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1. 发明授权

US10586327B2 Method and apparatus for detecting cell reprogramming 有权
公开(公告)号：US10586327B2
公开(公告)日：2020-03-10
申请号：US15894945
申请日：2018-02-13
申请人： Chung Yuan Christian University , RIKEN
发明人： Yuan-Hsiang Chang , Hideo Yokota , Kuniya Abe , Ming-Dar Tsai
IPC分类号： G06K9/00 , G06T7/00 , G02B21/16 , G02B21/36 , G01N33/58 , G01N33/50 , G01N21/64 , G06T7/90
摘要： Disclosed herein are methods for identifying cells undergoing reprogramming and reprogrammed cells from a fluorescence microscopic image of one or more cells. According to some embodiments, the method includes an image processing step, a cell detection step, and, optionally, a clustering step.

2. 发明授权

US11138737B2 Method and apparatus for predicting cell reprogramming 有权
公开(公告)号：US11138737B2
公开(公告)日：2021-10-05
申请号：US16719905
申请日：2019-12-18
申请人： Chung Yuan Christian University , RIKEN
发明人： Hideo Yokota , Kuniya Abe , Ming-Dar Tsai , Slo-Li Chu , Yuan-Hsiang Chang
IPC分类号： G06K9/00 , G06T7/00 , G06T7/11 , G06T7/187 , G01N33/50 , G02B21/36
摘要： Disclosed herein are methods for predicting the reprogramming process of cells from a microscopic image of one or more cells. According to some embodiments, the method includes capturing an image of region of interest (ROI) of every pixel of the microscopic image, followed by processing the ROI image with a trained convolutional neural network (CNN) model and a trained long short-term memory (LSTM) network so as to obtain predicted probability maps. Also disclosed herein are a storage medium and a system for executing the present methods.

3. 发明申请

US20180232879A1 METHOD AND APPARATUS FOR DETECTING CELL REPROGRAMMING 审中-公开
公开(公告)号：US20180232879A1
公开(公告)日：2018-08-16
申请号：US15894945
申请日：2018-02-13
申请人： Chung Yuan Christian University , RIKEN
发明人： Yuan-Hsiang CHANG , Hideo Yokota , Kuniya Abe , Ming-Dar TSAI
IPC分类号： G06T7/00 , G06T7/90 , G06K9/00 , G02B21/16 , G02B21/36 , G01N33/58 , G01N33/50 , G01N21/64
CPC分类号： G06T7/0012 , G01N21/6408 , G01N21/6428 , G01N21/6458 , G01N21/6486 , G01N33/5005 , G01N33/582 , G01N2021/6441 , G02B21/16 , G02B21/367 , G06K9/0014 , G06K9/00147 , G06K9/342 , G06K9/4628 , G06K9/4638 , G06K9/6267 , G06T5/004 , G06T7/11 , G06T7/12 , G06T7/136 , G06T7/155 , G06T7/187 , G06T7/90 , G06T2207/10024 , G06T2207/10056 , G06T2207/10064 , G06T2207/20081 , G06T2207/20084 , G06T2207/30024
摘要： Disclosed herein are methods for identifying cells undergoing reprogramming and reprogrammed cells from a fluorescence microscopic image of one or more cells. According to some embodiments, the method includes an image processing step, a cell detection step, and, optionally, a clustering step.

4. 发明授权

US10423819B2 Method and apparatus for image processing and visualization for analyzing cell kinematics in cell culture 有权
公开(公告)号：US10423819B2
公开(公告)日：2019-09-24
申请号：US15800047
申请日：2017-10-31
申请人： Chung Yuan Christian University
发明人： Yuan-Hsiang Chang , Hideo Yokota , Kuniya Abe , Ming-Dar Tsai
IPC分类号： G06K9/00 , G01N15/02 , G06T7/00 , G06T7/207 , G06T7/60 , G06T7/35 , G06T7/55 , G06T7/11 , G01N15/14 , G01N15/00 , G01N15/10
摘要： Disclosed herein are methods for analyzing cell kinematics in a nucleated cell culture from a time-series sequence of multiple fluorescence microscopic images of the nucleated cell culture. The method includes the steps of, (a) identifying every cell nucleus in each fluorescence microscopic image; (b) identifying every cell cluster using the cell nuclei identified in the step (a); and (c) tracking the cells and/or cell clusters using the cell nuclei and cell clusters identified for the fluorescence microscopic images in steps (a) and (b) respectively.

5. 发明申请

US20190130161A1 METHOD AND APPARATUS FOR IMAGE PROCESSING AND VISUALIZATION FOR ANALYZING CELL KINEMATICS IN CELL CULTURE 审中-公开
公开(公告)号：US20190130161A1
公开(公告)日：2019-05-02
申请号：US15800047
申请日：2017-10-31
申请人： Chung Yuan Christian University
发明人： Yuan-Hsiang CHANG , Hideo Yokota , Kuniya Abe , Ming-Dar TSAI
IPC分类号： G06K9/00 , G01N15/14 , G01N15/02 , G06T7/00 , G06T7/207 , G06T7/60 , G06T7/35 , G06T7/55 , G06T7/11
CPC分类号： G06K9/00127 , G01N15/02 , G01N15/1468 , G01N15/1475 , G01N2015/0003 , G01N2015/0065 , G01N2015/0092 , G01N2015/025 , G01N2015/1006 , G01N2015/1075 , G01N2015/1087 , G01N2015/1093 , G06T7/0002 , G06T7/11 , G06T7/207 , G06T7/35 , G06T7/55 , G06T7/60 , G06T2207/10056 , G06T2207/30024
摘要： Disclosed herein are methods for analyzing cell kinematics in a nucleated cell culture from a time-series sequence of multiple fluorescence microscopic images of the nucleated cell culture. The method includes the steps of, (a) identifying every cell nucleus in each fluorescence microscopic image; (b) identifying every cell cluster using the cell nuclei identified in the step (a); and (c) tracking the cells and/or cell clusters using the cell nuclei and cell clusters identified for the fluorescence microscopic images in steps (a) and (b) respectively.

6. 发明授权

US10765316B2 Ophthalmic information processing system, ophthalmic information processing method, and recording medium 有权
公开(公告)号：US10765316B2
公开(公告)日：2020-09-08
申请号：US15925922
申请日：2018-03-20
申请人： TOPCON CORPORATION , TOHOKU UNIVERSITY , RIKEN
发明人： Guangzhou An , Masahiro Akiba , Toru Nakazawa , Kazuko Omodaka , Hideo Yokota
IPC分类号： A61B3/14 , A61B3/00 , A61B3/10 , A61B3/12 , G06T7/00
摘要： An ophthalmic information processing system according to an embodiment includes a receiver and a processor. The receiver receives morphological data of an eye fundus of a subject. In addition, the receiver receives background data of the subject. The processor executes optic nerve head shape classification based on the morphological data and the background data received by the receiver.

7. 发明授权

US11361443B2 Identifying device, learning device, method, and storage medium 有权
公开(公告)号：US11361443B2
公开(公告)日：2022-06-14
申请号：US16877678
申请日：2020-05-19
申请人： RIKEN , National University Corporation Tokai National Higher Education and Research System
发明人： Taiki Furukawa , Hideo Yokota , Shintaro Oyama , Yoshinori Hasegawa , Yoshimune Shiratori
IPC分类号： G06T7/00 , G06T7/11 , G06K9/62
摘要： An aspect of the present invention allows for more accurately identifying a possible lesion in a human lung field. The aspect of the present invention includes an image obtaining section configured to obtain a chest cross-sectional image of a subject, a segmentation section configured to classify, into a plurality of segments, unit elements of the chest cross-sectional image, and an image dividing section configured to divide the chest cross-sectional image into a plurality of regions. A data deriving section is configured to derive data associated with the possible lesion, the data being derived on the basis of a segment of unit elements in the each region among the plurality of segments. An identifying section is configured to output an identification result, which is a result of identification of the possible lesion in the lung field of the subject.

8. 发明授权

US11493887B2 Radiation shield and optical lattice clock including radiation shield 有权
公开(公告)号：US11493887B2
公开(公告)日：2022-11-08
申请号：US16251619
申请日：2019-01-18
申请人： RIKEN
发明人： Hidetoshi Katori , Masao Takamoto , Ichiro Ushijima , Takehiro Tawara , Hideo Yokota
IPC分类号： G04F5/14 , G02B5/20 , H03L7/26
摘要： Provided according to an embodiment of the present disclosure is a radiation shield 10 including a shield wall surrounding a hollow region capable of accommodating therein atoms for an optical lattice clock 100, the shield wall having, provided therein, at least two apertures communicating with outside. A geometrical shape of an inner wall surface of the shield wall is configured such that a difference between BBR shifts found under two conditions does not exceed a predetermined value over a range of position of atoms, the BBR shifts being caused in atoms 2 by emitted radiation emitted by the inner wall surface, incoming radiation leaking in from the outside through the apertures, and a reflection component of the emitted radiation and incoming radiation at the inner wall surface, the two conditions being a condition where the inner wall surface exhibits mirror reflection and a condition where the inner wall surface exhibits diffuse reflection, the range being where clock transition operation is carried out in the optical lattice clock, the inner wall surface facing the hollow region. Provided according to other embodiments of the present disclosure also are the optical lattice clock 100 including such a radiation shield, and a design method for the radiation shield.

9. 发明授权

US11204243B2 Point cloud data extraction method and point cloud data extraction device 有权
公开(公告)号：US11204243B2
公开(公告)日：2021-12-21
申请号：US16461160
申请日：2018-02-28
申请人： RIKEN , TOPCON CORPORATION
发明人： Shin Yoshizawa , Hideo Yokota , Suguru Miyagawa
IPC分类号： G01B21/30 , G01B11/30 , G01C7/04 , G01B21/00
摘要： Target point cloud data about a specific road are extracted from perimeter point cloud data acquired by moving a road surface measurement device along a measurement route and scanning the surroundings thereof. A data storage unit stores trajectory point sequence data that represent, as a plurality of trajectory points, the perimeter point cloud data and a trajectory of the movement of the road surface measurement device. A trajectory point sequence setting unit acquires a trajectory point sequence at equal intervals from the trajectory point sequence data. An extraction area setting unit sets, as extraction areas, a column area Ci and a parallelepiped area Hi that are geometric areas disposed at predetermined positions below a trajectory point Xi. An approximate nearest neighbor search processing unit and an extraction processing unit extract, as the target point cloud data, point data that belong to this extraction area of the perimeter point cloud data.

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