专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07931154B2 Plasma separation membrane 有权
标题翻译：等离子体分离膜
公开(公告)号：US07931154B2
公开(公告)日：2011-04-26
申请号：US12307678
申请日：2007-06-25
申请人： Bernd Krause , Markus Hornung , Herman Goehl
发明人： Bernd Krause , Markus Hornung , Herman Goehl
IPC分类号： B01D69/08 , B01D71/68 , B01D63/02
CPC分类号： B01D67/0011 , B01D69/02 , B01D69/08 , B01D69/081 , B01D69/085 , B01D71/68 , B01D2325/022 , B01D2325/24 , B01D2325/28 , B01D2325/36
摘要： A process for manufacturing of an asymmetric hollow fiber membrane, comprising the steps of extruding a polymer solution through the outer ring slit of a hollow fiber spinning nozzle, simultaneously extruding a center fluid through the inner bore of the hollow fiber spinning nozzle, into a precipitation bath, whereby the polymer solution contains 10 to 26 wt-% of polysulfone (PSU), polyethersulfone (PES) or polyarylethersulfone (PAES), 8 to 15 wt-% polyvinylpyrrolidone (PVP) and 60 to 80 wt-% N-alkyl-2-pyrrolidone (NAP), the center fluid contains 60 to 70 wt-% N-alkyl-2-pyrrolidone (NAP) and 30 to 40 wt-% water, and the precipitation bath contains 70 to 82 wt-% N-alkyl-2-pyrrolidone (NAP) and 18 to 30 wt-% water.
摘要翻译：一种不对称中空纤维膜的制造方法，其特征在于，包括以下步骤：通过中空纤维纺丝喷嘴的外圈狭缝挤出聚合物溶液，同时将中心流体通过中空纤维纺丝喷嘴的内孔挤出成为沉淀物由此聚合物溶液含有10-26重量％的聚砜（PSU），聚醚砜（PES）或聚芳醚砜（PAES），8-15重量％聚乙烯吡咯烷酮（PVP）和60-80重量％N-烷基 - 2-吡咯烷酮（NAP），中心流体含有60〜70重量％的N-烷基-2-吡咯烷酮（NAP）和30〜40重量％的水，沉淀浴含有70〜82重量％的N-烷基 -2-吡咯烷酮（NAP）和18-30wt％水。

2. 发明申请

US20100012577A1 Plasma Separation Membrane 有权
标题翻译：等离子体分离膜
公开(公告)号：US20100012577A1
公开(公告)日：2010-01-21
申请号：US12307670
申请日：2007-06-25
申请人： Bernd Krause , Markus Hornung , Herman Goehl
发明人： Bernd Krause , Markus Hornung , Herman Goehl
IPC分类号： B01D69/08 , D01D5/24 , B32B1/00 , B32B1/08
CPC分类号： B01D69/087 , A61M1/3496 , B01D67/0011 , B01D69/02 , B01D69/08 , B01D71/44 , B01D71/68 , B01D2323/12 , Y10T428/1376 , Y10T428/139
摘要： A process for manufacturing of an asymmetric hollow fibre membrane, comprising the steps of extruding a polymer solution through the outer ring slit of a hollow fibre spinning nozzle, simultaneously extruding a centre fluid through the inner bore of the hollow fibre spinning nozzle, into a precipitation bath, whereby the polymer solution contains 10 to 26 wt-% of polysulfone (PSU), polyethersulfone (PES) or polyarylethersulfone (PAES), 8 to 15 wt-% polyvinylpyrrolidone (PVP), 55 to 75 wt-% N-alkyl-2-pyrrolidone (NAP) and 3 to 9 wt-% w ater the centre fluid contains 70 to 90 wt-% N-alkyl-2-pyrrolidone (NAP) and 10 to 30 wt-% water, and the precipitation bath contains 0 to 20 wt-% N-alkyl-2-pyrrolidone (NAP) and 80 to 100 wt-% water.
摘要翻译：一种不对称中空纤维膜的制造方法，其特征在于，包括以下步骤：通过中空纤维纺丝喷嘴的外圈狭缝挤出聚合物溶液，同时将中心流体通过中空纤维纺丝喷嘴的内孔挤出成为沉淀物由此聚合物溶液含有10-26重量％的聚砜（PSU），聚醚砜（PES）或聚芳醚砜（PAES），8-15重量％的聚乙烯吡咯烷酮（PVP），55-75重量％的N-烷基 - 2-吡咯烷酮（NAP）和3至9重量％的中心流体含有70-90重量％的N-烷基-2-吡咯烷酮（NAP）和10-30重量％的水，沉淀浴含有0 至20重量％的N-烷基-2-吡咯烷酮（NAP）和80至100重量％的水。

3. 发明授权

US08051991B2 Plasma separation membrane 有权
标题翻译：等离子体分离膜
公开(公告)号：US08051991B2
公开(公告)日：2011-11-08
申请号：US12307670
申请日：2007-06-25
申请人： Bernd Krause , Markus Hornung , Herman Goehl
发明人： Bernd Krause , Markus Hornung , Herman Goehl
IPC分类号： B01D63/02 , B01D69/08 , B01D71/68 , B01D61/00
CPC分类号： B01D69/087 , A61M1/3496 , B01D67/0011 , B01D69/02 , B01D69/08 , B01D71/44 , B01D71/68 , B01D2323/12 , Y10T428/1376 , Y10T428/139
摘要： A process for manufacturing of an asymmetric hollow fiber membrane, comprising the steps of extruding a polymer solution through the outer ring slit of a hollow fiber spinning nozzle, simultaneously extruding a center fluid through the inner bore of the hollow fiber spinning nozzle, into a precipitation bath, whereby the polymer solution contains 10 to 26 wt-% of polysulfone (PSU), polyethersulfone (PES) or polyarylethersulfone (PAES), 8 to 15 wt-% polyvinylpyrrolidone (PVP), 55 to 75 wt-% N-alkyl-2-pyrrolidone (NAP) and 3 to 9 wt-% water the centre fluid contains 70 to 90 wt-% N-alkyl-2-pyrrolidone (NAP) and 10 to 30 wt-% water, and the precipitation bath contains 0 to 20 wt-% N-alkyl-2-pyrrolidone (NAP) and 80 to 100 wt-% water.
摘要翻译：一种不对称中空纤维膜的制造方法，其特征在于，包括以下步骤：通过中空纤维纺丝喷嘴的外圈狭缝挤出聚合物溶液，同时将中心流体通过中空纤维纺丝喷嘴的内孔挤出成为沉淀物由此聚合物溶液含有10-26重量％的聚砜（PSU），聚醚砜（PES）或聚芳醚砜（PAES），8-15重量％的聚乙烯吡咯烷酮（PVP），55-75重量％的N-烷基 - 2-吡咯烷酮（NAP）和3〜9重量％的水，中心流体含有70〜90重量％的N-烷基-2-吡咯烷酮（NAP）和10〜30重量％的水，沉淀浴中含有0〜 20重量％的N-烷基-2-吡咯烷酮（NAP）和80-100重量％的水。

4. 发明申请

US20090283470A1 Plasma Separation Membrane 有权
标题翻译：等离子体分离膜
公开(公告)号：US20090283470A1
公开(公告)日：2009-11-19
申请号：US12307678
申请日：2007-06-25
申请人： Bernd Krause , Markus Hornung , Herman Goehl
发明人： Bernd Krause , Markus Hornung , Herman Goehl
IPC分类号： B01D69/08 , B01D67/00 , B01D69/02
CPC分类号： B01D67/0011 , B01D69/02 , B01D69/08 , B01D69/081 , B01D69/085 , B01D71/68 , B01D2325/022 , B01D2325/24 , B01D2325/28 , B01D2325/36
摘要： A process for manufacturing of an asymmetric hollow fibre membrane, comprising the steps of extruding a polymer solution through the outer ring slit of a hollow fibre spinning nozzle, simultaneously extruding a centre fluid through the inner bore of the hollow fibre spinning nozzle, into a precipitation bath, whereby the polymer solution contains 10 to 26 wt-% of polysulfone (PSU), polyethersulfone (PES) or polyarylethersulfone (PAES), 8 to 15 wt-% polyvinylpyrrolidone (PVP) and 60 to 80 wt-% N-alkyl-2-pyrrolidone (NAP), the centre fluid contains 60 to 70 wt-% N-alkyl-2-pyrrolidone (NAP) and 30 to 40 wt-% water, and the precipitation bath contains 70 to 82 wt-% N-alkyl-2-pyrrolidone (NAP) and 18 to 30 wt-% water.
摘要翻译：一种不对称中空纤维膜的制造方法，其特征在于，包括以下步骤：通过中空纤维纺丝喷嘴的外圈狭缝挤出聚合物溶液，同时将中心流体通过中空纤维纺丝喷嘴的内孔挤出成为沉淀物由此聚合物溶液含有10-26重量％的聚砜（PSU），聚醚砜（PES）或聚芳醚砜（PAES），8-15重量％聚乙烯吡咯烷酮（PVP）和60-80重量％N-烷基 - 2-吡咯烷酮（NAP），中心流体含有60〜70重量％的N-烷基-2-吡咯烷酮（NAP）和30〜40重量％的水，沉淀浴含有70〜82重量％的N-烷基 -2-吡咯烷酮（NAP）和18-30wt％水。

5. 发明申请

US20110031184A1 Hollow Fiber Membrane and Method for Manufacturing Thereof 有权
标题翻译：中空纤维膜及其制造方法
公开(公告)号：US20110031184A1
公开(公告)日：2011-02-10
申请号：US12446058
申请日：2007-10-11
申请人： Bernd Krause , Hermann Gohl , Markus Hornung , Carina Kraft
发明人： Bernd Krause , Hermann Gohl , Markus Hornung , Carina Kraft
IPC分类号： B01D69/08 , D01F9/00
CPC分类号： B01D71/68 , A61B5/14525 , A61M1/16 , B01D63/02 , B01D69/02 , B01D69/08 , B01D69/087 , B01D71/44 , B01D71/62 , B01D2323/06 , B01D2323/08 , B01D2323/12 , B01D2323/22 , B01D2325/022
摘要： The present invention concerns a semipermeable hollow fiber membrane having an outer wall surface, an inner wall surface and an interior lumen extending along the length thereof and having the selective layer on the outer wall surface with a surface roughness below 10 nm. According to the invention the membrane has the smallest pore size on the outer wall surface, and has an outer wall surface which is smooth, continuous and homogeneous in a nanoscopic scale and four to five distinct layers of different pore size and density. Further the present invention concerns a process for manufacturing thereof and the use thereof.
摘要翻译：本发明涉及一种具有外壁表面，内壁表面和沿其长度延伸的内腔的半透性中空纤维膜，并且在外壁表面上具有表面粗糙度低于10nm的选择层。根据本发明，膜在外壁表面具有最小的孔径，并且具有在纳米尺度上光滑，连续和均匀的外壁表面，以及不同孔径和密度的四至五个不同层。此外，本发明涉及其制造方法及其用途。

6. 发明授权

US08528744B2 Hydrophilic membranes with a non-ionic surfactant 有权
标题翻译：亲水膜与非离子表面活性剂
公开(公告)号：US08528744B2
公开(公告)日：2013-09-10
申请号：US12680531
申请日：2008-09-26
申请人： Bernd Krause , Markus Hornung , Silvia Koch , Doris Deppisch
发明人： Bernd Krause , Markus Hornung , Reinhold Deppisch , Silvia Koch
IPC分类号： B01D71/00 , B01D69/00 , B01D69/08 , B01D67/00
CPC分类号： B01D69/02 , A61M1/16 , A61M1/3496 , B01D67/0088
摘要： The invention relates to hydrophilic membranes which are supplemented or treated with a non-ionic surfactant and processes for preparing such membranes. The membranes are particularly suitable for plasma separation or for haemodialysis and haemodiafiltration, but can also advantageously be used in other applications. Accordingly, the invention is further directed to the use of such membranes for plasma separation, plasma filtration, micro filtration, plasma therapy, haemodialysis and haemodiafiltration or cell filtration applications, respectively. The treated hydrophilic membranes show excellent biocompatibility, such as reduced platelet drop and decreased TAT levels.
摘要翻译：本发明涉及用非离子表面活性剂补充或处理的亲水膜及其制备方法。该膜特别适用于血浆分离或用于血液透析和血液透析过滤，但也可有利地用于其它应用。因此，本发明进一步涉及这种膜用于血浆分离，血浆过滤，微过滤，血浆治疗，血液透析和血液透析或细胞过滤应用。经处理的亲水膜显示出优异的生物相容性，例如减少血小板降低和降低的TAT水平。

7. 发明申请

US20120208256A1 ENZYME-FUNCTIONALIZED SUPPORTS 审中-公开
标题翻译：酶功能化支持
公开(公告)号：US20120208256A1
公开(公告)日：2012-08-16
申请号：US13503204
申请日：2010-10-20
申请人： Ralf Flieg , Manuela Klotz , Markus Storr , Martin Rempfer , Wolfgang Freudemann , Cornelia Winz , Bernd Krause , Markus Hornung
发明人： Ralf Flieg , Manuela Klotz , Markus Storr , Martin Rempfer , Wolfgang Freudemann , Cornelia Winz , Bernd Krause , Markus Hornung
IPC分类号： C12N11/06 , C12N11/02
CPC分类号： C12N9/18 , C09D133/14 , C12N9/80 , C12N11/06 , C12N11/08
摘要： An immobilized enzyme comprises a solid support, an enzyme linked to the solid support and a spacer for coupling the enzyme to the solid support. A method for the production of immobilized enzymes comprises: providing a solid support having amino-functional groups coupled to the support surface; covalently coupling the amino-functional groups with a thermally labile radical initiator; and, contacting the support surface with a solution of polymerizable monomers. The polymerizable monomers comprise functional groups which do not take part in radical polymerization, under conditions where thermally initiated graft copolymerization of the monomers takes place, to form polymer chains on the surface of the support. If the polymer chains do not already comprise primary amino-functional groups, the method further comprises transforming the functional groups in the polymer chains into groups comprising primary amino-functional groups. The method further comprises coupling the enzyme to amino-functional groups of the polymer chains.
摘要翻译：固定化酶包括固体支持物，与固体支持物连接的酶和用于将酶偶联到固体支持物的间隔物。制备固定化酶的方法包括：提供具有与支持表面偶联的氨基官能团的固体支持物; 将氨基官能团与热不稳定的自由基引发剂共价偶联; 并且使支撑体表面与可聚合单体的溶液接触。可聚合单体包括在发生单体的热引发接枝共聚的条件下不参与自由基聚合的官能团，以在载体的表面上形成聚合物链。如果聚合物链不包括伯氨基官能团，则该方法还包括将聚合物链中的官能团转化为包含伯氨基官能团的基团。该方法还包括将酶偶联到聚合物链的氨基官能团。

8. 发明申请

US20090057225A1 Filtration Membrane 审中-公开
标题翻译：过滤膜
公开(公告)号：US20090057225A1
公开(公告)日：2009-03-05
申请号：US11887957
申请日：2006-04-06
申请人： Bernd Krause , Markus Hornung , Thomas Ertl , Markus Storr
发明人： Bernd Krause , Markus Hornung , Thomas Ertl , Markus Storr
IPC分类号： B01D71/68 , B01D67/00 , C08G75/00
CPC分类号： B01D71/44 , B01D67/0011 , B01D69/02 , B01D69/08 , B01D69/087 , B01D69/12 , B01D71/52 , B01D71/60 , B01D71/68 , B01D71/82 , B01D2325/02 , B01D2325/026 , B01D2325/12 , B01D2325/16 , B01D2325/42
摘要： The invention is directed to a ultrafiltration membrane that is capable for the retention of endotoxines and cytokine inducing substances (CIS) including bacterial DNA and/or DNA fragments from fluid and/or liquid media. The invention is further directed to a method of manufacturing such ultrafiltration membranes in a high quality and in an effective and time saving procedure, and to the use of such membranes for the retention of substances from fluids or liquids. The ultrafiltration membrane of the invention consists of a polymer blend comprising at least one hydrophobic polymer containing sulfur in its back bone, at least one hydrophilic, uncharged homo-polymer of polyvinylpyrrolidone and at least one polymer containing cationic charges. The method of manufacturing such a ultrafiltration membrane comprises dissolving at least one hydrophobic polymer containing sulfur in its back bone and at least one hydrophilic, uncharged polyvinylpyrrolidone and at least one polymer containing cationic charges in at least one solvent to form a polymer solution, subjecting the formed polymer solution to a diffusion-induced phase separation to prepare a ultrafiltration membrane, washing and subsequently drying of the ultrafiltration membrane.
摘要翻译：本发明涉及能够从流体和/或液体介质中保留包含细菌DNA和/或DNA片段的内毒素和细胞因子诱导物质（CIS）的超滤膜。本发明进一步涉及以高质量和有效且节省时间的方法制造这种超滤膜的方法，以及使用这种膜来保持来自流体或液体的物质。本发明的超滤膜由包含至少一种在其背骨中含有硫的疏水性聚合物，至少一种亲水的，不带电的聚乙烯吡咯烷酮的聚合物和至少一种含有阳离子电荷的聚合物组成的聚合物共混物构成。制造这种超滤膜的方法包括将至少一种含有硫的疏水性聚合物溶解在其背骨中，并且至少一种亲水的，不带电的聚乙烯吡咯烷酮和至少一种含至少一种溶剂中的阳离子电荷的聚合物形成聚合物溶液，形成的聚合物溶液进行扩散诱导的相分离以制备超滤膜，洗涤并随后干燥超滤膜。

9. 发明授权

US08596467B2 Hollow fiber membrane and method for manufacturing thereof 有权
公开(公告)号：US08596467B2
公开(公告)日：2013-12-03
申请号：US12446058
申请日：2007-10-11
申请人： Bernd Krause , Hermann Gohl , Markus Hornung , Carina Zweigart
发明人： Bernd Krause , Hermann Gohl , Markus Hornung , Carina Zweigart
IPC分类号： B01D69/08 , B01D69/12 , D01D5/24 , D01F1/08
CPC分类号： B01D71/68 , A61B5/14525 , A61M1/16 , B01D63/02 , B01D69/02 , B01D69/08 , B01D69/087 , B01D71/44 , B01D71/62 , B01D2323/06 , B01D2323/08 , B01D2323/12 , B01D2323/22 , B01D2325/022
摘要： The present invention concerns a semipermeable hollow fiber membrane having an outer wall surface, an inner wall surface and an interior lumen extending along the length thereof and having the selective layer on the outer wall surface with a surface roughness below 10 nm. According to the invention the membrane has the smallest pore size on the outer wall surface, and has an outer wall surface which is smooth, continuous and homogeneous in a nanoscopic scale and four to five distinct layers of different pore size and density. Further the present invention concerns a process for manufacturing thereof and the use thereof.

10. 发明申请

US20100320146A1 HYDROPHILIC MEMBRANES WITH A NON-IONIC SURFACTANT 有权
标题翻译：具有非离子表面活性剂的亲水膜
公开(公告)号：US20100320146A1
公开(公告)日：2010-12-23
申请号：US12680531
申请日：2008-09-26
申请人： Bernd Krause , Markus Hornung , Reinhold Deppisch , Doris Deppisch , Silvia Koch
发明人： Bernd Krause , Markus Hornung , Reinhold Deppisch , Doris Deppisch , Silvia Koch
IPC分类号： B01D71/06 , B01D71/68 , B01D69/08 , B01D61/24 , B01J20/00 , B01J20/26
CPC分类号： B01D69/02 , A61M1/16 , A61M1/3496 , B01D67/0088
摘要： The invention relates to hydrophilic membranes which are supplemented or treated with a non-ionic surfactant and processes for preparing such membranes. The membranes are particularly suitable for plasma separation or for haemodialysis and haemodiafiltration, but can also advantageously be used in other applications. Accordingly, the invention is further directed to the use of such membranes for plasma separation, plasma filtration, micro filtration, plasma therapy, haemodialysis and haemodiafiltration or cell filtration applications, respectively. The treated hydrophilic membranes show excellent biocompatibility, such as reduced platelet drop and decreased TAT levels.
摘要翻译：本发明涉及用非离子表面活性剂补充或处理的亲水膜及其制备方法。该膜特别适用于血浆分离或用于血液透析和血液透析过滤，但也可有利地用于其它应用。因此，本发明进一步涉及这种膜用于血浆分离，血浆过滤，微过滤，血浆治疗，血液透析和血液透析或细胞过滤应用。经处理的亲水膜显示出优异的生物相容性，例如减少血小板降低和降低的TAT水平。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式