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1. 发明授权

US09439986B2 Tricarbonyl technetium-99m, rhenium-185/187, or rhenium-188 labeled cyclic RGD derivatives and uses thereof 有权
标题翻译：三羰基锝-99m，铼-185 / 187或铼-188标记的环状RGD衍生物及其用途
公开(公告)号：US09439986B2
公开(公告)日：2016-09-13
申请号：US13699511
申请日：2011-05-24
申请人： Byung Chul Lee , Sang Eun Kim , Ji Sun Kim , Byung Seok Moon , Jae Ho Jung
发明人： Byung Chul Lee , Sang Eun Kim , Ji Sun Kim , Byung Seok Moon , Jae Ho Jung
IPC分类号： A61K51/00 , A61M36/14 , A61K51/08 , C07K7/64 , G01N33/574 , G01N33/60
CPC分类号： A61K51/088 , A61K51/082 , C07D273/06 , C07D498/06 , C07D498/16 , C07K7/64 , G01N33/574 , G01N33/60
摘要： The present invention relates to tricarbonyl technetium-99m or rhenium-188 labeled cyclic RGD derivatives, a preparation method thereof, and a pharmaceutical composition containing the derivative as an active ingredient for use in the diagnosis or treatment (radiotherapy) of angiogenesis-related diseases. The tricarbonyl technetium-99m or rhenium-188 labeled cyclic RGD derivatives of the present invention has a high subnanomolar affinity to integrin αvβ3 (also called as a vitronectin receptor) that is activated in an angiogenic action induced by a tumor, and acts exclusively upon cancer cells having selectively activated integrin αvβ3 because of a substantially low intake into the liver and intestines.
摘要翻译：本发明涉及三羰基锝-99m或铼-188标记的环状RGD衍生物，其制备方法和含有该衍生物作为血管生成相关疾病的诊断或治疗（放射治疗）的有效成分的药物组合物。本发明的三羰基锝-99m或铼-188标记的环状RGD衍生物在由肿瘤诱导的血管生成作用中被活化的整联蛋白αvβ3（也称为玻连蛋白受体）具有高的亚纳摩尔亲和力，并且仅起作用于癌症由于肝和肠的摄入量实质上较低，细胞选择性地激活整合素αvβ3。

2. 发明申请

US20130064766A1 TRICARBONYL TECHNETIUM-99m OR RHENIUM-188 LABELED CYCLIC RGD DERIVATIVES, A PREPARATION METHOD THEREOF, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVES AS AN ACTIVE INGREDIENT FOR USE IN THE DIAGNOSIS OR TREATMENT OF ANGIOGENESIS-RELATED DISEASES 有权
标题翻译：三溴联苯技术-99m或RHENIUM-188标记循环RGD衍生物及其制备方法，以及含有衍生物作为活性成分的药物组合物用于诊断或治疗血管发生相关性疾病
公开(公告)号：US20130064766A1
公开(公告)日：2013-03-14
申请号：US13699511
申请日：2011-05-24
申请人： Byung Chul Lee , Sang Eun Kim , Ji Sun Kim , Byung Seok Moon , Jae Ho Jung
发明人： Byung Chul Lee , Sang Eun Kim , Ji Sun Kim , Byung Seok Moon , Jae Ho Jung
IPC分类号： A61K51/08 , C07K1/13 , A61P9/00 , C07K7/64
CPC分类号： A61K51/088 , A61K51/082 , C07D273/06 , C07D498/06 , C07D498/16 , C07K7/64 , G01N33/574 , G01N33/60
摘要： The present invention relates to tricarbonyl technetium-99m or rhenium-188 labeled cyclic RGD derivatives, a preparation method thereof, and a pharmaceutical composition containing the derivative as an active ingredient for use in the diagnosis or treatment (radiotherapy) of angiogenesis-related diseases. The tricarbonyl technetium-99m or rhenium-188 labeled cyclic RGD derivatives of the present invention has a high subnanomolar affinity to integrin αvβ3 (also called as a vitronectin receptor) that is activated in an angiogenic action induced by a tumor, reflects a high tumor image of the tricatvonyl technetium-99m labeled cyclic RGD derivative after initial intake in an animal in which cancer cells are transplanted, and acts exclusively upon cancer cells having selectively activated integrin αvβ3 because of a substantially low intake into the liver and intestines, compared to existing known radioactive isotope labeled cyclic RGD derivatives. These results show that the rhenium-188 labeled derivative, a therapeutic nuclide using the same precursor as used in the technetium-99m labeling, effectively inhibits the growth of a tumor and demonstrates therapeutic efficacy when administered via tail vein injection to an animal model bearing tumor, compared to a case where only saline has been injected, thereby making it useful as a medicine for the diagnosis or treatment of angiogenesis-related diseases.
摘要翻译：本发明涉及三羰基锝-99m或铼-188标记的环状RGD衍生物，其制备方法和含有该衍生物作为血管生成相关疾病的诊断或治疗（放射治疗）的有效成分的药物组合物。本发明的三羰基锝-99m或铼-188标记的环状RGD衍生物在由肿瘤诱导的血管生成作用中被激活的整联蛋白αv＆bgr 3（也称为玻连蛋白受体）具有高亚纳摩尔亲和力，反映了高在移植了癌细胞的动物中，首先摄入三氯乙酰锝-99m标记的环状RGD衍生物的肿瘤图像，并且完全作用于具有选择性活化整联蛋白αv＆bgr3的癌细胞，因为进入肝脏和肠的摄入量很低，与现有已知的放射性同位素标记的环状RGD衍生物相比。这些结果表明，使用与锝-99m标记中使用的相同前体的治疗性核素的铼-188标记的衍生物有效地抑制肿瘤的生长，并且当通过尾静脉注射施用于携带肿瘤的动物模型时显示出治疗功效，与仅注射盐水的情况相比，可以用作诊断或治疗血管发生相关疾病的药物。

3. 发明申请

US20110250136A1 FLUORINATED BENZOTHIAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND IMAGING AGENT FOR DIAGNOSING ALTZHEIMER'S DISEASE USING THE SAME 审中-公开
标题翻译：氟化苯并噻唑衍生物，其制备方法及使用其诊断阿尔茨海默病的成像剂
公开(公告)号：US20110250136A1
公开(公告)日：2011-10-13
申请号：US13127696
申请日：2008-11-06
申请人： Sang Eun Kim , Byung Chul Lee , Ji Sun Kim , Young Sin Chun
发明人： Sang Eun Kim , Byung Chul Lee , Ji Sun Kim , Young Sin Chun
IPC分类号： A61K51/04 , C07D277/62
CPC分类号： C07D277/66 , A61K51/0453 , C07B59/002
摘要： The present invention relates to fluorinated benzothiazole derivatives, a preparation method thereof, and an imaging agent for diagnosing Alzheimer's disease using the same, and more particularly to fluorinated benzothiazole derivatives represented by Chemical Formula 1, derivatives of Chemical Formula 2 as a starting material for preparation thereof, a preparation method thereof, and an imaging agent for diagnosing Alzheimer's disease using fluorinated benzothiazole derivatives with a strong binding force to beta-amyloid plaque, which is a kind of biomarker for Alzheimer's disease. According to the present invention, fluorine-labeled benzothiazole derivatives, which have been difficult to synthesize by conventional methods, may be obtained by simple processes and the thus-obtained benzothiazole derivatives may be useful in diagnosing the presence and severity of Alzheimer's disease.
摘要翻译：本发明涉及氟化苯并噻唑衍生物，其制备方法和用于诊断阿尔茨海默氏病的显像剂，更具体地涉及化学式1所示的氟化苯并噻唑衍生物，作为制备原料的化学式2的衍生物其制备方法和用于使用对β-淀粉样蛋白斑具有强结合力的氟化苯并噻唑衍生物来诊断阿尔茨海默病的成像剂，其是阿尔茨海默氏病的一种生物标志物。根据本发明，通过常规方法难以合成的氟标记的苯并噻唑衍生物可以通过简单的方法获得，因此得到的苯并噻唑衍生物可用于诊断阿尔茨海默氏病的存在和严重性。

4. 发明申请

US20120242370A1 INVERTER, NAND GATE, AND NOR GATE 失效
标题翻译：逆变器，NAND门和NOR门
公开(公告)号：US20120242370A1
公开(公告)日：2012-09-27
申请号：US13355479
申请日：2012-01-20
申请人： Sang Hee Park , Chi Sun Hwang , Sung Min Yoon , Him Chan Oh , Kee Chan Park , Tao Ren , Hong Kyun Leem , Min Woo Oh , Ji Sun Kim , Jae Eun Pi , Byeong Hoon Kim , Byoung Gon Yu
发明人： Sang Hee Park , Chi Sun Hwang , Sung Min Yoon , Him Chan Oh , Kee Chan Park , Tao Ren , Hong Kyun Leem , Min Woo Oh , Ji Sun Kim , Jae Eun Pi , Byeong Hoon Kim , Byoung Gon Yu
IPC分类号： H03K19/094
CPC分类号： H03K3/012 , H03K19/094 , H03K19/20
摘要： Disclosed are an inverter, a NAND gate, and a NOR gate. The inverter includes: a pull-up unit constituted by a second thin film transistor outputting a first power voltage to an output terminal according to a voltage applied to a gate; a pull-down unit constituted by a fifth thin film transistor outputting a ground voltage to the output terminal according to an input signal applied to a gate; and a pull-up driver applying a second power voltage or the ground voltage to the gate of the second thin film transistor according to the input signal.
摘要翻译：公开了一种逆变器，NAND门和NOR门。逆变器包括：上拉单元，由根据施加到栅极的电压向输出端子输出第一电源电压的第二薄膜晶体管构成; 根据施加到门的输入信号，将由接地电压输出到输出端的第五薄膜晶体管构成的下拉单元; 以及根据输入信号将第二电源电压或接地电压施加到第二薄膜晶体管的栅极的上拉驱动器。

5. 发明授权

US08570066B2 Inverter, NAND gate, and NOR gate 失效
公开(公告)号：US08570066B2
公开(公告)日：2013-10-29
申请号：US13355479
申请日：2012-01-20
申请人： Sang Hee Park , Chi Sun Hwang , Sung Min Yoon , Him Chan Oh , Kee Chan Park , Tao Ren , Hong Kyun Leem , Min Woo Oh , Ji Sun Kim , Jae Eun Pi , Byeong Hoon Kim , Byoung Gon Yu
发明人： Sang Hee Park , Chi Sun Hwang , Sung Min Yoon , Him Chan Oh , Kee Chan Park , Tao Ren , Hong Kyun Leem , Min Woo Oh , Ji Sun Kim , Jae Eun Pi , Byeong Hoon Kim , Byoung Gon Yu
IPC分类号： H03K19/0175 , H03K19/094
CPC分类号： H03K3/012 , H03K19/094 , H03K19/20
摘要： Disclosed are an inverter, a NAND gate, and a NOR gate. The inverter includes: a pull-up unit constituted by a second thin film transistor outputting a first power voltage to an output terminal according to a voltage applied to a gate; a pull-down unit constituted by a fifth thin film transistor outputting a ground voltage to the output terminal according to an input signal applied to a gate; and a pull-up driver applying a second power voltage or the ground voltage to the gate of the second thin film transistor according to the input signal.

6. 发明申请

US20120180136A1 CONTENT MANAGEMENT METHOD AND APPARATUS OF MOBILE TERMINAL 有权
标题翻译：移动终端的内容管理方法和设备
公开(公告)号：US20120180136A1
公开(公告)日：2012-07-12
申请号：US13345572
申请日：2012-01-06
申请人： Ji Hwan Song , Ji Sun Kim
发明人： Ji Hwan Song , Ji Sun Kim
IPC分类号： G06F17/30 , G06F15/16
CPC分类号： G06F17/30557 , H04L63/083 , H04W12/08
摘要： A contents management method and apparatus of a mobile terminal provides improved security of private contents. A contents management method of a mobile terminal includes establishing a connection to at least one external terminal. The method also includes segmenting a content stored in the mobile terminal into segments and sharing the content by distributing the segments to the terminals. The method further includes integrating the segments distributed to the terminals into the content when a content execution command is input. The method still further includes storing the integrated content and deleting the integrated content in the mobile terminal when at least one of the terminals is disconnected.
摘要翻译：移动终端的内容管理方法和装置提供了私有内容的改进的安全性。移动终端的内容管理方法包括建立至少一个外部终端的连接。该方法还包括将存储在移动终端中的内容分割成段并通过将段分配到终端来共享内容。该方法还包括当输入内容执行命令时将分发给终端的段集成到内容中。该方法还包括当终端中的至少一个被断开时，存储集成内容并将其移除到移动终端中。

7. 发明授权

US08510853B2 Content management method and apparatus of mobile terminal 有权
标题翻译：移动终端的内容管理方法和装置
公开(公告)号：US08510853B2
公开(公告)日：2013-08-13
申请号：US13345572
申请日：2012-01-06
申请人： Ji Hwan Song , Ji Sun Kim
发明人： Ji Hwan Song , Ji Sun Kim
IPC分类号： G06F21/00
CPC分类号： G06F17/30557 , H04L63/083 , H04W12/08
摘要： A contents management method and apparatus of a mobile terminal provides improved security of private contents. A contents management method of a mobile terminal includes establishing a connection to at least one external terminal. The method also includes segmenting a content stored in the mobile terminal into segments and sharing the content by distributing the segments to the terminals. The method further includes integrating the segments distributed to the terminals into the content when a content execution command is input. The method still further includes storing the integrated content and deleting the integrated content in the mobile terminal when at least one of the terminals is disconnected.
摘要翻译：移动终端的内容管理方法和装置提供了私有内容的改进的安全性。移动终端的内容管理方法包括建立至少一个外部终端的连接。该方法还包括将存储在移动终端中的内容分割成段并通过将段分配到终端来共享内容。该方法还包括当输入内容执行命令时将分发给终端的段集成到内容中。该方法还包括当终端中的至少一个被断开时，存储集成内容并将其移除到移动终端中。

8. 发明申请

US20120090682A1 Solar Cell and Manufacturing Method Thereof 审中-公开
标题翻译：太阳能电池及其制造方法
公开(公告)号：US20120090682A1
公开(公告)日：2012-04-19
申请号：US12906562
申请日：2010-10-18
申请人： Dong Joon Oh , Hae Seok Lee , Eun Joo Lee , Hyun Woo Lee , Jun Young Choi , Ji Myung Shim , Kyeong Yeon Cho , Ji Sun Kim
发明人： Dong Joon Oh , Hae Seok Lee , Eun Joo Lee , Hyun Woo Lee , Jun Young Choi , Ji Myung Shim , Kyeong Yeon Cho , Ji Sun Kim
IPC分类号： H01L31/0232 , H01L31/0236
CPC分类号： H01L31/1804 , H01L31/02363 , H01L31/035281 , H01L31/068 , Y02E10/547 , Y02P70/521
摘要： A solar cell and a manufacturing method thereof are provided. The method includes forming a microstructure including a texturing on the surface of a semiconductor substrate of a first conductive type, forming a plurality of nanostructures on the surface of the semiconductor substrate, forming an emitter layer by implanting impurities of a second conductive type opposite to the first conductive type in a front face of the semiconductor substrate, forming an anti-reflective coating (ARC) on the emitter layer, forming a front electrode passing through a portion of the ARC and being coupled to the emitter layer, and forming a back electrode on a rear face of the semiconductor substrate of the first conductive type, the rear face being opposite to the face on which the front electrode is formed. A dominant light-collecting characteristic can be approached by forming nanostructures on a semiconductor substrate of a solar cell.
摘要翻译：提供太阳能电池及其制造方法。该方法包括在第一导电类型的半导体衬底的表面上形成包括纹理的微结构，在半导体衬底的表面上形成多个纳米结构，通过注入与第二导电类型相反的第二导电类型的杂质形成发射极层在所述半导体衬底的正面中的第一导电类型，在所述发射极层上形成抗反射涂层（ARC），形成通过所述ARC的一部分并与所述发射极层耦合的前电极，以及形成背电极在第一导电类型的半导体衬底的背面上，后表面与形成前电极的面相对。可以通过在太阳能电池的半导体衬底上形成纳米结构来接近主要的聚光特性。

9. 发明申请

US20110277824A1 Solar Cell and Method of Manufacturing the Same 审中-公开
标题翻译：太阳能电池及其制造方法
公开(公告)号：US20110277824A1
公开(公告)日：2011-11-17
申请号：US13106103
申请日：2011-05-12
申请人： Hyun Woo Lee , Hae Seok Lee , Eun Joo Lee , Jun Young Choi , Dong Joon Oh , Ji Myung Shim , Kyeong Yeon Cho , Ji Sun Kim , Il Hwan Kim , Jung Eun Shin
发明人： Hyun Woo Lee , Hae Seok Lee , Eun Joo Lee , Jun Young Choi , Dong Joon Oh , Ji Myung Shim , Kyeong Yeon Cho , Ji Sun Kim , Il Hwan Kim , Jung Eun Shin
IPC分类号： H01L31/02 , H01L31/18
CPC分类号： H01L31/1888 , H01L31/022441 , H01L31/022491 , H01L31/02327 , H01L31/1804 , Y02E10/547 , Y02P70/521
摘要： Provided are a solar cell and a method of manufacturing the same. The method includes implanting impurities of a second conductivity type opposite to a first conductivity type into a front surface of a semiconductor substrate of the first conductivity type to form an emitter layer, forming a mask layer on the emitter layer, patterning the mask layer by coating etching paste on a portion of the mask layer where a front electrode will be formed, implanting high-concentration impurities into the portion of the mask layer where the front electrode will be formed to form a heavily doped region, removing the remaining mask layer, forming an anti-reflective coating (ARC) on the emitter layer, forming the front electrode on the front surface of the semiconductor substrate, and forming a rear electrode on a rear surface of the semiconductor substrate. In the method of manufacturing the solar cell, the patterning of the front surface of the semiconductor substrate includes directly coating a corrosive emulsion on the mask layer using a screen printing process instead of complicated photolithography and etching processes so that a desired pattern can be formed using a relatively simple process.
摘要翻译：提供一种太阳能电池及其制造方法。该方法包括将与第一导电类型相反的第二导电类型的杂质注入到第一导电类型的半导体衬底的前表面中以形成发射极层，在发射极层上形成掩模层，通过涂覆对掩模层进行图案化在形成前电极的掩模层的一部分上蚀刻浆料，将高浓度杂质注入到将形成前电极的掩模层的部分中以形成重掺杂区域，去除剩余的掩模层，形成在发射极层上形成抗反射涂层（ARC），在半导体衬底的前表面上形成前电极，并在半导体衬底的后表面上形成后电极。在制造太阳能电池的方法中，半导体衬底的前表面的图案化包括使用丝网印刷工艺直接在掩模层上涂覆腐蚀性乳剂，而不是复杂的光刻和蚀刻工艺，从而可以使用一个比较简单的过程。

10. 发明申请

US20110061729A1 Solar Cell and Method of Manufacturing the Same 审中-公开
标题翻译：太阳能电池及其制造方法
公开(公告)号：US20110061729A1
公开(公告)日：2011-03-17
申请号：US12883812
申请日：2010-09-16
申请人： Hyun Woo Lee , Eun Joo Lee , Hae Seok Lee , Jun Young Choi , Dong Joon Oh , Ji Myung Shim , Kyeong Yeon Cho , Ji Sun Kim
发明人： Hyun Woo Lee , Eun Joo Lee , Hae Seok Lee , Jun Young Choi , Dong Joon Oh , Ji Myung Shim , Kyeong Yeon Cho , Ji Sun Kim
IPC分类号： H01L31/0216 , H01L31/18
CPC分类号： H01L31/068 , H01L31/02168 , H01L31/022425 , H01L31/1804 , Y02E10/547 , Y02P70/521
摘要： Provided are a solar cell and a method of manufacturing the same. The method includes implanting impurities of a second conductivity type opposite to a first conductivity type on the entire surface of a semiconductor substrate of the first conductivity type to form an emitter layer, forming a first anti-reflective coating (ARC) layer on the emitter layer, patterning a portion of the first anti-reflective coating (ARC) layer where a front electrode will be formed, forming a second anti-reflective coating (ARC) layer on the first anti-reflective coating (ARC) layer and the emitter layer, and forming the front electrode and a rear electrode on front and rear surfaces of the semiconductor substrate. In this method, a double structure of two anti-reflective coating (ARC) layers with different thicknesses may be formed to make electrode patterns distinct, thereby facilitating alignment of electrodes.
摘要翻译：提供一种太阳能电池及其制造方法。该方法包括在第一导电类型的半导体衬底的整个表面上植入与第一导电类型相反的第二导电类型的杂质以形成发射极层，在发射极层上形成第一抗反射涂层（ARC）层图案化形成前电极的第一抗反射涂层（ARC）层的一部分，在第一抗反射涂层（ARC）层和发射极层上形成第二抗反射涂层（ARC）层，以及在半导体衬底的前表面和后表面上形成前电极和后电极。在该方法中，可以形成具有不同厚度的两个抗反射涂层（ARC）层的双重结构，以使电极图案不同，从而有助于电极的对准。

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