在组织抽吸之前和之后检测组织接触
公开(公告)号：US20130324993A1
公开(公告)日：2013-12-05
申请号：US13486889
申请日：2012-06-01
申请人： John McCarthy , Timothy J. Lenihan , Eric R. Kanowsky
发明人： John McCarthy , Timothy J. Lenihan , Eric R. Kanowsky
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B5/01 , A61B5/0422 , A61B5/1405 , A61B5/150022 , A61B5/6852 , A61B5/6886 , A61B5/7405 , A61B18/12 , A61B18/1233 , A61B2017/00057 , A61B2017/0007 , A61B2018/00351 , A61B2018/00577 , A61B2018/00642 , A61B2018/0066 , A61B2018/00672 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00791 , A61B2018/00821 , A61B2018/00898 , A61B2018/0212 , A61B2018/1467 , A61B2018/1861 , A61B2090/065
摘要： The present invention provides systems and methods for radiometrically measuring temperature and detecting tissue contact during ablation. An interface module includes a first input/output (I/O) port for receiving radiometer and thermocouple signals from an integrated catheter tip (ICT) that includes a radiometer; a second I/O port for receiving ablative energy from an electrosurgical generator; a temperature display; a patient relay; a computer-readable medium storing radiometer and thermocouple parameters and instructions for causing the processor to: calculate a temperature adjacent to the ICT based on the radiometer and thermocouple signals and the parameters; causing the temperature display to display the calculated temperature; closing the patient relay to pass ablative energy from the second to the first I/O port; determining whether the ICT is in contact with tissue based on the radiometer signal. An output device indicates whether the ICT is determined to be in contact with the tissue.
摘要翻译：本发明提供了用于放射学测量温度和检测消融期间的组织接触的系统和方法。接口模块包括用于从包括辐射计的集成导管尖端（ICT）接收辐射计和热电偶信号的第一输入/输出（I / O）端口; 用于从电外科发生器接收烧蚀能量的第二I / O端口; 温度显示; 病人接力存储用于使处理器基于辐射计和热电偶信号和参数计算与ICT相邻的温度的辐射计和热电偶参数和指令的计算机可读介质; 使温度显示显示计算出的温度; 关闭患者继电器以将烧蚀能量从第二I / O端口传递到第一I / O端口; 基于辐射计信号确定ICT是否与组织接触。输出设备指示ICT是否被确定为与组织接触。

8. 发明申请

US20130204240A1 SYSTEMS AND METHODS FOR RADIOMETRICALLY MEASURING TEMPERATURE DURING TISSUE ABLATION 有权
标题翻译：组织吸收期间放射性测量温度的系统和方法
公开(公告)号：US20130204240A1
公开(公告)日：2013-08-08
申请号：US13368112
申请日：2012-02-07
申请人： John McCarthy , Timothy J. Lenihan , Eric R. Kanowsky
发明人： John McCarthy , Timothy J. Lenihan , Eric R. Kanowsky
IPC分类号： A61B18/14 , A61B18/18 , A61B18/02
CPC分类号： A61B18/1492 , A61B5/015 , A61B5/0402 , A61B18/02 , A61B18/12 , A61B18/1206 , A61B18/1815 , A61B2017/0007 , A61B2018/00029 , A61B2018/00351 , A61B2018/00577 , A61B2018/00648 , A61B2018/00678 , A61B2018/00708 , A61B2018/00714 , A61B2018/00791 , A61B2018/00797 , A61B2018/00821 , A61B2018/00898 , A61B2018/1861 , A61B2218/002 , A61N7/022
摘要： The present invention provides systems and methods for radiometrically measuring temperature during ablation. An interface module includes a processor; a first input/output (I/O) port configured to receive digital radiometer and thermocouple signals from an integrated catheter tip (ICT) that includes a radiometer; a second I/O port configured to receive ablative energy from an electrosurgical generator; a temperature display; a patient relay in communication with the first and second I/O ports and the processor; and a computer-readable medium storing radiometer and thermocouple operation parameters and instructions for causing the processor to: calculate a temperature adjacent to the ICT based on the radiometer and thermocouple signals and the operation parameters, causing the temperature display to display the calculated temperature, and closing the patient relay so as to pass ablative energy received on the second I/O port to the first I/O port.
摘要翻译：本发明提供了消融期间用于放射学测量温度的系统和方法。接口模块包括处理器; 配置为从包括辐射计的集成导管尖端（ICT）接收数字辐射计和热电偶信号的第一输入/输出（I / O）端口; 配置为从电外科发生器接收消融能量的第二I / O端口; 温度显示; 与所述第一和第二I / O端口和所述处理器通信的患者继电器; 以及存储辐射计和热电偶操作参数和指令的计算机可读介质，用于使处理器：基于辐射计和热电偶信号和操作参数计算与ICT相邻的温度，使温度显示显示计算出的温度;以及关闭患者继电器以便将在第二I / O端口上接收的烧蚀能量传递到第一I / O端口。

9. 发明申请

US20120035603A1 METHOD AND APPARATUS FOR MINIMIZING THERMAL TRAUMA TO AN ORGAN DURING TISSUE ABLATION OF A DIFFERENT ORGAN 审中-公开
标题翻译：在不同组织的组织消融期间将热TRAUMA最小化到组织的方法和装置
公开(公告)号：US20120035603A1
公开(公告)日：2012-02-09
申请号：US13142865
申请日：2010-01-20
申请人： Timothy J. Lenihan
发明人： Timothy J. Lenihan
IPC分类号： A61B18/18 , A61B18/04
CPC分类号： A61B18/00 , A61B5/01 , A61B5/0507 , A61B18/10 , A61B18/1492 , A61B90/04 , A61B2017/00084 , A61B2017/00243 , A61B2017/00274 , A61B2018/00011 , A61B2018/00023 , A61B2018/00351 , A61B2018/00505 , A61B2018/00547 , A61B2018/00642 , A61B2018/00702 , A61B2018/00744 , A61B2018/00767 , A61B2018/00791
摘要： A method of minimizing thermal trauma during tissue ablation includes the steps of placing an ablation catheter at an ablation site on a first organ in a patient's body, providing energy to the ablation catheter to heat first organ tissue at the ablation site, providing microwave radiometry apparatus including a probe containing a microwave antenna and a radiometer responsive to the antenna output for producing a temperature signal corresponding to the thermal radiation picked up by the antenna and positioning the probe in a body passage of a second organ in the patient's body having a wall portion adjacent to the ablation site so that the microwave antenna is located at a measurement site opposite the ablation site. Using the radiometry apparatus, the temperature at depth in the second organ tissue at the measurement site is measured to provide a corresponding temperature signal, and the ablation catheter is controlled in response to the temperature signal to maintain the temperature of the second organ tissue below a predetermined value that does not result in thermal trauma to the second organ tissue. Apparatus for carrying out the method is also disclosed.
摘要翻译：在组织消融期间最小化热创伤的方法包括以下步骤：将消融导管置于患者体内的第一器官上的消融部位，向消融导管提供能量以加热消融部位的第一器官组织，提供微波辐射测量装置包括包含微波天线和辐射计的探针，所述探针响应于所述天线输出，用于产生对应于由所述天线拾取的热辐射的温度信号，并将所述探针定位在所述患者体内的具有壁部分的第二器官的体通道中与消融部位相邻，使得微波天线位于与消融部位相对的测量部位。使用辐射测量装置，测量在测量部位的第二器官组织中的深度处的温度以提供相应的温度信号，并且响应于温度信号控制消融导管，以将第二器官组织的温度维持在低于不会导致第二器官组织的热损伤的预定值。还公开了用于执行该方法的装置。

10. 发明授权

US5702433A Kink-resistant steerable catheter assembly for microwave ablation 失效
标题翻译：用于微波消融的抗扭转导管组件
公开(公告)号：US5702433A
公开(公告)日：1997-12-30
申请号：US534345
申请日：1995-09-27
申请人： Kevin Taylor , Philip F. Latzgo , Timothy J. Lenihan
发明人： Kevin Taylor , Philip F. Latzgo , Timothy J. Lenihan
IPC分类号： A61M25/00 , A61M25/01 , A61F2/00
CPC分类号： A61M25/0144 , A61M25/0147 , A61M2025/0036 , A61M2025/0037 , A61M2025/004 , A61M2025/015 , A61M25/0074 , A61M25/008 , A61M25/0082
摘要： A kink-resistant steerable catheter assembly suitable for microwave ablation includes a handle, a catheter and a steering control. The catheter has (a) a flexible, torque-transmitting and axially incompressible proximal or body portion terminating in a proximal end attached to the handle, and (b) a flexible and axially compressible distal or tip portion terminating in a distal end. A coaxial cable is disposed in and extends through a large aperture in the catheter proximal portion, and a coaxial cable extension is generally centrally disposed in, substantially fills, and snugly extends through a large lumen in the catheter distal portion to reduce kinking. The control is disposed in and actuatable from the handle, for placing tension on one of a pair of steering wires while relaxing tension on the other of the pair of steering wires, thereby to bend the distal end of the coaxial cable extension toward the tensed one of the steering wires.
摘要翻译：适用于微波消融的抗扭转导管组件包括手柄，导管和转向控制装置。导管具有（a）柔性的，扭矩传递的和轴向不可压缩的近端或主体部分，其终止于附接到手柄的近端，以及（b）终止于远端的柔性且可轴向压缩的远端或尖端部分。同轴电缆设置在导管近端部分中并穿过导管近端部分中的大孔，并且同轴电缆延伸部通常居中设置在基本上填充并且紧密地延伸穿过导管远端部分中的大腔，以减少扭结。控制装置设置在手柄中并可从手柄驱动，用于在一对操纵线之一上张紧张力，同时放松一对转向线中的另一个上的张力，从而使同轴电缆延伸部的远端朝向张紧的一个的转向线。

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