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1. 发明授权

US09232485B2 System and method for selectively communicating with an implantable medical device 有权
标题翻译：用于与可植入医疗装置选择性地通信的系统和方法
公开(公告)号：US09232485B2
公开(公告)日：2016-01-05
申请号：US13974448
申请日：2013-08-23
申请人： Yongjian Wu , Allan Schwartz
发明人： Yongjian Wu , Allan Schwartz
IPC分类号： H04B7/00 , H04W52/42 , H04W4/00 , H04B13/00 , G06Q50/22
CPC分类号： H04W52/42 , G06F19/00 , G06Q50/22 , H04B13/005 , H04W4/80
摘要： A system may include a target implantable medical device (IMD) and an external device configured to selectively communicate with the target IMD. The external device may include a communication module configured to communicate with the target IMD, a response analysis module configured to receive and analyze a target response signal from the target IMD and other response signals from other IMDS, and a power adjustment module configured to receive one or more power-adjustment request signals from the response analysis module. The power adjustment module is configured to adaptively adjust a power of a transmission request over a first frequency band based on the one or more power-adjustment request signals until the response analysis module receives only the target response signal from the target IMD.
摘要翻译：系统可以包括目标可植入医疗设备（IMD）和被配置为选择性地与目标IMD通信的外部设备。外部设备可以包括被配置为与目标IMD进行通信的通信模块，被配置为从目标IMD接收和分析目标响应信号以及来自其他IMDS的其他响应信号的响应分析模块，以及被配置为接收一个或更多的来自响应分析模块的功率调整请求信号。功率调整模块被配置为基于一个或多个功率调整请求信号自适应地调整在第一频带上的传输请求的功率，直到响应分析模块仅从目标IMD仅接收到目标响应信号。

2. 发明申请

US20150056921A1 SYSTEM AND METHOD FOR SELECTIVELY COMMUNICATING WITH AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：用可选择医疗设备选择性通信的系统和方法
公开(公告)号：US20150056921A1
公开(公告)日：2015-02-26
申请号：US13974448
申请日：2013-08-23
申请人： Allan Schwartz , Yongjian Wu
发明人： Allan Schwartz , Yongjian Wu
IPC分类号： H04W52/42 , H04B13/00 , G06Q50/22 , H04W4/00
CPC分类号： H04W52/42 , G06F19/00 , G06Q50/22 , H04B13/005 , H04W4/80
摘要： A system may include a target implantable medical device (IMD) and an external device configured to selectively communicate with the target IMD. The external device may include a communication module configured to communicate with the target IMD, a response analysis module configured to receive and analyze a target response signal from the target IMD and other response signals from other IMDS, and a power adjustment module configured to receive one or more power-adjustment request signals from the response analysis module. The power adjustment module is configured to adaptively adjust a power of a transmission request over a first frequency band based on the one or more power-adjustment request signals until the response analysis module receives only the target response signal from the target IMD.
摘要翻译：系统可以包括目标可植入医疗设备（IMD）和被配置为选择性地与目标IMD通信的外部设备。外部设备可以包括被配置为与目标IMD进行通信的通信模块，被配置为从目标IMD接收和分析目标响应信号以及来自其他IMDS的其他响应信号的响应分析模块，以及被配置为接收一个或更多的来自响应分析模块的功率调整请求信号。功率调整模块被配置为基于一个或多个功率调整请求信号自适应地调整在第一频带上的传输请求的功率，直到响应分析模块仅从目标IMD仅接收到目标响应信号。

3. 发明申请

US20140198118A1 IMAGE BROWSING METHOD, SYSTEM AND COMPUTER STORAGE MEDIUM 审中-公开
标题翻译：图像浏览方法，系统和计算机存储介质
公开(公告)号：US20140198118A1
公开(公告)日：2014-07-17
申请号：US14112197
申请日：2012-08-13
申请人： Yuan Huang , Yongjian Wu , Zongyao Tang , Yucun Pan
发明人： Yuan Huang , Yongjian Wu , Zongyao Tang , Yucun Pan
IPC分类号： G06T1/60
CPC分类号： G06T1/60 , G06F3/14 , G09G2340/0407 , G09G2350/00 , G09G2360/121
摘要： An image browsing method, system and computer storage media are disclosed. The method includes: obtaining a user's operation request for an image; comparing the operation request with a preset condition, and determining whether to cache the image into a main cache. When it is required to cache the image into the main cache, further determining whether it is the first time that the image is rendered; if yes, employing a main thread to cache the image into the main cache, to obtain the image from the main cache, and to render the image. Otherwise, employing a main thread to obtain an image adapted to the capacity of the main cache from an image chain, and to render the image; and displaying the image rendered. This avoids unsmooth browsing of the image due to time-consuming creation of the images to be rendered, thereby allowing smooth image browsing.
摘要翻译：公开了图像浏览方法，系统和计算机存储介质。该方法包括：获得用户对图像的操作请求; 将操作请求与预设条件进行比较，以及确定是否将图像缓存到主缓存中。当需要将图像缓存到主缓存中时，进一步确定是否是第一次渲染图像; 如果是，使用主线程将图像缓存到主缓存中，从主缓存获取图像并呈现图像。否则，使用主线程从图像链中获得适合于主缓存的容量的图像，并且呈现图像; 并显示呈现的图像。这样可避免由于要渲染的图像的耗时创建而导致图像的不平滑浏览，从而允许平滑的图像浏览。

4. 发明授权

US07951588B2 Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells 有权
标题翻译：使用分子伴侣来增强哺乳动物细胞中分泌的重组蛋白的产生
公开(公告)号：US07951588B2
公开(公告)日：2011-05-31
申请号：US11818507
申请日：2007-06-14
申请人： Sham-Yuen Chan , Hsinyi Yvette Tang , Yiwen Tao , Yongjian Wu , Ruth Kelly
发明人： Sham-Yuen Chan , Hsinyi Yvette Tang , Yiwen Tao , Yongjian Wu , Ruth Kelly
IPC分类号： C12N5/00 , C12N5/07 , C12N5/071 , C12N5/10
CPC分类号： C12P21/02 , C07K14/435 , C07K14/755 , C07K14/8114 , C12N5/00 , C12N15/85 , C12N2501/07 , C12N2501/998 , C12N2510/02 , C12P21/00
摘要： The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least one chaperone protein.
摘要翻译：本发明涉及通过在哺乳动物宿主细胞中引入分子伴侣来增加分泌的重组蛋白产物的产生的方法。本发明还涉及通过共同表达至少一种分子伴侣蛋白来增强分泌的重组蛋白产物的表达的哺乳动物宿主细胞。

5. 发明申请

US20100023085A1 ADAPTABLE COMMUNICATION SENSITIVITY FOR AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：适用于可植入医疗器械的通信灵敏度
公开(公告)号：US20100023085A1
公开(公告)日：2010-01-28
申请号：US12179336
申请日：2008-07-24
申请人： Yongjian Wu , Benjamin T. Persson , Thanh Tieu , Dorin Panescu , Devanshi Shah , Lyle Frank Weaver
发明人： Yongjian Wu , Benjamin T. Persson , Thanh Tieu , Dorin Panescu , Devanshi Shah , Lyle Frank Weaver
IPC分类号： A61N1/375
CPC分类号： A61N1/37276 , H04W52/0245 , Y02D70/26
摘要： A wireless communication threshold for an implantable medical device is automatically adapted in an attempt to maintain optimum signal detection sensitivity. In some aspects, a threshold level may be adapted to account for current environmental conditions, implant conditions, device conditions, or other conditions that may affect the reception of wireless signals at the device. In some aspects, the determination of an optimum level for the threshold involves a tradeoff relating to effectively detecting target signals while avoiding detection of noise and/or interference. In some aspects, adaptation of a threshold may be based on maximum energy levels associated with one or more sets of RF energy sample data. In some aspects, adaptation of a threshold may be based on the number of false wakeups that occur during a period of time.
摘要翻译：可植入医疗装置的无线通信阈值自动适应于试图维持最佳信号检测灵敏度。在一些方面，阈值水平可以适应于考虑当前环境条件，植入条件，设备条件或可能影响在设备处的无线信号的接收的其他条件。在一些方面，确定阈值的最佳电平涉及与有效地检测目标信号有关的折中，同时避免噪声和/或干扰的检测。在一些方面，阈值的适应可以基于与一个或多个RF能量样本数据集相关联的最大能级。在一些方面，阈值的适应可以基于在一段时间内发生的假唤醒的数量。

6. 发明申请

US20090104664A1 Use of Molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells 有权
标题翻译：使用分子伴侣来增强哺乳动物细胞中分泌的重组蛋白的产生
公开(公告)号：US20090104664A1
公开(公告)日：2009-04-23
申请号：US11818507
申请日：2007-06-14
申请人： Sham-Yuen Chan , Hsinyi Yvette Tang , Yiwen Tao , Yongjian Wu , Ruth Kelly
发明人： Sham-Yuen Chan , Hsinyi Yvette Tang , Yiwen Tao , Yongjian Wu , Ruth Kelly
IPC分类号： C12P21/04 , C12N5/06 , C12N15/87
CPC分类号： C12P21/02 , C07K14/435 , C07K14/755 , C07K14/8114 , C12N5/00 , C12N15/85 , C12N2501/07 , C12N2501/998 , C12N2510/02 , C12P21/00
摘要： The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least one chaperone protein.
摘要翻译：本发明涉及通过在哺乳动物宿主细胞中引入分子伴侣来增加分泌的重组蛋白产物的产生的方法。本发明还涉及通过共同表达至少一种分子伴侣蛋白来增强分泌的重组蛋白产物的表达的哺乳动物宿主细胞。

7. 发明授权

US08898208B2 Method and system for processing images 有权
标题翻译：处理图像的方法和系统
公开(公告)号：US08898208B2
公开(公告)日：2014-11-25
申请号：US14129569
申请日：2012-05-30
申请人： Yongjian Wu , Yang Yang , Liqian Dong , Dong Chen
发明人： Yongjian Wu , Yang Yang , Liqian Dong , Dong Chen
IPC分类号： G06F17/30
CPC分类号： G06F17/30112 , G06F17/30 , G06F17/3028 , G06F17/30442
摘要： The present disclosure describes a method and a system for processing images. The method includes: determining a target folder selected by a user; searching for image information of the target folder, searching for information of all subfolders of the target folder, traversing all subfolders corresponding to the information of all subfolders and obtaining image information of all subfolders; and obtaining images according to the image information of the target folder and the image information of all subfolders, processing the obtained images and displaying the processed images in a flat-folder-view manner.
摘要翻译：本公开描述了一种用于处理图像的方法和系统。该方法包括：确定由用户选择的目标文件夹; 搜索目标文件夹的图像信息，搜索目标文件夹的所有子文件夹的信息，遍历与所有子文件夹的信息相对应的所有子文件夹，并获取所有子文件夹的图像信息; 并根据目标文件夹的图像信息和所有子文件夹的图像信息获得图像，处理所获得的图像并以平面文件夹的方式显示处理的图像。

8. 发明授权

US08409857B1 Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells 有权
标题翻译：使用分子伴侣来增强哺乳动物细胞中分泌的重组蛋白的产生
公开(公告)号：US08409857B1
公开(公告)日：2013-04-02
申请号：US13464543
申请日：2012-05-04
申请人： Sham-Yuen Chan , Hsinyi Yvette Tang , Yiwen Tao , Yongjian Wu , Ruth Kelly
发明人： Sham-Yuen Chan , Hsinyi Yvette Tang , Yiwen Tao , Yongjian Wu , Ruth Kelly
IPC分类号： C12N5/00 , C12N5/10 , C12N5/071
CPC分类号： C12P21/02 , C07K14/435 , C07K14/755 , C07K14/8114 , C12N5/00 , C12N15/85 , C12N2501/07 , C12N2501/998 , C12N2510/02 , C12P21/00
摘要： The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least one chaperone protein.
摘要翻译：本发明涉及通过在哺乳动物宿主细胞中引入分子伴侣来增加分泌的重组蛋白产物的产生的方法。本发明还涉及通过共同表达至少一种分子伴侣蛋白来增强分泌的重组蛋白产物的表达的哺乳动物宿主细胞。

9. 发明授权

US09233250B2 Systems and methods to synchronize commands sent to a multi-electrode lead (MEL) with a portion of a cardiac pacing cycle 有权
标题翻译：将发送到多电极引线（MEL）的命令与心脏起搏循环的一部分同步的系统和方法
公开(公告)号：US09233250B2
公开(公告)日：2016-01-12
申请号：US12648599
申请日：2009-12-29
申请人： Anne Shelchuk , Yongjian Wu , Chris Pontiga , April Pixley , Pajhand Iranitalab , Elisabeth M. Clem , Shohan Hossain , Jianchun Yi
发明人： Anne Shelchuk , Yongjian Wu , Chris Pontiga , April Pixley , Pajhand Iranitalab , Elisabeth M. Clem , Shohan Hossain , Jianchun Yi
IPC分类号： A61N1/00 , A61N1/368 , A61N1/37 , A61N1/39
CPC分类号： A61N1/368 , A61N1/3684 , A61N1/3686 , A61N1/3704 , A61N1/3912
摘要： Embodiments of the present invention concern the timing of sending one or more commands to control circuitry of a multi-electrode lead (MEL). In one embodiment, the one or more commands are sent to control circuitry within the MEL during a predetermined portion of a cardiac pacing cycle to avoid potential problems of prior systems that were not synchronized with the cardiac pacing cycle. In one embodiment, the one or more commands are sent when cardiac tissue is refractory from a cardiac pacing pulse, to prevent the command(s) from potentially undesirably stimulating cardiac tissue. The command sending can occur such that the one or more commands are sent between instances when sensing circuitry of the implantable cardiac stimulation device is being used to obtain one or more signals indicative of cardiac electrical activity, to prevent interference between the one or more commands with the signals indicative of cardiac electrical activity that are sensed.
摘要翻译：本发明的实施例涉及将一个或多个命令发送到多电极引线（MEL）的控制电路的定时。在一个实施例中，在心脏起搏循环的预定部分期间，将一个或多个命令发送到MEL内的控制电路，以避免与心脏起搏循环不同步的现有系统的潜在问题。在一个实施例中，当心脏组织从心脏起搏脉搏难治时发送一个或多个命令，以防止命令潜在地不期望地刺激心脏组织。命令发送可以发生，使得当使用可植入心脏刺激装置的感测电路来获得指示心脏电活动的一个或多个信号时，在实例之间发送一个或多个命令，以防止一个或多个命令之间的干扰指示感测到的心脏电活动的信号。

10. 发明申请

US20140143229A1 METHOD AND SYSTEM FOR PROCESSING IMAGES 有权
标题翻译：用于处理图像的方法和系统
公开(公告)号：US20140143229A1
公开(公告)日：2014-05-22
申请号：US14129569
申请日：2012-05-30
申请人： Yongjian Wu , Yang Yang , Liqian Dong , Dong Chen
发明人： Yongjian Wu , Yang Yang , Liqian Dong , Dong Chen
IPC分类号： G06F17/30
CPC分类号： G06F17/30112 , G06F17/30 , G06F17/3028 , G06F17/30442
摘要： The present disclosure describes a method and a system for processing images. The method includes: determining a target folder selected by a user; searching for image information of the target folder, searching for information of all subfolders of the target folder, traversing all subfolders corresponding to the information of all subfolders and obtaining image information of all subfolders; and obtaining images according to the image information of the target folder and the image information of all subfolders, processing the obtained images and displaying the processed images in a flat-folder-view manner.
摘要翻译：本公开描述了一种用于处理图像的方法和系统。该方法包括：确定由用户选择的目标文件夹; 搜索目标文件夹的图像信息，搜索目标文件夹的所有子文件夹的信息，遍历与所有子文件夹的信息相对应的所有子文件夹，并获取所有子文件夹的图像信息; 并根据目标文件夹的图像信息和所有子文件夹的图像信息获得图像，处理所获得的图像并以平面文件夹的方式显示处理的图像。

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