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1. 发明授权

US07050157B2 Reagent-less whole-blood glucose meter 有权
公开(公告)号：US07050157B2
公开(公告)日：2006-05-23
申请号：US10200384
申请日：2002-07-19
申请人： James R. Braig , Peter Rule , Robert D. Gaffney , Philip C. Hartstein , Julian M. Cortella , Kenneth I. Li , Bernhard B. Sterling , Peng Zheng , W. Dale Hall , Kenneth G. Witte , Mark D. Agostino , Daniel S. Goldberger
发明人： James R. Braig , Peter Rule , Robert D. Gaffney , Philip C. Hartstein , Julian M. Cortella , Kenneth I. Li , Bernhard B. Sterling , Peng Zheng , W. Dale Hall , Kenneth G. Witte , Mark D. Agostino , Daniel S. Goldberger
IPC分类号： G01N33/48
CPC分类号： A61B5/1455 , A61B5/01 , A61B5/14532 , A61B5/150022 , A61B5/150061 , A61B5/150213 , A61B5/150274 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150755 , A61B5/15087 , A61B5/151 , A61B5/157 , A61B5/6826 , A61B5/6838 , A61B2562/0295 , A61B2562/12 , G01N21/35
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

2. 发明授权

US07096124B2 Method of determining an analyte concentration in a sample from an absorption spectrum 失效
标题翻译：从吸收光谱确定样品中分析物浓度的方法
公开(公告)号：US07096124B2
公开(公告)日：2006-08-22
申请号：US11062110
申请日：2005-02-18
申请人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Kenneth G. Witte
发明人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Kenneth G. Witte
IPC分类号： G06F19/00
CPC分类号： A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B2562/0295 , G01N21/274 , G01N21/314 , G01N21/35 , G01N27/3271
摘要： A method determines an analyte concentration in a sample including the analyte and a substance. The method includes providing an absorption spectrum of the sample. The absorption spectrum has an absorption baseline. The method further includes shifting the absorption spectrum so that the absorption baseline approximately equals a selected absorption value in a selected absorption wavelength range. The method further includes subtracting a substance contribution from the absorption spectrum. Thus, the method provides a corrected absorption spectrum substantially free of a contribution from the substance.
摘要翻译：一种方法确定包含分析物和物质的样品中的分析物浓度。该方法包括提供样品的吸收光谱。吸收光谱具有吸收基线。该方法还包括移动吸收光谱，使得吸收基线大约等于所选吸收波长范围内的选定吸收值。该方法还包括从吸收光谱中减去物质贡献。因此，该方法提供基本上不含该物质的贡献的校正吸收光谱。

3. 发明授权

US06959211B2 Device for capturing thermal spectra from tissue 失效
标题翻译：用于从组织中捕获热谱的装置
公开(公告)号：US06959211B2
公开(公告)日：2005-10-25
申请号：US10213730
申请日：2002-08-06
申请人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian M. Cortella , Heidi M. Smith , Roger O. Herrera , Kenneth G. Witte , Philip C. Hartstein , Mark D. Agostino
发明人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian M. Cortella , Heidi M. Smith , Roger O. Herrera , Kenneth G. Witte , Philip C. Hartstein , Mark D. Agostino
IPC分类号： A61B5/00 , G01N21/01 , G01N21/03 , G01N21/35
CPC分类号： A61B5/01 , A61B5/061 , A61B5/14532 , A61B5/6824 , G01J3/0286 , G01J3/0291 , G01N21/01 , G01N21/35 , G01N2021/0389 , G01N2201/021 , G01N2201/0245
摘要： A device and method are provided for use with a noninvasive optical measurement system, such as a thermal gradient spectrometer, for improved determination of analyte concentrations within living tissue. In one embodiment, a wearable window is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The wearable window effectively replaces a window of the spectrometer, and thus forms an interface between the patient's skin and a thermal mass window of the spectrometer. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the wearable window is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the wearable window will again form an interface between the spectrometer and the same location of skin as before.
摘要翻译：提供了一种用于无创光学测量系统（例如热梯度光谱仪）的装置和方法，用于改善活体组织内分析物浓度的测定。在一个实施例中，可佩戴的窗户被固定到患者的前臂，从而隔离患者皮肤上的测量部位以确定血糖水平。穿戴式窗户有效地代替了光谱仪的窗口，从而形成了患者皮肤与光谱仪的热质量窗口之间的界面。当光谱仪必须临时从患者皮肤上移除时，例如允许患者移动，则将可佩戴的窗口固定在前臂上，以便在皮肤上保持一致的测量部位。当光谱仪后来重新连接到患者身上时，穿戴式窗户将再次形成光谱仪与以前相同的皮肤位置之间的界面。

4. 发明申请

US20080268486A1 DUAL MEASUREMENT ANALYTE DETECTION SYSTEM 审中-公开
标题翻译：双测量分析仪检测系统
公开(公告)号：US20080268486A1
公开(公告)日：2008-10-30
申请号：US12171205
申请日：2008-07-10
申请人： James R. Braig , Peter Rule , Kenneth G. Witte , Philip C. Hartstein , Bernhard B. Sterling
发明人： James R. Braig , Peter Rule , Kenneth G. Witte , Philip C. Hartstein , Bernhard B. Sterling
IPC分类号： C12Q1/54 , C12M1/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546
摘要： An analyte detection system is configured to measure concentrations of at least first and second analytes in a single material sample supported by a sample element. The measurement of a second analyte can be conditioned on a quantitative or qualitative result of the first measurement. In one embodiment, the first analyte is glucose and the second analyte is a ketone. According to such an embodiment the ketone is measured if the result of the glucose measurement exceeds a previously-specified value or falls outside of a previously-specified range.
摘要翻译：分析物检测系统被配置为测量由样品元素支持的单个材料样品中的至少第一和第二分析物的浓度。第二分析物的测量可以对第一次测量的定量或定性结果进行调节。在一个实施方案中，第一分析物是葡萄糖，第二分析物是酮。根据这样的实施方案，如果葡萄糖测量结果超过预先规定的值或者超出预先规定的范围，则测量酮。

5. 发明授权

US08140140B2 Analyte detection system for multiple analytes 有权
标题翻译：多种分析物的分析物检测系统
公开(公告)号：US08140140B2
公开(公告)日：2012-03-20
申请号：US11314176
申请日：2005-12-21
申请人： Bernhard B. Sterling , James R. Braig , Kenneth G. Witte , Peter Rule , Richard Keenan , W. Dale Hall
发明人： Bernhard B. Sterling , James R. Braig , Kenneth G. Witte , Peter Rule , Richard Keenan , W. Dale Hall
IPC分类号： A61B5/1455
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M2205/12 , A61M2230/20 , A61M2230/201 , G01N1/14 , G01N21/05 , G01N21/274 , G01N21/35 , G01N2021/0346
摘要： An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient; and a pump unit in operative engagement with the fluid handling network. The pump unit has an infusion mode in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further comprises a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample. In one implementation, the pump unit comprises a first pump operable in the infusion mode but not in the sample draw mode, and a second pump operable in the sample draw mode but not in the infusion mode.
摘要翻译：一种用于分析体液组成的装置。该装置包括流体处理网络，其包括被配置为保持患者体内与体液的流体连通的患者端; 以及与所述流体处理网络操作地接合的泵单元。泵单元具有输注模式，其中泵单元可操作以通过患者端向患者输送输注流体，以及抽样模式，其中泵单元可操作以从患者抽取体液样本，通过病人结束所述设备还包括定位成分析样品的至少一部分的光谱分析仪; 与光谱分析仪通信或并入其中的处理器; 以及可由处理器执行的存储的程序指令，以获得样本的两个或多个属性的测量。在一个实施方案中，泵单元包括可在输液模式中操作但不在样品抽取模式中的第一泵，以及可在样品抽取模式中操作但不在输注模式中的第二泵。

6. 发明申请

US20100221762A1 METHOD AND APPARATUS FOR DETERMINING AN ANALYTE CONCENTRATION IN A SAMPLE HAVING INTERFERENTS 有权
标题翻译：在具有干扰的样品中测定分析物浓度的方法和装置
公开(公告)号：US20100221762A1
公开(公告)日：2010-09-02
申请号：US12573821
申请日：2009-10-05
申请人： Bernhard B. Sterling , W. Dale Hall , Kenneth G. Witte , Mark Wechsler , Peng Zheng , Richard Keenan
发明人： Bernhard B. Sterling , W. Dale Hall , Kenneth G. Witte , Mark Wechsler , Peng Zheng , Richard Keenan
IPC分类号： C12Q1/58 , G06F19/00 , C12Q1/54 , C12Q1/02 , C12Q1/24
CPC分类号： G01N21/274 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1459 , A61B5/1495 , A61B2560/0223 , A61M5/14212 , A61M2230/20 , G01N21/35 , G01N35/00693 , G01N35/00712 , G01N2201/1215 , G01N2201/127
摘要： A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of known analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.
摘要翻译：描述了允许在干扰测量的化合物存在下从测量估计分析物浓度的方法和装置。该方法减少了在存在干扰物的情况下分析物浓度的误差。该方法包括使用对具有已知分析物范围和干扰化合物浓度的大群体获得的一组测量。从可能或可能不是其中一个群体的样本测量中，可能存在干扰物被识别，并且计算校准向量。

7. 发明申请

US20090045342A1 METHOD AND APPARATUS FOR DETERMINING AN ANALYTE CONCENTRATION IN A SAMPLE HAVING INTERFERENTS 审中-公开
标题翻译：在具有干扰的样品中测定分析物浓度的方法和装置
公开(公告)号：US20090045342A1
公开(公告)日：2009-02-19
申请号：US12140175
申请日：2008-06-16
申请人： Bernhard B. Sterling , W. Dale Hall , Kenneth G. Witte , Mark Wechsler , Peng Zheng , Richard Keenan
发明人： Bernhard B. Sterling , W. Dale Hall , Kenneth G. Witte , Mark Wechsler , Peng Zheng , Richard Keenan
IPC分类号： G01J5/02
CPC分类号： G01N21/274 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1459 , A61B5/1495 , A61B2560/0223 , A61M5/14212 , A61M2230/20 , G01N21/35 , G01N35/00693 , G01N35/00712 , G01N2201/1215 , G01N2201/127
摘要： A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of known analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.
摘要翻译：描述了允许在干扰测量的化合物存在下从测量估计分析物浓度的方法和装置。该方法减少了在存在干扰物的情况下分析物浓度的误差。该方法包括使用对具有已知分析物范围和干扰化合物浓度的大群体获得的一组测量。从可能或可能不是其中一个群体的样本测量中，可能存在干扰物被识别，并且计算校准向量。

8. 发明授权

US07388202B2 Method and apparatus for determining an analyte concentration in a sample having interferents 有权
标题翻译：用于确定具有干扰物的样品中的分析物浓度的方法和装置
公开(公告)号：US07388202B2
公开(公告)日：2008-06-17
申请号：US11256656
申请日：2005-10-21
申请人： Bernhard B. Sterling , W. Dale Hall , Kenneth G. Witte , Mark Wechsler , Peng Zheng , Richard Keenan
发明人： Bernhard B. Sterling , W. Dale Hall , Kenneth G. Witte , Mark Wechsler , Peng Zheng , Richard Keenan
IPC分类号： G01J1/00 , G01N21/35
CPC分类号： G01N21/274 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1459 , A61B5/1495 , A61B2560/0223 , A61M5/14212 , A61M2230/20 , G01N21/35 , G01N35/00693 , G01N35/00712 , G01N2201/1215 , G01N2201/127
摘要： A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of known analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.
摘要翻译：描述了允许在干扰测量的化合物存在下从测量估计分析物浓度的方法和装置。该方法减少了在存在干扰物的情况下分析物浓度的误差。该方法包括使用对具有已知分析物范围和干扰化合物浓度的大群体获得的一组测量。从可能或可能不是其中一个群体的样本测量中，可能存在干扰物被识别，并且计算校准向量。

9. 发明授权

US08620397B2 Method and apparatus for determining an analyte concentration in a sample having interferents 有权
标题翻译：用于确定具有干扰物的样品中的分析物浓度的方法和装置
公开(公告)号：US08620397B2
公开(公告)日：2013-12-31
申请号：US12573821
申请日：2009-10-05
申请人： Bernhard B. Sterling , W. Dale Hall , Kenneth G. Witte , Mark Wechsler , Peng Zheng , Richard Keenan
发明人： Bernhard B. Sterling , W. Dale Hall , Kenneth G. Witte , Mark Wechsler , Peng Zheng , Richard Keenan
IPC分类号： A61B5/1455 , G01N21/00
CPC分类号： G01N21/274 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1459 , A61B5/1495 , A61B2560/0223 , A61M5/14212 , A61M2230/20 , G01N21/35 , G01N35/00693 , G01N35/00712 , G01N2201/1215 , G01N2201/127
摘要： A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of known analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.
摘要翻译：描述了允许在干扰测量的化合物存在下从测量估计分析物浓度的方法和装置。该方法减少了在存在干扰物的情况下分析物浓度的误差。该方法包括使用对具有已知分析物范围和干扰化合物浓度的大群体获得的一组测量。从可能或可能不是其中一个群体的样本测量中，可能存在干扰物被识别，并且计算校准向量。

10. 发明授权

US06825044B2 Method for adjusting a blood analyte measurement 失效
标题翻译：用于调节血液分析物测量的方法
公开(公告)号：US06825044B2
公开(公告)日：2004-11-30
申请号：US10301927
申请日：2002-11-21
申请人： Peng Zheng , Jennifer H. Gable , W. Dale Hall , Kenneth G. Witte , James R. Braig
发明人： Peng Zheng , Jennifer H. Gable , W. Dale Hall , Kenneth G. Witte , James R. Braig
IPC分类号： G01N2164
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/1491
摘要： A device and method for determining analyte concentrations within a material sample are provided. A modulating temperature gradient is induced in the sample and resultant, emitted infrared radiation is measured at selected analyte absorbance peaks and reference wavelengths. The modulating temperature gradient is controlled by a surface temperature modulation. A transfer function relating the surface temperature modulation to a modulation of the measured infrared radiation is provided. Phase and magnitude differences in the transfer function are detected. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated and processed to determine analyte concentration in the material sample. A method for adjusting an analyte measurement is provided. The method provides a hydration correction process for calibration and correction whereby analyte concentrations within the material sample may be determined. The hydration correction process is particularly suitable for determining blood analyte concentrations within human tissue.
摘要翻译：提供了用于确定材料样品中的分析物浓度的装置和方法。在样品中诱导调制温度梯度，并在所选分析物的吸收峰和参考波长处测量发射的红外辐射。调制温度梯度由表面温度调制控制。提供了将表面温度调制与测量的红外辐射的调制相关联的传递函数。检测传递函数的相位和幅度差异。测量，相关和处理与分析物浓度有关的这些相位和幅度差异，以确定材料样品中的分析物浓度。提供了一种用于调节分析物测量的方法。该方法提供用于校准和校正的水合校正过程，从而可以确定材料样品中的分析物浓度。水合校正过程特别适用于测定人体组织内的血液分析物浓度。

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