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1. 发明授权

US08841345B2 Compositions and methods for treatment of premature ejaculation 有权
标题翻译：用于治疗早泄的组合物和方法
公开(公告)号：US08841345B2
公开(公告)日：2014-09-23
申请号：US10806072
申请日：2004-03-22
申请人： Mingqi Lu , Qin Wang , James L. Yeager , Y. Joseph Mo
发明人： Mingqi Lu , Qin Wang , James L. Yeager , Y. Joseph Mo
IPC分类号： A61K31/5575 , A61K31/445 , A61K9/00 , A61K9/06 , A61P15/00 , A61K31/736 , A61K31/465 , A61K31/00 , A61K31/165 , A61K31/167 , A61K31/557 , A61K47/36 , A61K47/18
CPC分类号： A61K9/0034 , A61K9/0014 , A61K31/00 , A61K31/165 , A61K31/167 , A61K31/20 , A61K31/445 , A61K31/4453 , A61K31/465 , A61K31/557 , A61K31/5575 , A61K31/736 , A61K45/06 , A61K47/10 , A61K47/14 , A61K47/18 , A61K47/26 , A61K47/32 , A61K47/36 , Y10S514/947 , A61K2300/00
摘要： Compositions and methods for the treatment of premature ejaculation are provided wherein a composition comprising a topical anesthetic, a shear-thinning polymeric thickener, a lipophilic component that is selected from the group consisting of an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, a liquid polyol and a mixture thereof, water and a buffer system that provides a buffered pH value for the composition in the range of about 3 to about 7.4 is administered to the penile meatus.
摘要翻译：提供了用于治疗早泄的组合物和方法，其中组合物包含局部麻醉剂，剪切稀化聚合物增稠剂，选自脂族C 1至C 8醇，脂族C 8至C 30酯的亲脂性组分，液体多元醇及其混合物，向组合物提供在约3至约7.4范围内提供缓冲pH值的水和缓冲系统施用于阴茎口。

2. 发明申请

US20090099266A1 Antifungal nail coat and method of use 审中-公开
标题翻译：抗真菌指甲外套及使用方法
公开(公告)号：US20090099266A1
公开(公告)日：2009-04-16
申请号：US12316009
申请日：2008-12-09
申请人： Stanley W. Kepka , Y. Joseph Mo , Hang-Yong Wang , Mingqi Lu , William R. Pfister
发明人： Stanley W. Kepka , Y. Joseph Mo , Hang-Yong Wang , Mingqi Lu , William R. Pfister
IPC分类号： A01N33/04 , A01P3/00
CPC分类号： A61K31/137 , A61K8/41 , A61K8/44 , A61K9/0014 , A61K9/08 , A61K9/7015 , A61K47/14 , A61K47/32 , A61Q3/02 , Y10S424/808
摘要： Antifungal nail coat compositions containing an allylamine, an N,N-di(C1-C8) alkylamino substituted, (C4-C18) alkyl (C2-C18) carboxylic ester or a pharmaceutically acceptable acid addition salt thereof, a hydrophilic polymer, and a pharmaceutically acceptable, volatile organic carrier are disclosed. The composition provides a substantially water-soluble, fungicidal coating upon contact with a fungally susceptible or infected nail.
摘要翻译：含有烯丙胺，N，N-二（C1-C8）烷基氨基取代的（C4-C18）烷基（C2-C18）羧酸酯或其药学上可接受的酸加成盐的抗真菌指甲油组合物，亲水性聚合物和公开了药学上可接受的挥发性有机载体。当与真菌感染或感染的指甲接触时，组合物提供基本上水溶性的杀真菌涂层。

3. 发明申请

US20200230068A1 COMPOSITIONS AND METHODS OF DELIVERY OF PHARMACOLOGICAL AGENTS 审中-公开
公开(公告)号：US20200230068A1
公开(公告)日：2020-07-23
申请号：US16641522
申请日：2018-08-08
申请人： Y. Joseph MO , Xudong YUAN , NAL PHARMACEUTICAL GROUP LIMITED
发明人： Y. Joseph MO , Xudong YUAN
IPC分类号： A61K9/50 , A61K45/06 , A61K31/337
摘要： Nanoparticles and microspheres are provided for delivering an anticancer agent or other active agents to a subject. The nanoparticles and the microspheres are formed from a core that is encased by a coating or shell that includes a somatostatin-albumin fusion protein or analogue thereof. The somatostatin-albumin fusion protein includes at least one albumin (or an analog thereof) moiety, at least one somatostatin moiety (e.g. SST-14, SST-28), and at least one spacer connecting albumin to albumin, somatostatin to somatostatin and/or albumin to somatostatin moieties.

4. 发明授权

US06841574B2 Topical stabilized prostaglandin E compound dosage forms 有权
标题翻译：局部稳定的前列腺素E化合物剂型
公开(公告)号：US06841574B2
公开(公告)日：2005-01-11
申请号：US10336481
申请日：2003-01-03
申请人： Y. Joseph Mo , Daniel W. Frank
发明人： Y. Joseph Mo , Daniel W. Frank
IPC分类号： A61K9/00 , A61K9/70 , A61K31/557 , A61K31/5575 , A61K31/19 , A61F13/00 , A61L15/16
CPC分类号： A61K9/7007 , A61K9/0034 , A61K31/557 , A61K31/5575 , Y10S514/947 , Y10S514/953
摘要： Compounds of prostaglandin E group (PGE compounds) are stabilized as non-aqueous compositions that include the compound together with a bulking agent that can be a non-aqueous liquid or a solid in a sheet, film or powder form. The composition can optionally include a skin penetration enhancer. A non-aqueous, solid dosage form comprises a PGE compound substantially uniformly distributed in a carrier sheet or film.
摘要翻译：前列腺素E组（PGE化合物）的化合物被稳定为非水性组合物，其包括化合物以及可以是非水性液体或片状，薄膜或粉末形式的固体的填充剂。组合物可以任选地包括皮肤渗透增强剂。非水性固体剂型包含基本均匀分布在载体片或膜中的PGE化合物。

5. 发明授权

US09155711B2 Transdermal drug delivery system containing donepezil 有权
标题翻译：含多奈哌齐的透皮给药系统
公开(公告)号：US09155711B2
公开(公告)日：2015-10-13
申请号：US13806565
申请日：2011-04-27
申请人： Hoo-Kyun Choi , Myung-Kwan Chun , Y. Joseph Mo
发明人： Hoo-Kyun Choi , Myung-Kwan Chun , Y. Joseph Mo
IPC分类号： A61K9/70 , A61K31/445
CPC分类号： A61K9/7046 , A61K9/7053 , A61K9/7061 , A61K31/445 , A61K47/10
摘要： The present invention provides a transdermal drug delivery system comprising a drug-containing matrix layer comprising: (a) donepezil or a pharmaceutically acceptable salt thereof as an active ingredient; and (b) an acrylate-rubber hybrid as an adhesive.
摘要翻译：本发明提供了包含含药基质层的透皮药物递送系统，其包含：（a）多奈哌齐或其药学上可接受的盐作为活性成分; 和（b）作为粘合剂的丙烯酸酯 - 橡胶混合物。

6. 发明授权

US08632813B2 Prostaglandin compositions and methods for the treatment of vasospasm 有权
标题翻译：前列腺素组合物和治疗血管痉挛的方法
公开(公告)号：US08632813B2
公开(公告)日：2014-01-21
申请号：US11875725
申请日：2007-10-19
申请人： Tian Wen , Liu Liu , Mingqi Lu , Jieshan Bai , Y. Joseph Mo
发明人： Tian Wen , Liu Liu , Mingqi Lu , Jieshan Bai , Y. Joseph Mo
IPC分类号： A61K9/14 , A61K31/5575 , A61K31/715 , A61K47/00 , A61F2/00
CPC分类号： A61K47/18 , A61K9/0014 , A61K31/5575 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/36
摘要： Compositions and methods for the treatment of vasospasm are provided comprising applying an amount of a semi-solid vasoactive prostaglandin composition to the affected tissue. Also provided are methods of improving microcirculation in a replanted body part.
摘要翻译：提供了用于治疗血管痉挛的组合物和方法，包括将一定量的半固体血管活性前列腺素组合物施用于受影响的组织。还提供了改善再植体部分中的微循环的方法。

7. 发明授权

US07462362B2 Antifungal nail coat and method of use 失效
标题翻译：抗真菌指甲外套及使用方法
公开(公告)号：US07462362B2
公开(公告)日：2008-12-09
申请号：US10514190
申请日：2004-03-22
申请人： Stanley W. Kepka , Y. Joseph Mo , Hang-Yong Wang , Mingqi Lu , William R. Pfister
发明人： Stanley W. Kepka , Y. Joseph Mo , Hang-Yong Wang , Mingqi Lu , William R. Pfister
IPC分类号： A61K8/00 , A61K8/18
CPC分类号： A61K31/137 , A61K8/41 , A61K8/44 , A61K9/0014 , A61K9/08 , A61K9/7015 , A61K47/14 , A61K47/32 , A61Q3/02 , Y10S424/808
摘要： A dual action antifungal nail coat composition and method of use for ameliorating or preventing fungal infection of the nails, and onychomycosis, in particular, is disclosed. Composition embodiments in the form of one-coat type and two-coat type suitable for daily fungicidal regimens are disclosed. A preferred antifungal nail coat composition comprises an effective fungicidal amount of antifungal agent, a permeation enhancing amount of a substantially non-volatile, permeation enhancer, a film-forming amount of a hydrophilic polymer, and a pharmaceutically acceptable, volatile carrier. The composition provides a substantially water-soluble fungicidal coating on contacting a fungally susceptible or infected nail.
摘要翻译：公开了一种双作用抗真菌指甲油组合物和用于改善或预防指甲真菌感染和甲真菌病的用途的方法。公开了适用于日常杀真菌方案的单涂层型和双层型形式的组合物实施方案。优选的抗真菌指甲涂层组合物包含有效杀真菌量的抗真菌剂，渗透促进量的基本上不挥发的渗透促进剂，成膜量的亲水性聚合物和药学上可接受的挥发性载体。组合物在接触真菌感染或感染的指甲时提供基本上水溶性的杀真菌涂层。

8. 发明授权

US06594527B2 Electrical stimulation apparatus and method 失效
标题翻译：电刺激装置及方法
公开(公告)号：US06594527B2
公开(公告)日：2003-07-15
申请号：US09824362
申请日：2001-04-02
申请人： Y. Joseph Mo
发明人： Y. Joseph Mo
IPC分类号： A61N118
CPC分类号： A61N1/36014 , A61N1/048 , A61N1/3756
摘要： An electrical stimulation apparatus and method for providing electrical stimulation to tissue. The electrical stimulation apparatus includes a base unit and an electrode module. The base unit is configured to be hand portable and contains a first electrical circuit and a first battery for supplying electrical energy to the first electrical circuit. A second electrical circuit and a second battery provide a time/date function. The base unit supports an LCD to provide a visual indication of the various functions of the electrical stimulation apparatus. The electrode module is programmable to enable the prescribing physician to set the treatment protocol for the electrical stimulation apparatus. The present apparatus is particularly well suited for the treatment of herpes simplex and herpes zoster.
摘要翻译：一种用于向组织提供电刺激的电刺激装置和方法。电刺激装置包括基座单元和电极模块。基本单元被配置为手提式的，并且包含用于向第一电路提供电能的第一电路和第一电池。第二电路和第二电池提供时间/日期功能。基座单元支持LCD以提供电刺激装置的各种功能的可视指示。电极模块是可编程的，使处方医师能够设置电刺激装置的治疗方案。本发明的装置特别适用于单纯疱疹和带状疱疹的治疗。

9. 发明申请

US20060067898A1 Antifungal nail coat and method of use 失效
标题翻译：抗真菌指甲外套及使用方法
公开(公告)号：US20060067898A1
公开(公告)日：2006-03-30
申请号：US10514190
申请日：2004-03-22
申请人： Stanley Kepka , Y. Joseph Mo , Hang-Yong Wang , Mingqi Lu , William Pfister
发明人： Stanley Kepka , Y. Joseph Mo , Hang-Yong Wang , Mingqi Lu , William Pfister
IPC分类号： A61K31/137 , A61K8/41
CPC分类号： A61K31/137 , A61K8/41 , A61K8/44 , A61K9/0014 , A61K9/08 , A61K9/7015 , A61K47/14 , A61K47/32 , A61Q3/02 , Y10S424/808
摘要： A dual action antifungal nail coat composition and method of use for ameliorating or preventing fungal infection of the nails, and onychomycosis, in particular, is disclosed. Composition embodiments in the form of one-coat type and two-coat type suitable for daily fungicidal regimens are disclosed. A preferred antifungal nail coat composition comprises an effective fungicidal amount of antifungal agent, a permeation enhancing amount of a substantially non-volatile, permeation enhancer, a film-forming amount of a hydrophilic polymer, and a pharmaceutically acceptable, volatile carrier. The composition provides a substantially water-soluble fungicidal coating on contacting a fungally susceptible or infected nail.
摘要翻译：公开了一种双作用抗真菌指甲油组合物和用于改善或预防指甲真菌感染和甲真菌病的用途的方法。公开了适用于日常杀真菌方案的单涂层型和双层型形式的组合物实施方案。优选的抗真菌指甲涂层组合物包含有效杀真菌量的抗真菌剂，渗透促进量的基本上不挥发的渗透促进剂，成膜量的亲水性聚合物和药学上可接受的挥发性载体。组合物在接触真菌感染或感染的指甲时提供基本上水溶性的杀真菌涂层。

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