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1. 发明授权

US09488650B2 Detection of conductive polymer-labeled analytes 有权
标题翻译：导电聚合物标记分析物的检测
公开(公告)号：US09488650B2
公开(公告)日：2016-11-08
申请号：US14480162
申请日：2014-09-08
申请人： BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
发明人： Evangelyn C. Alocilja , Emma Setterington
IPC分类号： G01N27/74 , G01N33/543 , G01N33/569 , B82Y15/00 , H01F1/00
CPC分类号： G01N33/56916 , B82Y15/00 , G01N27/745 , G01N33/54326 , G01N33/54333 , G01N33/56911 , G01N33/56983 , G01N2333/245 , H01F1/0054
摘要： The disclosure relates to the detection of analytes (e.g., biological pathogens such as bacteria or viruses) using a conductive polymer label. The disclosed detection system utilizing the conductive polymer label generally involves the formation of an analyte conjugate between the target analyte and a conductive polymer moiety conjugated to the target analyte. The conductive polymer portion of the analyte conjugate is electrically activated to form an electrically activated analyte conjugate having an increased electrical conductivity relative to the analyte conjugate as originally formed. The electrically activated analyte conjugate can then be detected by any suitable means, such as by conductimetric or electrochemical detection.
摘要翻译：本公开涉及使用导电聚合物标签检测分析物（例如生物病原体，例如细菌或病毒）。所公开的利用导电聚合物标记的检测系统通常涉及在目标分析物和与目标分析物缀合的导电聚合物部分之间形成分析物结合物。分析物缀合物的导电聚合物部分被电活化以形成相对于最初形成的分析物缀合物具有增加的电导率的电激活分析物缀合物。然后可以通过任何合适的方法，例如通过电导或电化学检测来检测电活化的分析物缀合物。

2. 发明授权

US11041855B2 Non-specific, wireless detection of electrically or magnetically labeled bacteria and/or virus 有权
公开(公告)号：US11041855B2
公开(公告)日：2021-06-22
申请号：US16978312
申请日：2019-03-05
申请人： BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
发明人： Premjeet Chahal , Evangelyn C. Alocilja , Saranraj Karuppuswami , Leann Lerie Matta
IPC分类号： G01N33/543 , G01N33/04 , G01N33/14 , G01N27/12 , G01N27/22 , G01N27/74
摘要： The disclosure relates to wireless detection of analytes (such as bacteria) labeled by electrically, dielectrically, or magnetically active nanoparticles, for example in quality control monitoring for food supply chain management. The disclosed apparatus includes a detection vessel or vial, a resonant sensor tag, an inductively coupled reader to induce and detect resonance in the sensor tag, and an active nanoparticle for labeling. The disclosed wireless detection apparatus and methods use active nanoparticles for the development of wireless sensor systems which can be designed to be compatible with the existing RFID technology infrastructure. For example, commercial RFID readers (e.g., hand-held) used for tracking and tracing operation can be used with the disclosed apparatus to induce and measure a corresponding resonance frequency.

3. 发明授权

US10359378B2 Nuclear magnetic resonance apparatus, systems, and methods 有权
公开(公告)号：US10359378B2
公开(公告)日：2019-07-23
申请号：US14400996
申请日：2013-05-13
申请人： BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
发明人： Evangelyn C. Alocilja , Yilun Luo
IPC分类号： G01V3/00 , G01N24/08 , G01R33/30 , G01R33/28 , G01R33/44
摘要： In one aspect, the disclosure relates to a nuclear magnetic resonance transceiver including: (a) a variable-frequency electromagnetic signal generator with (i) a frequency input and (ii) an EM signal output; (b) an electronic frequency controller including (i) a frequency output coupled to the frequency input of the variable-frequency EM signal generator, (ii) an intermediate frequency set-point input, and (iii) an intermediate frequency measurement input; (c) an NMR transmission probe with an EM signal input coupled to the EM signal output of the variable-frequency EM signal generator; (d) an NMR receiving probe with an EM signal output; and (e) an electronic mixer with (i) a first input coupled to the EM signal output of the NMR receiving probe, (ii) a second input coupled to the EM signal output of the variable-frequency EM signal generator, and (iii) a mixed EM signal output coupled to the frequency measurement input of the frequency controller.

4. 发明授权

US10451579B2 Nanoparticle-serialized oligonucleotide methods, compositions, and articles 有权
公开(公告)号：US10451579B2
公开(公告)日：2019-10-22
申请号：US15804039
申请日：2017-11-06
申请人： BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
发明人： Evangelyn C. Alocilja
IPC分类号： G01N27/327 , C12Q1/6811 , B82Y30/00
摘要： The disclosure relates to the use of nanoparticles that are coated with unique oligonucleotide (e.g., DNA) sequences of various base lengths (“nano-DNA”) that act as barcodes for product authentication, product serialization, brand protection, track-and-trace, intelligent supply chain, and law enforcement. The nano-DNA can be incorporated into inks, dyes, resins, labels, and other markings at all manufacturing levels, including the product (unit) level, to encode company and product-specific information. The nano-DNA can also be embedded in the product itself during the manufacturing process. Furthermore, the nano-DNA can be quickly, simply, and inexpensively monitored and verified using an electrochemical biosensor device in resource-limited field conditions.

5. 发明授权

US10203325B2 Metallic nanoparticle synthesis with carbohydrate capping agent 有权
公开(公告)号：US10203325B2
公开(公告)日：2019-02-12
申请号：US14356406
申请日：2012-11-07
申请人： BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
发明人： Evangelyn C. Alocilja , Hanna Miller
IPC分类号： G01N33/543 , C23C18/44 , B22F9/16 , C12Q1/6825 , G01N33/569
摘要： The disclosure relates to metal nanoparticle compositions and their methods of formation and use, in particular gold nanoparticles (AuNP) and gold-coated magnetic nanoparticles. Compositions according to the disclosure include aqueous suspensions of metal nanoparticles that are stabilized with one or more carbohydrate capping agents and/or that are functionalized with one or more binding pair members for capture/detection of a target analyte. The nanoparticle suspensions are stable for extended periods and can be functionalized as desired at a later point in time, typically prior to use in an assay for the detection of a target biological analyte. The stable nanoparticle suspension can be formed by the aqueous reduction of oxidized metal precursors at non-acidic pH values in the presence of a carbohydrate-based capping agent such as dextrin or other oligosaccharides.

6. 发明申请

US20180120251A1 Nanoparticle-Serialized Oligonucleotide Methods, Compositions, and Articles 审中-公开
公开(公告)号：US20180120251A1
公开(公告)日：2018-05-03
申请号：US15804039
申请日：2017-11-06
申请人： BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
发明人： Evangelyn C. Alocilja
IPC分类号： G01N27/327
CPC分类号： G01N27/3278 , B82Y30/00 , C12Q1/6811 , C12Q2563/155 , C12Q2563/185
摘要： The disclosure relates to the use of nanoparticles that are coated with unique oligonucleotide (e.g., DNA) sequences of various base lengths (“nano-DNA”) that act as barcodes for product authentication, product serialization, brand protection, track-and-trace, intelligent supply chain, and law enforcement. The nano-DNA can be incorporated into inks, dyes, resins, labels, and other markings at all manufacturing levels, including the product (unit) level, to encode company and product-specific information. The nano-DNA can also be embedded in the product itself during the manufacturing process. Furthermore, the nano-DNA can be quickly, simply, and inexpensively monitored and verified using an electrochemical biosensor device in resource-limited field conditions.

7. 发明授权

US09581590B2 Metallic nanoparticle synthesis with carbohydrate capping agent 有权
标题翻译：金属纳米粒子合成与碳水化合物封端剂
公开(公告)号：US09581590B2
公开(公告)日：2017-02-28
申请号：US13670630
申请日：2012-11-07
申请人： Board of Trustees of Michigan State University
发明人： Evangelyn C. Alocilja , Michael J. Anderson , Edith Torres-Chavolla
IPC分类号： B82Y30/00 , G01N33/543 , B22F9/16 , C12Q1/68 , G01N33/569 , C23C18/44
CPC分类号： G01N33/54326 , B22F9/16 , C12Q1/6825 , C23C18/44 , G01N33/5434 , G01N33/54346 , G01N33/56911
摘要： The disclosure relates to metal nanoparticle compositions and their methods of formation and use, in particular gold nanoparticles (AuNP) and gold-coated magnetic nanoparticles. Compositions according to the disclosure include aqueous suspensions of metal nanoparticles that are stabilized with one or more carbohydrate capping agents and/or that are functionalized with one or more binding pair members for capture/detection of a target analyte. The nanoparticle suspensions are stable for extended periods and can be functionalized as desired at a later point in time, typically prior to use in an assay for the detection of a target biological analyte. The stable nanoparticle suspension can be formed by the aqueous reduction of oxidized metal precursors at non-acidic pH values in the presence of a carbohydrate-based capping agent such as dextrin or other oligosaccharides.
摘要翻译：本公开涉及金属纳米颗粒组合物及其形成和使用方法，特别是金纳米颗粒（AuNP）和金涂覆的磁性纳米颗粒。根据本公开的组合物包括用一种或多种碳水化合物封端剂稳定的金属纳米颗粒和/或用一个或多个结合对成员进行功能化以捕获/检测靶分析物的水悬浮液。纳米颗粒悬浮液在较长时间内是稳定的，并且可以在随后的时间点根据需要进行功能化，通常在用于检测靶生物分析物的测定之前。稳定的纳米颗粒悬浮液可以通过在诸如糊精或其它寡糖的碳水化合物基封端剂存在下，在非酸性pH值下，通过氧化金属前体的水还原形成。

8. 发明申请

US20200371094A1 EXTRACTION AND DETECTION OF PATHOGENS USING CARBOHYDRATE-FUNCTIONALIZED BIOSENSORS 审中-公开
公开(公告)号：US20200371094A1
公开(公告)日：2020-11-26
申请号：US16990056
申请日：2020-08-11
申请人： BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY , USA AS REPRESENTED BY THE SECRETARY OF THE ARMY ON BEHALF OF USAMRMC
发明人： Evangelyn C. Alocilja , Barbara Christine Cloutier , Michael J. Anderson
IPC分类号： G01N33/543 , G01N27/327 , G01N33/569
摘要： The disclosure relates to the extraction and detection of pathogens using carbohydrate-functionalized biosensors. Immobilized carbohydrate moieties on the biosensor provide a means for non-specific binding of a plurality of target analytes. When a sample containing the target analyte is applied or otherwise transported to the biosensor detection surface, non-specific binding interactions between the carbohydrate moiety and the analyte immobilize/retain the analyte at the detection surface. The carbohydrate moiety is a stable binding pair member that allows on-sensor rinsing of a sample to enhance detection of an analyte in the sample. Specific analyte identification can be achieved with an analyte probe having a detection moiety and a binding pair member specific to the target analyte of interest.

9. 发明授权

US09448236B2 Biologically enhanced electrically-active magnetic nanoparticles for concentration, separation, and detection applications 有权
公开(公告)号：US09448236B2
公开(公告)日：2016-09-20
申请号：US14600245
申请日：2015-01-20
申请人： BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
发明人： Evangelyn C. Alocilja , Sudeshna Pal , Emma B. Setterington
IPC分类号： G01N33/553 , G01N33/543 , C12Q1/68 , G01N33/558 , G01N33/569 , G01N27/74
CPC分类号： G01N33/5438 , C12Q1/6813 , C12Q1/689 , G01N27/745 , G01N33/54333 , G01N33/54366 , G01N33/558 , G01N33/56911 , G01N33/56916 , Y10T428/2982 , Y10T436/25 , Y10T436/255
摘要： The disclosure generally relates to a particulate composition formed from a conductive polymer (e.g., conductive polyanilines, polypyrroles, polythiophenes) bound to magnetic nanoparticles (e.g., Fe(II)- and/or Fe(III)-based magnetic metal oxides). The particulate composition can be formed into a biologically enhanced, electrically active magnetic (BEAM) nanoparticle composition by further including a binding pair member (e.g., an antibody) bound to the conductive polymer of the particulate composition. Methods and kits employing the particulate composition and the BEAM nanoparticle composition also are disclosed.

10. 发明申请

US20140322823A1 Metallic Nanoparticle Synthesis with Carbohydrate Capping Agent 审中-公开
标题翻译：碳水化合物盖帽金属纳米粒子的合成
公开(公告)号：US20140322823A1
公开(公告)日：2014-10-30
申请号：US14356406
申请日：2012-11-07
申请人： BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
发明人： Evangelyn C. Alocilja , Hanna Miller
IPC分类号： G01N33/543 , C23C18/44
CPC分类号： G01N33/54326 , B22F9/16 , C12Q1/6825 , C23C18/44 , G01N33/5434 , G01N33/54346 , G01N33/56911
摘要： The disclosure relates to metal nanoparticle compositions and their methods of formation and use, in particular gold nanoparticles (AuNP) and gold-coated magnetic nanoparticles. Compositions according to the disclosure include aqueous suspensions of metal nanoparticles that are stabilized with one or more carbohydrate capping agents and/or that are functionalized with one or more binding pair members for capture/detection of a target analyte. The nanoparticle suspensions are stable for extended periods and can be functionalized as desired at a later point in time, typically prior to use in an assay for the detection of a target biological analyte. The stable nanoparticle suspension can be formed by the aqueous reduction of oxidized metal precursors at non-acidic pH values in the presence of a carbohydrate-based capping agent such as dextrin or other oligosaccharides.
摘要翻译：本公开涉及金属纳米颗粒组合物及其形成和使用方法，特别是金纳米颗粒（AuNP）和金涂覆的磁性纳米颗粒。根据本公开的组合物包括用一种或多种碳水化合物封端剂稳定的金属纳米颗粒和/或用一个或多个结合对成员进行功能化以捕获/检测靶分析物的水悬浮液。纳米颗粒悬浮液在较长时间内是稳定的，并且可以在随后的时间点根据需要进行功能化，通常在用于检测靶生物分析物的测定之前。稳定的纳米颗粒悬浮液可以通过在诸如糊精或其它寡糖的碳水化合物基封端剂存在下，在非酸性pH值下，通过氧化金属前体的水还原形成。

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