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1. 发明授权

US11605531B2 Ion focusing device 有权
公开(公告)号：US11605531B2
公开(公告)日：2023-03-14
申请号：US16956858
申请日：2018-12-13
申请人： Battelle Memorial Institute
发明人： Yehia M. Ibrahim , Richard D. Smith
IPC分类号： H01J49/06 , H01J37/317 , H01J37/08 , H01J37/21 , H01J37/05
摘要： Apparatus include a plurality of electrode arrangements spaced apart from each other opposite an ion propagation axis and defining an ion transfer channel that extends along the ion propagation axis that tapers between an input end that is situated to receive ions and an output end that is situated to couple the received ions to an input end of an ion guide. Methods include positioning a plurality of electrode arrangements at oblique angles opposite an ion propagation axis so as to form a ion transfer channel that tapers between an input end and an output end, and coupling the output end of the ion transfer channel to an input end of an ion optical element so as to direct ions in the ion transfer channel into the ion optical element. Related systems are also disclosed.

2. 发明授权

US09824874B2 Ion funnel device 有权
公开(公告)号：US09824874B2
公开(公告)日：2017-11-21
申请号：US14733517
申请日：2015-06-08
申请人： BATTELLE MEMORIAL INSTITUTE
发明人： Yehia M. Ibrahim , Tsung-Chi Chen , Marques B. Harrer , Keqi Tang , Richard D. Smith
IPC分类号： H01J49/06
CPC分类号： H01J49/066
摘要： An ion funnel device is disclosed. A first pair of electrodes is positioned in a first direction. A second pair of electrodes is positioned in a second direction. The device includes an RF voltage source and a DC voltage source. A RF voltage with a superimposed DC voltage gradient is applied to the first pair of electrodes, and a DC voltage gradient is applied to the second pair of electrodes.

3. 发明申请

US20160071715A1 ION MANIPULATION METHOD AND DEVICE 有权
标题翻译：离子操作方法和装置
公开(公告)号：US20160071715A1
公开(公告)日：2016-03-10
申请号：US14783055
申请日：2014-01-13
申请人： BATTELLE MEMORIAL INSTITUTE
发明人： Gordon A. Anderson , Erin M. Baker , Richard D. Smith , Yehia M. Ibrahim
IPC分类号： H01J49/06 , H01J49/02
CPC分类号： H01J49/062
摘要： An ion manipulation method and device is disclosed. The device includes a pair of substantially parallel surfaces. An array of inner electrodes is contained within, and extends substantially along the length of, each parallel surface. The device includes a first outer array of electrodes and a second outer array of electrodes. Each outer array of electrodes is positioned on either side of the inner electrodes, and is contained within and extends substantially along the length of each parallel surface. A DC voltage is applied to the first and second outer array of electrodes. A RF voltage, with a superimposed electric field, is applied to the inner electrodes by applying the DC voltages to each electrode. Ions either move between the parallel surfaces within an ion confinement area or along paths in the direction of the electric field, or can be trapped in the ion confinement area.
摘要翻译：公开了一种离子操作方法和装置。该装置包括一对基本平行的表面。内部电极的阵列包含在每个平行表面内并且基本上沿着每个平行表面的长度延伸。该装置包括电极的第一外部阵列和第二外部电极阵列。每个外部电极阵列位于内部电极的任一侧上，并且基本上沿着每个平行表面的长度容纳并延伸。 DC电压施加到第一和第二外部电极阵列。通过向每个电极施加直流电压，将具有叠加电场的RF电压施加到内部电极。离子在离子限制区域内的平行表面之间或沿着电场方向的路径移动，或者可以被捕获在离子限制区域中。

4. 发明申请

US20210351003A1 SYSTEMS AND METHODS FOR SELECTIVE MOLECULAR ION DEPOSITION 有权
公开(公告)号：US20210351003A1
公开(公告)日：2021-11-11
申请号：US17314928
申请日：2021-05-07
申请人： Battelle Memorial Institute
发明人： Sandilya V.B. Garimella , Yehia M. Ibrahim , Ailin Li , Richard D. Smith
IPC分类号： H01J37/317 , H01J27/02 , H01J37/30
摘要： Methods include directing a group of ions through a separation region of an ion manipulation apparatus, separating the group of ions in the separation region based on ion mobility, selecting a subset of the group of ions based on a dependence between ion mobility and ion arrival time of the separated ions at a deposition switch of the ion manipulation apparatus, and depositing the selected subset of ions on a substrate. Related systems and ion manipulation apparatus are disclosed. Also disclosed are methods and system that provide concurrent ion accumulation and ion separation in coupled and switchable electrode regions using traveling wave electric fields.

5. 发明授权

US10804089B2 Methods and systems for integrating ion manipulation devices 有权
公开(公告)号：US10804089B2
公开(公告)日：2020-10-13
申请号：US16032651
申请日：2018-07-11
申请人： Battelle Memorial Institute
发明人： Yehia M. Ibrahim , Richard D. Smith
IPC分类号： H01J49/00 , H01J49/06 , G01N27/62
摘要： A switch for coupling a first ion manipulation device to a second ion manipulation device comprises a first surface and a second surface, at least one first electrode coupled to each of the first and second surface and configured to receive a first voltage and generate a first potential, and at least one second electrode coupled to each of the first and second surface and configured to receive a second voltage and generate a second potential, wherein the first potential inhibits the motion of ions along a first direction and the second potential inhibits the motion of ions along a second direction different from the first direction.

6. 发明授权

US10466202B2 Method and apparatus for spatial compression and increased mobility resolution of ions 有权
公开(公告)号：US10466202B2
公开(公告)日：2019-11-05
申请号：US16027092
申请日：2018-07-03
申请人： Battelle Memorial Institute
发明人： Yehia M. Ibrahim , Sandilya Garimella , Richard D. Smith
IPC分类号： G01N27/62 , H01J49/02
摘要： Methods and apparatuses for ion peak compression and increasing resolution of ions are disclosed. Packets of ions are introduced into a device. A first electric field is applied for dispersing the ion packets temporally or spatially according to their mobilities. A second intermittent traveling wave is applied for regrouping or merging the dispersed ion packets into a lesser number of trapping regions with narrower peaks. The ions packets are compressed into the narrower peak regions by varying a duty cycle of the intermittent traveling wave.

7. 发明申请

US20190103261A1 METHODS AND SYSTEMS FOR INTEGRATING ION MANIPULATION DEVICES 审中-公开
公开(公告)号：US20190103261A1
公开(公告)日：2019-04-04
申请号：US16032651
申请日：2018-07-11
申请人： Battelle Memorial Institute
发明人： Yehia M. Ibrahim , Richard D. Smith
IPC分类号： H01J49/06 , G01N27/62
摘要： A switch for coupling a first ion manipulation device to a second ion manipulation device comprises a first surface and a second surface, at least one first electrode coupled to each of the first and second surface and configured to receive a first voltage and generate a first potential, and at least one second electrode coupled to each of the first and second surface and configured to receive a second voltage and generate a second potential, wherein the first potential inhibits the motion of ions along a first direction and the second potential inhibits the motion of ions along a second direction different from the first direction.

8. 发明申请

US20190057852A1 METHODS AND SYSTEMS FOR ION MANIPULATION 审中-公开
公开(公告)号：US20190057852A1
公开(公告)日：2019-02-21
申请号：US16103729
申请日：2018-08-14
申请人： Battelle Memorial Institute
发明人： Yehia M. Ibrahim , Aneesh Prabhakaran , Sandilya V.B. Garimella , Richard D. Smith , Ailin Li
IPC分类号： H01J49/06 , G01N27/62
摘要： An ion manipulation device comprises a plurality of electrode rings arranged longitudinally adjacent to each other and defining a central axis therethrough. At least one electrode ring comprises a plurality of electrodes arranged in a first planar pattern. Electrodes are configured to periodically receive a voltage to generate a circular traveling wave that rotates around the electrodes of each electrode ring to confine ions within an interior of the apparatus.

9. 发明申请

US20190056352A1 METHOD AND APPARATUS FOR SPATIAL COMPRESSION AND INCREASED MOBILITY RESOLUTION OF IONS 审中-公开
公开(公告)号：US20190056352A1
公开(公告)日：2019-02-21
申请号：US16027092
申请日：2018-07-03
申请人： Battelle Memorial Institute
发明人： Yehia M. Ibrahim , Sandilya Garimella , Richard D. Smith
IPC分类号： G01N27/62 , H01J49/02
摘要： Methods and apparatuses for ion peak compression and increasing resolution of ions are disclosed. Packets of ions are introduced into a device. A first electric field is applied for dispersing the ion packets temporally or spatially according to their mobilities. A second intermittent traveling wave is applied for regrouping or merging the dispersed ion packets into a lesser number of trapping regions with narrower peaks. The ions packets are compressed into the narrower peak regions by varying a duty cycle of the intermittent traveling wave.

10. 发明申请

US20180169657A1 NANOSCALE BIOCHEMICAL SAMPLE PREPARATION AND ANALYSIS 审中-公开
公开(公告)号：US20180169657A1
公开(公告)日：2018-06-21
申请号：US15897022
申请日：2018-02-14
申请人： Battelle Memorial Institute
发明人： Ryan T. Kelly , Ying Zhu , Richard D. Smith
IPC分类号： B01L3/00 , G01N1/28 , G01N30/88 , C12M1/00 , C12M1/34 , C40B60/04
CPC分类号： B01L3/502753 , C12M23/58 , C12M41/00 , C12Q1/6881 , C40B60/04 , G01N1/2813 , G01N30/88 , G01N33/4833 , G01N2001/284 , G01N2030/8831
摘要： Provided herein are methods and systems for biochemical analysis, including compositions and methods for processing and analysis of small cell populations and biological samples (e.g., a robotically controlled chip-based nanodroplet platform). In particular aspects, the methods described herein can reduce total processing volumes from conventional volumes to nanoliter volumes within a single reactor vessel (e.g., within a single droplet reactor) while minimizing losses, such as due to sample evaporation.

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