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1. 发明授权

US07858577B2 Use of the long pentraxin PTX3 for the treatment of diseases caused by an altered activation of the growth factor FGF-2 有权
标题翻译：使用长的pentraxin PTX3用于治疗由生长因子FGF-2的活化改变引起的疾病
公开(公告)号：US07858577B2
公开(公告)日：2010-12-28
申请号：US10416225
申请日：2001-11-08
申请人： Alberto Mantovani , Barbara Bottazzi , Marco Presta , Marco Rusnati
发明人： Alberto Mantovani , Barbara Bottazzi , Marco Presta , Marco Rusnati
IPC分类号： A61K38/00
CPC分类号： A61K45/06 , A61K38/1709 , A61K48/00 , A61K2300/00
摘要： The use of the long pentraxin PTX3 (PTX3) or one of its functional derivatives is described for the preparation of medicament which inhibits the biological activity of the growth factor FGF-2, useful for the prevention and treatment of diseases brought about by an altered activation of said growth factor FGF-2.
摘要翻译：描述了使用长五倍体PTX3（PTX3）或其功能性衍生物之一用于制备抑制生长因子FGF-2的生物活性的药物，其可用于预防和治疗由改变的活化引起的疾病的所述生长因子FGF-2。

2. 发明申请

US20050043230A1 Use of long pentraxin ptx3 for the treatment of fgf-8 mediated tumour diseases 审中-公开
标题翻译：使用长五倍素ptx3治疗fgf-8介导的肿瘤疾病
公开(公告)号：US20050043230A1
公开(公告)日：2005-02-24
申请号：US10492130
申请日：2003-04-04
申请人： Marco Presta , Marco Rusnati , Alberto Mantovani , Barbara Bottazzi
发明人： Marco Presta , Marco Rusnati , Alberto Mantovani , Barbara Bottazzi
IPC分类号： A61K38/17 , A61P35/00
CPC分类号： A61K38/1709 , A61K2300/00
摘要： The use is described of the long pentraxin PTX3 (PTX3) or one of its functional derivatives as an agent inhibiting the activity of growth factor FGF-8, for the preparation of a medicine for the treatment of tumour diseases associated with abnormal activation of growth factor FGF-8.
摘要翻译：描述了使用长五倍体PTX3（PTX3）或其功能衍生物之一作为抑制生长因子FGF-8活性的药剂，用于制备用于治疗与生长因子异常活化相关的肿瘤疾病的药物 FGF-8。

3. 发明申请

US20120009608A1 BIOMARKER FOR THE MONITORING AND PROGNOSIS OF CHRONIC MYELOPROLIFERATIVE DISORDERS 审中-公开
标题翻译：用于监测和预防慢性髓系白血病的生物标志物
公开(公告)号：US20120009608A1
公开(公告)日：2012-01-12
申请号：US12832608
申请日：2010-07-08
申请人： Barbara BOTTAZZI , Alberto Mantovani , Tiziano Barbui , Alessandro Rambaldi
发明人： Barbara BOTTAZZI , Alberto Mantovani , Tiziano Barbui , Alessandro Rambaldi
IPC分类号： G01N33/543 , G01N33/566
CPC分类号： G01N33/6893 , G01N2800/22 , G01N2800/222 , G01N2800/52
摘要： The invention provides a method for monitoring the progression of a myeloproliferative disease, particularly Polycythemia Vera (PV) and Essential Thrombocythemia (ET), or the response to pharmacological treatment with JAK2 inhibitors in a patient diagnosed positive for the same disease, or a method for predicting thrombotic events in a patient affected by the same myeloproliferative diseases, based on the measurement of PTX3 concentration in a blood, plasma or serum sample.
摘要翻译：本发明提供了一种用于监测骨髓增生性疾病，特别是红细胞增多症（PV）和基础性血小板增多症（ET）进展的方法，或对于同一疾病诊断为阳性的患者中用JAK2抑制剂进行药理学治疗的反应或方法基于血液，血浆或血清样品中PTX3浓度的测量，预测受相同骨髓增生性疾病影响的患者的血栓形成事件。

4. 发明授权

US08003109B2 Pharmaceutical compositions containing the long pentraxin PTX3 有权
标题翻译：含有长五倍子PTX3的药物组合物
公开(公告)号：US08003109B2
公开(公告)日：2011-08-23
申请号：US11882180
申请日：2007-07-31
申请人： Barbara Bottazzi , Martino Introna , Alberto Mantovani , Annunciata Vecchi
发明人： Barbara Bottazzi , Martino Introna , Alberto Mantovani , Annunciata Vecchi
IPC分类号： A61K39/00
CPC分类号： A61K38/1709 , A61K48/00 , C07K14/47 , C07K14/71 , Y02A50/481
摘要： Pharmaceutical compositions are described containing a long pentraxin PTX3, particularly human PTX3, for the therapy of infectious and inflammatory or tumor diseases; expression vectors containing cDNA coding for PTX3; recombinant host cells transfected with such vectors; a method for producing substantial amounts of PTX3 involving the culturing of such cells, and the use of said vectors in the gene therapy of tumors.
摘要翻译：描述的药物组合物含有长的pentraxin PTX3，特别是人PTX3，用于治疗感染性和炎性或肿瘤疾病; 含有编码PTX3的cDNA的表达载体; 用这些载体转染的重组宿主细胞; 用于生产涉及培养这种细胞的大量PTX3的方法，以及所述载体在肿瘤基因治疗中的用途。

5. 发明申请

US20080015153A1 Pharmaceutical compositions containing the long pentraxin PTX3 有权
标题翻译：含有长五倍子PTX3的药物组合物
公开(公告)号：US20080015153A1
公开(公告)日：2008-01-17
申请号：US11882180
申请日：2007-07-31
申请人： Barbara Bottazzi , Martiho Introna , Alberto Mantovani , Annunciata Vecchi
发明人： Barbara Bottazzi , Martiho Introna , Alberto Mantovani , Annunciata Vecchi
IPC分类号： A61K38/17 , A61P31/00 , A61P35/02
CPC分类号： A61K38/1709 , A61K48/00 , C07K14/47 , C07K14/71 , Y02A50/481
摘要： Pharmaceutical compositions are described containing a long pentraxin PTX3, particularly human PTX3, for the therapy of infectious and inflammatory or tumour diseases; expression vectors containing cDNA coding for PTX3; recombinant host cells transfected with such vectors; a method for producing substantial amounts of PTX3 involving the culturing of such cells, and the use of said vectors in the gene therapy of tumours.
摘要翻译：描述的药物组合物含有长的pentraxin PTX3，特别是人PTX3，用于治疗感染性和炎性或肿瘤疾病; 含有编码PTX3的cDNA的表达载体; 用这些载体转染的重组宿主细胞; 用于生产涉及培养这种细胞的大量PTX3的方法，以及所述载体在肿瘤基因治疗中的用途。

6. 发明申请

US20070191269A1 Medicament comprising ptx3, alone or in combination with tsg-6, for treating degenerative diseases of cartilage and bone and treating female infertility 审中-公开
标题翻译：包含单独或与tsg-6组合的ptx3的药物用于治疗软骨和骨的退行性疾病并治疗女性不育症
公开(公告)号：US20070191269A1
公开(公告)日：2007-08-16
申请号：US10584295
申请日：2004-12-21
申请人： Alberto Mantovani , Paolo Carminati , Barbara Bottazzi
发明人： Alberto Mantovani , Paolo Carminati , Barbara Bottazzi
IPC分类号： A61K38/17
CPC分类号： A61K38/1709 , A61K2300/00
摘要： The use of pentraxin PTX3 and of its combination with TSG-6 for the preparation of a medicament for the treatment of bone or cartilage diseases and for the treatment of female infertility is described.
摘要翻译：描述了使用pentraxin PTX3及其与TSG-6的组合来制备用于治疗骨或软骨疾病和治疗女性不孕症的药物。

7. 发明申请

US20070098722A1 Medicament comprising inhibitors of long pentraxin ptx3 审中-公开
标题翻译：药物包括长五倍素ptx3的抑制剂
公开(公告)号：US20070098722A1
公开(公告)日：2007-05-03
申请号：US10584292
申请日：2004-12-21
申请人： Barbara Bottazzi , Paolo Carminati , Cecilia Garlanda , Alberto Mantovani
发明人： Barbara Bottazzi , Paolo Carminati , Cecilia Garlanda , Alberto Mantovani
IPC分类号： A61K39/395 , A61K38/17
CPC分类号： C07K16/18 , A01K67/0275 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K38/1709 , A61K2039/505 , C07K14/4737 , C12N15/8509
摘要： The use of inhibitors of long pentraxin PTX3 for the preparation of a medicament for the prevention and treatment of autoimmune diseases and of degenerative diseases of bone and cartilage is described.
摘要翻译：描述了使用长五聚蛋白PTX3的抑制剂制备用于预防和治疗自身免疫疾病和骨和软骨退行性疾病的药物。

8. 发明授权

US07915004B2 Monoclonal antibodies, hybridomas, improved method for determining the protein PTX3 and kit for said determination 失效
标题翻译：单克隆抗体，杂交瘤，用于测定所述测定蛋白质PTX3和试剂盒的改进方法
公开(公告)号：US07915004B2
公开(公告)日：2011-03-29
申请号：US11587528
申请日：2005-04-27
申请人： Alberto Mantovani , Giuseppe Peri
发明人： Alberto Mantovani , Giuseppe Peri
IPC分类号： C07K16/18 , C12N5/16 , G01N33/53 , G01N33/535 , G01N33/545 , G01N33/577 , C12P21/08
CPC分类号： G01N33/6893 , G01N2333/47
摘要： Method for determining the level of PTX3 protein in a sample of a biological fluid; hybridoma capable of producing a rat anti-PTX3 monoclonal antibody where said hybridoma is selected from the group comprising MNB10 and Pen-3; specific anti-PTX3 rat monoclonal antibody selected from the monoclonal antibodies produced by the hybridomas MNB10 and Pen-3; kit for determining the level of PTX3 protein in a biological fluid wherein the said kit includes a rat anti-PTX3 monoclonal antibody.
摘要翻译：用于测定生物流体样品中PTX3蛋白水平的方法; 能够产生大鼠抗PTX3单克隆抗体的杂交瘤，其中所述杂交瘤选自MNB10和Pen-3; 选自由杂交瘤MNB10和Pen-3产生的单克隆抗体的特异性抗PTX3大鼠单克隆抗体; 用于确定生物流体中PTX3蛋白水平的试剂盒，其中所述试剂盒包括大鼠抗PTX3单克隆抗体。

9. 发明申请

US20110055746A1 SCUBA DIVING DEVICE PROVIDING UNDERWATER NAVIGATION AND COMMUNICATION CAPABILITY 审中-公开
标题翻译：提供水下导航和通信能力的SCUBA潜水装置
公开(公告)号：US20110055746A1
公开(公告)日：2011-03-03
申请号：US12600239
申请日：2008-05-08
申请人： Alberto Mantovani , Craig Oberlin
发明人： Alberto Mantovani , Craig Oberlin
IPC分类号： G06F3/048
CPC分类号： G02B27/017 , B63C11/26 , G02B2027/014
摘要： Devices and systems are provided which may be used to navigate and communicate while diving in dive sites and improve the safety of the diving experience. For example, in certain embodiments, a diver area system is provided which utilizes virtual underwater information to provide the user with their location, the location of other divers (or “buddies”), and/or location of a surface object (e.g., a dive boat). In certain embodiments, the devices and systems disclosed herein may provide user with their location relative to one or more buddies. The user can thus navigate intelligently throughout the dive site and track the location of their buddies which can improve dive safety and/or efficiency. Additionally, the user can communicate with one or more buddy divers and/or surface-based objects and individuals using embodiments of the disclosure.
摘要翻译：提供了设备和系统，可用于在潜水中潜水时进行导航和通信，并提高潜水体验的安全性。例如，在某些实施例中，提供了一种潜水员区域系统，其利用虚拟的水下信息来向用户提供他们的位置，其他潜水者（或“伙伴”）的位置和/或表面对象的位置（例如，潜水艇）。在某些实施例中，本文公开的设备和系统可以向用户提供相对于一个或多个伙伴的位置。因此，用户可以在整个潜水站点智能地导航，并跟踪其伙伴的位置，这可以提高潜水安全性和/或效率。另外，用户可以使用本公开的实施例与一个或多个伙伴潜水员和/或基于表面的对象和个人进行通信。

10. 发明授权

US07858755B2 Monoclonal antibodies that bind Chemerin polypeptide 有权
标题翻译：结合Chemerin多肽的单克隆抗体
公开(公告)号：US07858755B2
公开(公告)日：2010-12-28
申请号：US10893485
申请日：2004-07-16
申请人： Valerie Wittamer , Jean-François Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franssen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel LePoul , Cecile Loison , Frédéric Ooms
发明人： Valerie Wittamer , Jean-François Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franssen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel LePoul , Cecile Loison , Frédéric Ooms
IPC分类号： C07K16/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4702 , C07K14/575 , C07K16/18 , C07K16/28 , G01N33/74 , G01N2500/02
摘要： The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
摘要翻译：本发明涉及G蛋白偶联受体及其新型配体。本发明提供了用于鉴定调节G蛋白偶联受体活性的候选化合物的筛选试验，以及用于诊断和治疗与G蛋白偶联受体信号传导调节异常有关的疾病或病症的测定法。

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