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1. 发明申请

US20120207817A1 SMALL INTERFERING RNAS AND METHODS FOR PREVENTION, INHIBITION AND/OR TREATMENT OF MALIGNANT PROGRESSION OF BREAST CANCER 有权
标题翻译：用于预防，抑制和/或治疗乳腺癌恶化进展的小干扰RNA和方法
公开(公告)号：US20120207817A1
公开(公告)日：2012-08-16
申请号：US13027038
申请日：2011-02-14
申请人： Chia-Hwa Lee , Ching-Shui Huang , Ching-Shyang Chen , Shih-Hsin Tu , Ying-Jan Wang , Yu-Jia Chang , Ka-Wai Tam , Po-Li Wei , Tzu-Chun Cheng , Jan-Show Chu , Li-Ching Chen , Chih-Hsiung Wu , Yuan-Soon Ho
发明人： Chia-Hwa Lee , Ching-Shui Huang , Ching-Shyang Chen , Shih-Hsin Tu , Ying-Jan Wang , Yu-Jia Chang , Ka-Wai Tam , Po-Li Wei , Tzu-Chun Cheng , Jan-Show Chu , Li-Ching Chen , Chih-Hsiung Wu , Yuan-Soon Ho
IPC分类号： A61K9/127 , A61K31/713 , A61K31/4439 , A61K31/437 , A61P35/00 , A61K31/4355 , C12Q1/18 , C07H21/00 , C12Q1/68 , C07H21/02 , A61K31/34
CPC分类号： C07H21/02 , A61K31/4406 , A61K31/713 , C12N15/1138 , C12Q1/6809 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178 , G01N33/57415 , G01N2333/70571 , C12N2310/14 , C12N2310/531
摘要： The invention found that overexpression and activation of α9-nAChR are associated with tumorigenesis of breast cancer and create a number of small interfering RNAs to inhibit the expression of α9-nAChR so as to inhibit breast cancer. Therefore, the invention provides small interfering RNAs (siRNAs) for inhibiting expression of α9-nAChR so as to inhibit breast cancer, methods to prevent/inhibit/treat malignant progression of nicotine-derived-compound-induced breast cancer and method of determining malignant level of such breast cancer.
摘要翻译：本发明发现α9-nAChR的过表达和活化与乳腺癌的肿瘤发生相关，并产生许多小干扰RNA来抑制α9-nAChR的表达，从而抑制乳腺癌。因此，本发明提供用于抑制α9-nAChR表达以抑制乳腺癌的小干扰RNA（siRNA），预防/抑制/治疗尼古丁衍生化合物诱导的乳腺癌恶性进展的方法和确定恶性水平的方法的这种乳腺癌。

2. 发明申请

US20110159518A1 METHOD FOR THE DIAGNOSIS OF THE PRESENCE OF AN OVARIAN CANCER 审中-公开
标题翻译：用于诊断OVARIAN癌症的方法
公开(公告)号：US20110159518A1
公开(公告)日：2011-06-30
申请号：US13044289
申请日：2011-03-09
申请人： Sy-Jye Leu , Neng-Yao Shih , Yi-Yuan Yang , Ko-Jiunn Liu , I-Jen Huang , Yuan-Soon Ho , Suparat Charoenfuprasert , Yu-Ching Lee
发明人： Sy-Jye Leu , Neng-Yao Shih , Yi-Yuan Yang , Ko-Jiunn Liu , I-Jen Huang , Yuan-Soon Ho , Suparat Charoenfuprasert , Yu-Ching Lee
IPC分类号： G01N33/53 , C07H21/04 , C07K16/00
CPC分类号： C12N9/12 , C07K16/3069 , C07K2317/34 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N33/57449 , Y10S435/975
摘要： The invention provides an isolated antigen polypeptide that can be expressed in a subject with ovarian cancer. Also provided is the diagnosis of ovarian cancer by using the antigen polypeptide of the invention and the prevention and/or treatment of ovarian cancer by suppressing the gene of the antigen polypeptide of the invention.
摘要翻译：本发明提供可以在患有卵巢癌的受试者中表达的分离的抗原多肽。还提供了通过使用本发明的抗原多肽和通过抑制本发明的抗原多肽的基因来预防和/或治疗卵巢癌的卵巢癌的诊断。

3. 发明授权

US07807139B2 Use of outer membrane protein A (OMPA) in treatment/prevention/diagnosis of infections caused by Klebsiella pneumoniae and other gram-negative bacteria 有权
标题翻译：使用外膜蛋白A（OMPA）治疗/预防/诊断由肺炎克雷伯杆菌和其他革兰氏阴性细菌引起的感染
公开(公告)号：US07807139B2
公开(公告)日：2010-10-05
申请号：US12359205
申请日：2009-01-23
申请人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yueh-Lun Lee , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
发明人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yueh-Lun Lee , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
IPC分类号： A61K49/00 , A61K39/00 , A61K39/108
CPC分类号： G01N33/56916 , A61K38/164 , A61K39/025 , G01N2469/10 , Y02A50/474 , Y02A50/482 , Y02A50/484
摘要： The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Klebsiella pneumoniae and other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal.
摘要翻译：本发明提供一种通过施用有效量的外膜蛋白A（OmpA）来治疗和/或预防哺乳动物的中枢神经系统和/或外周血循环中由肺炎克雷伯杆菌和其它革兰氏阴性细菌引起的细菌感染的方法）或其衍生物。还提供了一种用于接种哺乳动物以在中枢神经系统和/或外周血循环中产生由肠杆菌科家族引起的细菌感染的抗体的方法，以及检测或诊断由中枢神经系统中肠杆菌科家族引起的细菌感染的方法和/或哺乳动物的外周血循环。

4. 发明授权

US08361984B2 Small interfering RNAs and methods for prevention, inhibition and/or treatment of malignant progression of breast cancer 有权
标题翻译：小干扰RNA和预防，抑制和/或治疗乳腺癌恶性进展的方法
公开(公告)号：US08361984B2
公开(公告)日：2013-01-29
申请号：US13027038
申请日：2011-02-14
申请人： Chia-Hwa Lee , Ching-Shui Huang , Ching-Shyang Chen , Shih-Hsin Tu , Ying-Jan Wang , Yu-Jia Chang , Ka-Wai Tam , Po-Li Wei , Tzu-Chun Cheng , Jan-Show Chu , Li-Ching Chen , Chih-Hsiung Wu , Yuan-Soon Ho
发明人： Chia-Hwa Lee , Ching-Shui Huang , Ching-Shyang Chen , Shih-Hsin Tu , Ying-Jan Wang , Yu-Jia Chang , Ka-Wai Tam , Po-Li Wei , Tzu-Chun Cheng , Jan-Show Chu , Li-Ching Chen , Chih-Hsiung Wu , Yuan-Soon Ho
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04
CPC分类号： C07H21/02 , A61K31/4406 , A61K31/713 , C12N15/1138 , C12Q1/6809 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178 , G01N33/57415 , G01N2333/70571 , C12N2310/14 , C12N2310/531
摘要： The invention found that overexpression and activation of α9-nAChR are associated with tumorigenesis of breast cancer and create a number of small interfering RNAs to inhibit the expression of α9-nAChR so as to inhibit breast cancer. Therefore, the invention provides small interfering RNAs (siRNAs) for inhibiting expression of α9-nAChR so as to inhibit breast cancer, methods to prevent/inhibit/treat malignant progression of nicotine-derived-compound-induced breast cancer and method of determining malignant level of such breast cancer.
摘要翻译：本发明发现α9-nAChR的过表达和活化与乳腺癌的肿瘤发生相关，并产生许多小干扰RNA来抑制α9-nAChR的表达，从而抑制乳腺癌。因此，本发明提供用于抑制α9-nAChR表达以抑制乳腺癌的小干扰RNA（siRNA），预防/抑制/治疗尼古丁衍生化合物诱导的乳腺癌恶性进展的方法和确定恶性水平的方法的这种乳腺癌。

5. 发明授权

US08361441B2 Detection and therapy of bacterial infection caused by Enterobacteriaceae 有权
标题翻译：检测和治疗由肠杆菌科引起的细菌感染
公开(公告)号：US08361441B2
公开(公告)日：2013-01-29
申请号：US12569363
申请日：2009-09-29
申请人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yung-Luen Shih , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
发明人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yung-Luen Shih , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
IPC分类号： A61K49/00 , A61K39/02 , A61K39/112
CPC分类号： A61K38/164 , C07K16/1232 , C07K2317/11 , C07K2317/23 , C07K2317/76 , G01N33/56916 , G01N33/6893 , G01N2800/26
摘要： The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Enterobacteriaceae bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal. An antibody and a kit on the basis of the vaccinating method and detecting/diagnosing method are also provided.
摘要翻译：本发明提供了一种通过将有效量的外膜蛋白A（OmpA）或其衍生物施用于哺乳动物的中枢神经系统和/或外周血循环中由肠杆菌科细菌引起的细菌感染的治疗和/或预防方法哺乳动物。还提供了一种用于接种哺乳动物以在中枢神经系统和/或外周血循环中产生由肠杆菌科家族引起的细菌感染的抗体的方法，以及检测或诊断由中枢神经系统中肠杆菌科家族引起的细菌感染的方法和/或哺乳动物的外周血循环。还提供了基于疫苗接种方法和检测/诊断方法的抗体和试剂盒。

6. 发明申请

US20120270799A1 METHOD OF IDENTIFYING A CANDIDATE COMPOUND WHICH MAY INHIBIT a9-nAchR OVEREXPRESSION OR ESTROGEN RECEPTOR-DEPENDENT TRANSCRIPTION IN NICOTINE-DERIVED-COMPOUND-INDUCED BREAST CANCER CELLS 有权
标题翻译：鉴定出可抑制非甾体类复方诱导型乳腺癌细胞中a9-nAchR过度表达或雌激素受体依赖性转录的候选化合物的方法
公开(公告)号：US20120270799A1
公开(公告)日：2012-10-25
申请号：US13091956
申请日：2011-04-21
申请人： Chia-Hwa Lee , Ya-Chieh Chang , Ching-Shyang Chen , Shih-Hsin Tu , Ying-Jan Wang , Li-Ching Chen , Yu-Jia Chang , Po-Li Wei , Hui-Wen Chang , Chien-Hsi Chang , Ching-Shui Huang , Chih-Hsiung Wu , Yuan-Soon Ho
发明人： Chia-Hwa Lee , Ya-Chieh Chang , Ching-Shyang Chen , Shih-Hsin Tu , Ying-Jan Wang , Li-Ching Chen , Yu-Jia Chang , Po-Li Wei , Hui-Wen Chang , Chien-Hsi Chang , Ching-Shui Huang , Chih-Hsiung Wu , Yuan-Soon Ho
IPC分类号： A61K38/02 , A61P35/00 , A61K31/138 , A61K31/4196 , C12Q1/02 , C12Q1/68
CPC分类号： A61K31/138 , A61K31/4196 , G01N33/57415 , G01N33/743 , G01N33/944
摘要： The invention relates to methods of identifying a candidate compound which may inhibit estrogen receptor-dependent transcription or α9-nAChR overexpression and proliferation of nicotine-derived-compound-induced breast cancer cells by using an activating protein 1 (AP1) polypeptide. The invention found that α9-nAChR has an activating protein 1 (AP1)-binding site, that the α9-nAChR promoter is located at the AP1-binding site, and that ERs specifically bind to the α9-nAChR promoter at the AP1-binding site, indicating that ER-induced α9-nAChR up-regulation plays a central role in the response to endogenous (E2) or exogenous (nicotine) stimulation.
摘要翻译：本发明涉及通过使用活化蛋白1（AP1）多肽鉴定可抑制雌激素受体依赖性转录或α9-nAChR过表达和尼古丁衍生化合物诱导的乳腺癌细胞增殖的候选化合物的方法。本发明发现α9-nAChR具有活化蛋白1（AP1） - 结合位点，α9-nAChR启动子位于AP1结合位点，ERs与AP1结合的α9-nAChR启动子特异性结合表明ER诱导的α9-nAChR上调在对内源（E2）或外源（尼古丁）刺激的反应中起着核心作用。

7. 发明申请

US20120208873A1 TEA POLYPHENOLS PRODUCTS FOR CEASING SMOKING AND TREATING AND/OR PREVENTING NICOTINE OR NICOTINE-DERIVED COMPOUNDS OR ESTROGEN INDUCED BREAST CANCER 审中-公开
标题翻译： TEA多酚产品，用于治疗和/或预防非甾体类衍生化合物或雌激素诱导的乳腺癌
公开(公告)号：US20120208873A1
公开(公告)日：2012-08-16
申请号：US13118919
申请日：2011-05-31
申请人： Shih-Hsin Tu , Chung-Yu Ku , Ching-Shyang Chen , Ching-Shui Huang , Chia-Hwa Lee , Li-Ching Chen , Min-Hsiung Pan , Hui-Wen Chang , Chien-Hsi Chang , Yu-Jia Chang , Po-Li Wei , Chih-Hsiung Wu , Yuan-Soon Ho
发明人： Shih-Hsin Tu , Chung-Yu Ku , Ching-Shyang Chen , Ching-Shui Huang , Chia-Hwa Lee , Li-Ching Chen , Min-Hsiung Pan , Hui-Wen Chang , Chien-Hsi Chang , Yu-Jia Chang , Po-Li Wei , Chih-Hsiung Wu , Yuan-Soon Ho
IPC分类号： A61K31/353 , A61P35/00
CPC分类号： A61K31/353 , A61K45/06 , A61K2300/00
摘要： This invention relates to methods of aiding smoking cessation and/or treating and/or preventing smoking addition or methods of treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer, which comprises administering to a subject an effective amount of a tea polyphenol. The invention uses catechins (such as epigallocatechin gallate (“EGCG”), epigallocatechin (“EGC”), epicatechin gallate (“ECG”), epicatechin (“EC”), gallocatechin gallate (“GCG”), gallocatechin (“GC”), catechin gallate (“CG”) and catechin (“C”)) in aiding smoking cessation and/or treating and/or preventing smoking addition or treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer.
摘要翻译：本发明涉及帮助戒烟和/或治疗和/或预防吸烟添加的方法或治疗和/或预防尼古丁或尼古丁衍生化合物或雌激素诱导的乳腺癌的方法，其包括向受试者施用有效量的茶多酚。本发明使用儿茶素没食子酸酯（“EGCG”），表没食子儿茶素（“EGC”），表儿茶素没食子酸酯（“ECG”），表儿茶素（“EC”），没食子儿茶素没食子酸酯（“GCG” ），儿茶素没食子酸酯（“CG”）和儿茶素（“C”））帮助戒烟和/或治疗和/或预防吸烟添加或治疗和/或预防尼古丁或尼古丁衍生的化合物或雌激素诱导的乳腺癌。

8. 发明申请

US20120208872A1 USE OF TEA POLYPHENOLS FOR TREATING AND/OR PREVENTING NICOTINE OR NICOTINE-DERIVED COMPOUNDS OR ESTROGEN INDUCED BREAST CANCER 审中-公开
标题翻译：用于治疗和/或预防NICOTINE或NICOTINE衍生化合物或雌激素诱导的乳腺癌的TEA多酚
公开(公告)号：US20120208872A1
公开(公告)日：2012-08-16
申请号：US13025401
申请日：2011-02-11
申请人： Shih-Hsin Tu , Chung-Yu Ku , Ching-Shyang Chen , Ching-Shui Huang , Chia-Hwa Lee , Li-Ching Chen , Min-Hsiung Pan , Hui-Wen Chang , Chien-Hsi Chang , Yu-Jia Chang , Po-Li Wei , Chih-Hsiung Wu , Yuan-Soon Ho
发明人： Shih-Hsin Tu , Chung-Yu Ku , Ching-Shyang Chen , Ching-Shui Huang , Chia-Hwa Lee , Li-Ching Chen , Min-Hsiung Pan , Hui-Wen Chang , Chien-Hsi Chang , Yu-Jia Chang , Po-Li Wei , Chih-Hsiung Wu , Yuan-Soon Ho
IPC分类号： A61K31/353 , A61P35/00
CPC分类号： A61K31/353 , A61K45/06 , A61K2300/00
摘要： This invention relates to methods of treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer, which comprises administering to a subject an effective amount of a tea polyphenol. The invention uses catechins (such as epigallocatechin gallate (“EGCG”), epigallocatechin (“EGC”), epicatechin gallate (“ECG”), epicatechin (“EC”), gallocatechin gallate (“GCG”), gallocatechin (“GC”), catechin gallate (“CG”) and catechin (“C”)) in treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer.
摘要翻译：本发明涉及治疗和/或预防尼古丁或尼古丁衍生化合物或雌激素诱导的乳腺癌的方法，其包括向受试者施用有效量的茶多酚。本发明使用儿茶素没食子酸酯（“EGCG”），表没食子儿茶素（“EGC”），表儿茶素没食子酸酯（“ECG”），表儿茶素（“EC”），没食子儿茶素没食子酸酯（“GCG” ），儿茶素没食子酸酯（“CG”）和儿茶素（“C”））治疗和/或预防尼古丁或尼古丁衍生的化合物或雌激素诱导的乳腺癌。

9. 发明授权

US08449881B2 Anti-α-enolase I antibodies for diagnosis and treatment of α-enolase I-associated diseases 有权
标题翻译：用于诊断和治疗α-烯醇酶I相关疾病的抗α-烯醇酶I抗体
公开(公告)号：US08449881B2
公开(公告)日：2013-05-28
申请号：US12695627
申请日：2010-01-28
申请人： Sy-Jye Leu , Yi-Yuan Yang , Neng-Yao Shih , I-Jen Huang , Ko-Jiunn Liu , Yu-Ching Lee , Yung-Leun Shih , Yu-Jia Chang , Bor-Yu Tsai , Yuan-Soon Ho
发明人： Sy-Jye Leu , Yi-Yuan Yang , Neng-Yao Shih , I-Jen Huang , Ko-Jiunn Liu , Yu-Ching Lee , Yung-Leun Shih , Yu-Jia Chang , Bor-Yu Tsai , Yuan-Soon Ho
IPC分类号： A61K39/395
CPC分类号： C07K16/40 , C07K2317/11 , C07K2317/23 , C07K2317/622 , G01N33/573
摘要： The invention relates to antibodies against α-enolase I, their pharmaceutical compositions and diagnosis and treatment uses. Particularly, the invention provides polyclonal anti-α-enolase I antibodies and monoclonal single-chain variable fragment (scFv) anti-α-enolase antibodies, pharmaceutical compositions containing the same and their uses in uses in diagnosis and treatment of cancers, autoimmune disorders, ischemia and bacterial infection.
摘要翻译：本发明涉及抗α-烯醇酶I的抗体，其药物组合物和诊断和治疗用途。特别地，本发明提供了多克隆抗-α-烯醇化酶I抗体和单克隆单链可变片段（scFv）抗-α-烯醇化酶抗体，含有该抗体的药物组合物及其用于诊断和治疗癌症，自身免疫疾病，缺血和细菌感染。

10. 发明申请

US20110313319A1 MEASURING METHOD FOR THE CONCENTRATION OF INTRAGASTRIC CONTENTS 审中-公开
标题翻译：浓度浓度测定方法
公开(公告)号：US20110313319A1
公开(公告)日：2011-12-22
申请号：US13220153
申请日：2011-08-29
申请人： Yuan-Soon Ho
发明人： Yuan-Soon Ho
IPC分类号： A61B5/00
CPC分类号： A61B5/1473 , A61B5/14507 , A61B5/4238 , A61B10/0045
摘要： A measuring method for the concentration of intragastric objects wherein a first concentration of a feeding liquor is measured. The intragastric objects and concentration thereof of the testee are measured to obtain the second concentration value. The feeding liquor of predefined volume is filled into the stomach of the testee. The intragastric contents are mixed and diluted to form an intragastric mixture. The stomach is then given time to digest the feeding liquor. The intragastric mixture is extracted and measured to obtain the third concentration value. The volume of intragastric objects is calculated as a relative value, so a relative volume could be measured by the volume of intragastric mixture and feeding liquor. According to the changes of said relative value with respect to the concentration and volume, the tester could judge the absorbing state of the testee's stomach as a basis of continuous feeding and feeding dose.
摘要翻译：一种测量胃内物质浓度的测量方法，其中测量进料液的第一浓度。测量受试者的胃内物质及其浓度以获得第二浓度值。预定体积的喂食液被填充到受试者的胃中。将胃内容物混合并稀释以形成胃内混合物。然后给予胃消化喂食液的时间。提取并测量胃内混合物以获得第三浓度值。胃内物体的体积计算为相对值，因此可以通过胃内混合物和进料液的体积来测量相对体积。根据所述相对值相对于浓度和体积的变化，测试者可以判断被测者的胃的吸收状态，作为连续喂食和喂食的基础。

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