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1. 发明申请

US20110129916A1 MONOCLONAL ANTIBODIES WITH SPECIFICITY FOR FETAL ERYTHROID CELLS 有权
标题翻译：具有特异性的胎牛血清细胞的单克隆抗体
公开(公告)号：US20110129916A1
公开(公告)日：2011-06-02
申请号：US12979535
申请日：2010-12-28
申请人： Christiane HOLLMANN , Silke Zimmermann , Stefan Stachelhaus , Winfried Albert
发明人： Christiane HOLLMANN , Silke Zimmermann , Stefan Stachelhaus , Winfried Albert
IPC分类号： C12N5/16 , C07K16/00 , C12N5/078
CPC分类号： G01N33/56966 , C07K16/28 , C07K2317/14 , G01N33/5094 , G01N33/577 , G01N33/80 , G01N2333/70582 , G01N2469/10 , Y10T436/25125 , Y10T436/25375
摘要： The present invention concerns a monoclonal antibody and corresponding hybridoma cells and antigens suitable for isolating fetal cells from maternal blood. The inventive monoclonal antibody reacts with a surface antigen present on fetal red blood cells including their nucleated precursor cells, but not with surface antigens on adult erythroid cell.
摘要翻译：本发明涉及一种单克隆抗体和相应的杂交瘤细胞和适合于从母体血液中分离胎儿细胞的抗原。本发明的单克隆抗体与存在于胎儿红细胞上的表面抗原（包括其有核的前体细胞）反应，但与成体红细胞上的表面抗原不反应。

2. 发明授权

US08536312B2 Monoclonal antibodies with specificity for fetal erythroid cells 有权
公开(公告)号：US08536312B2
公开(公告)日：2013-09-17
申请号：US12979535
申请日：2010-12-28
申请人： Christiane Hollmann , Silke Zimmermann , Stefan Stachelhaus , Winfried Albert
发明人： Christiane Hollmann , Silke Zimmermann , Stefan Stachelhaus , Winfried Albert
IPC分类号： C12P21/08 , G01N33/53 , C12M3/00
CPC分类号： G01N33/56966 , C07K16/28 , C07K2317/14 , G01N33/5094 , G01N33/577 , G01N33/80 , G01N2333/70582 , G01N2469/10 , Y10T436/25125 , Y10T436/25375
摘要： The present invention concerns a monoclonal antibody and corresponding hybridoma cells and antigens suitable for isolating fetal cells from maternal blood. The inventive monoclonal antibody reacts with a surface antigen present on fetal red blood cells including their nucleated precursor cells, but not with surface antigens on adult erythroid cell.

3. 发明授权

US07858757B2 Monoclonal antibodies with specificity for fetal erythroid cells 有权
标题翻译：具有胎儿红细胞特异性的单克隆抗体
公开(公告)号：US07858757B2
公开(公告)日：2010-12-28
申请号：US10599512
申请日：2005-03-31
申请人： Christiane Hollmann , Silke Zimmermann , Stefan Stachelhaus , Winfried Albert
发明人： Christiane Hollmann , Silke Zimmermann , Stefan Stachelhaus , Winfried Albert
IPC分类号： C12P21/08 , G01N33/53 , C12M3/00
CPC分类号： G01N33/56966 , C07K16/28 , C07K2317/14 , G01N33/5094 , G01N33/577 , G01N33/80 , G01N2333/70582 , G01N2469/10 , Y10T436/25125 , Y10T436/25375
摘要： The present invention concerns a monoclonal antibody and corresponding hybridoma cells and antigens suitable for isolating fetal cells from maternal blood. The monoclonal antibody reacts with a surface antigen present on fetal red blood cells including their nucleated precursor cells, but not with surface antigens on adult erythroid cell.
摘要翻译：本发明涉及一种单克隆抗体和相应的杂交瘤细胞和适合于从母体血液中分离胎儿细胞的抗原。单克隆抗体与存在于胎儿红细胞上的表面抗原（包括它们的有核前体细胞）反应，而不与成体红细胞上的表面抗原反应。

4. 发明申请

US20070275418A1 Monoclonal Antibodies With Specificity For Fetal Erythroid Cells 有权
标题翻译：胎儿红细胞特异性单克隆抗体
公开(公告)号：US20070275418A1
公开(公告)日：2007-11-29
申请号：US10599512
申请日：2005-03-31
申请人： Christiane Hollmann , Silke Zimmermann , Stefan Stachelhaus , Winfried Albert
发明人： Christiane Hollmann , Silke Zimmermann , Stefan Stachelhaus , Winfried Albert
IPC分类号： C07K16/18 , C07K14/00 , C12N5/06 , G01N33/567
CPC分类号： G01N33/56966 , C07K16/28 , C07K2317/14 , G01N33/5094 , G01N33/577 , G01N33/80 , G01N2333/70582 , G01N2469/10 , Y10T436/25125 , Y10T436/25375
摘要： The present invention concerns a monoclonal antibody and corresponding hybridoma cells and antigens suitable for isolating fetal cells from maternal blood. The monoclonal antibody reacts with a surface antigen present on fetal red blood cells including their nucleated precursor cells, but not with surface antigens on adult erythroid cell.
摘要翻译：本发明涉及一种单克隆抗体和相应的杂交瘤细胞和适合于从母体血液中分离胎儿细胞的抗原。单克隆抗体与存在于胎儿红细胞上的表面抗原（包括它们的有核前体细胞）反应，而不与成体红细胞上的表面抗原反应。

5. 发明申请

US20070276161A1 Monoclonal Antibodies With Specificity For Fetal Erythroid Cells 失效
标题翻译：胎儿红细胞特异性单克隆抗体
公开(公告)号：US20070276161A1
公开(公告)日：2007-11-29
申请号：US11661544
申请日：2005-08-04
申请人： Christine Hollmann , Silke Zimmermann , Stefan Stachelhaus , Winfried Albert
发明人： Christine Hollmann , Silke Zimmermann , Stefan Stachelhaus , Winfried Albert
IPC分类号： C07C213/10 , C07C215/02
CPC分类号： C07C213/10 , C07C215/08
摘要： Methods for improving color properties of triethanolamine, and triethanolamine compositions treated thereby, are disclosed, wherein the methods comprise: (a) providing a composition comprising triethanolamine; and (b) contacting the composition with an acid component and a basic component; wherein the acid component comprises an acid selected from the group consisting of phosphorous acid, hypophosphorous acid and mixtures thereof; and wherein the basic component comprises a compound selected from the group consisting of alkali metal hydroxides, alkaline earth metal hydroxides, ammonium hydroxides according to general formula (I), and mixtures thereof: [R1R2R3(2-hydroxyethyl)ammonium]hydroxide (I) wherein R1, R2 and R3 each independently represents a C1-30 alkyl or a C2-10 hydroxyalkyl; with the proviso that where the basic component comprises an alkali metal hydroxide, the molar ratio of acid component:basic component is 1:0.1 to 1:1, and where the basic component comprises an alkaline earth metal hydroxide, the molar ratio of acid component:basic component is 1:0.05 to 1:0.5.
摘要翻译：公开了用于改善三乙醇胺的颜色特性和由此处理的三乙醇胺组合物的方法，其中所述方法包括：（a）提供包含三乙醇胺的组合物; 和（b）使组合物与酸组分和碱性组分接触; 其中所述酸组分包含选自亚磷酸，次磷酸及其混合物的酸; 并且其中所述碱性组分包括选自碱金属氢氧化物，碱土金属氢氧化物，根据通式（I）的氢氧化铵的化合物及其混合物：<？在线公式描述=“在线公式“end =”lead“？> [R 1] R 2 R 3（2-羟乙基）铵]氢氧化物（I） in-line-formula description =“In-line Formulas”end =“tail”？>其中R 1，R 2和R 3，各自独立地表示C 1〜30的烷基或C 2〜10 N个羟基烷基; 条件是碱性成分含有碱金属氢氧化物时，酸成分：碱成分的摩尔比为1:0.1〜1:1，碱性成分含有碱土金属氢氧化物时，酸成分基本成分为1:0.05〜1:0.5。

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