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1. 发明申请

US20090018597A1 System and Method for Estimating Cardiac Pressure Based on Cardiac Electrical Conduction Delays Using an Implantable Medical Device 有权
公开(公告)号：US20090018597A1
公开(公告)日：2009-01-15
申请号：US11779350
申请日：2007-07-18
申请人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
发明人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
IPC分类号： A61N1/36
CPC分类号： A61B5/02156 , A61B5/0215 , A61B5/72 , A61N1/365 , A61N1/36564 , A61N1/36578 , A61N1/3682 , A61N1/3684 , A61N1/37258
摘要： Techniques are provided for estimating left atrial pressure (LAP) or other cardiac performance parameters based on measured conduction delays. In particular, LAP is estimated based interventricular conduction delays. Predetermined conversion factors stored within the device are used to convert the various the conduction delays into LAP values or other appropriate cardiac performance parameters. The conversion factors may be, for example, slope and baseline values derived during an initial calibration procedure performed by an external system, such as an external programmer. In some examples, the slope and baseline values may be periodically re-calibrated by the implantable device itself. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP or other cardiac performance parameters. Still further, techniques are described for estimating conduction delays based on impedance or admittance values and for tracking heart failure therefrom.

2. 发明授权

US08504153B2 System and method for estimating cardiac pressure based on cardiac electrical conduction delays using an implantable medical device 有权
公开(公告)号：US08504153B2
公开(公告)日：2013-08-06
申请号：US11779380
申请日：2007-07-18
申请人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
发明人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
IPC分类号： A61N1/365
CPC分类号： A61B5/02156 , A61B5/0215 , A61B5/72 , A61N1/365 , A61N1/36564 , A61N1/36578 , A61N1/3682 , A61N1/3684 , A61N1/37258
摘要： Techniques are provided for estimating left atrial pressure (LAP) or other cardiac performance parameters based on measured conduction delays. In particular, LAP is estimated based interventricular conduction delays. Predetermined conversion factors stored within the device are used to convert the various the conduction delays into LAP values or other appropriate cardiac performance parameters. The conversion factors may be, for example, slope and baseline values derived during an initial calibration procedure performed by an external system, such as an external programmer. In some examples, the slope and baseline values may be periodically re-calibrated by the implantable device itself. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP or other cardiac performance parameters. Still further, techniques are described for estimating conduction delays based on impedance or admittance values and for tracking heart failure therefrom.

3. 发明申请

US20090287267A1 System and Method for Estimating Cardiac Pressure Based on Cardiac Electrical Conduction Delays Using an Implantable Medical Device 有权
标题翻译：使用可植入医疗器械的基于心电导通延迟的估计心脏压力的系统和方法
公开(公告)号：US20090287267A1
公开(公告)日：2009-11-19
申请号：US11779380
申请日：2007-07-18
申请人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
发明人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
IPC分类号： A61N1/36
CPC分类号： A61B5/02156 , A61B5/0215 , A61B5/72 , A61N1/365 , A61N1/36564 , A61N1/36578 , A61N1/3682 , A61N1/3684 , A61N1/37258
摘要： Techniques are provided for estimating left atrial pressure (LAP) or other cardiac performance parameters based on measured conduction delays. In particular, LAP is estimated based interventricular conduction delays. Predetermined conversion factors stored within the device are used to convert the various the conduction delays into LAP values or other appropriate cardiac performance parameters. The conversion factors may be, for example, slope and baseline values derived during an initial calibration procedure performed by an external system, such as an external programmer. In some examples, the slope and baseline values may be periodically re-calibrated by the implantable device itself. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP or other cardiac performance parameters. Still further, techniques are described for estimating conduction delays based on impedance or admittance values and for tracking heart failure therefrom.
摘要翻译：提供了基于测量的传导延迟来估计左心房压力（LAP）或其他心脏性能参数的技术。特别地，LAP是基于室间传导延迟估计的。存储在装置内的预定转换因子用于将各种导通延迟转换为LAP值或其他适当的心脏性能参数。转换因子可以是例如由外部系统（诸如外部编程器）执行的初始校准过程期间导出的斜率和基线值。在一些示例中，可以通过可植入装置本身周期性地重新校准斜率和基线值。还描述了基于估计的LAP或其他心脏性能参数自适应地调整起搏参数的技术。此外，描述了用于基于阻抗或导纳值估计导通延迟并用于跟踪其心力衰竭的技术。

4. 发明授权

US08504152B2 System and method for estimating cardiac pressure based on cardiac electrical conduction delays using an implantable medical device 有权
公开(公告)号：US08504152B2
公开(公告)日：2013-08-06
申请号：US11779350
申请日：2007-07-18
申请人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
发明人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
IPC分类号： A61N1/365
CPC分类号： A61B5/02156 , A61B5/0215 , A61B5/72 , A61N1/365 , A61N1/36564 , A61N1/36578 , A61N1/3682 , A61N1/3684 , A61N1/37258
摘要： Techniques are provided for estimating left atrial pressure (LAP) or other cardiac performance parameters based on measured conduction delays. In particular, LAP is estimated based interventricular conduction delays. Predetermined conversion factors stored within the device are used to convert the various the conduction delays into LAP values or other appropriate cardiac performance parameters. The conversion factors may be, for example, slope and baseline values derived during an initial calibration procedure performed by an external system, such as an external programmer. In some examples, the slope and baseline values may be periodically re-calibrated by the implantable device itself. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP or other cardiac performance parameters. Still further, techniques are described for estimating conduction delays based on impedance or admittance values and for tracking heart failure therefrom.

5. 发明授权

US08280511B2 Systems and methods for use by an implantable medical device for detecting heart failure based on the independent information content of immittance vectors 有权
标题翻译：由植入式医疗装置用于根据导纳矢量的独立信息内容检测心力衰竭的系统和方法
公开(公告)号：US08280511B2
公开(公告)日：2012-10-02
申请号：US12168750
申请日：2008-07-07
申请人： Wenxia Zhao , Dorin Panescu , Anders Bjorling
发明人： Wenxia Zhao , Dorin Panescu , Anders Bjorling
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/053 , A61B5/0538 , A61N1/3627
摘要： Techniques are provided for detecting heart failure or other medical conditions within a patient using an implantable medical device, such as pacemaker or implantable cardioverter/defibrillator, or external system. In one example, physiological signals, such as immittance-based signals, are sensed within the patient along a plurality of different vectors, and the amount of independent informational content among the physiological signals of the different vectors is determined. Heart failure is then detected by the implantable device based on a significant increase in the amount of independent informational content among the physiological signals. In response, therapy may be controlled, diagnostic information stored, and/or warning signals generated. In other examples, at least some of these functions are performed by an external system.
摘要翻译：提供了用于使用可植入医疗装置（例如起搏器或植入式心律转复器/去纤颤器或外部系统）来检测患者心脏衰竭或其他医疗状况的技术。在一个示例中，沿着多个不同的向量在患者体内感测诸如基于导纳的信号的生理信号，并且确定不同矢量的生理信号中的独立信息内容的量。基于生理信号中独立信息内容量的显着增加，可植入装置检测心力衰竭。作为响应，可以控制治疗，存储诊断信息和/或生成警告信号。在其他示例中，这些功能中的至少一些由外部系统执行。

6. 发明申请

US20100004712A1 SYSTEMS AND METHODS FOR USE BY AN IMPLANTABLE MEDICAL DEVICE FOR DETECTING HEART FAILURE BASED ON THE INDEPENDENT INFORMATION CONTENT OF IMMITANCE VECTORS 有权
标题翻译：基于独立信息内容的可移植医疗设备用于检测心跳失败的系统和方法
公开(公告)号：US20100004712A1
公开(公告)日：2010-01-07
申请号：US12168750
申请日：2008-07-07
申请人： Wenxia Zhao , Dorin Panescu , Anders Bjorling
发明人： Wenxia Zhao , Dorin Panescu , Anders Bjorling
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/053 , A61B5/0538 , A61N1/3627
摘要： Techniques are provided for detecting heart failure or other medical conditions within a patient using an implantable medical device, such as pacemaker or implantable cardioverter/defibrillator, or external system. In one example, physiological signals, such as immittance-based signals, are sensed within the patient along a plurality of different vectors, and the amount of independent informational content among the physiological signals of the different vectors is determined. Heart failure is then detected by the implantable device based on a significant increase in the amount of independent informational content among the physiological signals. In response, therapy may be controlled, diagnostic information stored, and/or warning signals generated. In other examples, at least some of these functions are performed by an external system.
摘要翻译：提供了用于使用可植入医疗装置（例如起搏器或植入式心律转复器/去纤颤器或外部系统）来检测患者心脏衰竭或其他医疗状况的技术。在一个示例中，沿着多个不同的向量在患者体内感测诸如基于导纳的信号的生理信号，并且确定不同矢量的生理信号中的独立信息内容的量。基于生理信号中独立信息内容量的显着增加，可植入装置检测心力衰竭。作为响应，可以控制治疗，存储诊断信息和/或生成警告信号。在其他示例中，这些功能中的至少一些由外部系统执行。

7. 发明授权

US07546161B1 Methods for loss of capture and fusion avoidance in biventricular pacing therapy 有权
标题翻译：双心室起搏治疗中捕获和融合避免的方法
公开(公告)号：US07546161B1
公开(公告)日：2009-06-09
申请号：US11330316
申请日：2006-01-11
申请人： Anders Bjorling , Xiaoyi Min , Richard Williamson , Karin Jarverud , Nils Holmstrom
发明人： Anders Bjorling , Xiaoyi Min , Richard Williamson , Karin Jarverud , Nils Holmstrom
IPC分类号： A61N1/368
CPC分类号： A61N1/3712 , A61B5/0452 , A61N1/3684
摘要： An exemplary method includes delivering biventricular pacing therapy using one or more timing parameters, detecting loss of capture, deciding if fusion exists without adjusting the one or more timing parameters and, based on the deciding, calling for fusion avoidance or calling for a capture threshold search. Various other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：一种示例性方法包括使用一个或多个定时参数提供双心室起搏治疗，检测捕获的丢失，确定融合是否存在而不调整一个或多个定时参数，以及基于决定呼叫融合避免或调用捕获阈值搜索。还公开了各种其它示例性方法，装置，系统等。

8. 发明授权

US08554320B2 Medical implantable lead 有权
标题翻译：医用植入式铅
公开(公告)号：US08554320B2
公开(公告)日：2013-10-08
申请号：US13452639
申请日：2012-04-20
申请人： Anders Bjorling , Caroline Sparf
发明人： Anders Bjorling , Caroline Sparf
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/056 , A61N2001/0585
摘要： The invention relates to a medical implantable lead for monitoring and/or controlling an organ inside a human or animal body. The lead comprises a conducting arrangement having a first conducting coil of at least one electrically conducting wire for connecting a first electrode electrically to a connector to receive and/or transmit electric signals from and to the tissue, respectively. The lead is tapered in a distal portion and has a smaller cross sectional dimension at the distal portion than at the rest of the lead. The first conducting coil is terminated at a termination point on a distance from the distal end. The conducting arrangement has a first end conductor in the form of a non-coiled electric conductor or an eccentrically positioned small diameter coil which connects the first electrode electrically with the coil.
摘要翻译：本发明涉及用于监测和/或控制人或动物体内的器官的医用可植入引线。引线包括具有至少一个导电线的第一导电线圈的导电装置，用于将第一电极电连接到连接器，以分别从组织接收和/或发送电信号。引线在远端部分是锥形的，并且在远端部分具有比在其余引线更小的横截面尺寸。第一导电线圈在距离远端一定距离处的端接端处终止。该导电装置具有第一端部导体，该第一端部导体为非卷绕电导体或偏心定位的小直径线圈，其将第一电极与线圈电连接。

9. 发明申请

US20090076560A1 Biventricular Heart Stimulator and Method of Controlling a Biventricular Heart Stimulator 有权
标题翻译：双心室心脏刺激器和控制双心室心脏刺激器的方法
公开(公告)号：US20090076560A1
公开(公告)日：2009-03-19
申请号：US11885326
申请日：2005-03-02
申请人： Anders Bjorling , Nils Holmstrom
发明人： Anders Bjorling , Nils Holmstrom
IPC分类号： A61N1/37
CPC分类号： A61N1/3712 , A61N1/368 , A61N1/3684
摘要： In a biventricular heart stimulator and a method for controlling such a biventricular heart stimulator, successive stimulation pulses are delivered to the ventricles of a heart such that stimulation pulses in a single heartbeat cycle are respectively first delivered to the first ventricle and then to the second ventricle. Capture or loss of capture in response to stimulation pulses delivered to one ventricle is detected. As a result of a detected loss of capture, preventative measures are taken for preventing loss of capture in the other ventricle.
摘要翻译：在双心室心脏刺激器和用于控制这种双心室心脏刺激器的方法中，连续的刺激脉冲被递送到心脏的心室，使得单个心跳周期中的刺激脉冲分别首先被传送到第一脑室，然后被传送到第二脑室。检测到响应于输送到一个脑室的刺激脉冲的捕获或丢失。由于检测到的捕获损失，采取预防措施来防止在另一脑室中的捕获损失。

10. 发明授权

US07403813B1 Systems and methods for detection of VT and VF from remote sensing electrodes 有权
公开(公告)号：US07403813B1
公开(公告)日：2008-07-22
申请号：US10998026
申请日：2004-11-24
申请人： Taraneh Ghaffari Farazi , Gene A. Bornzin , Anders Bjorling , Yelena Nabutovsky , Kjell Noren
发明人： Taraneh Ghaffari Farazi , Gene A. Bornzin , Anders Bjorling , Yelena Nabutovsky , Kjell Noren
IPC分类号： A61B5/0468
CPC分类号： A61B5/0468 , A61N1/3621 , A61N1/36535 , A61N1/36542 , A61N1/36564
摘要： Methods and systems are provided for performing ventricular arrhythmia monitoring using at least two sensing channels that are each associated with different sensing vectors, for example by different pairs of extracardiac remote sensing electrodes. Myopotential associated with each of the sensing channels in monitored, and a ventricular arrhythmia monitoring mode is selected based thereon (e.g., based on determined myopotential levels). Ventricular arrhythmia monitoring is then performed using the selected monitoring mode. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.

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