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1. 发明申请

US20120116741A1 SYSTEMS AND METHODS OF CONSTRUCTING A PATIENT SPECIFIC NEURAL ELECTRICAL STIMULATION MODEL 审中-公开
标题翻译：建立患者特异性神经电刺激模型的系统和方法
公开(公告)号：US20120116741A1
公开(公告)日：2012-05-10
申请号：US13110771
申请日：2011-05-18
申请人： Charles Tak Ming Choi , Yi-Hsuan Lee
发明人： Charles Tak Ming Choi , Yi-Hsuan Lee
IPC分类号： G06G7/60
CPC分类号： G09B23/30 , A61B5/04001 , A61N1/36135
摘要： A system and a method of constructing a personalized or patient specific neural stimulation model. The method includes measuring an electro-physiology signal of an individual and establishing a personalized or patient specific neural stimulation model that has a preset model parameter and generates a human physiology parameter according to the model parameters; and analyzing the human physiology parameters and regulating the model parameters according to a parameter-optimizing algorithm, such that the human physiology parameters outputted by the personalized or patient specific neural stimulation model matches the measured electro-physiology signal.
摘要翻译：构建个性化或患者特异性神经刺激模型的系统和方法。该方法包括测量个体的电生理信号并建立具有预设模型参数的个性化或患者特异性神经刺激模型，并根据模型参数生成人体生理参数; 并根据参数优化算法分析人体生理参数和调节模型参数，使得个性化或患者特异性神经刺激模型输出的人体生理参数与测得的电生理信号匹配。

2. 发明申请

US20110230933A1 ELECTRICAL STIMULATION METHOD AND APPARATUS TO STIMULATE NERVE FIBERS 有权
标题翻译：电刺激方法和刺激神经纤维的装置
公开(公告)号：US20110230933A1
公开(公告)日：2011-09-22
申请号：US12987897
申请日：2011-01-10
申请人： CHARLES TAK-MING CHOI , Yi-Hsuan Lee
发明人： CHARLES TAK-MING CHOI , Yi-Hsuan Lee
IPC分类号： A61N1/36
CPC分类号： G10L25/00 , A61N1/36036 , A61N1/36185
摘要： The present invention provides an electrical stimulation method and apparatus to stimulate nerve fibers, turning on suitable combination of adjacent electrodes simultaneously to form virtual channels based on predetermined rules, so that the stimulation signal will generate or evoke a nerve response spectrum that matches the original signal spectrum presented as the input sound. The method includes the steps of receiving a sound signal by a receiving unit; dividing the received sound signal into a plurality of frequency bands by a processing unit; extracting a spectral peak from each of the frequency bands and determining a stimulation sequence of frequency bands by the processing unit; and selectively driving a plurality of electrode groups in a plurality of cycles based on the stimulation sequence of frequency bands and a determination rule by the processing unit, so that the nerve response that matches the original signal will be generated.
摘要翻译：本发明提供一种刺激神经纤维的电刺激方法和装置，基于预定的规则同时打开相邻电极的适当组合以形成虚拟通道，使得刺激信号将产生或引起与原始信号匹配的神经反应谱频谱呈现为输入声音。该方法包括以下步骤：接收单元接收声音信号; 通过处理单元将接收到的声音信号分成多个频带; 从每个频带提取频谱峰值，并由处理单元确定频带的刺激序列; 并且基于频带的刺激序列和由处理单元的确定规则以多个周期选择性地驱动多个电极组，从而将产生与原始信号匹配的神经反应。

3. 发明授权

US08521298B2 Electrical stimulation method and apparatus to stimulate nerve fibers 有权
标题翻译：刺激神经纤维的电刺激方法和装置
公开(公告)号：US08521298B2
公开(公告)日：2013-08-27
申请号：US12987897
申请日：2011-01-10
申请人： Charles Tak-Ming Choi , Yi-Hsuan Lee
发明人： Charles Tak-Ming Choi , Yi-Hsuan Lee
IPC分类号： A61N1/00 , A61N1/36
CPC分类号： G10L25/00 , A61N1/36036 , A61N1/36185
摘要： The present invention provides an electrical stimulation method and apparatus to stimulate nerve fibers, turning on suitable combination of adjacent electrodes simultaneously to form virtual channels based on predetermined rules, so that the stimulation signal will generate or evoke a nerve response spectrum that matches the original signal spectrum presented as the input sound. The method includes the steps of receiving a sound signal by a receiving unit; dividing the received sound signal into a plurality of frequency bands by a processing unit; extracting a spectral peak from each of the frequency bands and determining a stimulation sequence of frequency bands by the processing unit; and selectively driving a plurality of electrode groups in a plurality of cycles based on the stimulation sequence of frequency bands and a determination rule by the processing unit, so that the nerve response that matches the original signal will be generated.
摘要翻译：本发明提供一种刺激神经纤维的电刺激方法和装置，基于预定的规则同时打开相邻电极的适当组合以形成虚拟通道，使得刺激信号将产生或引起与原始信号匹配的神经反应谱频谱呈现为输入声音。该方法包括以下步骤：接收单元接收声音信号; 通过处理单元将接收到的声音信号分成多个频带; 从每个频带提取频谱峰值，并由处理单元确定频带的刺激序列; 并且基于频带的刺激序列和由处理单元的确定规则以多个周期选择性地驱动多个电极组，从而将产生与原始信号匹配的神经反应。

4. 发明授权

US08391509B2 Audio-separating apparatus and operation method thereof 有权
标题翻译：音频分离装置及其操作方法
公开(公告)号：US08391509B2
公开(公告)日：2013-03-05
申请号：US12626860
申请日：2009-11-27
申请人： Yi-Hsuan Lee , Charles Tak-Ming Choi
发明人： Yi-Hsuan Lee , Charles Tak-Ming Choi
IPC分类号： H04B15/00 , H04R29/00
CPC分类号： H04R3/007
摘要： This present invention discloses an audio-separating apparatus and operation method thereof. The audio-separating apparatus applies both blind source separation and noise reduction mechanisms. The audio-separating apparatus only uses one microphone to record mixed sound signals. After applying the noise reduction mechanism, noise reduced signals and the mixed sound signals are used as the inputs of the blind source separation. The method may avoid the spatial aliasing effect caused by using a microphone array to record the mixed sound signals. Besides, speech segment losses caused by processing the noise reduction will be effectively recovered, which may help the hearing impaired recognize target speech signals.
摘要翻译：本发明公开了一种音频分离装置及其操作方法。音频分离装置同时应用盲源分离和降噪机制。音频分离装置仅使用一个麦克风来记录混合声音信号。在应用降噪机构之后，将噪声降低信号和混合声音信号用作盲源分离的输入。该方法可以避免使用麦克风阵列记录混合声音信号引起的空间混叠效应。此外，通过处理噪声降低引起的语音段损耗将有效恢复，这可能有助于听力障碍者识别目标语音信号。

5. 发明授权

US08211695B2 Isolated transgenic mammalian neural cell for detection of a sample containing a chemical substance damage to neurological system or selection of drugs for treating neurodegenerative disorders 有权
标题翻译：分离的转基因哺乳动物神经细胞用于检测含有化学物质损伤神经系统或选择用于治疗神经变性疾病的药物的样品
公开(公告)号：US08211695B2
公开(公告)日：2012-07-03
申请号：US12751718
申请日：2010-03-31
申请人： Yi-Hsuan Lee , Cheng-Yu Wang , Shu-Hui Juan , Wen-Liang Chen , Kuo-Sheng Hung , Chun-Hua Lin
发明人： Yi-Hsuan Lee , Cheng-Yu Wang , Shu-Hui Juan , Wen-Liang Chen , Kuo-Sheng Hung , Chun-Hua Lin
IPC分类号： C12N5/00 , C12N5/02 , C12Q1/00 , C12Q1/68
CPC分类号： C12N15/85 , C12N2503/02 , C12N2517/02 , C12N2800/107 , C12N2830/002 , G01N33/5058
摘要： The invention is to provide an isolated transgenic mammalian neural cell, which comprises at least one heterologous vector expressing AhR/ARNT. Also provided is methods the detection of a sample containing a chemical substance damage to the nervous system and the selection of drugs for treating neurodegenerative disorders.
摘要翻译：本发明提供一种分离的转基因哺乳动物神经细胞，其包含至少一种表达AhR / ARNT的异源载体。还提供了检测包含对神经系统损伤的化学物质的样品和用于治疗神经变性疾病的药物的选择的方法。

6. 发明申请

US20110026736A1 AUDIO-SEPARATING APPARATUS AND OPERATION METHOD THEREOF 有权
标题翻译：音频分离装置及其操作方法
公开(公告)号：US20110026736A1
公开(公告)日：2011-02-03
申请号：US12626860
申请日：2009-11-27
申请人： Yi-Hsuan Lee , Charles Tak-Ming Choi
发明人： Yi-Hsuan Lee , Charles Tak-Ming Choi
IPC分类号： H04B15/00
CPC分类号： H04R3/007
摘要： This present invention discloses an audio-separating apparatus and operation method thereof. The audio-separating apparatus applies both blind source separation and noise reduction mechanisms. The audio-separating apparatus only uses one microphone to record mixed sound signals. After applying the noise reduction mechanism, noise reduced signals and the mixed sound signals are used as the inputs of the blind source separation. The method may avoid the spatial aliasing effect caused by using a microphone array to record the mixed sound signals. Besides, speech segment losses caused by processing the noise reduction will be effectively recovered, which may help the hearing impaired recognize target speech signals.
摘要翻译：本发明公开了一种音频分离装置及其操作方法。音频分离装置同时应用盲源分离和降噪机制。音频分离装置仅使用一个麦克风来记录混合声音信号。在应用降噪机构之后，将噪声降低信号和混合声音信号用作盲源分离的输入。该方法可以避免使用麦克风阵列记录混合声音信号引起的空间混叠效应。此外，通过处理噪声降低引起的语音段损耗将有效恢复，这可能有助于听力障碍者识别目标语音信号。

7. 发明申请

US20100292751A1 PARAMETER ADJUSTMENT DEVICE AND METHOD THEREOF 有权
标题翻译：参数调整装置及其方法
公开(公告)号：US20100292751A1
公开(公告)日：2010-11-18
申请号：US12627192
申请日：2009-11-30
申请人： Charles Tak Ming Choi , Yi-Hsuan Lee
发明人： Charles Tak Ming Choi , Yi-Hsuan Lee
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/36071 , A61N1/36036 , A61N1/36082 , A61N1/37235 , G06F19/00 , G16H40/63
摘要： A parameter adjustment device and method thereof for a stimulator is disclosed. The parameter adjustment device comprises a generation unit, a user interface and a process unit. The generation unit generates a test MAP based on a current MAP. The user interface displays the current MAP and the test MAP for choosing one of them as the preferred MAP, and displays a major and a minor for choosing again, the major and the minor is defined as a significant difference and a little difference between the test MAP and the current MAP respectively. The process unit computes the acceptance probability of the preferred MAP based on a major or minor probability correspondence relationship and determines a next MAP by comparing the acceptance probability with the test probability. When one of the termination conditions is satisfied in an iterative operation, the next MAP is outputted as the best MAP.
摘要翻译：公开了一种用于刺激器的参数调整装置及其方法。参数调整装置包括生成单元，用户界面和处理单元。生成单元基于当前MAP生成测试MAP。用户界面显示当前MAP和测试MAP，选择其中一个作为首选MAP，并显示主要和次要选择，主要和次要被定义为显着差异和测试之间的一点差异 MAP和当前MAP。处理单元基于主要或次要概率对应关系来计算优选MAP的接受概率，并通过将接受概率与测试概率进行比较来确定下一MAP。当在迭代操作中满足终止条件之一时，将下一MAP作为最佳MAP输出。

8. 发明申请

US20110244470A1 ISOLATED TRANSGENIC MAMMALIAN NEURAL CELL FOR DETECTION OF A SAMPLE CONTAINING A CHEMICAL SUBSTANCE DAMAGE TO NEUROLOGICAL SYSTEM OR SELECTION OF DRUGS FOR TREATING NEURODEGENERATIVE DISORDERS 有权
标题翻译：用于检测含有对神经系统的化学物质损伤的样品或选择用于治疗神经损伤性疾病的药物的分离的转基因马马里尼神经细胞
公开(公告)号：US20110244470A1
公开(公告)日：2011-10-06
申请号：US12751718
申请日：2010-03-31
申请人： Yi-Hsuan Lee , Cheng-Yu Wang , Shu-Hui Juan , Wen-Liang Chen , Kuo-Sheng Hung , Chun-Hua Lin
发明人： Yi-Hsuan Lee , Cheng-Yu Wang , Shu-Hui Juan , Wen-Liang Chen , Kuo-Sheng Hung , Chun-Hua Lin
IPC分类号： C12Q1/68 , C12N5/10
CPC分类号： C12N15/85 , C12N2503/02 , C12N2517/02 , C12N2800/107 , C12N2830/002 , G01N33/5058
摘要： The invention is to provide an isolated transgenic mammalian neural cell, which comprises at least one heterologous vector expressing AhR/ARNT. Also provided is methods the detection of a sample containing a chemical substance damage to the nervous system and the selection of drugs for treating neurodegenerative disorders.
摘要翻译：本发明提供一种分离的转基因哺乳动物神经细胞，其包含至少一种表达AhR / ARNT的异源载体。还提供了检测包含对神经系统损伤的化学物质的样品和用于治疗神经变性疾病的药物的选择的方法。

9. 发明申请

US20100167400A1 Composition for Increasing Intracellular Nitric Oxide and Method for the Same 审中-公开
标题翻译：用于增加细胞内一氧化氮的组合物及其方法
公开(公告)号：US20100167400A1
公开(公告)日：2010-07-01
申请号：US12087072
申请日：2007-01-01
申请人： Ting-Kai Leung , Yuan-Soon Ho , Huey-Fang Shang , Yi-Hsuan Lee , Yung-Sheng Lin , Ming-Yu Lin , Jiann-Shiun Kao
发明人： Ting-Kai Leung , Yuan-Soon Ho , Huey-Fang Shang , Yi-Hsuan Lee , Yung-Sheng Lin , Ming-Yu Lin , Jiann-Shiun Kao
IPC分类号： C12N5/078 , C12N5/00 , C12N5/09 , C12N5/079 , C01F7/02
CPC分类号： A61K41/0057 , A61K41/0019
摘要： A composition and a method for increasing intracellular nitric oxide is provided. The composition comprises a far-infrared ray releasing substance composed mainly of an oxide mineral for releasing a far-infrared ray, wherein the composition promotes generation of the nitric oxide via irradiation of the far-infrared ray from the far-infrared ray releasing substance. In another aspect, the method comprises setting an effective amount of a far-infrared ray releasing substance in a place close to a cell with an appropriate distance, and incubating the far-infrared ray releasing substance with the cell for a specific period, wherein the appropriate distance lies in an irradiation range of the far-infrared ray releasing substance.
摘要翻译：提供了一种用于增加细胞内一氧化氮的组合物和方法。该组合物包括主要由用于释放远红外线的氧化物矿物质组成的远红外线释放物质，其中该组合物通过远红外线释放物质的远红外线照射促进一氧化氮的产生。另一方面，该方法包括在适当距离的细胞附近设置有效量的远红外线释放物质，并将远红外线释放物质与细胞一起培养一段时间，其中适当的距离位于远红外线释放物质的照射范围内。

10. 发明授权

US08666503B2 Parameter adjustment device and method thereof 有权
标题翻译：参数调整装置及其方法
公开(公告)号：US08666503B2
公开(公告)日：2014-03-04
申请号：US12627192
申请日：2009-11-30
申请人： Charles Tak Ming Choi , Yi-Hsuan Lee
发明人： Charles Tak Ming Choi , Yi-Hsuan Lee
IPC分类号： A61N1/36
CPC分类号： A61N1/36071 , A61N1/36036 , A61N1/36082 , A61N1/37235 , G06F19/00 , G16H40/63
摘要： A parameter adjustment device and method thereof for a stimulator is disclosed. The parameter adjustment device comprises a generation unit, a user interface and a process unit. The generation unit generates a test MAP based on a current MAP. The user interface displays the current MAP and the test MAP for choosing one of them as the preferred MAP, and displays a major and a minor for choosing again, the major and the minor is defined as a significant difference and a little difference between the test MAP and the current MAP respectively. The process unit computes the acceptance probability of the preferred MAP based on a major or minor probability correspondence relationship and determines a next MAP by comparing the acceptance probability with the test probability. When one of the termination conditions is satisfied in an iterative operation, the next MAP is outputted as the best MAP.
摘要翻译：公开了一种用于刺激器的参数调整装置及其方法。参数调整装置包括生成单元，用户界面和处理单元。生成单元基于当前MAP生成测试MAP。用户界面显示当前MAP和测试MAP，选择其中一个作为首选MAP，并显示主要和次要选择，主要和次要被定义为显着差异和测试之间的一点差异 MAP和当前MAP。处理单元基于主要或次要概率对应关系来计算优选MAP的接受概率，并通过将接受概率与测试概率进行比较来确定下一MAP。当在迭代操作中满足终止条件之一时，将下一MAP作为最佳MAP输出。

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