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1. 发明授权

US08504153B2 System and method for estimating cardiac pressure based on cardiac electrical conduction delays using an implantable medical device 有权
公开(公告)号：US08504153B2
公开(公告)日：2013-08-06
申请号：US11779380
申请日：2007-07-18
申请人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
发明人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
IPC分类号： A61N1/365
CPC分类号： A61B5/02156 , A61B5/0215 , A61B5/72 , A61N1/365 , A61N1/36564 , A61N1/36578 , A61N1/3682 , A61N1/3684 , A61N1/37258
摘要： Techniques are provided for estimating left atrial pressure (LAP) or other cardiac performance parameters based on measured conduction delays. In particular, LAP is estimated based interventricular conduction delays. Predetermined conversion factors stored within the device are used to convert the various the conduction delays into LAP values or other appropriate cardiac performance parameters. The conversion factors may be, for example, slope and baseline values derived during an initial calibration procedure performed by an external system, such as an external programmer. In some examples, the slope and baseline values may be periodically re-calibrated by the implantable device itself. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP or other cardiac performance parameters. Still further, techniques are described for estimating conduction delays based on impedance or admittance values and for tracking heart failure therefrom.

2. 发明申请

US20090287267A1 System and Method for Estimating Cardiac Pressure Based on Cardiac Electrical Conduction Delays Using an Implantable Medical Device 有权
标题翻译：使用可植入医疗器械的基于心电导通延迟的估计心脏压力的系统和方法
公开(公告)号：US20090287267A1
公开(公告)日：2009-11-19
申请号：US11779380
申请日：2007-07-18
申请人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
发明人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
IPC分类号： A61N1/36
CPC分类号： A61B5/02156 , A61B5/0215 , A61B5/72 , A61N1/365 , A61N1/36564 , A61N1/36578 , A61N1/3682 , A61N1/3684 , A61N1/37258
摘要： Techniques are provided for estimating left atrial pressure (LAP) or other cardiac performance parameters based on measured conduction delays. In particular, LAP is estimated based interventricular conduction delays. Predetermined conversion factors stored within the device are used to convert the various the conduction delays into LAP values or other appropriate cardiac performance parameters. The conversion factors may be, for example, slope and baseline values derived during an initial calibration procedure performed by an external system, such as an external programmer. In some examples, the slope and baseline values may be periodically re-calibrated by the implantable device itself. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP or other cardiac performance parameters. Still further, techniques are described for estimating conduction delays based on impedance or admittance values and for tracking heart failure therefrom.
摘要翻译：提供了基于测量的传导延迟来估计左心房压力（LAP）或其他心脏性能参数的技术。特别地，LAP是基于室间传导延迟估计的。存储在装置内的预定转换因子用于将各种导通延迟转换为LAP值或其他适当的心脏性能参数。转换因子可以是例如由外部系统（诸如外部编程器）执行的初始校准过程期间导出的斜率和基线值。在一些示例中，可以通过可植入装置本身周期性地重新校准斜率和基线值。还描述了基于估计的LAP或其他心脏性能参数自适应地调整起搏参数的技术。此外，描述了用于基于阻抗或导纳值估计导通延迟并用于跟踪其心力衰竭的技术。

3. 发明申请

US20090018597A1 System and Method for Estimating Cardiac Pressure Based on Cardiac Electrical Conduction Delays Using an Implantable Medical Device 有权
公开(公告)号：US20090018597A1
公开(公告)日：2009-01-15
申请号：US11779350
申请日：2007-07-18
申请人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
发明人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
IPC分类号： A61N1/36
CPC分类号： A61B5/02156 , A61B5/0215 , A61B5/72 , A61N1/365 , A61N1/36564 , A61N1/36578 , A61N1/3682 , A61N1/3684 , A61N1/37258
摘要： Techniques are provided for estimating left atrial pressure (LAP) or other cardiac performance parameters based on measured conduction delays. In particular, LAP is estimated based interventricular conduction delays. Predetermined conversion factors stored within the device are used to convert the various the conduction delays into LAP values or other appropriate cardiac performance parameters. The conversion factors may be, for example, slope and baseline values derived during an initial calibration procedure performed by an external system, such as an external programmer. In some examples, the slope and baseline values may be periodically re-calibrated by the implantable device itself. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP or other cardiac performance parameters. Still further, techniques are described for estimating conduction delays based on impedance or admittance values and for tracking heart failure therefrom.

4. 发明授权

US08504152B2 System and method for estimating cardiac pressure based on cardiac electrical conduction delays using an implantable medical device 有权
公开(公告)号：US08504152B2
公开(公告)日：2013-08-06
申请号：US11779350
申请日：2007-07-18
申请人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
发明人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
IPC分类号： A61N1/365
CPC分类号： A61B5/02156 , A61B5/0215 , A61B5/72 , A61N1/365 , A61N1/36564 , A61N1/36578 , A61N1/3682 , A61N1/3684 , A61N1/37258
摘要： Techniques are provided for estimating left atrial pressure (LAP) or other cardiac performance parameters based on measured conduction delays. In particular, LAP is estimated based interventricular conduction delays. Predetermined conversion factors stored within the device are used to convert the various the conduction delays into LAP values or other appropriate cardiac performance parameters. The conversion factors may be, for example, slope and baseline values derived during an initial calibration procedure performed by an external system, such as an external programmer. In some examples, the slope and baseline values may be periodically re-calibrated by the implantable device itself. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP or other cardiac performance parameters. Still further, techniques are described for estimating conduction delays based on impedance or admittance values and for tracking heart failure therefrom.

5. 发明授权

US07546161B1 Methods for loss of capture and fusion avoidance in biventricular pacing therapy 有权
标题翻译：双心室起搏治疗中捕获和融合避免的方法
公开(公告)号：US07546161B1
公开(公告)日：2009-06-09
申请号：US11330316
申请日：2006-01-11
申请人： Anders Bjorling , Xiaoyi Min , Richard Williamson , Karin Jarverud , Nils Holmstrom
发明人： Anders Bjorling , Xiaoyi Min , Richard Williamson , Karin Jarverud , Nils Holmstrom
IPC分类号： A61N1/368
CPC分类号： A61N1/3712 , A61B5/0452 , A61N1/3684
摘要： An exemplary method includes delivering biventricular pacing therapy using one or more timing parameters, detecting loss of capture, deciding if fusion exists without adjusting the one or more timing parameters and, based on the deciding, calling for fusion avoidance or calling for a capture threshold search. Various other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：一种示例性方法包括使用一个或多个定时参数提供双心室起搏治疗，检测捕获的丢失，确定融合是否存在而不调整一个或多个定时参数，以及基于决定呼叫融合避免或调用捕获阈值搜索。还公开了各种其它示例性方法，装置，系统等。

6. 发明授权

US08750981B2 Systems and methods for assessing heart failure and controlling cardiac resynchronization therapy using hybrid impedance measurement configurations 有权
标题翻译：用于评估心力衰竭并使用混合阻抗测量配置控制心脏再同步治疗的系统和方法
公开(公告)号：US08750981B2
公开(公告)日：2014-06-10
申请号：US13217554
申请日：2011-08-25
申请人： Gene A. Bornzin , Xiaoyi Min , Laurence S. Sloman , Steve Koh
发明人： Gene A. Bornzin , Xiaoyi Min , Laurence S. Sloman , Steve Koh
IPC分类号： A61B5/05 , A61B5/053 , A61N1/36 , A61N1/368 , A61B5/0205
CPC分类号： A61B5/053 , A61B5/0205 , A61B5/0538 , A61B5/686 , A61N1/36185 , A61N1/3627 , A61N1/3686
摘要： Techniques are provided for use with an implantable medical device for detecting and assessing heart failure and for controlling cardiac resynchronization therapy (CRT) based on impedance signals obtained using hybrid impedance configurations. The hybrid configurations exploit right atrial (RA)-based impedance measurement vectors and/or left ventricular (LV)-based impedance measurement vectors. In one example, current is injected between the device case and a ring electrode in the right ventricle (RV) or RA. RA-based impedance values are measured along vectors between the device case and an RA electrode. LV-based impedance values are measured along vectors between the device case and one or more electrodes of the LV. Heart failure and other cardiac conditions are detected and tracked using the measured impedance values. CRT delay parameters are also optimized based impedance. In this manner, multiple hybrid impedance measurement configurations are exploited whereby different vectors are used to inject current and measure impedance.
摘要翻译：提供技术用于可植入医疗装置，用于基于使用混合阻抗配置获得的阻抗信号来检测和评估心力衰竭并用于控制心脏再同步治疗（CRT）。混合配置利用基于右心房（RA）的阻抗测量向量和/或左心室（LV））的阻抗测量向量。在一个示例中，电流注入到装置壳体和右心室（RV）或RA中的环形电极之间。基于RA的阻抗值是沿器件壳体和RA电极之间的矢量测量的。基于LV的阻抗值在器件壳体和LV的一个或多个电极之间的矢量上测量。使用测量的阻抗值检测和跟踪心力衰竭和其他心脏状况。 CRT延迟参数也是基于阻抗的优化。以这种方式，利用多个混合阻抗测量配置，由此使用不同的矢量来注入电流并测量阻抗。

7. 发明申请

US20140039238A1 SYSTEMS AND METHODS FOR CONTROLLING NEUROSTIMULATION OF ACUPUNCTURE SITES USING AN IMPLANTABLE CARDIAC RHYTHM MANAGEMENT DEVICE 有权
标题翻译：使用可植入式心脏管理装置控制针刺部位神经细胞的系统和方法
公开(公告)号：US20140039238A1
公开(公告)日：2014-02-06
申请号：US13563417
申请日：2012-07-31
申请人： Xiaoyi Min , Stuart Rosenberg , Taraneh Ghaffari Farazi , Timothy A. Fayram
发明人： Xiaoyi Min , Stuart Rosenberg , Taraneh Ghaffari Farazi , Timothy A. Fayram
IPC分类号： A61N1/365 , A61N2/00 , A61F7/00 , A61N1/39
CPC分类号： A61N1/36139 , A61B5/0215 , A61B5/042 , A61B5/0538 , A61B5/14532 , A61B5/4818 , A61B5/4836 , A61F7/00 , A61H39/002 , A61H39/06 , A61H2201/5002 , A61H2230/045 , A61H2230/305 , A61N1/3606 , A61N1/36114 , A61N1/36117 , A61N1/3621 , A61N1/3627 , A61N1/3962 , A61N2/02
摘要： Techniques are provided for use with an implantable cardiac rhythm management (CRMD) system equipped to deliver neurostimulation to acupuncture sites within anterior regions of the neck, thorax or abdomen of the patient. Parameters associated with the health of the patient are detected, such as parameters indicative of arrhythmia, heart failure and hypertension.
摘要翻译：技术提供用于与植入式心律管理（CRMD）系统一起使用，该系统被配备用于向患者的颈部，胸部或腹部前区域内的针灸位置递送神经刺激。检测与患者健康有关的参数，例如指示心律失常，心力衰竭和高血压的参数。

8. 发明授权

US08600520B2 Implantable lead assembly having a plurality of inductors 有权
标题翻译：具有多个电感器的可植入引线组件
公开(公告)号：US08600520B2
公开(公告)日：2013-12-03
申请号：US13449897
申请日：2012-04-18
申请人： Phong D. Doan , Xiaoyi Min , Virote Indravudh
发明人： Phong D. Doan , Xiaoyi Min , Virote Indravudh
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/086 , A61N1/3605 , A61N1/362 , H01F5/02 , H01F2005/025 , Y10T29/49002 , Y10T29/49071
摘要： In accordance with an embodiment, an implantable lead assembly is provided comprised of an elongated body including a distal end, a proximal end having a header connector portion for coupling the elongated body with an implantable medical device, and an intermediate segment located between the distal and proximal ends. An intermediate electrode is disposed at the intermediate segment along the elongated body. A conductor is disposed in the elongated body and electrically coupled with the header connector portion and the intermediate electrode. The conductor wound within the intermediate segment to form first and second inductive coils that are axially separated from each other by an inter-coil gap, wherein the first and second inductive coils have different self-resonant frequencies.
摘要翻译：根据一个实施例，提供一种可植入引线组件，其包括细长主体，其包括远端，近端具有用于将细长主体与可植入医疗装置连接的插头连接器部分，以及位于远端和近端中间电极沿着细长体设置在中间部分。导体设置在细长主体中并与插头连接器部分和中间电极电耦合。导体缠绕在中间段内以形成通过线圈间隙彼此轴向分离的第一和第二感应线圈，其中第一和第二感应线圈具有不同的自谐振频率。

9. 发明申请

US20130123876A1 SYSTEMS AND METHODS FOR DETERMINING INDUCTANCE AND CAPACITANCE VALUES FOR USE WITH LC FILTERS WITHIN IMPLANTABLE MEDICAL DEVICE LEADS TO REDUCE LEAD HEATING DURING MRI 有权
标题翻译：用于确定电导率和电容值的系统和方法，用于在可植入医疗器械中使用LC过滤器，在MRI期间减少引线加热
公开(公告)号：US20130123876A1
公开(公告)日：2013-05-16
申请号：US11955268
申请日：2007-12-12
申请人： Xiaoyi Min
发明人： Xiaoyi Min
IPC分类号： A61N1/375
CPC分类号： A61N1/056 , A61N1/086 , A61N1/3718 , G01R33/3685
摘要： Techniques are provided for configuring filters for reducing heating within pacing/sensing leads of a pacemaker or implantable cardioverter-defibrillator that might occur due to induced currents during a magnetic resonance imaging (MRI) procedure or in the presence of other sources of strong radio frequency (RF) fields. In particular, techniques are provided for selecting inductors and capacitors for use in LC filters while taking into account the tolerances of the component devices, as well as the target impedance of the components and the particular RF frequencies to be filtered.
摘要翻译：提供了用于配置用于减少起搏器或植入式心律转复除颤器的起搏/感测引线内的加热的技术，其可能由于在磁共振成像（MRI）程序期间的感应电流或其它强射频源的存在而发生 RF）字段。特别地，提供了用于选择用于LC滤波器的电感器和电容器的技术，同时考虑到组件装置的公差以及组件的目标阻抗和要滤波的特定RF频率。

10. 发明申请

US20130110127A1 MULTI-PIECE DUAL-CHAMBER LEADLESS INTRA-CARDIAC MEDICAL DEVICE AND METHOD OF IMPLANTING SAME 有权
公开(公告)号：US20130110127A1
公开(公告)日：2013-05-02
申请号：US13352005
申请日：2012-01-17
申请人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Xiaoyi Min
发明人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Xiaoyi Min
IPC分类号： A61N1/05 , A61B19/00
CPC分类号： A61N1/059 , A61N1/0573 , A61N1/36521 , A61N1/37288 , A61N1/3756
摘要： A leadless intra-cardiac medical device (LIMD) includes an electrode assembly configured to be anchored within a first wall portion of a first chamber of a heart. The electrode assembly includes an electrode main body having a first securing helix, an electrode wire segment extending from the body, and a first segment-terminating contact positioned on the electrode wire segment. The device further includes a housing assembly configured to be anchored within a second wall portion of a second chamber of the heart. The housing assembly includes a body having a second securing helix, a housing wire segment extending from the body, and a second segment-terminating contact positioned on the housing wire segment. The device also includes a connector block that electrically connects the electrode wire segment to the housing wire segment by retaining the first and second segment-terminating contacts.

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